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Conserved domains on  [gi|18700014|ref|NP_570948|]
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cadherin-related family member 1 precursor [Mus musculus]

Protein Classification

cadherin repeat domain-containing protein( domain architecture ID 10182011)

cadherin repeat domain-containing protein similar to Homo sapiens desmoglein-2, which is involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion; cadherins are are calcium-dependent cell adhesion proteins that preferentially interact with themselves in connecting cells

CATH:  2.60.40.60
Gene Ontology:  GO:0007156|GO:0005509
PubMed:  17158740|28268172|27782885|11736639
SCOP:  4007535

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 139-242 4.58e-27

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 105.86  E-value: 4.58e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18700014 139 PYIIRVPENIPAGSSIFKVQAEDKDTGSGGSVTYSLQNLH-SSKFSMDRHSGVLRLQagATLDYEKSRAHYITVIAKDGG 217
Cdd:cd11304   1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNeDGLFSIDPSTGEITTA--KPLDREEQSSYTLTVTATDGG 78

                        90       100
                ....*....|....*....|....*
gi 18700014 218 GRlrgadmVFSATTTVTINVEDVQD 242
Cdd:cd11304  79 GP------PLSSTATVTITVLDVND 97
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 478-573 5.51e-27

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 105.47  E-value: 5.51e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18700014 478 YIARIPENAPGGSNVVAVTAVDPDTGPWGKVHYSIY-GTGSDLFLIHPSTGLIYTQpwASLDAEGTSRYNFYVKAEDMDG 556
Cdd:cd11304   2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVsGNEDGLFSIDPSTGEITTA--KPLDREEQSSYTLTVTATDGGG 79

                        90
                ....*....|....*....
gi 18700014 557 --RYSLAEVFVTLLDVNDH 573
Cdd:cd11304  80 ppLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 251-350 3.19e-21

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 88.91  E-value: 3.19e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18700014 251 PYYGYVYEDTLPGSEVLTVVAIDGDRGKPNHILYRLLNES-DGIFEINETSGAISVLQSpalLRRE---VYELHVQVTEv 326
Cdd:cd11304   1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNeDGLFSIDPSTGEITTAKP---LDREeqsSYTLTVTATD- 76

                        90       100
                ....*....|....*....|....
gi 18700014 327 nsPGSPAAQATVPVTIRIVDLNNH 350
Cdd:cd11304  77 --GGGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 580-679 1.59e-16

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 75.81  E-value: 1.59e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18700014 580 SVQEKTMVLGTPLKIEATDQDaEEPNNLVDYSITRAEPVNVFDIDAHTGEIRLKNSIrslealhnitpsgDY----SWSL 655
Cdd:cd11304   5 SVPENAPPGTVVLTVSATDPD-SGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPL-------------DReeqsSYTL 70

                        90       100
                ....*....|....*....|....
gi 18700014 656 QVQAKDRGSPSFSTTALLKIDITD 679
Cdd:cd11304  71 TVTATDGGGPPLSSTATVTITVLD 94
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 364-469 2.33e-11

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 60.79  E-value: 2.33e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18700014 364 FELSMFEHPPQGEILrgLKITVNDSDQGANAKFNLRLVG--PGGIFRVVPQTvlneAQVTIIvensAAIDFEKSKLLTFK 441
Cdd:cd11304   2 YEVSVPENAPPGTVV--LTVSATDPDSGENGEVTYSIVSgnEDGLFSIDPST----GEITTA----KPLDREEQSSYTLT 71

                        90       100
                ....*....|....*....|....*...
gi 18700014 442 LLAIEVNTPeKFSSTADIVIQLLDTNDN 469
Cdd:cd11304  72 VTATDGGGP-PLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 42-130 4.34e-11

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 60.02  E-value: 4.34e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18700014  42 FSLPEDTPVGSHVYTLNGTDP---EGDPISYHISfDPSTRSVFSVDPNFGNITLVEELDREREDEIEAIISISDGLNLVA 118
Cdd:cd11304   4 VSVPENAPPGTVVLTVSATDPdsgENGEVTYSIV-SGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPPL 82

