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Conserved domains on  [gi|125817880|ref|XP_696478|]
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protein HIRA [Danio rerio]

Protein Classification

WD40 and Hira domain-containing protein( domain architecture ID 11456814)

WD40 and Hira domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Hira pfam07569
TUP1-like enhancer of split; The Hira proteins are found in a range of eukaryotes and are ...
 757-955 2.57e-66

TUP1-like enhancer of split; The Hira proteins are found in a range of eukaryotes and are implicated in the assembly of repressive chromatin. These proteins also contain pfam00400.


:

Pssm-ID: 462211  Cd Length: 221  Bit Score: 222.11  E-value: 2.57e-66
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125817880   757 GRRLIPSIMLPAPMSALHCSGHFVMALMASATLSVWDVQKQTALVKNESLNPILSGT---------DATVSQSLITQQGV 827
Cdd:pfam07569    1 GRRLLPPIVLGSPASFLECSGSYLLAVTSVGLLYVWDIKKQKALLPPVSLAPLLDSSsrysdkltrAPTITSASLTSNGV 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125817880   828 AVVSLSNGKTYCFNSSLETWNLIADKQDSLV-QCADFRNCLSSQDVLGSMGPLALTQGR------NLSAGRLASRLSSTP 900
Cdd:pfam07569   81 PIVTLSNGDGYLYDKSLETWLRISDSWWALGsQYWDSTGSSRSSSQSSAAGILSFLERKtneellRKGRGRLLQRLAKTL 160

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 125817880   901 H------HLQQGMTLAFLENQLSSALMLLSASEYRHWLLIYARFLVNEGYEHRLRELCQDL 955
Cdd:pfam07569  161 LmkegfeNFETVVTLAHLENRLAAALLLGSPDEYRHWLLMYAKRLAEEGLKGRLRELCKEL 221
WD40 COG2319
WD40 repeat [General function prediction only];
11-352 9.47e-46

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 170.09  E-value: 9.47e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125817880   11 HNGkPIFSVDIHPDGTKFATGGqgeDSGKVVIWNMAPvlreedekneniPKLLCQMDNHLACVNCVRWSNNGLYLASGGD 90
Cdd:COG2319   119 HTG-AVRSVAFSPDGKTLASGS---ADGTVRLWDLAT------------GKLLRTLTGHSGAVTSVAFSPDGKLLASGSD 182

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125817880   91 DKLVMVWkraafigpstvfgsssklaNVEQWRCVTILRNHTGDVMDVAWSPHDVWLASCSVDNTIVIWNARKfPEIVMTL 170
Cdd:COG2319   183 DGTVRLW-------------------DLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLAT-GKLLRTL 242

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125817880  171 KGHTGLVKGLTWDPVGKYIASQADDHSLKVWRTMDWQLETNITkpfsecGGTTHVLRLSWSPDGQYLVSAhamnNSGPTA 250
Cdd:COG2319   243 TGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLT------GHSGGVNSVAFSPDGKLLASG----SDDGTV 312

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125817880  251 QIIERDGWKTNMDFVGHRKAVTVVKFNPkifkkkqkNGSTpkpscpyccCAVGSKDRSLSVWLTSLKRPLVVIHDlFDKS 330
Cdd:COG2319   313 RLWDLATGKLLRTLTGHTGAVRSVAFSP--------DGKT---------LASGSDDGTVRLWDLATGELLRTLTG-HTGA 374

                         330       340
                  ....*....|....*....|..
gi 125817880  331 IMDITWTLNGLGLLVCSMDGTV 352
Cdd:COG2319   375 VTSVAFSPDGRTLASGSADGTV 396
 
Name Accession Description Interval E-value
Hira pfam07569
TUP1-like enhancer of split; The Hira proteins are found in a range of eukaryotes and are ...
 757-955 2.57e-66

TUP1-like enhancer of split; The Hira proteins are found in a range of eukaryotes and are implicated in the assembly of repressive chromatin. These proteins also contain pfam00400.


