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    ankmy2a ankyrin repeat and MYND domain containing 2a [ Danio rerio (zebrafish) ]

    Gene ID: 334389, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ankmy2aprovided by ZNC
    Official Full Name
    ankyrin repeat and MYND domain containing 2aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-6321
    See related
    Ensembl:ENSDARG00000005948 AllianceGenome:ZFIN:ZDB-GENE-030131-6321
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fi46e08; zgc:55491; wu:fi46e08
    Summary
    Predicted to enable metal ion binding activity. Acts upstream of or within regulation of smoothened signaling pathway. Predicted to be located in cilium. Is expressed in neural tube. Orthologous to human ANKMY2 (ankyrin repeat and MYND domain containing 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See ankmy2a in Genome Data Viewer
    Location:
    chromosome: 15
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 15 NC_007126.7 (34573311..34590820, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 15 NC_007126.6 (34715342..34732851, complement)

    Chromosome 15 - NC_007126.7Genomic Context describing neighboring genes Neighboring gene mesenchyme homeobox 2a Neighboring gene CDP-L-ribitol pyrophosphorylase A Neighboring gene sclerostin domain containing 1a Neighboring gene leucine rich repeat containing 72 Neighboring gene tetraspanin 13a Neighboring gene LINE-1 reverse transcriptase homolog

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Role of the ANKMY2-FKBP38 axis in regulation of the Sonic hedgehog (Shh) signaling pathway. Saita S, et al. J Biol Chem, 2014 Sep 12. PMID 25077969, Free PMC Article
    2. The zebrafish maternal-effect gene mission impossible encodes the DEAH-box helicase Dhx16 and is essential for the expression of downstream endodermal genes. Putiri E, et al. Dev Biol, 2011 May 15. PMID 21396359, Free PMC Article
    3. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
    4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within regulation of smoothened signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    located_in cilium IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ankyrin repeat and MYND domain-containing protein 2a

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_199894.1 → NP_956188.1  ankyrin repeat and MYND domain-containing protein 2a

      See identical proteins and their annotated locations for NP_956188.1

      Status: PROVISIONAL

      Source sequence(s)
      BC044410
      UniProtKB/TrEMBL
      Q803N0
      Related
      ENSDARP00000003452.6, ENSDART00000003674.8
      Conserved Domains (4) summary
      cd00204
      Location:16 → 132
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam01753
      Location:320 → 357
      zf-MYND; MYND finger
      pfam12796
      Location:16 → 110
      Ank_2; Ankyrin repeats (3 copies)
      sd00045
      Location:16 → 43
      ANK; ANK repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007126.7 Reference GRCz11 Primary Assembly

      Range
      34573311..34590820 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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