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    CG10026 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35226, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG10026provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0032785
    Locus tag
    Dmel_CG10026
    See related
    AllianceGenome:FB:FBgn0032785
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG10026
    Summary
    Predicted to enable phosphatidylinositol bisphosphate binding activity. Predicted to be involved in intermembrane lipid transfer. Predicted to be located in late endosome. Is expressed in adult head; embryonic ventral epidermis; and embryonic/larval fat body. Human ortholog(s) of this gene implicated in familial isolated deficiency of vitamin E. Orthologous to human TTPA (alpha tocopherol transfer protein). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG10026 in Genome Data Viewer
    Location:
    37E1-37E1; 2-54 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (19454256..19457723)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (19454256..19457723)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Ran GTPase activating protein Neighboring gene Heparan sulfate 2-O-sulfotransferase Neighboring gene Topoisomerase 2 Neighboring gene traffic jam Neighboring gene long non-coding RNA:CR45722

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification of genes associated with resilience/vulnerability to sleep deprivation and starvation in Drosophila. Thimgan MS, et al. Sleep, 2015 May 1. PMID 25409104, Free PMC Article
    2. Crtc modulates fasting programs associated with 1-C metabolism and inhibition of insulin signaling. Wang T, et al. Proc Natl Acad Sci U S A, 2021 Mar 23. PMID 33723074, Free PMC Article
    3. Gene expression following induction of regeneration in Drosophila wing imaginal discs. Expression profile of regenerating wing discs. Blanco E, et al. BMC Dev Biol, 2010 Sep 2. PMID 20813047, Free PMC Article
    4. Cold acclimation wholly reorganizes the Drosophila melanogaster transcriptome and metabolome. MacMillan HA, et al. Sci Rep, 2016 Jun 30. PMID 27357258, Free PMC Article
    5. Next-generation large-scale binary protein interaction network for Drosophila melanogaster. Tang HW, et al. Nat Commun, 2023 Apr 15. PMID 37061542, Free PMC Article

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables phosphatidylinositol bisphosphate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatidylinositol bisphosphate binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in intermembrane lipid transfer ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in late endosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG10026-PA
    CG10026-PB
    CG10026-PC
    CG10026-PD

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      19454256..19457723
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_165301.2 → NP_724195.1  uncharacterized protein Dmel_CG10026, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_724195.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VIW1
      Related
      FBpp0080777
      Conserved Domains (2) summary
      smart01100
      Location:34 → 81
      CRAL_TRIO_N; CRAL/TRIO, N-terminal domain
      pfam00650
      Location:107 → 255
      CRAL_TRIO; CRAL/TRIO domain

    2. NM_001273652.1 → NP_001260581.1  uncharacterized protein Dmel_CG10026, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260581.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VIW1
      Conserved Domains (2) summary
      smart01100
      Location:34 → 81
      CRAL_TRIO_N; CRAL/TRIO, N-terminal domain
      pfam00650
      Location:107 → 255
      CRAL_TRIO; CRAL/TRIO domain

    3. NM_136124.3 → NP_609968.3  uncharacterized protein Dmel_CG10026, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609968.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8T9G7
      Related
      FBpp0080778
      Conserved Domains (2) summary
      smart01100
      Location:43 → 90
      CRAL_TRIO_N; CRAL/TRIO, N-terminal domain
      cd00170
      Location:112 → 265
      SEC14; Sec14p-like lipid-binding domain. Found in secretory proteins, such as S. cerevisiae phosphatidylinositol transfer protein (Sec14p), and in lipid regulated proteins such as RhoGAPs, RhoGEFs and neurofibromin (NF1). SEC14 domain of Dbl is known to ...

    4. NM_165302.3 → NP_724196.1  uncharacterized protein Dmel_CG10026, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_724196.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VIW1
      Related
      FBpp0080779
      Conserved Domains (2) summary
      smart01100
      Location:34 → 81
      CRAL_TRIO_N; CRAL/TRIO, N-terminal domain
      pfam00650
      Location:107 → 255
      CRAL_TRIO; CRAL/TRIO domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8T9G7 Q8T9G7
    Q9VIW1 Q9VIW1

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