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Conserved domains on  [gi|442628404|ref|NP_001260581|]
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uncharacterized protein Dmel_CG10026, isoform D [Drosophila melanogaster]

Protein Classification

SEC14 family lipid-binding protein( domain architecture ID 10661176)

SEC14 family lipid-binding protein contains a lipid-binding domain that is found in secretory proteins and in lipid regulated proteins

Gene Ontology:  GO:1902936|GO:0008289
PubMed:  12767229|17428729

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
SEC14 cd00170
Sec14p-like lipid-binding domain; Sec14p-like lipid-binding domains are found in secretory ...
108-256 1.24e-36

Sec14p-like lipid-binding domain; Sec14p-like lipid-binding domains are found in secretory proteins, such as S. cerevisiae phosphatidylinositol transfer protein (Sec14p), and in lipid regulated proteins such as RhoGAPs, RhoGEFs and neurofibromin (NF1). SEC14 domain of Dbl is known to associate with G protein beta/gamma subunits.


:

Pssm-ID: 469559 [Multi-domain]  Cd Length: 156  Bit Score: 127.84  E-value: 1.24e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628404 108 ILTVTPYRDQHGHRILIYRFGLWRPNQVTVDDIFRATIVLQELGSLEPISQIVGGVGIFDLKDLGLEHilHLSPSVAQKM 187
Cdd:cd00170   10 GIGYLGGRDKEGRPVLVFRAGWDPPKLLDLEELLRYLVYLLEKALRELEEQVEGFVVIIDLKGFSLSN--LSDLSLLKKL 87
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 442628404 188 IALLVTSMPIRTSALHIVNQNWVFNAAFKIFKPFLNAAMREKLYIHGSDMTSLHKHINPEHLPKRYGGL 256
Cdd:cd00170   88 LKILQDHYPERLKKIYIVNAPWIFSALWKIVKPFLSEKTRKKIVFLGSDLEELLEYIDPDQLPKELGGT 156
CRAL_TRIO_N smart01100
CRAL/TRIO, N-terminal domain;
34-81 1.22e-09

CRAL/TRIO, N-terminal domain;


:

Pssm-ID: 215024  Cd Length: 48  Bit Score: 52.94  E-value: 1.22e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 442628404    34 DKVIEQFRNYILEHNECQPHRSDAKYLEKFLRARYWKIENSYKLLCSY 81
Cdd:smart01100   1 EEALEELRELLEKHPDLLPPRLDDAFLLRFLRARKFDVEKAKEMLEKY 48
 
Name Accession Description Interval E-value
SEC14 cd00170
Sec14p-like lipid-binding domain; Sec14p-like lipid-binding domains are found in secretory ...
108-256 1.24e-36

Sec14p-like lipid-binding domain; Sec14p-like lipid-binding domains are found in secretory proteins, such as S. cerevisiae phosphatidylinositol transfer protein (Sec14p), and in lipid regulated proteins such as RhoGAPs, RhoGEFs and neurofibromin (NF1). SEC14 domain of Dbl is known to associate with G protein beta/gamma subunits.


Pssm-ID: 469559 [Multi-domain]  Cd Length: 156  Bit Score: 127.84  E-value: 1.24e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628404 108 ILTVTPYRDQHGHRILIYRFGLWRPNQVTVDDIFRATIVLQELGSLEPISQIVGGVGIFDLKDLGLEHilHLSPSVAQKM 187
Cdd:cd00170   10 GIGYLGGRDKEGRPVLVFRAGWDPPKLLDLEELLRYLVYLLEKALRELEEQVEGFVVIIDLKGFSLSN--LSDLSLLKKL 87
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 442628404 188 IALLVTSMPIRTSALHIVNQNWVFNAAFKIFKPFLNAAMREKLYIHGSDMTSLHKHINPEHLPKRYGGL 256
Cdd:cd00170   88 LKILQDHYPERLKKIYIVNAPWIFSALWKIVKPFLSEKTRKKIVFLGSDLEELLEYIDPDQLPKELGGT 156
CRAL_TRIO pfam00650
CRAL/TRIO domain;
113-255 5.93e-33

