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Conserved domains on  [gi|15218650|ref|NP_176717|]
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Leucine-rich repeat (LRR) family protein [Arabidopsis thaliana]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 1000136)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PLN00113 super family cl33413
leucine-rich repeat receptor-like protein kinase; Provisional
 38-665 7.80e-86

leucine-rich repeat receptor-like protein kinase; Provisional


The actual alignment was detected with superfamily member PLN00113:

Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 290.98  E-value: 7.80e-86
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218650   38 LLIFRVSIHDLNRSLSTWYGS-SCSNWTGLACQNpTGKVLSLTLSGLNLSSQIHPSLCKLSSLQSLDLSHNNFSGNIP-S 115
Cdd:PLN00113  34 LLSFKSSINDPLKYLSNWNSSaDVCLWQGITCNN-SSRVVSIDLSGKNISGKISSAIFRLPYIQTINLSNNQLSGPIPdD 112

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218650  116 CFGSLRNLRTLNLSRNRFVGSIPATFVSLkeLREVVLSENRdLGGVVPHWFGNFSmNLERVDFSFCSFVGELPESLLYLK 195
Cdd:PLN00113 113 IFTTSSSLRYLNLSNNNFTGSIPRGSIPN--LETLDLSNNM-LSGEIPNDIGSFS-SLKVLDLGGNVLVGKIPNSLTNLT 188

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218650  196 SLKYLNLESNNMTGTL-RDFQQ--PLVVLNLASNQFSGTLPCFYASRPSLSILNIAENSLVGGLPSCLGSLKELSHLNLS 272
Cdd:PLN00113 189 SLEFLTLASNQLVGQIpRELGQmkSLKWIYLGYNNLSGEIPYEIGGLTSLNHLDLVYNNLTGPIPSSLGNLKNLQYLFLY 268

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218650  273 FNGFNYEISPRLMFSEKLVMLDLSHNGFSGRLPSRISETTEklgLVLLDLSHNSFSGDIPLRITELKSLQALRLSHNLLT 352
Cdd:PLN00113 269 QNKLSGPIPPSIFSLQKLISLDLSDNSLSGEIPELVIQLQN---LEILHLFSNNFTGKIPVALTSLPRLQVLQLWSNKFS 345

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218650  353 GDIPARIGNLTYLQVIDLSHNALTGSIPLNIVGCFQLLALMISNNNLSGEIQPELDALDSLKILDISNNHISGEIPLTLA 432
Cdd:PLN00113 346 GEIPKNLGKHNNLTVLDLSTNNLTGEIPEGLCSSGNLFKLILFSNSLEGEIPKSLGACRSLRRVRLQDNSFSGELPSEFT 425

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218650  433 GLKSLEIVDISSNNLSGNLNEAITKWSNLKYLSLARNKFSGTLPSwLFKFDKIQMIDYSSNRFSWFIPddnlnsTRFKdf 512
Cdd:PLN00113 426 KLPLVYFLDISNNNLQGRINSRKWDMPSLQMLSLARNKFFGGLPD-SFGSKRLENLDLSRNQFSGAVP------RKLG-- 496

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218650  513 qtgggegfaeppgkveikisaavvakdelsfsyNLLSMVGIDLSDNLLHGEIPEALFRQKNIEYLNLSYNFLEGQLP-RL 591
Cdd:PLN00113 497 ---------------------------------SLSELMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQLSGQIPaSF 543

                        570       580       590       600       610       620       630
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 15218650  592 EKLPRLKALDLSHNSLSGQVIGNISAPPGLTLLNLSHNCFSGIITEKEG-LGKFPGALAGNPELCVETPGSKCDP 665
Cdd:PLN00113 544 SEMPVLSQLDLSQNQLSGEIPKNLGNVESLVQVNISHNHLHGSLPSTGAfLAINASAVAGNIDLCGGDTTSGLPP 618
 
Name Accession Description Interval E-value
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 38-665 7.80e-86

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 290.98  E-value: 7.80e-86
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218650   38 LLIFRVSIHDLNRSLSTWYGS-SCSNWTGLACQNpTGKVLSLTLSGLNLSSQIHPSLCKLSSLQSLDLSHNNFSGNIP-S 115
Cdd:PLN00113  34 LLSFKSSINDPLKYLSNWNSSaDVCLWQGITCNN-SSRVVSIDLSGKNISGKISSAIFRLPYIQTINLSNNQLSGPIPdD 112

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218650  116 CFGSLRNLRTLNLSRNRFVGSIPATFVSLkeLREVVLSENRdLGGVVPHWFGNFSmNLERVDFSFCSFVGELPESLLYLK 195
Cdd:PLN00113 113 IFTTSSSLRYLNLSNNNFTGSIPRGSIPN--LETLDLSNNM-LSGEIPNDIGSFS-SLKVLDLGGNVLVGKIPNSLTNLT 188

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218650  196 SLKYLNLESNNMTGTL-RDFQQ--PLVVLNLASNQFSGTLPCFYASRPSLSILNIAENSLVGGLPSCLGSLKELSHLNLS 272
Cdd:PLN00113 189 SLEFLTLASNQLVGQIpRELGQmkSLKWIYLGYNNLSGEIPYEIGGLTSLNHLDLVYNNLTGPIPSSLGNLKNLQYLFLY 268

