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Conserved domains on  [gi|78711846|ref|NP_731853|]
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arginine phosphatase [Drosophila melanogaster]

Protein Classification

low molecular weight protein-tyrosine-phosphatase( domain architecture ID 11611401)

low molecular weight protein-tyrosine-phosphatase is a small soluble single-domain enzyme that catalyzes the dephosphorylation of O-phosphotyrosine groups in phosphoproteins

EC:  3.1.3.48
Gene Ontology:  GO:0004725|GO:0006470
PubMed:  12678841|12882518|27676368
SCOP:  4000436

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LMWPTP cd16343
Low molecular weight protein tyrosine phosphatase; Low molecular weight protein tyrosine ...
 1-151 1.07e-61

Low molecular weight protein tyrosine phosphatase; Low molecular weight protein tyrosine phosphatases (LMW-PTP) are a family of small soluble single-domain enzymes that are characterized by a highly conserved active site motif (V/I)CXGNXCRS and share no sequence similarity with other types of protein tyrosine phosphatases (PTPs). LMW-PTPs play important roles in many biological processes and are widely distributed in prokaryotes and eukaryotes.


:

Pssm-ID: 319971  Cd Length: 147  Bit Score: 186.87  E-value: 1.07e-61
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78711846   1 MKVLFVCIGNTCRSPMAEAILKHLVVKRNLQDWYVDSAGLRSWNVGLEPQARGQQLLKQHGLK-TNHLGRMISAQDFYDF 79
Cdd:cd16343   1 KKILFVCLGNICRSPMAEAVLRHLLPKAGGDDVEVDSAGTSAWHGGEPPDPRARAVLKEHGIDlSGHRARQLTAEDFDEF 80

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 78711846  80 DYIFAMDNSNLLELEHMAAsltPSPTCKIQLLGSYIGRKEDEiIEDPYFiQGMGGFNAAYLQILESCERFLQ 151
Cdd:cd16343  81 DLILAMDESNLRDLRRLAP---AEARGKVFLLGDFDPEGGKD-VPDPYY-GGREGFEEVYDLIERACEGLLE 147
 
Name Accession Description Interval E-value
LMWPTP cd16343
Low molecular weight protein tyrosine phosphatase; Low molecular weight protein tyrosine ...
 1-151 1.07e-61

Low molecular weight protein tyrosine phosphatase; Low molecular weight protein tyrosine phosphatases (LMW-PTP) are a family of small soluble single-domain enzymes that are characterized by a highly conserved active site motif (V/I)CXGNXCRS and share no sequence similarity with other types of protein tyrosine phosphatases (PTPs). LMW-PTPs play important roles in many biological processes and are widely distributed in prokaryotes and eukaryotes.


Pssm-ID: 319971  Cd Length: 147  Bit Score: 186.87  E-value: 1.07e-61
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78711846   1 MKVLFVCIGNTCRSPMAEAILKHLVVKRNLQDWYVDSAGLRSWNVGLEPQARGQQLLKQHGLK-TNHLGRMISAQDFYDF 79
Cdd:cd16343   1 KKILFVCLGNICRSPMAEAVLRHLLPKAGGDDVEVDSAGTSAWHGGEPPDPRARAVLKEHGIDlSGHRARQLTAEDFDEF 80

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 78711846  80 DYIFAMDNSNLLELEHMAAsltPSPTCKIQLLGSYIGRKEDEiIEDPYFiQGMGGFNAAYLQILESCERFLQ 151
Cdd:cd16343  81 DLILAMDESNLRDLRRLAP---AEARGKVFLLGDFDPEGGKD-VPDPYY-GGREGFEEVYDLIERACEGLLE 147
LMWPc pfam01451
Low molecular weight phosphotyrosine protein phosphatase;
3-150 3.94e-39

Low molecular weight phosphotyrosine protein phosphatase;