                        90
                ....*....|....*
gi 18700014 119 E---KVVILVTDAND 130
Cdd:cd11304  83 SstaTVTITVLDVND 97
 
Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 139-242 4.58e-27

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 105.86  E-value: 4.58e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18700014 139 PYIIRVPENIPAGSSIFKVQAEDKDTGSGGSVTYSLQNLH-SSKFSMDRHSGVLRLQagATLDYEKSRAHYITVIAKDGG 217
Cdd:cd11304   1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNeDGLFSIDPSTGEITTA--KPLDREEQSSYTLTVTATDGG 78

                        90       100
                ....*....|....*....|....*
gi 18700014 218 GRlrgadmVFSATTTVTINVEDVQD 242
Cdd:cd11304  79 GP------PLSSTATVTITVLDVND 97
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 478-573 5.51e-27

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 105.47  E-value: 5.51e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18700014 478 YIARIPENAPGGSNVVAVTAVDPDTGPWGKVHYSIY-GTGSDLFLIHPSTGLIYTQpwASLDAEGTSRYNFYVKAEDMDG 556
Cdd:cd11304   2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVsGNEDGLFSIDPSTGEITTA--KPLDREEQSSYTLTVTATDGGG 79

                        90
                ....*....|....*....
gi 18700014 557 --RYSLAEVFVTLLDVNDH 573
Cdd:cd11304  80 ppLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 251-350 3.19e-21

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 88.91  E-value: 3.19e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18700014 251 PYYGYVYEDTLPGSEVLTVVAIDGDRGKPNHILYRLLNES-DGIFEINETSGAISVLQSpalLRRE---VYELHVQVTEv 326
Cdd:cd11304   1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNeDGLFSIDPSTGEITTAKP---LDREeqsSYTLTVTATD- 76

                        90       100
                ....*....|....*....|....
gi 18700014 327 nsPGSPAAQATVPVTIRIVDLNNH 350
Cdd:cd11304  77 --GGGPPLSSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
478-568 4.75e-18

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 79.65  E-value: 4.75e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18700014   478 YIARIPENAPGGSNVVAVTAVDPDTGPWGKVHYSIYGTGSD-LFLIHPSTGLIYTQpwASLDAEGTSRYNFYVKAEDMD- 555
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGgNFRIDPDTGDISTT--KPLDRESIGEYELTVEATDSGg 78

                          90
                  ....*....|....
gi 18700014   556 -GRYSLAEVFVTLL 568
Cdd:pfam00028  79 pPLSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
140-238 2.03e-17

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 78.11  E-value: 2.03e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18700014   140 YIIRVPENIPAGSSIFKVQAEDKDTGSGGSVTYSLQNLHSS-KFSMDRHSGVLRLQagATLDYEKSRAHYITVIAKDGGG 218
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGgNFRIDPDTGDISTT--KPLDRESIGEYELTVEATDSGG 78

                          90       100
                  ....*....|....*....|
gi 18700014   219 RLRgadmvfSATTTVTINVE 238
Cdd:pfam00028  79 PPL------SSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 158-245 4.15e-17

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 76.62  E-value: 4.15e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18700014    158 QAEDKDTGSGGSVTYSL-QNLHSSKFSMDRHSGVLRLQAgaTLDYEKSRAHYITVIAKDGGGRLRgadmvfSATTTVTIN 236
Cdd:smart00112   1 SATDADSGENGKVTYSIlSGNDDGLFSIDPETGEITTTK--PLDREEQPEYTLTVEATDGGGPPL------SSTATVTIT 72


                   ....*....
gi 18700014    237 VEDVQDTAP 245
Cdd:smart00112  73 VLDVNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 496-575 6.25e-17

