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    COAB 4-phospho-panto-thenoylcysteine synthetase [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 837789, updated on 18-Sep-2024

    Summary

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    Official Symbol
    COAB
    Official Full Name
    4-phospho-panto-thenoylcysteine synthetase
    Primary source
    TAIR:AT1G12350
    Locus tag
    AT1G12350
    See related
    Araport:AT1G12350
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    4-phospho-panto-thenoylcysteine synthetase; ATCOAB; F5O11.36; F5O11_36
    Summary
    At1g12350 encodes phosphopantothenoylcysteine synthetase (phosphopantothenoylcysteine ligase). Its molecular function was shown to add cysteine forming (R)-4#Aeo-phospho-N-pantothenoylcysteine (PPC)
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    Genomic context

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    See COAB in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    10
    Sequence:
    Chromosome: 1; NC_003070.9 (4198337..4200849)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene cyclin-dependent kinase-like protein Neighboring gene Cornichon family protein Neighboring gene Sec1/munc18-like (SM) proteins superfamily Neighboring gene photolyase 1 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. 4'-phosphopantetheine and coenzyme A biosynthesis in plants. Kupke T, et al. J Biol Chem, 2003 Oct 3. PMID 12860978
    2. Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana. Theologis A, et al. Nature, 2000 Dec 14. PMID 11130712

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    NM_001332031.1
    NM_101107.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables phosphopantothenate--cysteine ligase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within coenzyme A biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in coenzyme A biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    4-phospho-panto-thenoylcysteine synthetase
    NP_563904.2
    • 4-phospho-panto-thenoylcysteine synthetase (COAB); FUNCTIONS IN: phosphopantothenate--cysteine ligase activity, catalytic activity; INVOLVED IN: coenzyme A biosynthetic process; LOCATED IN: chloroplast; CONTAINS InterPro DOMAIN/s: DNA/pantothenate metabolism flavoprotein, C-terminal (InterPro:IPR007085); BEST Arabidopsis thaliana protein match is: DNA / pantothenate metabolism flavoprotein (TAIR:AT5G02080.1); Has 721 Blast hits to 697 proteins in 349 species: Archae - 42; Bacteria - 251; Metazoa - 127; Fungi - 134; Plants - 66; Viruses - 4; Other Eukaryotes - 97 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      4198337..4200849
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_101107.4 → NP_563904.2  4-phospho-panto-thenoylcysteine synthetase [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_563904.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8GXR5
      UniProtKB/TrEMBL
      A0A5S9U0A8, A0A654EAR2
      Conserved Domains (1) summary
      PRK05579
      Location:26 → 267
      PRK05579; bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated

    2. NM_001332031.1 → NP_001321808.1  4-phospho-panto-thenoylcysteine synthetase [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8GXR5
      UniProtKB/TrEMBL
      A0A5S9U0A8, A0A654EAR2
      Conserved Domains (1) summary
      PRK05579
      Location:26 → 267
      PRK05579; bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8GXR5.1

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