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Conserved domains on  [gi|1207183063|ref|XP_021333980|]
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DNA replication complex GINS protein SLD5 isoform X1 [Danio rerio]

Protein Classification

DNA replication complex GINS protein SLD5( domain architecture ID 16826204)

DNA replication complex GINS protein SLD5 is a component of the heterotetrameric GINS complex; the GINS complex is essential for both the initiation and elongation stages of eukaryotic DNA replication

Gene Ontology:  GO:0006261
PubMed:  22918584|20070258

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
GINS_A_Sld5 cd11711
Alpha-helical domain of GINS complex protein Sld5; Sld5 is a component of GINS tetrameric ...
20-140 3.10e-43

Alpha-helical domain of GINS complex protein Sld5; Sld5 is a component of GINS tetrameric protein complex, and within the complex Sld5 interacts with Psf1 via its N-terminal A-domain, and with Psf2 through a combination of the A and B domains. Sld5 in Drosophila is required for normal cell cycle progression and the maintenance of genomic integrity. GINS is a complex of four subunits (Sld5, Psf1, Psf2 and Psf3) that is involved in both initiation and elongation stages of eukaryotic chromosome replication. Besides being essential for the maintenance of genomic integrity, GINS plays a central role in coordinating DNA replication with cell cycle checkpoints and is involved in cell growth. The eukaryotic GINS subunits are homologous and homologs are also found in the archaea; the complex is not found in bacteria. The four subunits of the complex consist of two domains each, termed the alpha-helical (A) and beta-strand (B) domains. The A and B domains of Sld5/Psf1 are permuted with respect to Psf1/Psf3.


:

Pssm-ID: 212549  Cd Length: 119  Bit Score: 140.82  E-value: 3.10e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207183063  20 LISRLEEAWLNEKFSPELLENKSELVECVMEQLTHMEENLQRVR---KGDLKASVHRMEIDRIRFVLSSFLRSRLKKIEK 96
Cdd:cd11711     1 DLELLKRAWVNEKFAPELLPYQEELVERVLEQIEQQEENLEELKaseKDDLRLSLHEMELERIRFLLRSYLRTRLQKIEK 80
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1207183063  97 FFPHVLEKEKsradgDPSFLSPEEFAFAKEYLANTEVYLRAVAL 140
Cdd:cd11711    81 YALHILSEEE-----LPSRLSPEELEFAKRYAELLENHLKSSVL 119
GINS_B_Sld5 cd21692
beta-strand (B) domain of GINS complex protein Sld5; Sld5 is a component of the GINS (named ...
159-201 6.23e-11

beta-strand (B) domain of GINS complex protein Sld5; Sld5 is a component of the GINS (named from the Japanese go-ichi-ni-san, meaning 5-1-2-3 for the Sld5, Psf1, Psf2, and Psf3 subunits) tetrameric protein complex, within which Sld5 interacts with Psf1 via its N-terminal A-domain, and with Psf2 through a combination of the A and B domains. In Drosophila, Sld5 is required for normal cell cycle progression and the maintenance of genomic integrity. GINS is a complex of four subunits (Sld5, Psf1, Psf2 and Psf3) that is involved in both initiation and elongation stages of eukaryotic chromosome replication. Besides being essential for the maintenance of genomic integrity, GINS plays a central role in coordinating DNA replication with cell cycle checkpoints and is involved in cell growth. The eukaryotic GINS subunits Sld5, Psf1, Psf2 and Psf3 are homologous, and homologs are also found in archaea; the complex is not found in bacteria. Each subunit of the complex consists of two domains called the alpha-helical (A) and beta-strand (B) domains. The A and B domains of Sld5/Psf1 are permuted with respect to Psf1/Psf3. This model represents the B-domain of GINS subunit Sld5.