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 76.23  E-value: 6.25e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18700014    496 TAVDPDTGPWGKVHYSI-YGTGSDLFLIHPSTGLIYTQpwASLDAEGTSRYNFYVKAEDMDG--RYSLAEVFVTLLDVND 572
Cdd:smart00112   1 SATDADSGENGKVTYSIlSGNDDGLFSIDPETGEITTT--KPLDREEQPEYTLTVEATDGGGppLSSTATVTITVLDVND 78


                   ...
gi 18700014    573 HYP 575
Cdd:smart00112  79 NAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 580-679 1.59e-16

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 75.81  E-value: 1.59e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18700014 580 SVQEKTMVLGTPLKIEATDQDaEEPNNLVDYSITRAEPVNVFDIDAHTGEIRLKNSIrslealhnitpsgDY----SWSL 655
Cdd:cd11304   5 SVPENAPPGTVVLTVSATDPD-SGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPL-------------DReeqsSYTL 70

                        90       100
                ....*....|....*....|....
gi 18700014 656 QVQAKDRGSPSFSTTALLKIDITD 679
Cdd:cd11304  71 TVTATDGGGPPLSSTATVTITVLD 94
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 596-679 2.23e-11

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 60.44  E-value: 2.23e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18700014    596 ATDQDaEEPNNLVDYSITRAEPVNVFDIDAHTGEIRLKNSIrslealhnitpsgDY----SWSLQVQAKDRGSPSFSTTA 671
Cdd:smart00112   2 ATDAD-SGENGKVTYSILSGNDDGLFSIDPETGEITTTKPL-------------DReeqpEYTLTVEATDGGGPPLSSTA 67


                   ....*...
gi 18700014    672 LLKIDITD 679
Cdd:smart00112  68 TVTITVLD 75
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 364-469 2.33e-11

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 60.79  E-value: 2.33e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18700014 364 FELSMFEHPPQGEILrgLKITVNDSDQGANAKFNLRLVG--PGGIFRVVPQTvlneAQVTIIvensAAIDFEKSKLLTFK 441
Cdd:cd11304   2 YEVSVPENAPPGTVV--LTVSATDPDSGENGEVTYSIVSgnEDGLFSIDPST----GEITTA----KPLDREEQSSYTLT 71

                        90       100
                ....*....|....*....|....*...
gi 18700014 442 LLAIEVNTPeKFSSTADIVIQLLDTNDN 469
Cdd:cd11304  72 VTATDGGGP-PLSSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
252-344 3.38e-11

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 60.39  E-value: 3.38e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18700014   252 YYGYVYEDTLPGSEVLTVVAIDGDRGKPNHILYRLLN-ESDGIFEINETSGAISVLQSpalLRREV---YELHVQVTevn 327
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGgGPGGNFRIDPDTGDISTTKP---LDRESigeYELTVEAT--- 74

                          90
                  ....*....|....*..
gi 18700014   328 SPGSPAAQATVPVTIRI 344
Cdd:pfam00028  75 DSGGPPLSSTATVTITV 91
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 42-130 4.34e-11

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 60.02  E-value: 4.34e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18700014  42 FSLPEDTPVGSHVYTLNGTDP---EGDPISYHISfDPSTRSVFSVDPNFGNITLVEELDREREDEIEAIISISDGLNLVA 118
Cdd:cd11304   4 VSVPENAPPGTVVLTVSATDPdsgENGEVTYSIV-SGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPPL 82

                        90
                ....*....|....*
gi 18700014 119 E---KVVILVTDAND 130
Cdd:cd11304  83 SstaTVTITVLDVND 97
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 270-352 4.49e-11

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 59.67  E-value: 4.49e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18700014    270 VAIDGDRGKPNHILYRLLNESD-GIFEINETSGAISVLQSpalLRRE---VYELHVQVTEVnspGSPAAQATVPVTIRIV 345
Cdd:smart00112   1 SATDADSGENGKVTYSILSGNDdGLFSIDPETGEITTTKP---LDREeqpEYTLTVEATDG---GGPPLSSTATVTITVL 74