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218650  273 FNGFNYEISPRLMFSEKLVMLDLSHNGFSGRLPSRISETTEklgLVLLDLSHNSFSGDIPLRITELKSLQALRLSHNLLT 352
Cdd:PLN00113 269 QNKLSGPIPPSIFSLQKLISLDLSDNSLSGEIPELVIQLQN---LEILHLFSNNFTGKIPVALTSLPRLQVLQLWSNKFS 345

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218650  353 GDIPARIGNLTYLQVIDLSHNALTGSIPLNIVGCFQLLALMISNNNLSGEIQPELDALDSLKILDISNNHISGEIPLTLA 432
Cdd:PLN00113 346 GEIPKNLGKHNNLTVLDLSTNNLTGEIPEGLCSSGNLFKLILFSNSLEGEIPKSLGACRSLRRVRLQDNSFSGELPSEFT 425

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218650  433 GLKSLEIVDISSNNLSGNLNEAITKWSNLKYLSLARNKFSGTLPSwLFKFDKIQMIDYSSNRFSWFIPddnlnsTRFKdf 512
Cdd:PLN00113 426 KLPLVYFLDISNNNLQGRINSRKWDMPSLQMLSLARNKFFGGLPD-SFGSKRLENLDLSRNQFSGAVP------RKLG-- 496

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218650  513 qtgggegfaeppgkveikisaavvakdelsfsyNLLSMVGIDLSDNLLHGEIPEALFRQKNIEYLNLSYNFLEGQLP-RL 591
Cdd:PLN00113 497 ---------------------------------SLSELMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQLSGQIPaSF 543

                        570       580       590       600       610       620       630
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 15218650  592 EKLPRLKALDLSHNSLSGQVIGNISAPPGLTLLNLSHNCFSGIITEKEG-LGKFPGALAGNPELCVETPGSKCDP 665
Cdd:PLN00113 544 SEMPVLSQLDLSQNQLSGEIPKNLGNVESLVQVNISHNHLHGSLPSTGAfLAINASAVAGNIDLCGGDTTSGLPP 618
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
242-595 7.70e-25

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 107.71  E-value: 7.70e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218650 242 LSILNIAENSLVGGLPSCLGSLKELSHLNLSFNGFNYEISprlmfseKLVMLDLSHNGFSgRLPSRISETTEklgLVLLD 321
Cdd:COG4886  74 LLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNEELSNLT-------NLESLDLSGNQLT-DLPEELANLTN---LKELD 142

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218650 322 LSHNSFSgDIPLRITELKSLQALRLSHNLLTgDIPARIGNLTYLQVIDLSHNALTgSIPLNIVGCFQLLALMISNNNLSg 401
Cdd:COG4886 143 LSNNQLT-DLPEPLGNLTNLKSLDLSNNQLT-DLPEELGNLTNLKELDLSNNQIT-DLPEPLGNLTNLEELDLSGNQLT- 218

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218650 402 EIQPELDALDSLKILDISNNHISgEIPlTLAGLKSLEIVDISSNNLSGNLNEAitKWSNLKYLSLARNKFSGTLPSWLFK 481
Cdd:COG4886 219 DLPEPLANLTNLETLDLSNNQLT-DLP-ELGNLTNLEELDLSNNQLTDLPPLA--NLTNLKTLDLSNNQLTDLKLKELEL 294

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218650 482 FDKIQMIDYSSNRFSWFIPDDNLNSTRFKDFQTGGGEGFAEPPGKVEIKISAAVVAKDELSFSYNLLSMVGIDLSDNLLH 561
Cdd:COG4886 295 LLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGL 374

                       330       340       350
                ....*....|....*....|....*....|....
gi 15218650 562 GEIPEALFRQKNIEYLNLSYNFLEGQLPRLEKLP 595
Cdd:COG4886 375 LEATLLTLALLLLTLLLLLLTTTAGVLLLTLALL 408
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 338-469 7.22e-10

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 59.41  E-value: 7.22e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218650 338 LKSLQALRLSHNLLTgdipaRI---GNLTYLQVIDLSHNALTgsiplnIV----GCFQLLALMISNNNL-SGE---IQPE 406
Cdd:cd21340  45 LTNLTHLYLQNNQIE-----KIenlENLVNLKKLYLGGNRIS------VVegleNLTNLEELHIENQRLpPGEkltFDPR 113

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 15218650 407 -LDAL-DSLKILDISNNHISGEIPltLAGLKSLEIVDISSNNLS--GNLNEAITKWSNLKYLSLARN 469
Cdd:cd21340 114 sLAALsNSLRVLNISGNNIDSLEP--LAPLRNLEQLDASNNQISdlEELLDLLSSWPSLRELDLTGN 178
LRR_8 pfam13855
Leucine rich repeat;
553-607 1.18e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 40.59  E-value: 1.18e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 15218650   553 IDLSDNLLHGEIPEALFRQKNIEYLNLSYNFLEGQLPR-LEKLPRLKALDLSHNSL 607
Cdd:pfam13855   6 LDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGaFSGLPSLRYLDLSGNRL 61
 
