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    hira histone cell cycle regulator a [ Danio rerio (zebrafish) ]

    Gene ID: 568076, updated on 9-Dec-2024

    Summary

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    Official Symbol
    hiraprovided by ZNC
    Official Full Name
    histone cell cycle regulator aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-6296
    See related
    Ensembl:ENSDARG00000013434 AllianceGenome:ZFIN:ZDB-GENE-030131-6296
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fb97b07; wu:fb97b07; wu:fi43b08; si:ch211-188g24.3
    Summary
    Predicted to contribute to nucleosome binding activity. Predicted to be involved in chromatin remodeling. Predicted to act upstream of or within DNA-templated transcription; chromatin organization; and regulation of DNA-templated transcription. Predicted to be located in chromatin. Predicted to be part of HIR complex. Is expressed in telencephalon. Orthologous to human HIRA (histone cell cycle regulator). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See hira in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 5 NC_007116.7 (18047198..18072848)
    105 previous assembly GRCz10 (GCF_000002035.5) 5 NC_007116.6 (17543145..17568852)

    Chromosome 5 - NC_007116.7Genomic Context describing neighboring genes Neighboring gene activating signal cointegrator 1 complex subunit 2 Neighboring gene ring finger protein 215 Neighboring gene si:dkey-215k6.1 Neighboring gene uncharacterized LOC137495575

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. An essential role of variant histone H3.3 for ectomesenchyme potential of the cranial neural crest. Cox SG, et al. PLoS Genet, 2012 Sep. PMID 23028350, Free PMC Article
    2. Comparative mapping of the 22q11.2 deletion region and the potential of simple model organisms. Guna A, et al. J Neurodev Disord, 2015. PMID 26137170, Free PMC Article
    3. Mitochondrial proteins encoded by the 22q11.2 neurodevelopmental locus regulate neural stem and progenitor cell proliferation. Campbell PD, et al. Mol Psychiatry, 2023 Sep. PMID 37794116, Free PMC Article
    4. A network of epigenetic regulators guides developmental haematopoiesis in vivo. Huang HT, et al. Nat Cell Biol, 2013 Dec. PMID 24240475, Free PMC Article
    5. Comprehensive expression map of transcription regulators in the adult zebrafish telencephalon reveals distinct neurogenic niches. Diotel N, et al. J Comp Neurol, 2015 Jun 1. PMID 25556858, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    contributes_to nucleosome binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within chromatin organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromatin remodeling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of HIR complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in chromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    protein HIRA
    Names
    HIR histone cell cycle regulation defective homolog A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007116.7 Reference GRCz11 Primary Assembly

      Range
      18047198..18072848
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_691386.8 → XP_696478.2  protein HIRA

      UniProtKB/TrEMBL
      A0A8N7URB3, A2CEX6
      Related
      ENSDARP00000119160.1, ENSDART00000132164.2
      Conserved Domains (5) summary
      COG2319
      Location:12 → 382
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:11 → 352
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      pfam07569
      Location:756 → 947
      Hira; TUP1-like enhancer of split
      pfam09453
      Location:448 → 469
      HIRA_B; HIRA B motif
      sd00039
      Location:16 → 65
      7WD40; WD40 repeat [structural motif]
    Nucleotide Protein Strain
    Heading Accession and Version

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