                   ....*..
gi 18700014    346 DLNNHPP 352
Cdd:smart00112  75 DVNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 384-471 5.88e-09

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 53.51  E-value: 5.88e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18700014    384 TVNDSDQGANAKFNLRLVG--PGGIFRVVPQTvlneaqvtIIVENSAAIDFEKSKLLTFKLLAIEVNTPEKfSSTADIVI 461
Cdd:smart00112   1 SATDADSGENGKVTYSILSgnDDGLFSIDPET--------GEITTTKPLDREEQPEYTLTVEATDGGGPPL-SSTATVTI 71

                           90
                   ....*....|
gi 18700014    462 QLLDTNDNVP 471
Cdd:smart00112  72 TVLDVNDNAP 81
Cadherin pfam00028
Cadherin domain;
590-678 4.52e-07

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 48.45  E-value: 4.52e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18700014   590 TPLKIEATDQDaEEPNNLVDYSITRAEPVNVFDIDAHTGEIRLKNSI-RSLEALHNITpsgdyswslqVQAKDRGSPSFS 668
Cdd:pfam00028  14 EVLTVTATDPD-LGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLdRESIGEYELT----------VEATDSGGPPLS 82

                          90
                  ....*....|
gi 18700014   669 TTALLKIDIT 678
Cdd:pfam00028  83 STATVTITVL 92
Cadherin pfam00028
Cadherin domain;
42-95 6.92e-04

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 39.59  E-value: 6.92e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 18700014    42 FSLPEDTPVGSHVYTLNGTDPEGDP---ISYHISFDPSTRSvFSVDPNFGNITLVEE 95
Cdd:pfam00028   3 ASVPENAPVGTEVLTVTATDPDLGPngrIFYSILGGGPGGN-FRIDPDTGDISTTKP 58
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 61-133 2.80e-03

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 37.33  E-value: 2.80e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 18700014     61 DPEGDPISYHISfDPSTRSVFSVDPNFGNITLVEELDREREDEIEAIISISDG--LNLVAE-KVVILVTDANDEAP 133
Cdd:smart00112   7 SGENGKVTYSIL-SGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGggPPLSSTaTVTITVLDVNDNAP 81
 
Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 139-242 4.58e-27

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 105.86  E-value: 4.58e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18700014 139 PYIIRVPENIPAGSSIFKVQAEDKDTGSGGSVTYSLQNLH-SSKFSMDRHSGVLRLQagATLDYEKSRAHYITVIAKDGG 217
Cdd:cd11304   1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNeDGLFSIDPSTGEITTA--KPLDREEQSSYTLTVTATDGG 78

                        90       100
                ....*....|....*....|....*
gi 18700014 218 GRlrgadmVFSATTTVTINVEDVQD 242
Cdd:cd11304  79 GP------PLSSTATVTITVLDVND 97
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 478-573 5.51e-27

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 105.47  E-value: 5.51e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18700014 478 YIARIPENAPGGSNVVAVTAVDPDTGPWGKVHYSIY-GTGSDLFLIHPSTGLIYTQpwASLDAEGTSRYNFYVKAEDMDG 556
Cdd:cd11304   2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVsGNEDGLFSIDPSTGEITTA--KPLDREEQSSYTLTVTATDGGG 79

                        90
                ....*....|....*....
gi 18700014 557 --RYSLAEVFVTLLDVNDH 573
Cdd:cd11304  80 ppLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 251-350 3.19e-21

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 88.91  E-value: 3.19e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18700014 251 PYYGYVYEDTLPGSEVLTVVAIDGDRGKPNHILYRLLNES-DGIFEINETSGAISVLQSpalLRRE---VYELHVQVTEv 326
Cdd:cd11304   1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNeDGLFSIDPSTGEITTAKP---LDREeqsSYTLTVTATD- 76

                        90       100
                ....*....|....*....|....
gi 18700014 327 nsPGSPAAQATVPVTIRIVDLNNH 350
Cdd:cd11304  77 --GGGPPLSSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
478-568 4.75e-18

