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    TNC tenascin C [ Bos taurus (domestic cattle) ]

    Gene ID: 540664, updated on 1-Jan-2025

    Summary

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    Official Symbol
    TNCprovided by VGNC
    Official Full Name
    tenascin Cprovided by VGNC
    Primary source
    VGNC:VGNC:36152
    See related
    Ensembl:ENSBTAG00000000575
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See TNC in Genome Data Viewer
    Location:
    chromosome: 8
    Exon count:
    30
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 8 NC_037335.1 (104208978..104311445, complement)

    Chromosome 8 - NC_037335.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107132740 Neighboring gene TNF superfamily member 8 Neighboring gene uncharacterized LOC101908167 Neighboring gene uncharacterized LOC112447848 Neighboring gene uncharacterized LOC132346016 Neighboring gene uncharacterized LOC132346051 Neighboring gene uncharacterized LOC132346017

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037335.1 Chromosome 8 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. YAP/TAZ regulates the expression of proteoglycan 4 and tenascin C in superficial-zone chondrocytes. Delve E, et al. Eur Cell Mater, 2020 Jan 9. PMID 31917459
    2. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. YAP/TAZ regulates the expression of proteoglycan 4 and tenascin C in superficial-zone chondrocytes.
      Title: YAP/TAZ regulates the expression of proteoglycan 4 and tenascin C in superficial-zone chondrocytes.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC140517

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in perisynaptic extracellular matrix IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    tenascin
    Names
    tenascin C (hexabrachion)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001372074.1 → NP_001359003.1  tenascin precursor

      Status: VALIDATED

      Source sequence(s)
      NKLS02000008
      UniProtKB/TrEMBL
      A0A3Q1LKE5, A0A3Q1MPD2, F1MRZ5
      Related
      ENSBTAP00000060030.1, ENSBTAT00000069637.2
      Conserved Domains (5) summary
      pfam07974
      Location:440 → 465
      EGF_2; EGF-like domain
      cl00085
      Location:1980 → 2189
      FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...
      pfam00041
      Location:1888 → 1965
      fn3; Fibronectin type III domain
      pfam01414
      Location:330 → 372
      DSL; Delta serrate ligand
      pfam18720
      Location:408 → 434
      EGF_Tenascin; Tenascin EGF domain

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037335.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      104208978..104311445 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_010808269.4 → XP_010806571.1  tenascin isoform X14

      UniProtKB/TrEMBL
      A0JN60
      Related
      ENSBTAP00000060350.2, ENSBTAT00000077578.2
      Conserved Domains (5) summary
      cd00063
      Location:986 → 1065
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:1342 → 1414
      fn3; Fibronectin type III domain
      pfam07974
      Location:440 → 465
      EGF_2; EGF-like domain
      cl00085
      Location:1434 → 1643
      FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...
      cl19567
      Location:332 → 372
      DSL; Delta serrate ligand

    2. XM_024995899.2 → XP_024851667.1  tenascin isoform X13

      UniProtKB/TrEMBL
      A0JN60
      Conserved Domains (5) summary
      cd00063
      Location:986 → 1065
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07974
      Location:440 → 465
      EGF_2; EGF-like domain
      cl00085
      Location:1434 → 1643
      FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...
      pfam00041
      Location:1342 → 1414
      fn3; Fibronectin type III domain
      cl19567
      Location:332 → 372
      DSL; Delta serrate ligand

    3. XM_010808268.4 → XP_010806570.1  tenascin isoform X12

      UniProtKB/TrEMBL
      A0JN60
      Conserved Domains (4) summary
      cd00063
      Location:986 → 1065
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:1433 → 1505
      fn3; Fibronectin type III domain
      pfam07974
      Location:440 → 465
      EGF_2; EGF-like domain
      cl00085
      Location:1525 → 1734
      FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...

    4. XM_005210552.5 → XP_005210609.1  tenascin isoform X11

      UniProtKB/TrEMBL
      A0A3Q1MPD2
      Conserved Domains (4) summary
      cd00063
      Location:986 → 1065
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:1524 → 1596
      fn3; Fibronectin type III domain
      pfam07974
      Location:440 → 465
      EGF_2; EGF-like domain
      cl00085
      Location:1616 → 1825
      FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...

    5. XM_010808265.4 → XP_010806567.1  tenascin isoform X8

      UniProtKB/TrEMBL
      A0A3Q1LIW2, A0A3Q1MPD2
      Related
      ENSBTAP00000059134.1, ENSBTAT00000084692.2
      Conserved Domains (4) summary
      cd00063
      Location:804 → 891
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:1706 → 1778
      fn3; Fibronectin type III domain
      pfam07974
      Location:440 → 465
      EGF_2; EGF-like domain
      cl00085
      Location:1798 → 2007
      FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...