Pssm-ID: 460216  Cd Length: 142  Bit Score: 129.80  E-value: 3.94e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78711846     3 VLFVCIGNTCRSPMAEAILKHLVVKRNLQD-WYVDSAGLRSWnVGLEPQARGQQLLKQHGLKTN-HLGRMISAQDFYDFD 80
Cdd:pfam01451   1 ILFVCTGNICRSPMAEAIFRRELEKAGLGDkVEVDSAGTGAW-PGNPADPRAVEVLKEHGIDLSgHYARQLSTEDFASFD 79

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78711846    81 YIFAMDNSNLLELEHMAASLTpspTCKIQLLGSYigrKEDEIIEDPYFiQGMGGFNAAYLQILESCERFL 150
Cdd:pfam01451  80 LILAMDSEHKRDLCPLAPERY---RAKVMLLGEY---GEQLDIPDPYY-GSIDAFEEVRDLIERRCRQLL 142
Wzb COG0394
Protein-tyrosine-phosphatase [Signal transduction mechanisms];
1-152 1.62e-36

Protein-tyrosine-phosphatase [Signal transduction mechanisms];


Pssm-ID: 440163  Cd Length: 137  Bit Score: 122.96  E-value: 1.62e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78711846   1 MKVLFVCIGNTCRSPMAEAILKHLVVKRnlqdWYVDSAGLRSwnvGLEPQARGQQLLKQHGLKT-NHLGRMISAQDFYDF 79
Cdd:COG0394   4 KRVLFVCTGNICRSPMAEALLRHLAGGR----VEVDSAGTEP---GGPVDPRAVAVLAERGIDLsGHRSRQLDEEDLPEF 76

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 78711846  80 DYIFAMDNSNLLELEHMAasltpsPTCKIQLLgsyigrkeDEIIEDPYFiQGMGGFNAAYLQILESCERFLQH 152
Cdd:COG0394  77 DLVITMCDSAAEELCPLF------PGAAKLLL--------HWDVPDPYY-GGLEAFREVRDEIERRIEALLAK 134
LMWPc smart00226
Low molecular weight phosphatase family;
3-150 1.08e-34

Low molecular weight phosphatase family;


Pssm-ID: 197586  Cd Length: 134  Bit Score: 117.96  E-value: 1.08e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78711846      3 VLFVCIGNTCRSPMAEAILKHLVVKRnlqdWYVDSAGLRSWnVGLEPQARGQQLLKQHGLKTNHLGRMISAQDFYDFDYI 82
Cdd:smart00226   1 ILFVCTGNICRSPMAEALFKAYVGDR----VKIDSAGTGAW-VGGGADPRAVKVLKEHGIDLSHHASQLTSSDFKNADLV 75

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 78711846     83 FAMDNSNLLELEHMaaslTPSPTCKIQLLGSYigrkedEIIEDPYFiQGMGGFNAAYLQILESCERFL 150
Cdd:smart00226  76 LAMDGSHLRNICRL----KPPSRAKVELFGHY------VDVDDPYY-GGIDGFERVYDELENALQEFL 132
PRK10126 PRK10126
low molecular weight protein-tyrosine-phosphatase Wzb;
2-156 1.96e-15

low molecular weight protein-tyrosine-phosphatase Wzb;


Pssm-ID: 182256  Cd Length: 147  Bit Score: 69.17  E-value: 1.96e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78711846    2 KVLFVCIGNTCRSPMAEAILkhlvvKRNLQDWYVDSAGLRSWnVGLEPQARGQQLLKQHGLK-TNHLGRMISAQDFYDFD 80
Cdd:PRK10126   4 NILVVCVGNICRSPTAERLL-----QRYHPELKVESAGLGAL-VGKGADPTAISVAAEHQLSlEGHCARQISRRLCRNYD 77

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 78711846   81 YIFAMDNSNLLELEHMAasltPSPTCKIQLLGSYIGRKEdeiIEDPYFiQGMGGFNAAYLQILESCERFLQHYKSD 156
Cdd:PRK10126  78 LILTMEKRHIERLCEMA----PEMRGKVMLFGHWDNECE---IPDPYR-KSREAFEAVYTLLERSARQWAQALNAE 145
 
Name Accession Description Interval E-value
LMWPTP cd16343
Low molecular weight protein tyrosine phosphatase; Low molecular weight protein tyrosine ...
 1-151 1.07e-61

Low molecular weight protein tyrosine phosphatase; Low molecular weight protein tyrosine phosphatases (LMW-PTP) are a family of small soluble single-domain enzymes that are characterized by a highly conserved active site motif (V/I)CXGNXCRS and share no sequence similarity with other types of protein tyrosine phosphatases (PTPs). LMW-PTPs play important roles in many biological processes and are widely distributed in prokaryotes and eukaryotes.