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 79.65  E-value: 4.75e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18700014   478 YIARIPENAPGGSNVVAVTAVDPDTGPWGKVHYSIYGTGSD-LFLIHPSTGLIYTQpwASLDAEGTSRYNFYVKAEDMD- 555
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGgNFRIDPDTGDISTT--KPLDRESIGEYELTVEATDSGg 78

                          90
                  ....*....|....
gi 18700014   556 -GRYSLAEVFVTLL 568
Cdd:pfam00028  79 pPLSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
140-238 2.03e-17

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 78.11  E-value: 2.03e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18700014   140 YIIRVPENIPAGSSIFKVQAEDKDTGSGGSVTYSLQNLHSS-KFSMDRHSGVLRLQagATLDYEKSRAHYITVIAKDGGG 218
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGgNFRIDPDTGDISTT--KPLDRESIGEYELTVEATDSGG 78

                          90       100
                  ....*....|....*....|
gi 18700014   219 RLRgadmvfSATTTVTINVE 238
Cdd:pfam00028  79 PPL------SSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 158-245 4.15e-17

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 76.62  E-value: 4.15e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18700014    158 QAEDKDTGSGGSVTYSL-QNLHSSKFSMDRHSGVLRLQAgaTLDYEKSRAHYITVIAKDGGGRLRgadmvfSATTTVTIN 236
Cdd:smart00112   1 SATDADSGENGKVTYSIlSGNDDGLFSIDPETGEITTTK--PLDREEQPEYTLTVEATDGGGPPL------SSTATVTIT 72


                   ....*....
gi 18700014    237 VEDVQDTAP 245
Cdd:smart00112  73 VLDVNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 496-575 6.25e-17

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 76.23  E-value: 6.25e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18700014    496 TAVDPDTGPWGKVHYSI-YGTGSDLFLIHPSTGLIYTQpwASLDAEGTSRYNFYVKAEDMDG--RYSLAEVFVTLLDVND 572
Cdd:smart00112   1 SATDADSGENGKVTYSIlSGNDDGLFSIDPETGEITTT--KPLDREEQPEYTLTVEATDGGGppLSSTATVTITVLDVND 78


                   ...
gi 18700014    573 HYP 575
Cdd:smart00112  79 NAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 580-679 1.59e-16

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 75.81  E-value: 1.59e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18700014 580 SVQEKTMVLGTPLKIEATDQDaEEPNNLVDYSITRAEPVNVFDIDAHTGEIRLKNSIrslealhnitpsgDY----SWSL 655
Cdd:cd11304   5 SVPENAPPGTVVLTVSATDPD-SGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPL-------------DReeqsSYTL 70

                        90       100
                ....*....|....*....|....
gi 18700014 656 QVQAKDRGSPSFSTTALLKIDITD 679
Cdd:cd11304  71 TVTATDGGGPPLSSTATVTITVLD 94
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 596-679 2.23e-11

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 60.44  E-value: 2.23e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18700014    596 ATDQDaEEPNNLVDYSITRAEPVNVFDIDAHTGEIRLKNSIrslealhnitpsgDY----SWSLQVQAKDRGSPSFSTTA 671
Cdd:smart00112   2 ATDAD-SGENGKVTYSILSGNDDGLFSIDPETGEITTTKPL-------------DReeqpEYTLTVEATDGGGPPLSSTA 67


                   ....*...
gi 18700014    672 LLKIDITD 679
Cdd:smart00112  68 TVTITVLD 75
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 364-469 2.33e-11

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 60.79  E-value: 2.33e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18700014 364 FELSMFEHPPQGEILrgLKITVNDSDQGANAKFNLRLVG--PGGIFRVVPQTvlneAQVTIIvensAAIDFEKSKLLTFK 441
Cdd:cd11304   2 YEVSVPENAPPGTVV--LTVSATDPDSGENGEVTYSIVSgnEDGLFSIDPST----GEITTA----KPLDREEQSSYTLT 71

