DNA replication complex GINS protein SLD5 isoform X1 [Danio rerio]
DNA replication complex GINS protein SLD5( domain architecture ID 16826204)
DNA replication complex GINS protein SLD5 is a component of the heterotetrameric GINS complex; the GINS complex is essential for both the initiation and elongation stages of eukaryotic DNA replication
List of domain hits
Name | Accession | Description | Interval | E-value | |||
GINS_A_Sld5 | cd11711 | Alpha-helical domain of GINS complex protein Sld5; Sld5 is a component of GINS tetrameric ... |
20-140 | 3.10e-43 | |||
Alpha-helical domain of GINS complex protein Sld5; Sld5 is a component of GINS tetrameric protein complex, and within the complex Sld5 interacts with Psf1 via its N-terminal A-domain, and with Psf2 through a combination of the A and B domains. Sld5 in Drosophila is required for normal cell cycle progression and the maintenance of genomic integrity. GINS is a complex of four subunits (Sld5, Psf1, Psf2 and Psf3) that is involved in both initiation and elongation stages of eukaryotic chromosome replication. Besides being essential for the maintenance of genomic integrity, GINS plays a central role in coordinating DNA replication with cell cycle checkpoints and is involved in cell growth. The eukaryotic GINS subunits are homologous and homologs are also found in the archaea; the complex is not found in bacteria. The four subunits of the complex consist of two domains each, termed the alpha-helical (A) and beta-strand (B) domains. The A and B domains of Sld5/Psf1 are permuted with respect to Psf1/Psf3. : Pssm-ID: 212549 Cd Length: 119 Bit Score: 140.82 E-value: 3.10e-43
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GINS_B_Sld5 | cd21692 | beta-strand (B) domain of GINS complex protein Sld5; Sld5 is a component of the GINS (named ... |
159-201 | 6.23e-11 | |||
beta-strand (B) domain of GINS complex protein Sld5; Sld5 is a component of the GINS (named from the Japanese go-ichi-ni-san, meaning 5-1-2-3 for the Sld5, Psf1, Psf2, and Psf3 subunits) tetrameric protein complex, within which Sld5 interacts with Psf1 via its N-terminal A-domain, and with Psf2 through a combination of the A and B domains. In Drosophila, Sld5 is required for normal cell cycle progression and the maintenance of genomic integrity. GINS is a complex of four subunits (Sld5, Psf1, Psf2 and Psf3) that is involved in both initiation and elongation stages of eukaryotic chromosome replication. Besides being essential for the maintenance of genomic integrity, GINS plays a central role in coordinating DNA replication with cell cycle checkpoints and is involved in cell growth. The eukaryotic GINS subunits Sld5, Psf1, Psf2 and Psf3 are homologous, and homologs are also found in archaea; the complex is not found in bacteria. Each subunit of the complex consists of two domains called the alpha-helical (A) and beta-strand (B) domains. The A and B domains of Sld5/Psf1 are permuted with respect to Psf1/Psf3. This model represents the B-domain of GINS subunit Sld5. : Pssm-ID: 412028 Cd Length: 55 Bit Score: 55.63 E-value: 6.23e-11
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Name | Accession | Description | Interval | E-value | ||||
GINS_A_Sld5 | cd11711 | Alpha-helical domain of GINS complex protein Sld5; Sld5 is a component of GINS tetrameric ... |
20-140 | 3.10e-43 | ||||
Alpha-helical domain of GINS complex protein Sld5; Sld5 is a component of GINS tetrameric protein complex, and within the complex Sld5 interacts with Psf1 via its N-terminal A-domain, and with Psf2 through a combination of the A and B domains. Sld5 in Drosophila is required for normal cell cycle progression and the maintenance of genomic integrity. GINS is a complex of four subunits (Sld5, Psf1, Psf2 and Psf3) that is involved in both initiation and elongation stages of eukaryotic chromosome replication. Besides being essential for the maintenance of genomic integrity, GINS plays a central role in coordinating DNA replication with cell cycle checkpoints and is involved in cell growth. The eukaryotic GINS subunits are homologous and homologs are also found in the archaea; the complex is not found in bacteria. The four subunits of the complex consist of two domains each, termed the alpha-helical (A) and beta-strand (B) domains. The A and B domains of Sld5/Psf1 are permuted with respect to Psf1/Psf3. Pssm-ID: 212549 Cd Length: 119 Bit Score: 140.82 E-value: 3.10e-43
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COG5086 | COG5086 | Uncharacterized conserved protein [Function unknown]; |
17-201 | 1.61e-12 | ||||
Uncharacterized conserved protein [Function unknown]; Pssm-ID: 227418 [Multi-domain] Cd Length: 218 Bit Score: 63.83 E-value: 1.61e-12
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GINS_B_Sld5 | cd21692 | beta-strand (B) domain of GINS complex protein Sld5; Sld5 is a component of the GINS (named ... |
159-201 | 6.23e-11 | ||||
beta-strand (B) domain of GINS complex protein Sld5; Sld5 is a component of the GINS (named from the Japanese go-ichi-ni-san, meaning 5-1-2-3 for the Sld5, Psf1, Psf2, and Psf3 subunits) tetrameric protein complex, within which Sld5 interacts with Psf1 via its N-terminal A-domain, and with Psf2 through a combination of the A and B domains. In Drosophila, Sld5 is required for normal cell cycle progression and the maintenance of genomic integrity. GINS is a complex of four subunits (Sld5, Psf1, Psf2 and Psf3) that is involved in both initiation and elongation stages of eukaryotic chromosome replication. Besides being essential for the maintenance of genomic integrity, GINS plays a central role in coordinating DNA replication with cell cycle checkpoints and is involved in cell growth. The eukaryotic GINS subunits Sld5, Psf1, Psf2 and Psf3 are homologous, and homologs are also found in archaea; the complex is not found in bacteria. Each subunit of the complex consists of two domains called the alpha-helical (A) and beta-strand (B) domains. The A and B domains of Sld5/Psf1 are permuted with respect to Psf1/Psf3. This model represents the B-domain of GINS subunit Sld5. Pssm-ID: 412028 Cd Length: 55 Bit Score: 55.63 E-value: 6.23e-11