Pssm-ID: 462211  Cd Length: 221  Bit Score: 222.11  E-value: 2.57e-66
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125817880   757 GRRLIPSIMLPAPMSALHCSGHFVMALMASATLSVWDVQKQTALVKNESLNPILSGT---------DATVSQSLITQQGV 827
Cdd:pfam07569    1 GRRLLPPIVLGSPASFLECSGSYLLAVTSVGLLYVWDIKKQKALLPPVSLAPLLDSSsrysdkltrAPTITSASLTSNGV 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125817880   828 AVVSLSNGKTYCFNSSLETWNLIADKQDSLV-QCADFRNCLSSQDVLGSMGPLALTQGR------NLSAGRLASRLSSTP 900
Cdd:pfam07569   81 PIVTLSNGDGYLYDKSLETWLRISDSWWALGsQYWDSTGSSRSSSQSSAAGILSFLERKtneellRKGRGRLLQRLAKTL 160

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 125817880   901 H------HLQQGMTLAFLENQLSSALMLLSASEYRHWLLIYARFLVNEGYEHRLRELCQDL 955
Cdd:pfam07569  161 LmkegfeNFETVVTLAHLENRLAAALLLGSPDEYRHWLLMYAKRLAEEGLKGRLRELCKEL 221
WD40 COG2319
WD40 repeat [General function prediction only];
11-352 9.47e-46

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 170.09  E-value: 9.47e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125817880   11 HNGkPIFSVDIHPDGTKFATGGqgeDSGKVVIWNMAPvlreedekneniPKLLCQMDNHLACVNCVRWSNNGLYLASGGD 90
Cdd:COG2319   119 HTG-AVRSVAFSPDGKTLASGS---ADGTVRLWDLAT------------GKLLRTLTGHSGAVTSVAFSPDGKLLASGSD 182

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125817880   91 DKLVMVWkraafigpstvfgsssklaNVEQWRCVTILRNHTGDVMDVAWSPHDVWLASCSVDNTIVIWNARKfPEIVMTL 170
Cdd:COG2319   183 DGTVRLW-------------------DLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLAT-GKLLRTL 242

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125817880  171 KGHTGLVKGLTWDPVGKYIASQADDHSLKVWRTMDWQLETNITkpfsecGGTTHVLRLSWSPDGQYLVSAhamnNSGPTA 250
Cdd:COG2319   243 TGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLT------GHSGGVNSVAFSPDGKLLASG----SDDGTV 312

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125817880  251 QIIERDGWKTNMDFVGHRKAVTVVKFNPkifkkkqkNGSTpkpscpyccCAVGSKDRSLSVWLTSLKRPLVVIHDlFDKS 330
Cdd:COG2319   313 RLWDLATGKLLRTLTGHTGAVRSVAFSP--------DGKT---------LASGSDDGTVRLWDLATGELLRTLTG-HTGA 374

                         330       340
                  ....*....|....*....|..
gi 125817880  331 IMDITWTLNGLGLLVCSMDGTV 352
Cdd:COG2319   375 VTSVAFSPDGRTLASGSADGTV 396
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 11-352 3.33e-43

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 159.04  E-value: 3.33e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125817880   11 HNGkPIFSVDIHPDGTKFATGGQgedSGKVVIWNMAPvlreedekneniPKLLCQMDNHLACVNCVRWSNNGLYLASGGD 90
Cdd:cd00200     8 HTG-GVTCVAFSPDGKLLATGSG---DGTIKVWDLET------------GELLRTLKGHTGPVRDVAASADGTYLASGSS 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125817880   91 DKLVMVWkraafigpstvfgsssklaNVEQWRCVTILRNHTGDVMDVAWSPHDVWLASCSVDNTIVIWNARKFpEIVMTL 170
Cdd:cd00200    72 DKTIRLW-------------------DLETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETG-KCLTTL 131

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125817880  171 KGHTGLVKGLTWDPVGKYIASQADDHSLKVWRTMDWQLETNItkpfsecggTTH---VLRLSWSPDGQYLVSAhAMNNsg 247
Cdd:cd00200   132 RGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATL---------TGHtgeVNSVAFSPDGEKLLSS-SSDG-- 199