Pssm-ID: 319971  Cd Length: 147  Bit Score: 186.87  E-value: 1.07e-61
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78711846   1 MKVLFVCIGNTCRSPMAEAILKHLVVKRNLQDWYVDSAGLRSWNVGLEPQARGQQLLKQHGLK-TNHLGRMISAQDFYDF 79
Cdd:cd16343   1 KKILFVCLGNICRSPMAEAVLRHLLPKAGGDDVEVDSAGTSAWHGGEPPDPRARAVLKEHGIDlSGHRARQLTAEDFDEF 80

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 78711846  80 DYIFAMDNSNLLELEHMAAsltPSPTCKIQLLGSYIGRKEDEiIEDPYFiQGMGGFNAAYLQILESCERFLQ 151
Cdd:cd16343  81 DLILAMDESNLRDLRRLAP---AEARGKVFLLGDFDPEGGKD-VPDPYY-GGREGFEEVYDLIERACEGLLE 147
LMWPc pfam01451
Low molecular weight phosphotyrosine protein phosphatase;
3-150 3.94e-39

Low molecular weight phosphotyrosine protein phosphatase;


Pssm-ID: 460216  Cd Length: 142  Bit Score: 129.80  E-value: 3.94e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78711846     3 VLFVCIGNTCRSPMAEAILKHLVVKRNLQD-WYVDSAGLRSWnVGLEPQARGQQLLKQHGLKTN-HLGRMISAQDFYDFD 80
Cdd:pfam01451   1 ILFVCTGNICRSPMAEAIFRRELEKAGLGDkVEVDSAGTGAW-PGNPADPRAVEVLKEHGIDLSgHYARQLSTEDFASFD 79

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78711846    81 YIFAMDNSNLLELEHMAASLTpspTCKIQLLGSYigrKEDEIIEDPYFiQGMGGFNAAYLQILESCERFL 150
Cdd:pfam01451  80 LILAMDSEHKRDLCPLAPERY---RAKVMLLGEY---GEQLDIPDPYY-GSIDAFEEVRDLIERRCRQLL 142
Wzb COG0394
Protein-tyrosine-phosphatase [Signal transduction mechanisms];
1-152 1.62e-36

Protein-tyrosine-phosphatase [Signal transduction mechanisms];


Pssm-ID: 440163  Cd Length: 137  Bit Score: 122.96  E-value: 1.62e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78711846   1 MKVLFVCIGNTCRSPMAEAILKHLVVKRnlqdWYVDSAGLRSwnvGLEPQARGQQLLKQHGLKT-NHLGRMISAQDFYDF 79
Cdd:COG0394   4 KRVLFVCTGNICRSPMAEALLRHLAGGR----VEVDSAGTEP---GGPVDPRAVAVLAERGIDLsGHRSRQLDEEDLPEF 76

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 78711846  80 DYIFAMDNSNLLELEHMAasltpsPTCKIQLLgsyigrkeDEIIEDPYFiQGMGGFNAAYLQILESCERFLQH 152
Cdd:COG0394  77 DLVITMCDSAAEELCPLF------PGAAKLLL--------HWDVPDPYY-GGLEAFREVRDEIERRIEALLAK 134
LMWPc smart00226
Low molecular weight phosphatase family;
3-150 1.08e-34

Low molecular weight phosphatase family;