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SLD5_C | pfam16922 | DNA replication complex GINS protein SLD5 C-terminus; The C-terminal domain of DNA replication ... |
159-201 | 1.32e-09 | ||||
DNA replication complex GINS protein SLD5 C-terminus; The C-terminal domain of DNA replication complex GINS protein SLD5 is important in the assembly of the GINS complex, a complex which is involved in initiation of DNA replication and progression of DNA replication forks. Pssm-ID: 465315 Cd Length: 57 Bit Score: 52.15 E-value: 1.32e-09
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Name | Accession | Description | Interval | E-value | ||||
GINS_A_Sld5 | cd11711 | Alpha-helical domain of GINS complex protein Sld5; Sld5 is a component of GINS tetrameric ... |
20-140 | 3.10e-43 | ||||
Alpha-helical domain of GINS complex protein Sld5; Sld5 is a component of GINS tetrameric protein complex, and within the complex Sld5 interacts with Psf1 via its N-terminal A-domain, and with Psf2 through a combination of the A and B domains. Sld5 in Drosophila is required for normal cell cycle progression and the maintenance of genomic integrity. GINS is a complex of four subunits (Sld5, Psf1, Psf2 and Psf3) that is involved in both initiation and elongation stages of eukaryotic chromosome replication. Besides being essential for the maintenance of genomic integrity, GINS plays a central role in coordinating DNA replication with cell cycle checkpoints and is involved in cell growth. The eukaryotic GINS subunits are homologous and homologs are also found in the archaea; the complex is not found in bacteria. The four subunits of the complex consist of two domains each, termed the alpha-helical (A) and beta-strand (B) domains. The A and B domains of Sld5/Psf1 are permuted with respect to Psf1/Psf3. Pssm-ID: 212549 Cd Length: 119 Bit Score: 140.82 E-value: 3.10e-43
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GINS_A | cd11581 | Alpha-helical domain of GINS complex proteins; Sld5, Psf1, Psf2 and Psf3; The GINS complex is ... |
21-132 | 2.07e-16 | ||||
Alpha-helical domain of GINS complex proteins; Sld5, Psf1, Psf2 and Psf3; The GINS complex is involved in both initiation and elongation stages of eukaryotic chromosome replication, with GINS being the component that most likely serves as the replicative helicase that unwinds duplex DNA ahead of the moving replication fork. In eukaryotes, GINS is a tetrameric arrangement of four subunits Sld5, Psf1, Psf2 and Psf3. The GINS complex has been found in eukaryotes and archaea, but not in bacteria. The four subunits of the complex are homologous and consist of two domains each, termed the alpha-helical (A) and beta-strand (B) domains. The A and B domains of Sld5/Psf1 are permuted with respect to Psf1/Psf3. Pssm-ID: 212547 Cd Length: 103 Bit Score: 71.37 E-value: 2.07e-16
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COG5086 | COG5086 | Uncharacterized conserved protein [Function unknown]; |
17-201 | 1.61e-12 | ||||
Uncharacterized conserved protein [Function unknown]; Pssm-ID: 227418 [Multi-domain] Cd Length: 218 Bit Score: 63.83 E-value: 1.61e-12
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GINS_B_Sld5 | cd21692 | beta-strand (B) domain of GINS complex protein Sld5; Sld5 is a component of the GINS (named ... |
159-201 | 6.23e-11 | ||||
beta-strand (B) domain of GINS complex protein Sld5; Sld5 is a component of the GINS (named from the Japanese go-ichi-ni-san, meaning 5-1-2-3 for the Sld5, Psf1, Psf2, and Psf3 subunits) tetrameric protein complex, within which Sld5 interacts with Psf1 via its N-terminal A-domain, and with Psf2 through a combination of the A and B domains. In Drosophila, Sld5 is required for normal cell cycle progression and the maintenance of genomic integrity. GINS is a complex of four subunits (Sld5, Psf1, Psf2 and Psf3) that is involved in both initiation and elongation stages of eukaryotic chromosome replication. Besides being essential for the maintenance of genomic integrity, GINS plays a central role in coordinating DNA replication with cell cycle checkpoints and is involved in cell growth. The eukaryotic GINS subunits Sld5, Psf1, Psf2 and Psf3 are homologous, and homologs are also found in archaea; the complex is not found in bacteria. Each subunit of the complex consists of two domains called the alpha-helical (A) and beta-strand (B) domains. The A and B domains of Sld5/Psf1 are permuted with respect to Psf1/Psf3. This model represents the B-domain of GINS subunit Sld5. Pssm-ID: 412028 Cd Length: 55 Bit Score: 55.63 E-value: 6.23e-11
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SLD5_C | pfam16922 | DNA replication complex GINS protein SLD5 C-terminus; The C-terminal domain of DNA replication ... |
159-201 | 1.32e-09 | ||||
DNA replication complex GINS protein SLD5 C-terminus; The C-terminal domain of DNA replication complex GINS protein SLD5 is important in the assembly of the GINS complex, a complex which is involved in initiation of DNA replication and progression of DNA replication forks. Pssm-ID: 465315 Cd Length: 57 Bit Score: 52.15 E-value: 1.32e-09
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Blast search parameters | ||||
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