                        90       100
                ....*....|....*....|....*...
gi 18700014 442 LLAIEVNTPeKFSSTADIVIQLLDTNDN 469
Cdd:cd11304  72 VTATDGGGP-PLSSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
252-344 3.38e-11

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 60.39  E-value: 3.38e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18700014   252 YYGYVYEDTLPGSEVLTVVAIDGDRGKPNHILYRLLN-ESDGIFEINETSGAISVLQSpalLRREV---YELHVQVTevn 327
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGgGPGGNFRIDPDTGDISTTKP---LDRESigeYELTVEAT--- 74

                          90
                  ....*....|....*..
gi 18700014   328 SPGSPAAQATVPVTIRI 344
Cdd:pfam00028  75 DSGGPPLSSTATVTITV 91
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 42-130 4.34e-11

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 60.02  E-value: 4.34e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18700014  42 FSLPEDTPVGSHVYTLNGTDP---EGDPISYHISfDPSTRSVFSVDPNFGNITLVEELDREREDEIEAIISISDGLNLVA 118
Cdd:cd11304   4 VSVPENAPPGTVVLTVSATDPdsgENGEVTYSIV-SGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPPL 82

                        90
                ....*....|....*
gi 18700014 119 E---KVVILVTDAND 130
Cdd:cd11304  83 SstaTVTITVLDVND 97
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 270-352 4.49e-11

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 59.67  E-value: 4.49e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18700014    270 VAIDGDRGKPNHILYRLLNESD-GIFEINETSGAISVLQSpalLRRE---VYELHVQVTEVnspGSPAAQATVPVTIRIV 345
Cdd:smart00112   1 SATDADSGENGKVTYSILSGNDdGLFSIDPETGEITTTKP---LDREeqpEYTLTVEATDG---GGPPLSSTATVTITVL 74


                   ....*..
gi 18700014    346 DLNNHPP 352
Cdd:smart00112  75 DVNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 384-471 5.88e-09

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 53.51  E-value: 5.88e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18700014    384 TVNDSDQGANAKFNLRLVG--PGGIFRVVPQTvlneaqvtIIVENSAAIDFEKSKLLTFKLLAIEVNTPEKfSSTADIVI 461
Cdd:smart00112   1 SATDADSGENGKVTYSILSgnDDGLFSIDPET--------GEITTTKPLDREEQPEYTLTVEATDGGGPPL-SSTATVTI 71

                           90
                   ....*....|
gi 18700014    462 QLLDTNDNVP 471
Cdd:smart00112  72 TVLDVNDNAP 81
Cadherin pfam00028
Cadherin domain;
590-678 4.52e-07

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 48.45  E-value: 4.52e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18700014   590 TPLKIEATDQDaEEPNNLVDYSITRAEPVNVFDIDAHTGEIRLKNSI-RSLEALHNITpsgdyswslqVQAKDRGSPSFS 668
Cdd:pfam00028  14 EVLTVTATDPD-LGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLdRESIGEYELT----------VEATDSGGPPLS 82

                          90
                  ....*....|
gi 18700014   669 TTALLKIDIT 678
Cdd:pfam00028  83 STATVTITVL 92
Cadherin pfam00028
Cadherin domain;
42-95 6.92e-04

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 39.59  E-value: 6.92e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 18700014    42 FSLPEDTPVGSHVYTLNGTDPEGDP---ISYHISFDPSTRSvFSVDPNFGNITLVEE 95
Cdd:pfam00028   3 ASVPENAPVGTEVLTVTATDPDLGPngrIFYSILGGGPGGN-FRIDPDTGDISTTKP 58
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 61-133 2.80e-03

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 37.33  E-value: 2.80e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 18700014     61 DPEGDPISYHISfDPSTRSVFSVDPNFGNITLVEELDREREDEIEAIISISDG--LNLVAE-KVVILVTDANDEAP 133
Cdd:smart00112   7 SGENGKVTYSIL-SGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGggPPLSSTaTVTITVLDVNDNAP 81
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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