Pssm-ID: 197586  Cd Length: 134  Bit Score: 117.96  E-value: 1.08e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78711846      3 VLFVCIGNTCRSPMAEAILKHLVVKRnlqdWYVDSAGLRSWnVGLEPQARGQQLLKQHGLKTNHLGRMISAQDFYDFDYI 82
Cdd:smart00226   1 ILFVCTGNICRSPMAEALFKAYVGDR----VKIDSAGTGAW-VGGGADPRAVKVLKEHGIDLSHHASQLTSSDFKNADLV 75

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 78711846     83 FAMDNSNLLELEHMaaslTPSPTCKIQLLGSYigrkedEIIEDPYFiQGMGGFNAAYLQILESCERFL 150
Cdd:smart00226  76 LAMDGSHLRNICRL----KPPSRAKVELFGHY------VDVDDPYY-GGIDGFERVYDELENALQEFL 132
LMWPAP cd16344
low molecular weight protein arginine phosphatase; Low molecular weight protein arginine ...
 1-127 9.47e-29

low molecular weight protein arginine phosphatase; Low molecular weight protein arginine phosphatases are part of the low molecular weight phosphatase (LMWP) family. They share a highly conserved active site motif (V/I)CXGNTCRS. It has been shown that the conserved threonine, which in many LMWPTPs is an isoleucine, confers specificity to phosphoarginine over phosphotyrosine.


Pssm-ID: 319972  Cd Length: 142  Bit Score: 103.28  E-value: 9.47e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78711846   1 MKVLFVCIGNTCRSPMAEAILKHLVVKRNLQdwyVDSAGLRSWNvGLE--PQArgQQLLKQHGLK-TNHLGRMISAQDFY 77
Cdd:cd16344   1 MKILFVCTGNTCRSPMAEAILKKLLEELDVE---VKSAGIFAVD-GSPasPNA--VEVLKEKGIDlSGHRSQQLTEELLE 74

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 78711846  78 DFDYIFAMDNSnlleleHMAA--SLTPSPTCKIQLLGSYIGRKEDEIIeDPY 127
Cdd:cd16344  75 WADLILTMTES------HKQAllSLYPEAADKVFTLKEYVGGEDGDIS-DPF 119
LMWP cd00115
Low molecular weight phosphatase family; Low molecular weight phosphatases (LMWPs) are a group ...
 3-151 1.17e-27

Low molecular weight phosphatase family; Low molecular weight phosphatases (LMWPs) are a group of small soluble enzymes that are characterized by a highly conserved active site motif (V/I)CXGNXCRS and share no sequence similarity with other types of protein tyrosine phosphatases (PTPs). This family includes protein tyrosine phosphatases, arginine phosphatases and arsenate reductases.


Pssm-ID: 319970  Cd Length: 137  Bit Score: 100.26  E-value: 1.17e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78711846   3 VLFVCIGNTCRSPMAEAILKHLVVKRnlqdWYVDSAGLRSWnVGLEPQARGQQLLKQHGLKTNHLGRMISAQDFYDFDYI 82
Cdd:cd00115   2 ILFICTGNICRSPMAEAIFKQLLGDE----WKVDSAGTGAH-HGEGADPRAVRVLKEVGIDISHRSDQIKSEHLDNYDLV 76

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 78711846  83 FAMDNSNLLELEHMAasltpsPTCKIQLLGSYIGRkEDEIIEDPYFIQgMGGFNAAYLQILESCERFLQ 151
Cdd:cd00115  77 LVMDGSNLDKIPRIF------PEARGKTWLPHVKL-EHGEIDDPYRGD-IEDFRRVRDELENASKRFAE 137
PRK10126 PRK10126
low molecular weight protein-tyrosine-phosphatase Wzb;
2-156 1.96e-15

low molecular weight protein-tyrosine-phosphatase Wzb;


Pssm-ID: 182256  Cd Length: 147  Bit Score: 69.17  E-value: 1.96e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78711846    2 KVLFVCIGNTCRSPMAEAILkhlvvKRNLQDWYVDSAGLRSWnVGLEPQARGQQLLKQHGLK-TNHLGRMISAQDFYDFD 80
Cdd:PRK10126   4 NILVVCVGNICRSPTAERLL-----QRYHPELKVESAGLGAL-VGKGADPTAISVAAEHQLSlEGHCARQISRRLCRNYD 77

