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Helz2 helicase with zinc finger 2, transcriptional coactivator [ Mus musculus (house mouse) ]

Gene ID: 229003, updated on 27-Nov-2024

Summary

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Official Symbol
Helz2provided by MGI
Official Full Name
helicase with zinc finger 2, transcriptional coactivatorprovided by MGI
Primary source
MGI:MGI:2385169
See related
Ensembl:ENSMUSG00000027580 AllianceGenome:MGI:2385169
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
PDIP1; mPDIP1; Pric285; mKIAA1769
Summary
Predicted to enable RNA binding activity; RNA helicase activity; and exoribonuclease II activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II and regulatory ncRNA-mediated post-transcriptional gene silencing. Predicted to be located in cytoplasm. Predicted to be active in P granule and cytosol. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; respiratory system; and telencephalon. Orthologous to human HELZ2 (helicase with zinc finger 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in spleen adult (RPKM 53.3), thymus adult (RPKM 35.0) and 18 other tissues See more
Orthologs
human all
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Genomic context

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See Helz2 in Genome Data Viewer
Location:
2 H4; 2 103.63 cM
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (180869408..180883851, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (181227615..181242058, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 40033 Neighboring gene src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites Neighboring gene STARR-positive B cell enhancer ABC_E4531 Neighboring gene fibronectin type III domain containing 11 Neighboring gene heterogeneous nuclear ribonucleoprotein A3 pseudogene Neighboring gene glucocorticoid modulatory element binding protein 2 Neighboring gene proviral integration site 2 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Protection against high-fat diet-induced obesity in Helz2-deficient male mice due to enhanced expression of hepatic leptin receptor. Yoshino S, et al. Endocrinology, 2014 Sep. PMID 25004093
  2. SFPQ associated with a co-activator for PPARγ, HELZ2, regulates key nuclear factors for adipocyte differentiation. Katano-Toki A, et al. Biochem Biophys Res Commun, 2021 Jul 12. PMID 34052659
  3. THRAP3 interacts with HELZ2 and plays a novel role in adipocyte differentiation. Katano-Toki A, et al. Mol Endocrinol, 2013 May. PMID 23525231, Free PMC Article
  4. LCP1 preferentially binds clasped αMβ2 integrin and attenuates leukocyte adhesion under flow. Tseng HY, et al. J Cell Sci, 2018 Nov 21. PMID 30333137, Free PMC Article
  5. Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2004 Jun 30. PMID 15368895

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. SFPQ associated with a co-activator for PPARgamma, HELZ2, regulates key nuclear factors for adipocyte differentiation.
    Title: SFPQ associated with a co-activator for PPARγ, HELZ2, regulates key nuclear factors for adipocyte differentiation.
  2. Expression of Lepr in the liver, but not in the hypothalamus, was up-regulated in Helz2 knockout mice.
    Title: Protection against high-fat diet-induced obesity in Helz2-deficient male mice due to enhanced expression of hepatic leptin receptor.
  3. Thrap3 could play indispensable roles in terminal differentiation of adipocytes by enhancing PPARgamma-mediated gene activation cooperatively with Helz2.
    Title: THRAP3 interacts with HELZ2 and plays a novel role in adipocyte differentiation.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (1)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC63178

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables ATP-dependent H2AZ histone chaperone activity IEA
Inferred from Electronic Annotation
more info
  
enables ATP-dependent H3-H4 histone complex chaperone activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA clamp loader activity IEA
Inferred from Electronic Annotation
more info
  
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA helicase activity ISO
Inferred from Sequence Orthology
more info
  
enables RNA helicase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables chromatin extrusion motor activity IEA
Inferred from Electronic Annotation
more info
  
enables cohesin loader activity IEA
Inferred from Electronic Annotation
more info
  
enables exoribonuclease II activity ISO
Inferred from Sequence Orthology
more info
  
enables exoribonuclease II activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in chromatin looping IEA
Inferred from Electronic Annotation
more info
  
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in regulatory ncRNA-mediated post-transcriptional gene silencing IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in P granule IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
3'-5' exoribonuclease HELZ2
Names
ATP-dependent RNA helicase PRIC285
PPAR gamma-DNA-binding domain interacting protein1
PPAR-gamma DBD-interacting protein 1
PPAR-gamma DNA-binding domain-interacting protein 1
helicase with zinc finger domain 2
peroxisomal proliferator-activated receptor A interacting complex 285
NP_898985.2
XP_006500662.1
XP_006500664.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_183162.2 → NP_898985.2  3'-5' exoribonuclease HELZ2

    See identical proteins and their annotated locations for NP_898985.2

    Status: VALIDATED

    Source sequence(s)
    AK157942, AK168622, AL845506, BF453182
    Consensus CDS
    CCDS38380.1
    UniProtKB/Swiss-Prot
    B9A0U1, E9QAM5
    UniProtKB/TrEMBL
    A2AS05
    Related
    ENSMUSP00000104459.2, ENSMUST00000108831.8
    Conserved Domains (4) summary
    smart00955
    Location:1567 → 1924
    RNB; This domain is the catalytic domain of ribonuclease II
    cd18040
    Location:2448 → 2724
    DEXXc_HELZ2-C; C-terminal DEXX-box helicase domain of HELZ2
    pfam13087
    Location:2704 → 2909
    AAA_12; AAA domain
    cl28899
    Location:760 → 990
    DEAD-like_helicase_N; N-terminal helicase domain of the DEAD-box helicase superfamily

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    180869408..180883851 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006500601.3 → XP_006500664.1  3'-5' exoribonuclease HELZ2 isoform X2

    UniProtKB/TrEMBL
    A2AS03, A2AS05
    Related
    ENSMUSP00000091756.5, ENSMUST00000094203.11
    Conserved Domains (4) summary
    smart00955
    Location:1567 → 1924
    RNB; This domain is the catalytic domain of ribonuclease II
    cd18040
    Location:2448 → 2724
    DEXXc_HELZ2-C; C-terminal DEXX-box helicase domain of HELZ2
    pfam13087
    Location:2704 → 2909
    AAA_12; AAA domain
    cl28899
    Location:760 → 990
    DEAD-like_helicase_N; N-terminal helicase domain of the DEAD-box helicase superfamily

  2. XM_006500599.3 → XP_006500662.1  3'-5' exoribonuclease HELZ2 isoform X1

    See identical proteins and their annotated locations for XP_006500662.1

    UniProtKB/Swiss-Prot
    B9A0U1, E9QAM5
    UniProtKB/TrEMBL
    A2AS05
    Related
    ENSMUSP00000112917.2, ENSMUST00000121484.2
    Conserved Domains (4) summary
    smart00955
    Location:1567 → 1924
    RNB; This domain is the catalytic domain of ribonuclease II
    cd18040
    Location:2448 → 2724
    DEXXc_HELZ2-C; C-terminal DEXX-box helicase domain of HELZ2
    pfam13087
    Location:2704 → 2909
    AAA_12; AAA domain
    cl28899
    Location:760 → 990
    DEAD-like_helicase_N; N-terminal helicase domain of the DEAD-box helicase superfamily

RNA

  1. XR_003952779.1 RNA Sequence

  2. XR_004940251.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
E9QAM5.1 GenPept UniProtKB/Swiss-Prot:E9QAM5

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