CRAL/TRIO domain;


Pssm-ID: 459890 [Multi-domain]  Cd Length: 151  Bit Score: 118.13  E-value: 5.93e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628404  113 PYRDQHGHRILIYRFGLWRPNQVTVDDIFRATIVLQELGSLE-PISQIVGGVGIFDLKDLGLEHILHLSPSVAQKMIALL 191
Cdd:pfam00650   7 HGRDKEGRPVLYLRLGRHDPKKSSEEELVRFLVLVLERALLLmPEGQVEGLTVIIDLKGLSLSNMDWWSISLLKKIIKIL 86
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 442628404  192 VTSMPIRTSALHIVNQNWVFNAAFKIFKPFLNAAMREKLYIH-GSDMTSLHKHINPEHLPKRYGG 255
Cdd:pfam00650  87 QDNYPERLGKILIVNAPWIFNTIWKLIKPFLDPKTREKIVFLkNSNEEELEKYIPPEQLPKEYGG 151
SEC14 smart00516
Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p); Domain ...
116-255 2.45e-24

Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p); Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p) and in RhoGAPs, RhoGEFs and the RasGAP, neurofibromin (NF1). Lipid-binding domain. The SEC14 domain of Dbl is known to associate with G protein beta/gamma subunits.


Pssm-ID: 214706 [Multi-domain]  Cd Length: 158  Bit Score: 95.83  E-value: 2.45e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628404   116 DQHGHRILIYRFGLWRPNQVTVDDIFRATIVLQELG--SLEPISQIVGGVGIFDLKDLGlehILHLSPSVAQKMIALLVT 193
Cdd:smart00516  16 DKDGRPVLIERAGRFDLKSVTLEELLRYLVYVLEKIlqEEKKTGGIEGFTVIFDLKGLS---MSNPDLSVLRKILKILQD 92
                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 442628404   194 SMPIRTSALHIVNQNWVFNAAFKIFKPFLNAAMREKLYIHGSDMTS-LHKHINPEHLPKRYGG 255
Cdd:smart00516  93 HYPERLGKVYIINPPWFFRVLWKIIKPFLDEKTREKIRFVGNDSKEeLLEYIDKEQLPEELGG 155
CRAL_TRIO_N smart01100
CRAL/TRIO, N-terminal domain;
34-81 1.22e-09

CRAL/TRIO, N-terminal domain;


Pssm-ID: 215024  Cd Length: 48  Bit Score: 52.94  E-value: 1.22e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 442628404    34 DKVIEQFRNYILEHNECQPHRSDAKYLEKFLRARYWKIENSYKLLCSY 81
Cdd:smart01100   1 EEALEELRELLEKHPDLLPPRLDDAFLLRFLRARKFDVEKAKEMLEKY 48
 
Name Accession Description Interval E-value
SEC14 cd00170
Sec14p-like lipid-binding domain; Sec14p-like lipid-binding domains are found in secretory ...
108-256 1.24e-36

Sec14p-like lipid-binding domain; Sec14p-like lipid-binding domains are found in secretory proteins, such as S. cerevisiae phosphatidylinositol transfer protein (Sec14p), and in lipid regulated proteins such as RhoGAPs, RhoGEFs and neurofibromin (NF1). SEC14 domain of Dbl is known to associate with G protein beta/gamma subunits.


Pssm-ID: 469559 [Multi-domain]  Cd Length: 156  Bit Score: 127.84  E-value: 1.24e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628404 108 ILTVTPYRDQHGHRILIYRFGLWRPNQVTVDDIFRATIVLQELGSLEPISQIVGGVGIFDLKDLGLEHilHLSPSVAQKM 187
Cdd:cd00170   10 GIGYLGGRDKEGRPVLVFRAGWDPPKLLDLEELLRYLVYLLEKALRELEEQVEGFVVIIDLKGFSLSN--LSDLSLLKKL 87
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 442628404 188 IALLVTSMPIRTSALHIVNQNWVFNAAFKIFKPFLNAAMREKLYIHGSDMTSLHKHINPEHLPKRYGGL 256
Cdd:cd00170   88 LKILQDHYPERLKKIYIVNAPWIFSALWKIVKPFLSEKTRKKIVFLGSDLEELLEYIDPDQLPKELGGT 156
CRAL_TRIO pfam00650
CRAL/TRIO domain;
113-255 5.93e-33

