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    Cdhr1 cadherin-related family member 1 [ Mus musculus (house mouse) ]

    Gene ID: 170677, updated on 9-Dec-2024

    Summary

    Official Symbol
    Cdhr1provided by MGI
    Official Full Name
    cadherin-related family member 1provided by MGI
    Primary source
    MGI:MGI:2157782
    See related
    Ensembl:ENSMUSG00000021803 AllianceGenome:MGI:2157782
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Prcad; Pcdh21; mKIAA1775
    Summary
    Predicted to enable calcium ion binding activity. Acts upstream of or within photoreceptor cell maintenance. Located in photoreceptor outer segment membrane. Is expressed in several structures, including central nervous system; heart; metanephros; salivary gland primordium; and sensory organ. Human ortholog(s) of this gene implicated in cone-rod dystrophy 15. Orthologous to human CDHR1 (cadherin related family member 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in frontal lobe adult (RPKM 31.5), CNS E18 (RPKM 5.0) and 2 other tissues See more
    Orthologs
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    Genomic context

    See Cdhr1 in Genome Data Viewer
    Location:
    14 B; 14 21.29 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (36799806..36820304, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (37077849..37098347, complement)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene retinal G protein coupled receptor Neighboring gene leucine-rich repeat, immunoglobulin-like and transmembrane domains 1 Neighboring gene leucine-rich repeat, immunoglobulin-like and transmembrane domains 2 Neighboring gene G protein coupled receptor 15 ligand Neighboring gene growth hormone inducible transmembrane protein Neighboring gene STARR-positive B cell enhancer ABC_E751

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (2)  1 citation

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in cell adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in homophilic cell adhesion via plasma membrane adhesion molecules IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within photoreceptor cell maintenance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in photoreceptor cell maintenance ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in photoreceptor cell morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in photoreceptor cell morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in photoreceptor cell outer segment organization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in photoreceptor cell outer segment organization ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in photoreceptor outer segment membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    cadherin-related family member 1
    Names
    photoreceptor cadherin
    protocadherin-21

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_130878.3NP_570948.1  cadherin-related family member 1 precursor

      See identical proteins and their annotated locations for NP_570948.1

      Status: VALIDATED

      Source sequence(s)
      BC058270, CF741547
      Consensus CDS
      CCDS26952.1
      UniProtKB/Swiss-Prot
      Q8CFQ4, Q8CH99, Q8VHP6
      Related
      ENSMUSP00000022337.10, ENSMUST00000022337.11
      Conserved Domains (1) summary
      cd11304
      Location:139242
      Cadherin_repeat; Cadherin tandem repeat domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      36799806..36820304 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)