Name Accession Description Interval E-value
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 38-665 7.80e-86

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 290.98  E-value: 7.80e-86
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218650   38 LLIFRVSIHDLNRSLSTWYGS-SCSNWTGLACQNpTGKVLSLTLSGLNLSSQIHPSLCKLSSLQSLDLSHNNFSGNIP-S 115
Cdd:PLN00113  34 LLSFKSSINDPLKYLSNWNSSaDVCLWQGITCNN-SSRVVSIDLSGKNISGKISSAIFRLPYIQTINLSNNQLSGPIPdD 112

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218650  116 CFGSLRNLRTLNLSRNRFVGSIPATFVSLkeLREVVLSENRdLGGVVPHWFGNFSmNLERVDFSFCSFVGELPESLLYLK 195
Cdd:PLN00113 113 IFTTSSSLRYLNLSNNNFTGSIPRGSIPN--LETLDLSNNM-LSGEIPNDIGSFS-SLKVLDLGGNVLVGKIPNSLTNLT 188

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218650  196 SLKYLNLESNNMTGTL-RDFQQ--PLVVLNLASNQFSGTLPCFYASRPSLSILNIAENSLVGGLPSCLGSLKELSHLNLS 272
Cdd:PLN00113 189 SLEFLTLASNQLVGQIpRELGQmkSLKWIYLGYNNLSGEIPYEIGGLTSLNHLDLVYNNLTGPIPSSLGNLKNLQYLFLY 268

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218650  273 FNGFNYEISPRLMFSEKLVMLDLSHNGFSGRLPSRISETTEklgLVLLDLSHNSFSGDIPLRITELKSLQALRLSHNLLT 352
Cdd:PLN00113 269 QNKLSGPIPPSIFSLQKLISLDLSDNSLSGEIPELVIQLQN---LEILHLFSNNFTGKIPVALTSLPRLQVLQLWSNKFS 345

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218650  353 GDIPARIGNLTYLQVIDLSHNALTGSIPLNIVGCFQLLALMISNNNLSGEIQPELDALDSLKILDISNNHISGEIPLTLA 432
Cdd:PLN00113 346 GEIPKNLGKHNNLTVLDLSTNNLTGEIPEGLCSSGNLFKLILFSNSLEGEIPKSLGACRSLRRVRLQDNSFSGELPSEFT 425

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218650  433 GLKSLEIVDISSNNLSGNLNEAITKWSNLKYLSLARNKFSGTLPSwLFKFDKIQMIDYSSNRFSWFIPddnlnsTRFKdf 512
Cdd:PLN00113 426 KLPLVYFLDISNNNLQGRINSRKWDMPSLQMLSLARNKFFGGLPD-SFGSKRLENLDLSRNQFSGAVP------RKLG-- 496

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218650  513 qtgggegfaeppgkveikisaavvakdelsfsyNLLSMVGIDLSDNLLHGEIPEALFRQKNIEYLNLSYNFLEGQLP-RL 591
Cdd:PLN00113 497 ---------------------------------SLSELMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQLSGQIPaSF 543

                        570       580       590       600       610       620       630
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 15218650  592 EKLPRLKALDLSHNSLSGQVIGNISAPPGLTLLNLSHNCFSGIITEKEG-LGKFPGALAGNPELCVETPGSKCDP 665
Cdd:PLN00113 544 SEMPVLSQLDLSQNQLSGEIPKNLGNVESLVQVNISHNHLHGSLPSTGAfLAINASAVAGNIDLCGGDTTSGLPP 618
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
242-595 7.70e-25

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 107.71  E-value: 7.70e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218650 242 LSILNIAENSLVGGLPSCLGSLKELSHLNLSFNGFNYEISprlmfseKLVMLDLSHNGFSgRLPSRISETTEklgLVLLD 321
Cdd:COG4886  74 LLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNEELSNLT-------NLESLDLSGNQLT-DLPEELANLTN---LKELD 142

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218650 322 LSHNSFSgDIPLRITELKSLQALRLSHNLLTgDIPARIGNLTYLQVIDLSHNALTgSIPLNIVGCFQLLALMISNNNLSg 401
Cdd:COG4886 143 LSNNQLT-DLPEPLGNLTNLKSLDLSNNQLT-DLPEELGNLTNLKELDLSNNQIT-DLPEPLGNLTNLEELDLSGNQLT- 218

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218650 402 EIQPELDALDSLKILDISNNHISgEIPlTLAGLKSLEIVDISSNNLSGNLNEAitKWSNLKYLSLARNKFSGTLPSWLFK 481
Cdd:COG4886 219 DLPEPLANLTNLETLDLSNNQLT-DLP-ELGNLTNLEELDLSNNQLTDLPPLA--NLTNLKTLDLSNNQLTDLKLKELEL 294

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218650 482 FDKIQMIDYSSNRFSWFIPDDNLNSTRFKDFQTGGGEGFAEPPGKVEIKISAAVVAKDELSFSYNLLSMVGIDLSDNLLH 561
Cdd:COG4886 295 LLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGL 374