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125817880  248 pTAQIIERDGWKTNMDFVGHRKAVTVVKFNPkifkkkqkNGSTpkpscpyccCAVGSKDRSLSVWLTSLKRPLVVI--Hd 325
Cdd:cd00200   200 -TIKLWDLSTGKCLGTLRGHENGVNSVAFSP--------DGYL---------LASGSEDGTIRVWDLRTGECVQTLsgH- 260

                         330       340
                  ....*....|....*....|....*..
gi 125817880  326 lfDKSIMDITWTLNGLGLLVCSMDGTV 352
Cdd:cd00200   261 --TNSVTSLAWSPDGKRLASGSADGTI 285
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 120-159 1.74e-09

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 53.86  E-value: 1.74e-09
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 125817880    120 QWRCVTILRNHTGDVMDVAWSPHDVWLASCSVDNTIVIWN 159
Cdd:smart00320    1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
121-159 4.18e-09

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 52.73  E-value: 4.18e-09
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 125817880   121 WRCVTILRNHTGDVMDVAWSPHDVWLASCSVDNTIVIWN 159
Cdd:pfam00400    1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PTZ00420 PTZ00420
coronin; Provisional
 124-201 2.48e-05

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 48.02  E-value: 2.48e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125817880  124 VTILRNHTGDVMDVAWSP-HDVWLASCSVDNTIVIWNARKFPEIV-------MTLKGHTGLVKGLTWDPVGKYI-ASQAD 194
Cdd:PTZ00420   67 VIKLKGHTSSILDLQFNPcFSEILASGSEDLTIRVWEIPHNDESVkeikdpqCILKGHKKKISIIDWNPMNYYImCSSGF 146


                  ....*..
gi 125817880  195 DHSLKVW 201
Cdd:PTZ00420  147 DSFVNIW 153
 
Name Accession Description Interval E-value
Hira pfam07569
TUP1-like enhancer of split; The Hira proteins are found in a range of eukaryotes and are ...
 757-955 2.57e-66

TUP1-like enhancer of split; The Hira proteins are found in a range of eukaryotes and are implicated in the assembly of repressive chromatin. These proteins also contain pfam00400.


Pssm-ID: 462211  Cd Length: 221  Bit Score: 222.11  E-value: 2.57e-66
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125817880   757 GRRLIPSIMLPAPMSALHCSGHFVMALMASATLSVWDVQKQTALVKNESLNPILSGT---------DATVSQSLITQQGV 827
Cdd:pfam07569    1 GRRLLPPIVLGSPASFLECSGSYLLAVTSVGLLYVWDIKKQKALLPPVSLAPLLDSSsrysdkltrAPTITSASLTSNGV 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125817880   828 AVVSLSNGKTYCFNSSLETWNLIADKQDSLV-QCADFRNCLSSQDVLGSMGPLALTQGR------NLSAGRLASRLSSTP 900
Cdd:pfam07569   81 PIVTLSNGDGYLYDKSLETWLRISDSWWALGsQYWDSTGSSRSSSQSSAAGILSFLERKtneellRKGRGRLLQRLAKTL 160

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 125817880   901 H------HLQQGMTLAFLENQLSSALMLLSASEYRHWLLIYARFLVNEGYEHRLRELCQDL 955
Cdd:pfam07569  161 LmkegfeNFETVVTLAHLENRLAAALLLGSPDEYRHWLLMYAKRLAEEGLKGRLRELCKEL 221
WD40 COG2319
WD40 repeat [General function prediction only];
11-352 9.47e-46

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 170.09  E-value: 9.47e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125817880   11 HNGkPIFSVDIHPDGTKFATGGqgeDSGKVVIWNMAPvlreedekneniPKLLCQMDNHLACVNCVRWSNNGLYLASGGD 90
Cdd:COG2319   119 HTG-AVRSVAFSPDGKTLASGS---ADGTVRLWDLAT------------GKLLRTLTGHSGAVTSVAFSPDGKLLASGSD 182

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125817880   91 DKLVMVWkraafigpstvfgsssklaNVEQWRCVTILRNHTGDVMDVAWSPHDVWLASCSVDNTIVIWNARKfPEIVMTL 170
Cdd:COG2319   183 DGTVRLW-------------------DLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLAT-GKLLRTL 242