CRAL/TRIO domain;


Pssm-ID: 459890 [Multi-domain]  Cd Length: 151  Bit Score: 118.13  E-value: 5.93e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628404  113 PYRDQHGHRILIYRFGLWRPNQVTVDDIFRATIVLQELGSLE-PISQIVGGVGIFDLKDLGLEHILHLSPSVAQKMIALL 191
Cdd:pfam00650   7 HGRDKEGRPVLYLRLGRHDPKKSSEEELVRFLVLVLERALLLmPEGQVEGLTVIIDLKGLSLSNMDWWSISLLKKIIKIL 86
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 442628404  192 VTSMPIRTSALHIVNQNWVFNAAFKIFKPFLNAAMREKLYIH-GSDMTSLHKHINPEHLPKRYGG 255
Cdd:pfam00650  87 QDNYPERLGKILIVNAPWIFNTIWKLIKPFLDPKTREKIVFLkNSNEEELEKYIPPEQLPKEYGG 151
SEC14 smart00516
Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p); Domain ...
116-255 2.45e-24

Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p); Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p) and in RhoGAPs, RhoGEFs and the RasGAP, neurofibromin (NF1). Lipid-binding domain. The SEC14 domain of Dbl is known to associate with G protein beta/gamma subunits.


Pssm-ID: 214706 [Multi-domain]  Cd Length: 158  Bit Score: 95.83  E-value: 2.45e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628404   116 DQHGHRILIYRFGLWRPNQVTVDDIFRATIVLQELG--SLEPISQIVGGVGIFDLKDLGlehILHLSPSVAQKMIALLVT 193
Cdd:smart00516  16 DKDGRPVLIERAGRFDLKSVTLEELLRYLVYVLEKIlqEEKKTGGIEGFTVIFDLKGLS---MSNPDLSVLRKILKILQD 92
                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 442628404   194 SMPIRTSALHIVNQNWVFNAAFKIFKPFLNAAMREKLYIHGSDMTS-LHKHINPEHLPKRYGG 255
Cdd:smart00516  93 HYPERLGKVYIINPPWFFRVLWKIIKPFLDEKTREKIRFVGNDSKEeLLEYIDKEQLPEELGG 155
CRAL_TRIO_N smart01100
CRAL/TRIO, N-terminal domain;
34-81 1.22e-09

CRAL/TRIO, N-terminal domain;


Pssm-ID: 215024  Cd Length: 48  Bit Score: 52.94  E-value: 1.22e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 442628404    34 DKVIEQFRNYILEHNECQPHRSDAKYLEKFLRARYWKIENSYKLLCSY 81
Cdd:smart01100   1 EEALEELRELLEKHPDLLPPRLDDAFLLRFLRARKFDVEKAKEMLEKY 48
CRAL_TRIO_2 pfam13716
Divergent CRAL/TRIO domain; This family includes divergent members of the CRAL-TRIO domain ...
163-255 2.97e-05

Divergent CRAL/TRIO domain; This family includes divergent members of the CRAL-TRIO domain family. This family includes ECM25 that contains a divergent CRAL-TRIO domain identified by Gallego and colleagues.


Pssm-ID: 463965 [Multi-domain]  Cd Length: 140  Bit Score: 43.08  E-value: 2.97e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628404  163 VGIFDLKDLGLEHilHLSPSVAQKMIALLVTSMPIRTSALHIVNQNWVFNAAFK-IFKPFLNAAMREKLyIHGSDMTSLH 241
Cdd:pfam13716  43 VVVVDHTGVTSEN--FPSLSFLKKAYDLLPRAFKKNLKAVYVVHPSTFLRTFLKtLGSLLGSKKLRKKV-HYVSSLSELW 119
                          90
                  ....*....|....
gi 442628404  242 KHINPEHLPKRYGG 255
Cdd:pfam13716 120 EGIDREQLPTELPG 133
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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