                       330       340       350
                ....*....|....*....|....*....|....
gi 15218650 562 GEIPEALFRQKNIEYLNLSYNFLEGQLPRLEKLP 595
Cdd:COG4886 375 LEATLLTLALLLLTLLLLLLTTTAGVLLLTLALL 408
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
165-507 1.97e-22

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 100.39  E-value: 1.97e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218650 165 WFGNFSMNLERVDFSFCSFVGELPESLLYLKSLKYLNLESNNMTGTLRDFQQPLVVLNLASNQFSGTLPCFYASRPSLSI 244
Cdd:COG4886  21 LTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTE 100

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218650 245 LNIAENSLvgglpscLGSLKELSHLNLSFNGFNyEISPRLMFSEKLVMLDLSHNGFSgRLPSRISETTEklgLVLLDLSH 324
Cdd:COG4886 101 LDLSGNEE-------LSNLTNLESLDLSGNQLT-DLPEELANLTNLKELDLSNNQLT-DLPEPLGNLTN---LKSLDLSN 168

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218650 325 NSFSgDIPLRITELKSLQALRLSHNLLTgDIPARIGNLTYLQVIDLSHNALTgSIPLNIVGCFQLLALMISNNNLSgEIq 404
Cdd:COG4886 169 NQLT-DLPEELGNLTNLKELDLSNNQIT-DLPEPLGNLTNLEELDLSGNQLT-DLPEPLANLTNLETLDLSNNQLT-DL- 243

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218650 405 PELDALDSLKILDISNNHISgEIPlTLAGLKSLEIVDISSNNLSGNLNEAITKWSNLKYLSLARNKFSGTLPSWLFKFDK 484
Cdd:COG4886 244 PELGNLTNLEELDLSNNQLT-DLP-PLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLT 321

                       330       340
                ....*....|....*....|...
gi 15218650 485 IQMIDYSSNRFSWFIPDDNLNST 507
Cdd:COG4886 322 TLLLLLLLLKGLLVTLTTLALSL 344
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
244-643 2.22e-20

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 94.23  E-value: 2.22e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218650 244 ILNIAENSLVGGLPSCLGSLKELSHLNLSFNGFNYEISPRLMFSEKLVMLDLSHNGFSGRLPSRISETTEKLGLVLLDLS 323
Cdd:COG4886   1 LLLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218650 324 HNSFSGDIPLRITELKSLQALRLSHNLLtgdiparIGNLTYLQVIDLSHNALTgSIPLNIVGCFQLLALMISNNNLSgEI 403
Cdd:COG4886  81 LLSLLLLGLTDLGDLTNLTELDLSGNEE-------LSNLTNLESLDLSGNQLT-DLPEELANLTNLKELDLSNNQLT-DL 151

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218650 404 QPELDALDSLKILDISNNHISgEIPLTLAGLKSLEIVDISSNNLSgNLNEAITKWSNLKYLSLARNKFSgTLPSWLFKFD 483
Cdd:COG4886 152 PEPLGNLTNLKSLDLSNNQLT-DLPEELGNLTNLKELDLSNNQIT-DLPEPLGNLTNLEELDLSGNQLT-DLPEPLANLT 228

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218650 484 KIQMIDYSSNRFSwfipddnlnstrfkdfqtgggegfaeppgkveikisaavvakdelsfsynllsmvgidlsdnllhgE 563
Cdd:COG4886 229 NLETLDLSNNQLT------------------------------------------------------------------D 242

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218650 564 IPEaLFRQKNIEYLNLSYNFLEGqLPRLEKLPRLKALDLSHNSLSGQVIGNISAPPGLTLLNLSHNCFSGIITEKEGLGK 643
Cdd:COG4886 243 LPE-LGNLTNLEELDLSNNQLTD-LPPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLL 320
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 413-700 2.53e-18

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 89.91  E-value: 2.53e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218650  413 LKILDISNNHISGEIPLTLAGLKSLEIVDISSNNLSGNLNEAI-TKWSNLKYLSLARNKFSGTLPSWLFKFdkIQMIDYS 491
Cdd:PLN00113  71 VVSIDLSGKNISGKISSAIFRLPYIQTINLSNNQLSGPIPDDIfTTSSSLRYLNLSNNNFTGSIPRGSIPN--LETLDLS 148

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218650  492 SNRFSWFIPDD--NLNSTRFKDFqtgGGEGFAeppGKVEIKISaavvakdelsfsyNLLSMVGIDLSDNLLHGEIPEALF 569
Cdd:PLN00113 149 NNMLSGEIPNDigSFSSLKVLDL---GGNVLV---GKIPNSLT-------------NLTSLEFLTLASNQLVGQIPRELG 209

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218650  570 RQKNIEYLNLSYNFLEGQLP-RLEKLPRLKALDLSHNSLSGQVignisaPPGLTLLNLSHNCFsgiitekeglgkfpgal 648
Cdd:PLN00113 210 QMKSLKWIYLGYNNLSGEIPyEIGGLTSLNHLDLVYNNLTGPI------PSSLGNLKNLQYLF----------------- 266