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125817880  171 KGHTGLVKGLTWDPVGKYIASQADDHSLKVWRTMDWQLETNITkpfsecGGTTHVLRLSWSPDGQYLVSAhamnNSGPTA 250
Cdd:COG2319   243 TGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLT------GHSGGVNSVAFSPDGKLLASG----SDDGTV 312

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125817880  251 QIIERDGWKTNMDFVGHRKAVTVVKFNPkifkkkqkNGSTpkpscpyccCAVGSKDRSLSVWLTSLKRPLVVIHDlFDKS 330
Cdd:COG2319   313 RLWDLATGKLLRTLTGHTGAVRSVAFSP--------DGKT---------LASGSDDGTVRLWDLATGELLRTLTG-HTGA 374

                         330       340
                  ....*....|....*....|..
gi 125817880  331 IMDITWTLNGLGLLVCSMDGTV 352
Cdd:COG2319   375 VTSVAFSPDGRTLASGSADGTV 396
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 11-352 3.33e-43

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 159.04  E-value: 3.33e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125817880   11 HNGkPIFSVDIHPDGTKFATGGQgedSGKVVIWNMAPvlreedekneniPKLLCQMDNHLACVNCVRWSNNGLYLASGGD 90
Cdd:cd00200     8 HTG-GVTCVAFSPDGKLLATGSG---DGTIKVWDLET------------GELLRTLKGHTGPVRDVAASADGTYLASGSS 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125817880   91 DKLVMVWkraafigpstvfgsssklaNVEQWRCVTILRNHTGDVMDVAWSPHDVWLASCSVDNTIVIWNARKFpEIVMTL 170
Cdd:cd00200    72 DKTIRLW-------------------DLETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETG-KCLTTL 131

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125817880  171 KGHTGLVKGLTWDPVGKYIASQADDHSLKVWRTMDWQLETNItkpfsecggTTH---VLRLSWSPDGQYLVSAhAMNNsg 247
Cdd:cd00200   132 RGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATL---------TGHtgeVNSVAFSPDGEKLLSS-SSDG-- 199

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125817880  248 pTAQIIERDGWKTNMDFVGHRKAVTVVKFNPkifkkkqkNGSTpkpscpyccCAVGSKDRSLSVWLTSLKRPLVVI--Hd 325
Cdd:cd00200   200 -TIKLWDLSTGKCLGTLRGHENGVNSVAFSP--------DGYL---------LASGSEDGTIRVWDLRTGECVQTLsgH- 260

                         330       340
                  ....*....|....*....|....*..
gi 125817880  326 lfDKSIMDITWTLNGLGLLVCSMDGTV 352
Cdd:cd00200   261 --TNSVTSLAWSPDGKRLASGSADGTI 285
WD40 COG2319
WD40 repeat [General function prediction only];
15-366 2.56e-40

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 154.30  E-value: 2.56e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125817880   15 PIFSVDIHPDGTKFATGGqgeDSGKVVIWNMAPvlreedekneniPKLLCQMDNHLACVNCVRWSNNGLYLASGGDDKLV 94
Cdd:COG2319    80 AVLSVAFSPDGRLLASAS---ADGTVRLWDLAT------------GLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTV 144

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125817880   95 MVWkraafigpstvfgsssklaNVEQWRCVTILRNHTGDVMDVAWSPHDVWLASCSVDNTIVIWNARKFPEIVmTLKGHT 174
Cdd:COG2319   145 RLW-------------------DLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLR-TLTGHT 204

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125817880  175 GLVKGLTWDPVGKYIASQADDHSLKVWRTMDWQLETNITkpfsecGGTTHVLRLSWSPDGQYLVSAHAmnnsGPTAQIIE 254
Cdd:COG2319   205 GAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLT------GHSGSVRSVAFSPDGRLLASGSA----DGTVRLWD 274

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125817880  255 RDGWKTNMDFVGHRKAVTVVKFNPkifkkkqkNGSTpkpscpyccCAVGSKDRSLSVWLTSLKRPLVVIHDlFDKSIMDI 334
Cdd:COG2319   275 LATGELLRTLTGHSGGVNSVAFSP--------DGKL---------LASGSDDGTVRLWDLATGKLLRTLTG-HTGAVRSV 336