:

Pssm-ID: 412028  Cd Length: 55  Bit Score: 55.63  E-value: 6.23e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1207183063 159 PCLDSFVFLRVKEKQENILVEPETDEqreyVVDLDQGSQHIMR 201
Cdd:cd21692     1 PNLDSFVFCRVLEDVGDVLVDPDGDE----EVDLEKGDIHLIR 39
 
Name Accession Description Interval E-value
GINS_A_Sld5 cd11711
Alpha-helical domain of GINS complex protein Sld5; Sld5 is a component of GINS tetrameric ...
20-140 3.10e-43

Alpha-helical domain of GINS complex protein Sld5; Sld5 is a component of GINS tetrameric protein complex, and within the complex Sld5 interacts with Psf1 via its N-terminal A-domain, and with Psf2 through a combination of the A and B domains. Sld5 in Drosophila is required for normal cell cycle progression and the maintenance of genomic integrity. GINS is a complex of four subunits (Sld5, Psf1, Psf2 and Psf3) that is involved in both initiation and elongation stages of eukaryotic chromosome replication. Besides being essential for the maintenance of genomic integrity, GINS plays a central role in coordinating DNA replication with cell cycle checkpoints and is involved in cell growth. The eukaryotic GINS subunits are homologous and homologs are also found in the archaea; the complex is not found in bacteria. The four subunits of the complex consist of two domains each, termed the alpha-helical (A) and beta-strand (B) domains. The A and B domains of Sld5/Psf1 are permuted with respect to Psf1/Psf3.


Pssm-ID: 212549  Cd Length: 119  Bit Score: 140.82  E-value: 3.10e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207183063  20 LISRLEEAWLNEKFSPELLENKSELVECVMEQLTHMEENLQRVR---KGDLKASVHRMEIDRIRFVLSSFLRSRLKKIEK 96
Cdd:cd11711     1 DLELLKRAWVNEKFAPELLPYQEELVERVLEQIEQQEENLEELKaseKDDLRLSLHEMELERIRFLLRSYLRTRLQKIEK 80
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1207183063  97 FFPHVLEKEKsradgDPSFLSPEEFAFAKEYLANTEVYLRAVAL 140
Cdd:cd11711    81 YALHILSEEE-----LPSRLSPEELEFAKRYAELLENHLKSSVL 119
COG5086 COG5086
Uncharacterized conserved protein [Function unknown];
17-201 1.61e-12

Uncharacterized conserved protein [Function unknown];


Pssm-ID: 227418 [Multi-domain]  Cd Length: 218  Bit Score: 63.83  E-value: 1.61e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207183063  17 PAELISRLEEAWLNEKFSPELLENKSELVECVM----EQLTHMEENLQRVRKGDLKASVHRMEIDRIRFVLSSFLRSRLK 92
Cdd:COG5086    20 SFPDLNDLILAWQNERSTPRLLPYALHLIDRFLdrisEQTEHVKIALGKSIAKNNESILMETELERVKFVVRSYIRTRLK 99
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207183063  93 KIEKFFPHVLEKEKSRAdgdpsFLSPEEFAFakeYLANTEVYLRAVA---LKHMPPNLQSVD----MMKAVPEPCLDSFV 165
Cdd:COG5086   100 KIDKNLYYDLSDENSLI-----LLSGGELAY---YEKHSLIYIDLLKdsdLYVTPQKFHKVHdfvgFYCMTDEPDWNKFV 171
                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 1207183063 166 FLRVKEKQEnilvEPETDEQREYvVDLDQGSQHIMR 201
Cdd:COG5086   172 FGAVNEDLQ----ENDTVGEKEL-LELFKGDFFVAR 202
GINS_B_Sld5 cd21692
beta-strand (B) domain of GINS complex protein Sld5; Sld5 is a component of the GINS (named ...
159-201 6.23e-11

beta-strand (B) domain of GINS complex protein Sld5; Sld5 is a component of the GINS (named from the Japanese go-ichi-ni-san, meaning 5-1-2-3 for the Sld5, Psf1, Psf2, and Psf3 subunits) tetrameric protein complex, within which Sld5 interacts with Psf1 via its N-terminal A-domain, and with Psf2 through a combination of the A and B domains. In Drosophila, Sld5 is required for normal cell cycle progression and the maintenance of genomic integrity. GINS is a complex of four subunits (Sld5, Psf1, Psf2 and Psf3) that is involved in both initiation and elongation stages of eukaryotic chromosome replication. Besides being essential for the maintenance of genomic integrity, GINS plays a central role in coordinating DNA replication with cell cycle checkpoints and is involved in cell growth. The eukaryotic GINS subunits Sld5, Psf1, Psf2 and Psf3 are homologous, and homologs are also found in archaea; the complex is not found in bacteria. Each subunit of the complex consists of two domains called the alpha-helical (A) and beta-strand (B) domains. The A and B domains of Sld5/Psf1 are permuted with respect to Psf1/Psf3. This model represents the B-domain of GINS subunit Sld5.