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 15218650  649 agnpelcvetpgskcdpanidasqeeIYQNELvEGPISIWIFCLSAFISFDF 700
Cdd:PLN00113 267 --------------------------LYQNKL-SGPIPPSIFSLQKLISLDL 291
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
306-687 3.80e-18

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 87.30  E-value: 3.80e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218650 306 SRISETTEKLGLVLLDLSHNSFSGDIPLRITELKSLQALRLSHNLLTGDIPARIGNLTYLQVIDLSHNALTGSIPLNIVG 385
Cdd:COG4886   8 LTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLL 87

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218650 386 CFQLLALMISNNNLSGEIQPELDALDSLKILDISNNHISgEIPLTLAGLKSLEIVDISSNNLSgNLNEAITKWSNLKYLS 465
Cdd:COG4886  88 GLTDLGDLTNLTELDLSGNEELSNLTNLESLDLSGNQLT-DLPEELANLTNLKELDLSNNQLT-DLPEPLGNLTNLKSLD 165

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218650 466 LARNKFSgTLPSWLFKFDKIQMIDYSSNRFSwfipddnlnstrfkdfqtgggegfaeppgkveiKISAAVvakdelsfsY 545
Cdd:COG4886 166 LSNNQLT-DLPEELGNLTNLKELDLSNNQIT---------------------------------DLPEPL---------G 202

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218650 546 NLLSMVGIDLSDNLLHgEIPEALFRQKNIEYLNLSYNFLEgQLPRLEKLPRLKALDLSHNSLSGqvIGNISAPPGLTLLN 625
Cdd:COG4886 203 NLTNLEELDLSGNQLT-DLPEPLANLTNLETLDLSNNQLT-DLPELGNLTNLEELDLSNNQLTD--LPPLANLTNLKTLD 278

                       330       340       350       360       370       380
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 15218650 626 LSHNCFSGIITEKEGLGKFPGALAGNPELCVETPGSKCDPANIDASQEEIYQNELVEGPISI 687
Cdd:COG4886 279 LSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTL 340
PLN03150 PLN03150
hypothetical protein; Provisional
 320-434 1.18e-14

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 77.55  E-value: 1.18e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218650  320 LDLSHNSFSGDIPLRITELKSLQALRLSHNLLTGDIPARIGNLTYLQVIDLSHNALTGSIPlnivgcfqllalmisnnnl 399
Cdd:PLN03150 423 LGLDNQGLRGFIPNDISKLRHLQSINLSGNSIRGNIPPSLGSITSLEVLDLSYNSFNGSIP------------------- 483

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 15218650  400 sgeiqPELDALDSLKILDISNNHISGEIPLTLAGL 434
Cdd:PLN03150 484 -----ESLGQLTSLRILNLNGNSLSGRVPAALGGR 513
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
218-453 2.16e-14

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 75.74  E-value: 2.16e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218650 218 LVVLNLASNQFSgTLPCFYASRPSLSILNIAENSLvGGLPSCLGSLKELSHLNLSFNGFNyEISPRLMFSEKLVMLDLSH 297
Cdd:COG4886 138 LKELDLSNNQLT-DLPEPLGNLTNLKSLDLSNNQL-TDLPEELGNLTNLKELDLSNNQIT-DLPEPLGNLTNLEELDLSG 214

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218650 298 NGFSgRLPSRISETTEklgLVLLDLSHNSFSgDIPlRITELKSLQALRLSHNLLTgDIPArIGNLTYLQVIDLSHNALTG 377
Cdd:COG4886 215 NQLT-DLPEPLANLTN---LETLDLSNNQLT-DLP-ELGNLTNLEELDLSNNQLT-DLPP-LANLTNLKTLDLSNNQLTD 286

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 15218650 378 SIPLNIVGCFQLLALMISNNNLSGEIQPELDALDSLKILDISNNHISGEIPLTLAGLKSLEIVDISSNNLSGNLNE 453
Cdd:COG4886 287 LKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLL 362
PLN03150 PLN03150
hypothetical protein; Provisional
 391-479 3.47e-11

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 66.38  E-value: 3.47e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218650  391 ALMISNNNLSGEIQPELDALDSLKILDISNNHISGEIPLTLAGLKSLEIVDISSNNLSGNLNEAITKWSNLKYLSLARNK 470
Cdd:PLN03150 422 GLGLDNQGLRGFIPNDISKLRHLQSINLSGNSIRGNIPPSLGSITSLEVLDLSYNSFNGSIPESLGQLTSLRILNLNGNS 501


                 ....*....
gi 15218650  471 FSGTLPSWL 479
Cdd:PLN03150 502 LSGRVPAAL 510
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
76-456 9.73e-11

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 64.57  E-value: 9.73e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218650  76 LSLTLSGLNLSSQIHPSLCKLSSLQSLDLSHNNFSGNIPscFGSLRNLRTLNLSRNRfVGSIPATFVSLKELREVVLSEN 155
Cdd:COG4886  70 SLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNEE--LSNLTNLESLDLSGNQ-LTDLPEELANLTNLKELDLSNN 146