                         330       340       350
                  ....*....|....*....|....*....|..
gi 125817880  335 TWTLNGLGLLVCSMDGTVAFLDFSQDELGDPL 366
Cdd:COG2319   337 AFSPDGKTLASGSDDGTVRLWDLATGELLRTL 368
WD40 COG2319
WD40 repeat [General function prediction only];
69-362 7.05e-36

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 141.20  E-value: 7.05e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125817880   69 HLACVNCVRWSNNGLYLASGGDDKLVMVWkraafigpstvfgsssklaNVEQWRCVTILRNHTGDVMDVAWSPHDVWLAS 148
Cdd:COG2319    77 HTAAVLSVAFSPDGRLLASASADGTVRLW-------------------DLATGLLLRTLTGHTGAVRSVAFSPDGKTLAS 137

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125817880  149 CSVDNTIVIWNARKfPEIVMTLKGHTGLVKGLTWDPVGKYIASQADDHSLKVWRTMDWQLETNITkpfsecGGTTHVLRL 228
Cdd:COG2319   138 GSADGTVRLWDLAT-GKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLT------GHTGAVRSV 210

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125817880  229 SWSPDGQYLVSAHAmnnsGPTAQIIERDGWKTNMDFVGHRKAVTVVKFNPkifkkkqkNGSTpkpscpyccCAVGSKDRS 308
Cdd:COG2319   211 AFSPDGKLLASGSA----DGTVRLWDLATGKLLRTLTGHSGSVRSVAFSP--------DGRL---------LASGSADGT 269

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....
gi 125817880  309 LSVWLTSLKRPLVVIHDLFDkSIMDITWTLNGLGLLVCSMDGTVAFLDFSQDEL 362
Cdd:COG2319   270 VRLWDLATGELLRTLTGHSG-GVNSVAFSPDGKLLASGSDDGTVRLWDLATGKL 322
WD40 COG2319
WD40 repeat [General function prediction only];
10-203 1.53e-32

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 131.19  E-value: 1.53e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125817880   10 NHNGKPIFSVDIHPDGTKFATGGqgeDSGKVVIWNMAPvlreedekneniPKLLCQMDNHLACVNCVRWSNNGLYLASGG 89
Cdd:COG2319   243 TGHSGSVRSVAFSPDGRLLASGS---ADGTVRLWDLAT------------GELLRTLTGHSGGVNSVAFSPDGKLLASGS 307

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125817880   90 DDKLVMVWkraafigpstvfgsssklaNVEQWRCVTILRNHTGDVMDVAWSPHDVWLASCSVDNTIVIWNARKFPEIVmT 169
Cdd:COG2319   308 DDGTVRLW-------------------DLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLR-T 367

                         170       180       190
                  ....*....|....*....|....*....|....
gi 125817880  170 LKGHTGLVKGLTWDPVGKYIASQADDHSLKVWRT 203
Cdd:COG2319   368 LTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDL 401
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 14-202 8.67e-31

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 123.21  E-value: 8.67e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125817880   14 KPIFSVDIHPDGTKFATGGqgeDSGKVVIWNMapvlreedEKNENIPKLLCqmdnHLACVNCVRWSNNGLYLASGGDDKL 93
Cdd:cd00200    94 SYVSSVAFSPDGRILSSSS---RDKTIKVWDV--------ETGKCLTTLRG----HTDWVNSVAFSPDGTFVASSSQDGT 158

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125817880   94 VMVW------------------KRAAFIGPSTVFGSSS-----KLANVEQWRCVTILRNHTGDVMDVAWSPHDVWLASCS 150
Cdd:cd00200   159 IKLWdlrtgkcvatltghtgevNSVAFSPDGEKLLSSSsdgtiKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGS 238

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 125817880  151 VDNTIVIWNARKFpEIVMTLKGHTGLVKGLTWDPVGKYIASQADDHSLKVWR 202
Cdd:cd00200   239 EDGTIRVWDLRTG-ECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
96-366 2.91e-27

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 115.39  E-value: 2.91e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125817880   96 VWKRAAFIGPSTVFGSSSKLANVEQWRCVTILRNHTGDVMDVAWSPHDVWLASCSVDNTIVIWNARKfPEIVMTLKGHTG 175
Cdd:COG2319    43 AASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLAT-GLLLRTLTGHTG 121

