Eme1 essential meiotic structure-specific endonuclease 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Eme1provided by RGD
Official Full Name: essential meiotic structure-specific endonuclease 1provided by RGD
Primary source: RGD:1309067
See related: EnsemblRapid:ENSRNOG00000024420 AllianceGenome:RGD:1309067
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable DNA binding activity. Predicted to contribute to crossover junction DNA endonuclease activity. Predicted to be involved in DNA metabolic process and mitotic intra-S DNA damage checkpoint signaling. Predicted to act upstream of or within response to intra-S DNA damage checkpoint signaling. Predicted to be located in heterochromatin. Predicted to be part of Holliday junction resolvase complex. Orthologous to human EME1 (essential meiotic structure-specific endonuclease 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Thymus (RPKM 135.2), Heart (RPKM 113.8) and 9 other tissues See more
Orthologs: human mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 10q26

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (80083585..80092450, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (79586718..79595515, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (82366820..82375510, complement)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Markers

RH140667 (e-PCR)
- UniSTS:222735

EME1__7583 (e-PCR)
- UniSTS:466148

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA binding	ISO Inferred from Sequence Orthology more info
contributes_to crossover junction DNA endonuclease activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in double-strand break repair	IBA Inferred from Biological aspect of Ancestor more info
involved_in double-strand break repair	ISO Inferred from Sequence Orthology more info
involved_in mitotic intra-S DNA damage checkpoint signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in replication fork processing	IBA Inferred from Biological aspect of Ancestor more info
involved_in replication fork processing	ISO Inferred from Sequence Orthology more info
involved_in resolution of meiotic recombination intermediates	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within response to intra-S DNA damage checkpoint signaling	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of Holliday junction resolvase complex	IBA Inferred from Biological aspect of Ancestor more info
located_in chromatin	ISO Inferred from Sequence Orthology more info
part_of endodeoxyribonuclease complex	ISO Inferred from Sequence Orthology more info
located_in heterochromatin	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

Go to the top of the page Help

Preferred Names: crossover junction endonuclease EME1

Names: essential meiotic endonuclease 1 homolog 1

NP_001099300.2

EC 3.1.22.-

XP_038941509.1

EC 3.1.22.-

XP_038941510.1

EC 3.1.22.-

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001105830.3 → NP_001099300.2 crossover junction endonuclease EME1

See identical proteins and their annotated locations for NP_001099300.2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000010

UniProtKB/TrEMBL

A0A8I5ZKR0, D3ZCS5

Related

ENSRNOP00000029101.2, ENSRNOT00000032693.5

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086028.1 Reference GRCr8

Range

80083585..80092450 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039085581.2 → XP_038941509.1 crossover junction endonuclease EME1 isoform X1

Conserved Domains (1) summary

cl41760
Location:1 → 190

XPF_nuclease-like; nuclease domain of XPF/MUS81 family proteins
XM_039085582.2 → XP_038941510.1 crossover junction endonuclease EME1 isoform X2

Conserved Domains (1) summary

cl41760
Location:1 → 131

XPF_nuclease-like; nuclease domain of XPF/MUS81 family proteins