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218650 156 R--DLggvvPHWFGNFSmNLERVDFSFCSfVGELPEsllylkslkylnlESNNMTGtlrdfqqpLVVLNLASNQFSgTLP 233
Cdd:COG4886 147 QltDL----PEPLGNLT-NLKSLDLSNNQ-LTDLPE-------------ELGNLTN--------LKELDLSNNQIT-DLP 198

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218650 234 CFYASRPSLSILNIAENSLvGGLPSCLGSLKELSHLNLSFNGFNYEisPRLMFSEKLVMLDLSHNGFSGrlpsrISETTE 313
Cdd:COG4886 199 EPLGNLTNLEELDLSGNQL-TDLPEPLANLTNLETLDLSNNQLTDL--PELGNLTNLEELDLSNNQLTD-----LPPLAN 270

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218650 314 KLGLVLLDLSHNSFSGDIPLRITELKSLQALRLSHNLLTGDIPARIGNLTYLQVIDLSHNALTGSIPLNIVGCFQLLALM 393
Cdd:COG4886 271 LTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALL 350

                       330       340       350       360       370       380
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 15218650 394 ISNNNLSGEIQPELDALDSLKILDISNNHISGEIPLTLAGLKSLEIVDISSNNLSGNLNEAIT 456
Cdd:COG4886 351 TLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLTTTAGVLLLTLALLDAVNT 413
PLN03150 PLN03150
hypothetical protein; Provisional
 368-455 1.52e-10

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 64.45  E-value: 1.52e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218650  368 IDLSHNALTGSIPLNIVGCFQLLALMISNNNLSGEIQPELDALDSLKILDISNNHISGEIPLTLAGLKSLEIVDISSNNL 447
Cdd:PLN03150 423 LGLDNQGLRGFIPNDISKLRHLQSINLSGNSIRGNIPPSLGSITSLEVLDLSYNSFNGSIPESLGQLTSLRILNLNGNSL 502


                 ....*...
gi 15218650  448 SGNLNEAI 455
Cdd:PLN03150 503 SGRVPAAL 510
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 338-469 7.22e-10

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 59.41  E-value: 7.22e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218650 338 LKSLQALRLSHNLLTgdipaRI---GNLTYLQVIDLSHNALTgsiplnIV----GCFQLLALMISNNNL-SGE---IQPE 406
Cdd:cd21340  45 LTNLTHLYLQNNQIE-----KIenlENLVNLKKLYLGGNRIS------VVegleNLTNLEELHIENQRLpPGEkltFDPR 113

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 15218650 407 -LDAL-DSLKILDISNNHISGEIPltLAGLKSLEIVDISSNNLS--GNLNEAITKWSNLKYLSLARN 469
Cdd:cd21340 114 sLAALsNSLRVLNISGNNIDSLEP--LAPLRNLEQLDASNNQISdlEELLDLLSSWPSLRELDLTGN 178
PLN03150 PLN03150
hypothetical protein; Provisional
 552-652 1.74e-09

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 60.99  E-value: 1.74e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218650  552 GIDLSDNLLHGEIPEALFRQKNIEYLNLSYNFLEGQLP-RLEKLPRLKALDLSHNSLSGQVIGNISAPPGLTLLNLSHNC 630
Cdd:PLN03150 422 GLGLDNQGLRGFIPNDISKLRHLQSINLSGNSIRGNIPpSLGSITSLEVLDLSYNSFNGSIPESLGQLTSLRILNLNGNS 501

                         90       100
                 ....*....|....*....|..
gi 15218650  631 FSgiitekeglGKFPGALAGNP 652
Cdd:PLN03150 502 LS---------GRVPAALGGRL 514
PLN03150 PLN03150
hypothetical protein; Provisional
 289-360 1.77e-09

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 60.99  E-value: 1.77e-09
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 15218650  289 KLVMLDLSHNGFSGRLPSRISETTeklGLVLLDLSHNSFSGDIPLRITELKSLQALRLSHNLLTGDIPARIG 360
Cdd:PLN03150 443 HLQSINLSGNSIRGNIPPSLGSIT---SLEVLDLSYNSFNGSIPESLGQLTSLRILNLNGNSLSGRVPAALG 511
PLN03150 PLN03150
hypothetical protein; Provisional
 553-656 3.18e-09

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 60.21  E-value: 3.18e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218650  553 IDLSDNLLHGEIPEALFRQKNIEYLNLSYNFLEGQLPR-LEKLPRLKALDLSHNSLSGQVIGNISappGLTLLNLSHNcf 631
Cdd:PLN03150 447 INLSGNSIRGNIPPSLGSITSLEVLDLSYNSFNGSIPEsLGQLTSLRILNLNGNSLSGRVPAALG---GRLLHRASFN-- 521

                         90       100
                 ....*....|....*....|....*
gi 15218650  632 sgiITEKEGLGKFPGALAGNPELCV 656
Cdd:PLN03150 522 ---FTDNAGLCGIPGLRACGPHLSV 543
PLN03150 PLN03150
hypothetical protein; Provisional
 44-180 7.09e-09

