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    Parp14 poly (ADP-ribose) polymerase family, member 14 [ Mus musculus (house mouse) ]

    Gene ID: 547253, updated on 9-Dec-2024

    Summary

    Official Symbol
    Parp14provided by MGI
    Official Full Name
    poly (ADP-ribose) polymerase family, member 14provided by MGI
    Primary source
    MGI:MGI:1919489
    See related
    Ensembl:ENSMUSG00000034422 AllianceGenome:MGI:1919489
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    ARTD8; CoaSt6; mKIAA1268; 1600029O10Rik
    Summary
    Predicted to enable several functions, including NAD+ binding activity; NAD+-protein poly-ADP-ribosyltransferase activity; and transcription corepressor activity. Involved in negative regulation of type II interferon-mediated signaling pathway and positive regulation of interleukin-4-mediated signaling pathway. Located in cytoplasm. Is expressed in hemolymphoid system; intestine; and urogenital sinus. Orthologous to human PARP14 (poly(ADP-ribose) polymerase family member 14). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in large intestine adult (RPKM 6.0), bladder adult (RPKM 4.4) and 21 other tissues See more
    Orthologs
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    Genomic context

    See Parp14 in Genome Data Viewer
    Location:
    16 B3; 16 25.43 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (35652262..35691904, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (35831892..35871518, complement)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 49 member 4 Neighboring gene predicted gene, 25967 Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:35747524-35747731 Neighboring gene Hspb associated protein 1 Neighboring gene STARR-seq mESC enhancer starr_40745 Neighboring gene STARR-positive B cell enhancer mm9_chr16:35817422-35817723 Neighboring gene predicted gene, 26838 Neighboring gene STARR-seq mESC enhancer starr_40746 Neighboring gene STARR-seq mESC enhancer starr_40747 Neighboring gene STARR-seq mESC enhancer starr_40750 Neighboring gene predicted gene, 41467 Neighboring gene 60S ribosomal protein L35a pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Gene trapped (1) 

    Interactions

    General gene information

    Clone Names

    • KIAA1268, MGC29390

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables NAD+ binding  
    enables NAD+-histone H2BE18 glutamate ADP-ribosyltransferase activity  
    enables NAD+-histone H2BE2 glutamate ADP-ribosyltransferase activity  
    enables NAD+-histone H2BE35 glutamate ADP-ribosyltransferase activity  
    enables NAD+-protein ADP-ribosyltransferase activity  
    enables NAD+-protein ADP-ribosyltransferase activity  
    enables NAD+-protein ADP-ribosyltransferase activity  
    enables NAD+-protein poly-ADP-ribosyltransferase activity  
    enables NAD+-protein poly-ADP-ribosyltransferase activity  
    enables NAD+-protein poly-ADP-ribosyltransferase activity  
    enables enzyme binding  
    enables enzyme binding  
    enables nucleotidyltransferase activity  
    enables protein binding PubMed 
    enables transcription corepressor activity  
    Component Evidence Code Pubs
    is_active_in cytoplasm  
    located_in cytoplasm PubMed 
    located_in cytoplasm  
    located_in cytosol  
    located_in cytosol  
    is_active_in nucleus  
    located_in nucleus  
    located_in plasma membrane  
    located_in plasma membrane  

    General protein information

    Preferred Names
    protein mono-ADP-ribosyltransferase PARP14
    Names
    ADP-ribosyltransferase diphtheria toxin-like 8
    PARP-14
    collaborator of STAT6
    poly [ADP-ribose] polymerase 14
    NP_001034619.2
    XP_006522455.1
    XP_006522457.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001039530.3NP_001034619.2  protein mono-ADP-ribosyltransferase PARP14

      See identical proteins and their annotated locations for NP_001034619.2

      Status: VALIDATED

      Source sequence(s)
      AC129574
      Consensus CDS
      CCDS28143.1
      UniProtKB/Swiss-Prot
      E9QP48, Q2EMV9, Q571C6, Q8BN35, Q8VDT6
      UniProtKB/TrEMBL
      B2RSI3
      Related
      ENSMUSP00000037657.9, ENSMUST00000042665.9
      Conserved Domains (8) summary
      COG2110
      Location:812991
      YmdB; O-acetyl-ADP-ribose deacetylase (regulator of RNase III), contains Macro domain [Translation, ribosomal structure and biogenesis]
      cd01439
      Location:16951815
      TCCD_inducible_PARP_like; Poly(ADP-ribose) polymerases catalyse the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a regulatory component ...
      cd02903
      Location:10251167
      Macro_BAL_like; Macro domain, BAL_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). ...
      cd02907
      Location:812987
      Macro_Af1521_BAL_like; Macro domain, Af1521- and BAL-like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose ...
      cd12300
      Location:687
      RRM1_PAR14; RNA recognition motif 1 in vertebrate poly [ADP-ribose] polymerase 14 (PARP-14)
      cd12543
      Location:226300
      RRM2_PAR14; RNA recognition motif 2 in vertebrate poly [ADP-ribose] polymerase 14 (PARP-14)
      pfam00644
      Location:16441817
      PARP; Poly(ADP-ribose) polymerase catalytic domain
      cl00019
      Location:12401365
      Macro; Macro domain, a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Some macro domains recognize poly ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      35652262..35691904 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006522392.5XP_006522455.1  protein mono-ADP-ribosyltransferase PARP14 isoform X1

      UniProtKB/TrEMBL
      B2RSI3
      Conserved Domains (5) summary
      smart00506
      Location:12401358
      A1pp; Appr-1"-p processing enzyme
      cd01439
      Location:17241844
      TCCD_inducible_PARP_like; Poly(ADP-ribose) polymerases catalyse the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a regulatory component ...
      cd12300
      Location:687
      RRM1_PAR14; RNA recognition motif 1 in vertebrate poly [ADP-ribose] polymerase 14 (PARP-14)
      cd12543
      Location:226300
      RRM2_PAR14; RNA recognition motif 2 in vertebrate poly [ADP-ribose] polymerase 14 (PARP-14)
      cl00019
      Location:812986
      Macro; Macro domain, a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Some macro domains recognize poly ...
    2. XM_006522394.5XP_006522457.2  protein mono-ADP-ribosyltransferase PARP14 isoform X2

      UniProtKB/TrEMBL
      B2RSI3
      Conserved Domains (5) summary
      smart00506
      Location:12451363
      A1pp; Appr-1"-p processing enzyme
      cd01439
      Location:17001820
      TCCD_inducible_PARP_like; Poly(ADP-ribose) polymerases catalyse the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a regulatory component ...
      cd12300
      Location:692
      RRM1_PAR14; RNA recognition motif 1 in vertebrate poly [ADP-ribose] polymerase 14 (PARP-14)
      cd12543
      Location:231305
      RRM2_PAR14; RNA recognition motif 2 in vertebrate poly [ADP-ribose] polymerase 14 (PARP-14)
      cl00019
      Location:817991
      Macro; Macro domain, a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Some macro domains recognize poly ...
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