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125817880  176 LVKGLTWDPVGKYIASQADDHSLKVWRTMDWQLETNITkpfsecGGTTHVLRLSWSPDGQYLVSAHamnnSGPTAQIIER 255
Cdd:COG2319   122 AVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLT------GHSGAVTSVAFSPDGKLLASGS----DDGTVRLWDL 191

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125817880  256 DGWKTNMDFVGHRKAVTVVKFNPkifkkkqkNGSTpkpscpyccCAVGSKDRSLSVWLTSLKRPLVVIHDlFDKSIMDIT 335
Cdd:COG2319   192 ATGKLLRTLTGHTGAVRSVAFSP--------DGKL---------LASGSADGTVRLWDLATGKLLRTLTG-HSGSVRSVA 253

                         250       260       270
                  ....*....|....*....|....*....|.
gi 125817880  336 WTLNGLGLLVCSMDGTVAFLDFSQDELGDPL 366
Cdd:COG2319   254 FSPDGRLLASGSADGTVRLWDLATGELLRTL 284
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 123-362 1.27e-24

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 105.11  E-value: 1.27e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125817880  123 CVTILRNHTGDVMDVAWSPHDVWLASCSVDNTIVIWNArKFPEIVMTLKGHTGLVKGLTWDPVGKYIASQADDHSLKVWR 202
Cdd:cd00200     1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDL-ETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWD 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125817880  203 TMDWQLETNITkpfsecGGTTHVLRLSWSPDGQYLVSAHamnnsgptaqiieRDG----WKTN-----MDFVGHRKAVTV 273
Cdd:cd00200    80 LETGECVRTLT------GHTSYVSSVAFSPDGRILSSSS-------------RDKtikvWDVEtgkclTTLRGHTDWVNS 140

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125817880  274 VKFNP-KIFkkkqkngstpkpscpyccCAVGSKDRSLSVWLTSLKRPLVVIHDlFDKSIMDITWTLNGLGLLVCSMDGTV 352
Cdd:cd00200   141 VAFSPdGTF------------------VASSSQDGTIKLWDLRTGKCVATLTG-HTGEVNSVAFSPDGEKLLSSSSDGTI 201

                         250
                  ....*....|
gi 125817880  353 AFLDFSQDEL 362
Cdd:cd00200   202 KLWDLSTGKC 211
WD40 COG2319
WD40 repeat [General function prediction only];
11-161 8.32e-22

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 99.22  E-value: 8.32e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125817880   11 HNGKPIFSVDIHPDGTKFATGGqgeDSGKVVIWNMAPvlreedekneniPKLLCQMDNHLACVNCVRWSNNGLYLASGGD 90
Cdd:COG2319   286 GHSGGVNSVAFSPDGKLLASGS---DDGTVRLWDLAT------------GKLLRTLTGHTGAVRSVAFSPDGKTLASGSD 350

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 125817880   91 DKLVMVWkraafigpstvfgsssklaNVEQWRCVTILRNHTGDVMDVAWSPHDVWLASCSVDNTIVIWNAR 161
Cdd:COG2319   351 DGTVRLW-------------------DLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 11-159 4.04e-19

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 88.93  E-value: 4.04e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125817880   11 HNGkPIFSVDIHPDGTKFATGGqgeDSGKVVIWNMapvlreedekneNIPKLLCQMDNHLACVNCVRWSNNGLYLASGGD 90
Cdd:cd00200   176 HTG-EVNSVAFSPDGEKLLSSS---SDGTIKLWDL------------STGKCLGTLRGHENGVNSVAFSPDGYLLASGSE 239

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 125817880   91 DKLVMVWkraafigpstvfgsssklaNVEQWRCVTILRNHTGDVMDVAWSPHDVWLASCSVDNTIVIWN 159
Cdd:cd00200   240 DGTIRVW-------------------DLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
115-367 5.50e-17

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 84.58  E-value: 5.50e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125817880  115 LANVEQWRCVTILRNHTGDVMDVAWSPHDVWLASCSVDNTIVIWNARKFPEIVmTLKGHTGLVKGLTWDPVGKYIASQAD 194
Cdd:COG2319    20 LLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLA-TLLGHTAAVLSVAFSPDGRLLASASA 98