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 59.06  E-value: 7.09e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218650   44 SIHDLNRSLST-----WYGSSCSN----WTGLACQ--NPTGKVLsltLSGLNLSSQ-----IHPSLCKLSSLQSLDLSHN 107
Cdd:PLN03150 376 ALQTLKSSLGLplrfgWNGDPCVPqqhpWSGADCQfdSTKGKWF---IDGLGLDNQglrgfIPNDISKLRHLQSINLSGN 452

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 15218650  108 NFSGNIPSCFGSLRNLRTLNLSRNRFVGSIPATFVSLKELREVVLSENRdLGGVVPHWFGnfSMNLERVDFSF 180
Cdd:PLN03150 453 SIRGNIPPSLGSITSLEVLDLSYNSFNGSIPESLGQLTSLRILNLNGNS-LSGRVPAALG--GRLLHRASFNF 522
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
231-479 1.43e-08

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 58.17  E-value: 1.43e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218650  231 TLPcfyASRPSLSILNIAENSLVGGLPSCL-GSLKELShlnlsFNGFNYEISPRLMfSEKLVMLDLSHNgfsgrlpsRIS 309
Cdd:PRK15370 192 TIP---ACIPEQITTLILDNNELKSLPENLqGNIKTLY-----ANSNQLTSIPATL-PDTIQEMELSIN--------RIT 254

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218650  310 ETTEKL--GLVLLDLSHNSFSGdIPLRITElkSLQALRLSHNLLTGdIPARI-GNLTYLQVIDLSHNALTGSIPLNivgc 386
Cdd:PRK15370 255 ELPERLpsALQSLDLFHNKISC-LPENLPE--ELRYLSVYDNSIRT-LPAHLpSGITHLNVQSNSLTALPETLPPG---- 326

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218650  387 fqlLALMISNNN----LSGEIQPELdaldslKILDISNNHISgEIPLTLAglKSLEIVDISSN---NLSGNLNEAitkws 459
Cdd:PRK15370 327 ---LKTLEAGENaltsLPASLPPEL------QVLDVSKNQIT-VLPETLP--PTITTLDVSRNaltNLPENLPAA----- 389

                        250       260
                 ....*....|....*....|...
gi 15218650  460 nLKYLSLARN---KFSGTLPSWL 479
Cdd:PRK15370 390 -LQIMQASRNnlvRLPESLPHFR 411
PLN03150 PLN03150
hypothetical protein; Provisional
 245-332 2.76e-08

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 57.13  E-value: 2.76e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218650  245 LNIAENSLVGGLPSCLGSLKELSHLNLSFNGFNYEISPRLMFSEKLVMLDLSHNGFSGRLPSRISETTEklgLVLLDLSH 324
Cdd:PLN03150 423 LGLDNQGLRGFIPNDISKLRHLQSINLSGNSIRGNIPPSLGSITSLEVLDLSYNSFNGSIPESLGQLTS---LRILNLNG 499


                 ....*...
gi 15218650  325 NSFSGDIP 332
Cdd:PLN03150 500 NSLSGRVP 507
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 245-496 7.85e-08

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 54.67  E-value: 7.85e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218650 245 LNIAENSLVGG----LPSCLGSLKELSHLNLSFNgfNYEISPR--------LMFSEKLVMLDLSHNGFSGRLPSRISETT 312
Cdd:cd00116  28 LRLEGNTLGEEaakaLASALRPQPSLKELCLSLN--ETGRIPRglqsllqgLTKGCGLQELDLSDNALGPDGCGVLESLL 105

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218650 313 EKLGLVLLDLSHNSFSGDI-PLRITELKSLQ----ALRLSHNLLTGDIPARIGNL----TYLQVIDLSHNALTGSiplni 383
Cdd:cd00116 106 RSSSLQELKLNNNGLGDRGlRLLAKGLKDLPpaleKLVLGRNRLEGASCEALAKAlranRDLKELNLANNGIGDA----- 180

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218650 384 vgCFQLLAlmisnnnlsgeiqPELDALDSLKILDISNNHISGE----IPLTLAGLKSLEIVDISSNNL---------SGN 450
Cdd:cd00116 181 --GIRALA-------------EGLKANCNLEVLDLNNNGLTDEgasaLAETLASLKSLEVLNLGDNNLtdagaaalaSAL 245

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|
gi 15218650 451 LNEAITkwsnLKYLSLARNKF----SGTLPSWLFKFDKIQMIDYSSNRFS 496
Cdd:cd00116 246 LSPNIS----LLTLSLSCNDItddgAKDLAEVLAEKESLLELDLRGNKFG 291
PLN03150 PLN03150
hypothetical protein; Provisional
 221-306 2.31e-06

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 50.97  E-value: 2.31e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218650  221 LNLASNQFSGTLPCFYASRPSLSILNIAENSLVGGLPSCLGSLKELSHLNLSFNGFNYEISPRLMFSEKLVMLDLSHNGF 300
Cdd:PLN03150 423 LGLDNQGLRGFIPNDISKLRHLQSINLSGNSIRGNIPPSLGSITSLEVLDLSYNSFNGSIPESLGQLTSLRILNLNGNSL 502