Pssm-ID: 412028  Cd Length: 55  Bit Score: 55.63  E-value: 6.23e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1207183063 159 PCLDSFVFLRVKEKQENILVEPETDEqreyVVDLDQGSQHIMR 201
Cdd:cd21692     1 PNLDSFVFCRVLEDVGDVLVDPDGDE----EVDLEKGDIHLIR 39
SLD5_C pfam16922
DNA replication complex GINS protein SLD5 C-terminus; The C-terminal domain of DNA replication ...
159-201 1.32e-09

DNA replication complex GINS protein SLD5 C-terminus; The C-terminal domain of DNA replication complex GINS protein SLD5 is important in the assembly of the GINS complex, a complex which is involved in initiation of DNA replication and progression of DNA replication forks.


Pssm-ID: 465315  Cd Length: 57  Bit Score: 52.15  E-value: 1.32e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1207183063 159 PCLDSFVFLRVKEKQENILVEPETDEQReyVVDLDQGSQHIMR 201
Cdd:pfam16922   1 PDLDTFVFCRVLKDVGGVTVEGEGEDGD--VVELEKGDVYVLR 41
 
Name Accession Description Interval E-value
GINS_A_Sld5 cd11711
Alpha-helical domain of GINS complex protein Sld5; Sld5 is a component of GINS tetrameric ...
20-140 3.10e-43

Alpha-helical domain of GINS complex protein Sld5; Sld5 is a component of GINS tetrameric protein complex, and within the complex Sld5 interacts with Psf1 via its N-terminal A-domain, and with Psf2 through a combination of the A and B domains. Sld5 in Drosophila is required for normal cell cycle progression and the maintenance of genomic integrity. GINS is a complex of four subunits (Sld5, Psf1, Psf2 and Psf3) that is involved in both initiation and elongation stages of eukaryotic chromosome replication. Besides being essential for the maintenance of genomic integrity, GINS plays a central role in coordinating DNA replication with cell cycle checkpoints and is involved in cell growth. The eukaryotic GINS subunits are homologous and homologs are also found in the archaea; the complex is not found in bacteria. The four subunits of the complex consist of two domains each, termed the alpha-helical (A) and beta-strand (B) domains. The A and B domains of Sld5/Psf1 are permuted with respect to Psf1/Psf3.


Pssm-ID: 212549  Cd Length: 119  Bit Score: 140.82  E-value: 3.10e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207183063  20 LISRLEEAWLNEKFSPELLENKSELVECVMEQLTHMEENLQRVR---KGDLKASVHRMEIDRIRFVLSSFLRSRLKKIEK 96
Cdd:cd11711     1 DLELLKRAWVNEKFAPELLPYQEELVERVLEQIEQQEENLEELKaseKDDLRLSLHEMELERIRFLLRSYLRTRLQKIEK 80
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1207183063  97 FFPHVLEKEKsradgDPSFLSPEEFAFAKEYLANTEVYLRAVAL 140
Cdd:cd11711    81 YALHILSEEE-----LPSRLSPEELEFAKRYAELLENHLKSSVL 119
GINS_A cd11581
Alpha-helical domain of GINS complex proteins; Sld5, Psf1, Psf2 and Psf3; The GINS complex is ...
21-132 2.07e-16

Alpha-helical domain of GINS complex proteins; Sld5, Psf1, Psf2 and Psf3; The GINS complex is involved in both initiation and elongation stages of eukaryotic chromosome replication, with GINS being the component that most likely serves as the replicative helicase that unwinds duplex DNA ahead of the moving replication fork. In eukaryotes, GINS is a tetrameric arrangement of four subunits Sld5, Psf1, Psf2 and Psf3. The GINS complex has been found in eukaryotes and archaea, but not in bacteria. The four subunits of the complex are homologous and consist of two domains each, termed the alpha-helical (A) and beta-strand (B) domains. The A and B domains of Sld5/Psf1 are permuted with respect to Psf1/Psf3.