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 78711846   81 YIFAMDNSNLLELEHMAasltPSPTCKIQLLGSYIGRKEdeiIEDPYFiQGMGGFNAAYLQILESCERFLQHYKSD 156
Cdd:PRK10126  78 LILTMEKRHIERLCEMA----PEMRGKVMLFGHWDNECE---IPDPYR-KSREAFEAVYTLLERSARQWAQALNAE 145
LMWP_ArsC cd16345
Arsenate reductase of the LMWP family; Arsenate reductase plays an important role in the ...
 2-85 1.57e-14

Arsenate reductase of the LMWP family; Arsenate reductase plays an important role in the reduction of intracellular arsenate to arsenite, an important step in arsenic detoxification. The reduction involves three different thiolate nucleophiles. In arsenate reductases of the LMWP family, reduction can be coupled with thioredoxin (Trx)/thioredoxin reductase (TrxR) or glutathione (GSH)/glutaredoxin (Grx).


Pssm-ID: 319973  Cd Length: 132  Bit Score: 66.32  E-value: 1.57e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78711846   2 KVLFVCIGNTCRSPMAEAILKHLvvkrnLQD-WYVDSAGLRSwnVGLEPQARgqQLLKQHGLKTNHLgRMISAQDFYD-- 78
Cdd:cd16345   1 KVLFLCTGNSARSQMAEALLRHL-----GGDrFEAYSAGSEP--AGVNPLAI--EVMKEIGIDISGQ-RSKSLDEFLGqe 70


                ....*..
gi 78711846  79 FDYIFAM 85
Cdd:cd16345  71 FDYVITV 77
etp PRK11391
phosphotyrosine-protein phosphatase; Provisional
 3-127 8.32e-13

phosphotyrosine-protein phosphatase; Provisional


Pssm-ID: 138553  Cd Length: 144  Bit Score: 61.96  E-value: 8.32e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78711846    3 VLFVCIGNTCRSPMAEAILkhlvvKRNLQDWYVDSAGLRSWnVGLEPQARGQQLLKQHGLKTN-HLGRMISAQDFYDFDY 81
Cdd:PRK11391   5 ILVVCTGNICRSPIGERLL-----RKRLPGVKVKSAGVHGL-VKHPADATAADVAANHGVSLEgHAGRKLTAEMARNYDL 78

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 78711846   82 IFAMdnsnllELEHMA--ASLTPSPTCKIQLLGSYIGRKEdeiIEDPY 127
Cdd:PRK11391  79 ILAM------ESEHIAqvTAIAPEVRGKTMLFGQWLEQKE---IPDPY 117
COG4551 COG4551
Predicted protein tyrosine phosphatase [General function prediction only];
1-88 1.89e-06

Predicted protein tyrosine phosphatase [General function prediction only];


Pssm-ID: 443615  Cd Length: 109  Bit Score: 44.44  E-value: 1.89e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78711846   1 MKVLFVCIGNTCRSPMAEAILkhlvvkRNLQDWYVDSAglrswnvGLEPQARgqqllkqhglktnhlgRMISAQDFYDFD 80
Cdd:COG4551   2 MNVLFVCSRNRWRSPTAEQVF------RNHPGVEVRSA-------GTSPDAR----------------VPVTAELIEWAD 52


                ....*...
gi 78711846  81 YIFAMDNS 88
Cdd:COG4551  53 VIFVMEKK 60
PRK13530 PRK13530
arsenate reductase (thioredoxin);
5-51 2.20e-05

arsenate reductase (thioredoxin);


Pssm-ID: 237415  Cd Length: 133  Bit Score: 42.04  E-value: 2.20e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 78711846    5 FVCIGNTCRSPMAEAILKHLVVkrnlQDWYVDSAGLRSWnvGLEPQA 51
Cdd:PRK13530   8 FLCTGNSCRSQMAEGWGKQYLG----DKWNVYSAGIEAH--GVNPNA 48
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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