                 ....*.
gi 15218650  301 SGRLPS 306
Cdd:PLN03150 503 SGRVPA 508
PLN03150 PLN03150
hypothetical protein; Provisional
 416-500 1.64e-05

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 48.27  E-value: 1.64e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218650  416 LDISNNHISGEIPLTLAGLKSLEIVDISSNNLSGNLNEAITKWSNLKYLSLARNKFSGTLPSWLFKFDKIQMIDYSSNRF 495
Cdd:PLN03150 423 LGLDNQGLRGFIPNDISKLRHLQSINLSGNSIRGNIPPSLGSITSLEVLDLSYNSFNGSIPESLGQLTSLRILNLNGNSL 502


                 ....*
gi 15218650  496 SWFIP 500
Cdd:PLN03150 503 SGRVP 507
LRR_8 pfam13855
Leucine rich repeat;
553-607 1.18e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 40.59  E-value: 1.18e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 15218650   553 IDLSDNLLHGEIPEALFRQKNIEYLNLSYNFLEGQLPR-LEKLPRLKALDLSHNSL 607
Cdd:pfam13855   6 LDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGaFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
412-471 2.28e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 39.82  E-value: 2.28e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218650   412 SLKILDISNNHISGEIPLTLAGLKSLEIVDISSNNLSGNLNEAITKWSNLKYLSLARNKF 471
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
392-447 4.82e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 38.66  E-value: 4.82e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 15218650   392 LMISNNNLSGeIQPE-LDALDSLKILDISNNHISGEIPLTLAGLKSLEIVDISSNNL 447
Cdd:pfam13855   6 LDLSNNRLTS-LDDGaFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PLN03150 PLN03150
hypothetical protein; Provisional
 216-274 5.38e-04

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 43.27  E-value: 5.38e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 15218650  216 QPLVVLNLASNQFSGTLPCFYASRPSLSILNIAENSLVGGLPSCLGSLKELSHLNLSFN 274
Cdd:PLN03150 442 RHLQSINLSGNSIRGNIPPSLGSITSLEVLDLSYNSFNGSIPESLGQLTSLRILNLNGN 500
LRR_8 pfam13855
Leucine rich repeat;
106-156 1.23e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 37.50  E-value: 1.23e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 15218650   106 HNNFSGNIPSCFGSLRNLRTLNLSRNRFVGSIPATFVSLKELREVVLSENR 156
Cdd:pfam13855  10 NNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNR 60
LRR_8 pfam13855
Leucine rich repeat;
436-495 2.75e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 36.73  E-value: 2.75e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218650   436 SLEIVDISSNNLSGNLNEAITKWSNLKYLSLARNKFSGTLPSWLFKFDKIQMIDYSSNRF 495
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
340-399 2.98e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 36.35  E-value: 2.98e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218650   340 SLQALRLSHNLLTGDIPARIGNLTYLQVIDLSHNALTGSIPLNIVGCFQLLALMISNNNL 399
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRRNT_2 pfam08263
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 31-68 5.68e-03

Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.


Pssm-ID: 462411 [Multi-domain]  Cd Length: 41  Bit Score: 35.35  E-value: 5.68e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 15218650    31 DPQDKASLLIFRVSIHDLNRSLSTWY--GSSCSNWTGLAC 68
Cdd:pfam08263   1 LNDDGQALLAFKSSLNDPPGALSSWNssSSDPCSWTGVTC 40
LRR_8 pfam13855
Leucine rich repeat;
316-375 6.61e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 35.58  E-value: 6.61e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218650   316 GLVLLDLSHNSFSGDIPLRITELKSLQALRLSHNLLTGDIPARIGNLTYLQVIDLSHNAL 375
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 412-453 8.73e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 34.53  E-value: 8.73e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 15218650   412 SLKILDISNNHISgEIPLtLAGLKSLEIVDISSNNLSGNLNE 453
Cdd:pfam12799   2 NLEVLDLSNNQIT-DIPP-LAKLPNLETLDLSGNNKITDLSD 41
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 260-424 8.86e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 38.23  E-value: 8.86e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218650 260 LGSLKELSHLNLsfngFNYEIS--PRLMFSEKLVMLDLSHNgfsgrlpsRISETtEKLG----LVLLDLSHNsfsgdipl 333
Cdd:cd21340  20 LSLCKNLKVLYL----YDNKITkiENLEFLTNLTHLYLQNN--------QIEKI-ENLEnlvnLKKLYLGGN-------- 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218650 334 RITE------LKSLQALRLSH-NLLTGDI----PARIGNLTY-LQVIDLSHNALTGSIPLniVGCFQLLALMISNNNLS- 400
Cdd:cd21340  79 RISVveglenLTNLEELHIENqRLPPGEKltfdPRSLAALSNsLRVLNISGNNIDSLEPL--APLRNLEQLDASNNQISd 156

                       170       180
                ....*....|....*....|....*
gi 15218650 401 -GEIQPELDALDSLKILDISNNHIS 424
Cdd:cd21340 157 lEELLDLLSSWPSLRELDLTGNPVC 181
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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