Pssm-ID: 212547  Cd Length: 103  Bit Score: 71.37  E-value: 2.07e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207183063  21 ISRLEEAWLNEKFSPELLENKSELVECVMEQLTHMEENLQRVRKGDLKASVHRMEIDRIRFVLSSFLRSRLKKIEKFFPH 100
Cdd:cd11581     1 VEKLAEAIHNERKSENLLPPPPDFMEEVKELLHRLSKRQRSETQEILEHRLKILELSYIRDLLKTYLNSRLDKIRDLSPE 80
                          90       100       110
                  ....*....|....*....|....*....|..
gi 1207183063 101 VLekeksradgdPSFLSPEEFAFAKEYLANTE 132
Cdd:cd11581    81 FL----------PSNLTEEEIGYFQTYWKEVA 102
COG5086 COG5086
Uncharacterized conserved protein [Function unknown];
17-201 1.61e-12

Uncharacterized conserved protein [Function unknown];


Pssm-ID: 227418 [Multi-domain]  Cd Length: 218  Bit Score: 63.83  E-value: 1.61e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207183063  17 PAELISRLEEAWLNEKFSPELLENKSELVECVM----EQLTHMEENLQRVRKGDLKASVHRMEIDRIRFVLSSFLRSRLK 92
Cdd:COG5086    20 SFPDLNDLILAWQNERSTPRLLPYALHLIDRFLdrisEQTEHVKIALGKSIAKNNESILMETELERVKFVVRSYIRTRLK 99
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207183063  93 KIEKFFPHVLEKEKSRAdgdpsFLSPEEFAFakeYLANTEVYLRAVA---LKHMPPNLQSVD----MMKAVPEPCLDSFV 165
Cdd:COG5086   100 KIDKNLYYDLSDENSLI-----LLSGGELAY---YEKHSLIYIDLLKdsdLYVTPQKFHKVHdfvgFYCMTDEPDWNKFV 171
                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 1207183063 166 FLRVKEKQEnilvEPETDEQREYvVDLDQGSQHIMR 201
Cdd:COG5086   172 FGAVNEDLQ----ENDTVGEKEL-LELFKGDFFVAR 202
GINS_B_Sld5 cd21692
beta-strand (B) domain of GINS complex protein Sld5; Sld5 is a component of the GINS (named ...
159-201 6.23e-11

beta-strand (B) domain of GINS complex protein Sld5; Sld5 is a component of the GINS (named from the Japanese go-ichi-ni-san, meaning 5-1-2-3 for the Sld5, Psf1, Psf2, and Psf3 subunits) tetrameric protein complex, within which Sld5 interacts with Psf1 via its N-terminal A-domain, and with Psf2 through a combination of the A and B domains. In Drosophila, Sld5 is required for normal cell cycle progression and the maintenance of genomic integrity. GINS is a complex of four subunits (Sld5, Psf1, Psf2 and Psf3) that is involved in both initiation and elongation stages of eukaryotic chromosome replication. Besides being essential for the maintenance of genomic integrity, GINS plays a central role in coordinating DNA replication with cell cycle checkpoints and is involved in cell growth. The eukaryotic GINS subunits Sld5, Psf1, Psf2 and Psf3 are homologous, and homologs are also found in archaea; the complex is not found in bacteria. Each subunit of the complex consists of two domains called the alpha-helical (A) and beta-strand (B) domains. The A and B domains of Sld5/Psf1 are permuted with respect to Psf1/Psf3. This model represents the B-domain of GINS subunit Sld5.


Pssm-ID: 412028  Cd Length: 55  Bit Score: 55.63  E-value: 6.23e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1207183063 159 PCLDSFVFLRVKEKQENILVEPETDEqreyVVDLDQGSQHIMR 201
Cdd:cd21692     1 PNLDSFVFCRVLEDVGDVLVDPDGDE----EVDLEKGDIHLIR 39
SLD5_C pfam16922
DNA replication complex GINS protein SLD5 C-terminus; The C-terminal domain of DNA replication ...
159-201 1.32e-09

DNA replication complex GINS protein SLD5 C-terminus; The C-terminal domain of DNA replication complex GINS protein SLD5 is important in the assembly of the GINS complex, a complex which is involved in initiation of DNA replication and progression of DNA replication forks.


Pssm-ID: 465315  Cd Length: 57  Bit Score: 52.15  E-value: 1.32e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1207183063 159 PCLDSFVFLRVKEKQENILVEPETDEQReyVVDLDQGSQHIMR 201
Cdd:pfam16922   1 PDLDTFVFCRVLKDVGGVTVEGEGEDGD--VVELEKGDVYVLR 41
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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