CLV2 Leucine-rich repeat (LRR) family protein [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: CLV2
Official Full Name: Leucine-rich repeat (LRR) family protein
Primary source: TAIR:AT1G65380
Locus tag: AT1G65380
See related: Araport:AT1G65380
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: AtRLP10; clavata 2; Receptor Like Protein 10; T8F5.16; T8F5_16
Summary: Receptor-like protein containing leucine-rich repeats. Regulates both meristem and organ development in Arabidopsis.
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Genomic context

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See CLV2 in Genome Data Viewer

Location:: chromosome: 1

Exon count:: 1

Sequence:: Chromosome: 1; NC_003070.9 (24286742..24289329)

Chromosome 1 - NC_003070.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003070.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CLAVATA Signaling Ensures Reproductive Development in Plants across Thermal Environments.
Title: CLAVATA Signaling Ensures Reproductive Development in Plants across Thermal Environments.
CLV signaling involves the secretion of the CLV3 peptide and its perception by a number of Leucine-Rich-Repeat (LRR) receptors, including the receptor-like kinase CLV1 and the receptor-like protein CLV2 coupled with the CORYNE (CRN) pseudokinase. CLV2, and its maize ortholog FASCIATED EAR2 (FEA2) appear to function in signaling by CLV3 and several related CLV3/EMBRYO-SURROUNDING REGION (CLE) peptide ligands
Title: The CLAVATA receptor FASCIATED EAR2 responds to distinct CLE peptides by signaling through two downstream effectors.
study reports that the receptor-like protein CLAVATA 2 (CLV2) and the pseudokinase CORYNE (CRN) are necessary to fully sense root-active CLE peptides
Title: Perception of root-active CLE peptides requires CORYNE function in the phloem vasculature.
CLV1 and CLV2, two receptors involved in CLV3 perception during plant development, contribute to bacterial wilt through a signalling pathway involving the miR169/NF-YA module.
Title: Arabidopsis CLAVATA1 and CLAVATA2 receptors contribute to Ralstonia solanacearum pathogenicity through a miR169-dependent pathway.
Gene NANA regulates cell proliferation in Arabidopsis thaliana shoot apical meristem without interaction with CLV2.
Title: [The gene NANA regulates cell proliferation in Arabidopsis thaliana shoot apical meristem without interaction with CLV1, CLV2, CLV3].
Parallel signaling pathways involving CLV1, CLV2, and RPK2 are important for nematode parasitism.
Title: Synergistic interaction of CLAVATA1, CLAVATA2, and RECEPTOR-LIKE PROTEIN KINASE 2 in cyst nematode parasitism of Arabidopsis.
Over-expression of CLV2 in wild-type plants unexpectedly resulted in a multi-carpel phenotype, mimicking the clv2 mutant, which suggests a co-suppression effect on the endogenous CLV2.
Title: New aspects of CLAVATA2, a versatile gene in the regulation of Arabidopsis development.
Our results suggest a model in which CLV1/BAM1 and CLV2/CRN complexes act in separate, parallel pathways in shoot meristems, while the CLV1, CLV2, and CRN receptors function together in a linear pathway during fruit development.
Title: CLAVATA signaling pathway receptors of Arabidopsis regulate cell proliferation in fruit organ formation as well as in meristems.
Data report detection of distinct CLV2-CRN heteromultimeric and CLV1-BAM multimeric complexes in transient expression in tobacco and in Arabidopsis meristems.
Title: CLAVATA2 forms a distinct CLE-binding receptor complex regulating Arabidopsis stem cell specification.
The results therefore imply that the CLE14/CLE20 peptides may act through the CLV2-CRN receptor kinase, and that their availabilities and/or abundances may be affected by cytokinin activity in planta.
Title: CLE14/CLE20 peptides may interact with CLAVATA2/CORYNE receptor-like kinases to irreversibly inhibit cell division in the root meristem of Arabidopsis.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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NM_105212.3

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables peptide receptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within anatomical structure morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in maintenance of root meristem identity	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within meristem development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phloem development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of flower development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of meristem growth	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within signal transduction	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in endoplasmic reticulum membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISM Inferred from Sequence Model more info

General protein information

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Preferred Names: Leucine-rich repeat (LRR) family protein

NP_176717.1

clavata 2 (CLV2); CONTAINS InterPro DOMAIN/s: Leucine-rich repeat (InterPro:IPR001611); BEST Arabidopsis thaliana protein match is: Leucine-rich repeat protein kinase family protein (TAIR:AT5G63930.1); Has 98590 Blast hits to 28947 proteins in 1129 species: Archae - 27; Bacteria - 4991; Metazoa - 24209; Fungi - 1144; Plants - 60409; Viruses - 6; Other Eukaryotes - 7804 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003070.9 Reference assembly

Range

24286742..24289329

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_105212.3 → NP_176717.1 Leucine-rich repeat (LRR) family protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_176717.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O80809, Q84JK9, Q84JT8, Q84JU7, Q84K94, Q84VM8, Q84VM9, Q84VN0, Q9SPE8, Q9SPE9

UniProtKB/TrEMBL

A0A7G2E3B0

Conserved Domains (2) summary

PLN00113
Location:38 → 665

PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional

sd00033
Location:266 → 289

LRR_RI; leucine-rich repeat [structural motif]