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125817880  195 DHSLKVWRTMDWQLETNITkpfsecGGTTHVLRLSWSPDGQYLVSAHAmnnsGPTAQIIERDGWKTNMDFVGHRKAVTVV 274
Cdd:COG2319    99 DGTVRLWDLATGLLLRTLT------GHTGAVRSVAFSPDGKTLASGSA----DGTVRLWDLATGKLLRTLTGHSGAVTSV 168

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125817880  275 KFNPkifkkkqkNGSTPkpscpycccAVGSKDRSLSVWLTSLKRPLVVI--HdlfDKSIMDITWTLNGLGLLVCSMDGTV 352
Cdd:COG2319   169 AFSP--------DGKLL---------ASGSDDGTVRLWDLATGKLLRTLtgH---TGAVRSVAFSPDGKLLASGSADGTV 228

                         250
                  ....*....|....*
gi 125817880  353 AFLDFSQDELGDPLN 367
Cdd:COG2319   229 RLWDLATGKLLRTLT 243
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 120-159 1.74e-09

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 53.86  E-value: 1.74e-09
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 125817880    120 QWRCVTILRNHTGDVMDVAWSPHDVWLASCSVDNTIVIWN 159
Cdd:smart00320    1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
121-159 4.18e-09

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 52.73  E-value: 4.18e-09
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 125817880   121 WRCVTILRNHTGDVMDVAWSPHDVWLASCSVDNTIVIWN 159
Cdd:pfam00400    1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 61-98 5.36e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 46.92  E-value: 5.36e-07
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 125817880     61 KLLCQMDNHLACVNCVRWSNNGLYLASGGDDKLVMVWK 98
Cdd:smart00320    3 ELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 165-201 1.31e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 45.77  E-value: 1.31e-06
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 125817880    165 EIVMTLKGHTGLVKGLTWDPVGKYIASQADDHSLKVW 201
Cdd:smart00320    3 ELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
61-97 8.72e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 43.49  E-value: 8.72e-06
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 125817880    61 KLLCQMDNHLACVNCVRWSNNGLYLASGGDDKLVMVW 97
Cdd:pfam00400    2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
WD40 pfam00400
WD domain, G-beta repeat;
165-201 2.45e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 42.33  E-value: 2.45e-05
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 125817880   165 EIVMTLKGHTGLVKGLTWDPVGKYIASQADDHSLKVW 201
Cdd:pfam00400    2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
PTZ00420 PTZ00420
coronin; Provisional
 124-201 2.48e-05

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 48.02  E-value: 2.48e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125817880  124 VTILRNHTGDVMDVAWSP-HDVWLASCSVDNTIVIWNARKFPEIV-------MTLKGHTGLVKGLTWDPVGKYI-ASQAD 194
Cdd:PTZ00420   67 VIKLKGHTSSILDLQFNPcFSEILASGSEDLTIRVWEIPHNDESVkeikdpqCILKGHKKKISIIDWNPMNYYImCSSGF 146


                  ....*..
gi 125817880  195 DHSLKVW 201
Cdd:PTZ00420  147 DSFVNIW 153
COG4946 COG4946
Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown] ...
 130-245 8.20e-04

Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown];


Pssm-ID: 443973 [Multi-domain]  Cd Length: 1072  Bit Score: 43.49  E-value: 8.20e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125817880  130 HTGDVMD--VAWSPHDVWLASCSvDNT----IVIWNARKFPEIVMTLKGHTGLVKGLTWDPVGKYIAsqADDHSLKVWrT 203
Cdd:COG4946   339 NTPGVRErlPAWSPDGKSIAYFS-DASgeyeLYIAPADGSGEPKQLTLGDLGRVFNPVWSPDGKKIA--FTDNRGRLW-V 414

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 125817880  204 MDwqLETNITKPFSECGGTTHVLRLSWSPDGQYLVSAHAMNN 245
Cdd:COG4946   415 VD--LASGKVRKVDTDGYGDGISDLAWSPDSKWLAYSKPGPN 454
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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