    6. XM_010808264.4 → XP_010806566.1  tenascin isoform X7

      UniProtKB/TrEMBL
      A0A3Q1MPD2
      Conserved Domains (4) summary
      cd00063
      Location:804 → 891
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:1797 → 1869
      fn3; Fibronectin type III domain
      pfam07974
      Location:440 → 465
      EGF_2; EGF-like domain
      cl00085
      Location:1889 → 2098
      FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...

    7. XM_010808263.4 → XP_010806565.1  tenascin isoform X3

      UniProtKB/TrEMBL
      A0A3Q1MPD2
      Conserved Domains (4) summary
      cd00063
      Location:804 → 891
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:1980 → 2052
      fn3; Fibronectin type III domain
      pfam00147
      Location:2072 → 2281
      Fibrinogen_C; Fibrinogen beta and gamma chains, C-terminal globular domain
      pfam07974
      Location:440 → 465
      EGF_2; EGF-like domain

    8. XM_005210551.5 → XP_005210608.1  tenascin isoform X9

      UniProtKB/TrEMBL
      A0A3Q1NBB0, F1MRZ5
      Related
      ENSBTAP00000068605.2, ENSBTAT00000086148.2
      Conserved Domains (4) summary
      cd00063
      Location:804 → 891
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:1706 → 1778
      fn3; Fibronectin type III domain
      pfam07974
      Location:440 → 465
      EGF_2; EGF-like domain
      cl00085
      Location:1798 → 2007
      FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...

    9. XM_059889196.1 → XP_059745179.1  tenascin isoform X10

      UniProtKB/TrEMBL
      F1MRZ5

    10. XM_005210550.5 → XP_005210607.1  tenascin isoform X6

      UniProtKB/TrEMBL
      A0A3Q1LLF1, A0A3Q1MPD2, F1MRZ5
      Related
      ENSBTAP00000057383.1, ENSBTAT00000073405.2
      Conserved Domains (4) summary
      cd00063
      Location:804 → 891
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:1797 → 1869
      fn3; Fibronectin type III domain
      pfam07974
      Location:440 → 465
      EGF_2; EGF-like domain
      cl00085
      Location:1889 → 2098
      FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...

    11. XM_059889195.1 → XP_059745178.1  tenascin isoform X2

      UniProtKB/TrEMBL
      A0A3Q1MPD2, F1MRZ5

    12. XM_005210549.5 → XP_005210606.1  tenascin isoform X5

      UniProtKB/TrEMBL
      A0A3Q1LU83, A0A3Q1MPD2, F1MRZ5
      Related
      ENSBTAP00000058769.2, ENSBTAT00000077992.2
      Conserved Domains (4) summary
      cd00063
      Location:804 → 891
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:1888 → 1960
      fn3; Fibronectin type III domain
      pfam00147
      Location:1980 → 2189
      Fibrinogen_C; Fibrinogen beta and gamma chains, C-terminal globular domain
      pfam07974
      Location:440 → 465
      EGF_2; EGF-like domain

    13. XM_005210547.5 → XP_005210604.1  tenascin isoform X4

      UniProtKB/TrEMBL
      A0A3Q1M1X4, A0A3Q1MPD2, F1MRZ5
      Related
      ENSBTAP00000063753.2, ENSBTAT00000066849.2
      Conserved Domains (4) summary
      cd00063
      Location:804 → 891
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:1979 → 2051
      fn3; Fibronectin type III domain
      pfam00147
      Location:2071 → 2280
      Fibrinogen_C; Fibrinogen beta and gamma chains, C-terminal globular domain
      pfam07974
      Location:440 → 465
      EGF_2; EGF-like domain

    14. XM_005210546.5 → XP_005210603.1  tenascin isoform X1

      UniProtKB/TrEMBL
      A0A3Q1MPD2, F1MRZ5, F1MRZ6
      Related
      ENSBTAP00000000752.7, ENSBTAT00000000752.7
      Conserved Domains (4) summary
      cd00063
      Location:804 → 891
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:2071 → 2143
      fn3; Fibronectin type III domain
      pfam00147
      Location:2163 → 2372
      Fibrinogen_C; Fibrinogen beta and gamma chains, C-terminal globular domain
      pfam07974
      Location:440 → 465
      EGF_2; EGF-like domain

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001078026.2: Suppressed sequence

      Description
      NM_001078026.2: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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