fpgs folylpolyglutamate synthase [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: fpgsprovided by ZNC
Official Full Name: folylpolyglutamate synthaseprovided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-2781
See related: Ensembl:ENSDARG00000044809 AllianceGenome:ZFIN:ZDB-GENE-040426-2781
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: fk51d09; zgc:63807; wu:fk49h03; wu:fk51d09
Summary: Predicted to enable tetrahydrofolylpolyglutamate synthase activity. Predicted to be involved in tetrahydrofolylpolyglutamate biosynthetic process. Predicted to act upstream of or within folic acid-containing compound biosynthetic process and one-carbon metabolic process. Predicted to be located in mitochondrial inner membrane and mitochondrial matrix. Predicted to be active in cytosol and mitochondrion. Is expressed in several structures, including alar plate midbrain region; liver; nervous system; optic vesicle; and yolk syncytial layer. Orthologous to human FPGS (folylpolyglutamate synthase). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 21

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	21	NC_007132.7 (6114290..6134490)
105	previous assembly	GRCz10 (GCF_000002035.5)	21	NC_007132.6 (6009202..6028982)

Chromosome 21 - NC_007132.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

fk49h03.x1 (e-PCR)
- UniSTS:201081

fk51d09.x1 (e-PCR)
- UniSTS:201108

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables acid-amino acid ligase activity	IEA Inferred from Electronic Annotation more info
enables ligase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables tetrahydrofolylpolyglutamate synthase activity	IBA Inferred from Biological aspect of Ancestor more info
enables tetrahydrofolylpolyglutamate synthase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within folic acid-containing compound biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within one-carbon metabolic process	IEA Inferred from Electronic Annotation more info
involved_in tetrahydrofolylpolyglutamate biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in tetrahydrofolylpolyglutamate biosynthetic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrial inner membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrial matrix	IEA Inferred from Electronic Annotation more info
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: folylpolyglutamate synthase, mitochondrial

NP_998602.2

EC 6.3.2.17

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_213437.2 → NP_998602.2 folylpolyglutamate synthase, mitochondrial

Status: VALIDATED

Source sequence(s)

BX530036, EH592151

UniProtKB/TrEMBL

A0A8M1PF71, F1Q7N0

Related

ENSDARP00000118992.1, ENSDART00000141607.3

Conserved Domains (2) summary

PLN02881
Location:47 → 566

PLN02881; tetrahydrofolylpolyglutamate synthase

pfam02875
Location:356 → 437

Mur_ligase_C; Mur ligase family, glutamate ligase domain