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    gins4 GINS complex subunit 4 (Sld5 homolog) [ Danio rerio (zebrafish) ]

    Gene ID: 572562, updated on 9-Dec-2024

    Summary

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    Official Symbol
    gins4provided by ZNC
    Official Full Name
    GINS complex subunit 4 (Sld5 homolog)provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040801-59
    See related
    Ensembl:ENSDARG00000016044 AllianceGenome:ZFIN:ZDB-GENE-040801-59
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    im:7137690; zgc:100817
    Summary
    Predicted to be involved in double-strand break repair via break-induced replication. Predicted to act upstream of or within DNA-templated DNA replication. Predicted to be located in nucleus. Predicted to be part of GINS complex. Orthologous to human GINS4 (GINS complex subunit 4). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See gins4 in Genome Data Viewer
    Location:
    chromosome: 8
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 8 NC_007119.7 (52415574..52431522)
    105 previous assembly GRCz10 (GCF_000002035.5) 8 NC_007119.6 (52429085..52444993)

    Chromosome 8 - NC_007119.7Genomic Context describing neighboring genes Neighboring gene AT-rich interactive domain 5A Neighboring gene cytochrome c oxidase subunit 5Bb Neighboring gene protein phosphatase 1 regulatory subunit 3C2, duplicate b Neighboring gene phytanoyl-CoA 2-hydroxylase interacting protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Zebrafish macrophage developmental arrest underlies depletion of microglia and reveals Csf1r-independent metaphocytes. Kuil LE, et al. Elife, 2020 May 5. PMID 32367800, Free PMC Article
    2. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC100817, MGC158574

    Gene Ontology Provided by ZFIN

    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA replication IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within DNA-templated DNA replication IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in double-strand break repair via break-induced replication IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of GINS complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    DNA replication complex GINS protein SLD5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001003546.2 → NP_001003546.2  DNA replication complex GINS protein SLD5

      Status: VALIDATED

      Source sequence(s)
      EE697537, EH534241, EH566551
      UniProtKB/TrEMBL
      A0A2R8Q9M1, A0A8M1N188
      Related
      ENSDARP00000151126.1, ENSDART00000191424.1
      Conserved Domains (3) summary
      cd11711
      Location:20 → 140
      GINS_A_Sld5; Alpha-helical domain of GINS complex protein Sld5
      COG5086
      Location:17 → 217
      COG5086; Uncharacterized conserved protein [Function unknown]
      pfam16922
      Location:159 → 217
      SLD5_C; DNA replication complex GINS protein SLD5 C-terminus

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007119.7 Reference GRCz11 Primary Assembly

      Range
      52415574..52431522
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021478305.2 → XP_021333980.1  DNA replication complex GINS protein SLD5 isoform X1

      UniProtKB/TrEMBL
      A0A8M9QIP2
      Conserved Domains (2) summary
      cd11711
      Location:20 → 140
      GINS_A_Sld5; Alpha-helical domain of GINS complex protein Sld5
      pfam16922
      Location:159 → 201
      SLD5_C; DNA replication complex GINS protein SLD5 C-terminus
    Nucleotide Protein Strain
    Heading Accession and Version

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