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Conserved domains on  [gi|30682728|ref|NP_563904|]
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4-phospho-panto-thenoylcysteine synthetase [Arabidopsis thaliana]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
PRK05579 super family cl35341
bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated
26-267 2.80e-15

bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated


The actual alignment was detected with superfamily member PRK05579:

Pssm-ID: 235513 [Multi-domain]  Cd Length: 399  Bit Score: 75.56  E-value: 2.80e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30682728   26 EEIVANLNQFIElNSSCQGgmRRIVcVTSGGTTVPLEQrcVRYIDNFSSGNRGAASTENFVKAGYAVIfLYRRGTCQPyc 105
Cdd:PRK05579 171 EEIVAAAERALS-PKDLAG--KRVL-ITAGPTREPIDP--VRYITNRSSGKMGYALARAAARRGADVT-LVSGPVNLP-- 241
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30682728  106 rylpdDPflecfefPDAKNIQVHGShsgavkmavmdqqaavaegrllklpfstiyeyLQMLrliATILKDVGPCSMFYLA 185
Cdd:PRK05579 242 -----TP-------AGVKRIDVESA--------------------------------QEML---DAVLAALPQADIFIMA 274
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30682728  186 AAVSDFYVpwLSMTEHKIESGSGPLDIRLAQVPKMLSILRSNWAPKAFCISFKLETDskILLEKATKALQKYKVHAVVAN 265
Cdd:PRK05579 275 AAVADYRP--ATVAEGKIKKGEGELTLELVPNPDILAEVAALKDKRPFVVGFAAETG--DVLEYARAKLKRKGLDLIVAN 350

                 ..
gi 30682728  266 EL 267
Cdd:PRK05579 351 DV 352
 
Name Accession Description Interval E-value
PRK05579 PRK05579
bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated
26-267 2.80e-15

bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated


Pssm-ID: 235513 [Multi-domain]  Cd Length: 399  Bit Score: 75.56  E-value: 2.80e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30682728   26 EEIVANLNQFIElNSSCQGgmRRIVcVTSGGTTVPLEQrcVRYIDNFSSGNRGAASTENFVKAGYAVIfLYRRGTCQPyc 105
Cdd:PRK05579 171 EEIVAAAERALS-PKDLAG--KRVL-ITAGPTREPIDP--VRYITNRSSGKMGYALARAAARRGADVT-LVSGPVNLP-- 241
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30682728  106 rylpdDPflecfefPDAKNIQVHGShsgavkmavmdqqaavaegrllklpfstiyeyLQMLrliATILKDVGPCSMFYLA 185
Cdd:PRK05579 242 -----TP-------AGVKRIDVESA--------------------------------QEML---DAVLAALPQADIFIMA 274
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30682728  186 AAVSDFYVpwLSMTEHKIESGSGPLDIRLAQVPKMLSILRSNWAPKAFCISFKLETDskILLEKATKALQKYKVHAVVAN 265
Cdd:PRK05579 275 AAVADYRP--ATVAEGKIKKGEGELTLELVPNPDILAEVAALKDKRPFVVGFAAETG--DVLEYARAKLKRKGLDLIVAN 350

                 ..
gi 30682728  266 EL 267
Cdd:PRK05579 351 DV 352
coaBC_dfp TIGR00521
phosphopantothenoylcysteine decarboxylase / phosphopantothenate--cysteine ligase; This model ...
22-267 1.02e-14

phosphopantothenoylcysteine decarboxylase / phosphopantothenate--cysteine ligase; This model represents a bifunctional enzyme that catalyzes the second and third steps (cysteine ligation, EC 6.3.2.5, and decarboxylation, EC 4.1.1.36) in the biosynthesis of coenzyme A (CoA) from pantothenate in bacteria. In early descriptions of this flavoprotein, a ts mutation in one region of the protein appeared to cause a defect in DNA metaobolism rather than an increased need for the pantothenate precursor beta-alanine. This protein was then called dfp, for DNA/pantothenate metabolism flavoprotein. The authors responsible for detecting phosphopantothenate--cysteine ligase activity suggest renaming this bifunctional protein coaBC for its role in CoA biosynthesis. This enzyme contains the FMN cofactor, but no FAD or pyruvoyl group. The amino-terminal region contains the phosphopantothenoylcysteine decarboxylase activity. [Biosynthesis of cofactors, prosthetic groups, and carriers, Pantothenate and coenzyme A]


Pssm-ID: 273116 [Multi-domain]  Cd Length: 391  Bit Score: 73.94  E-value: 1.02e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30682728    22 LKNKEEIVANLNQFIELNSSCQGgmRRIVcVTSGGTTVPLEQrcVRYIDNFSSGNRGAASTENFVKAGYAVIFLYrrGTC 101
Cdd:TIGR00521 163 LAEPETIVKAAEREFSPKEDLEG--KRVL-ITAGPTREPIDP--VRFISNLSSGKMGLALAEAAYKRGADVTLIT--GPV 235
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30682728   102 QpycryLPDDPFLecfefpdaKNIQVhgshSGAVKMAvmdqQAAVAEgrllklpfstiyeylqmlrliatILKDvgpCSM 181
Cdd:TIGR00521 236 S-----LLTPPGV--------KSIKV----STAEEML----EAALNE-----------------------LAKD---FDI 268
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30682728   182 FYLAAAVSDFYVpwLSMTEHKIESGSGPLDIRLAQVPKMLSILRSNWaPKAFCISFKLETDsKILLEKATKALQKYKVHA 261
Cdd:TIGR00521 269 FISAAAVADFKP--KTVFEGKIKKQGEELSLKLVKNPDIIAEVRKIK-KHQVIVGFKAETN-DDLIKYAKEKLKKKNLDM 344

                  ....*.
gi 30682728   262 VVANEL 267
Cdd:TIGR00521 345 IVANDV 350
DFP pfam04127
DNA / pantothenate metabolism flavoprotein; The DNA/pantothenate metabolism flavoprotein (EC:4. ...
47-267 3.69e-14

DNA / pantothenate metabolism flavoprotein; The DNA/pantothenate metabolism flavoprotein (EC:4.1.1.36) affects synthesis of DNA, and pantothenate metabolism.


Pssm-ID: 461186 [Multi-domain]  Cd Length: 183  Bit Score: 69.36  E-value: 3.69e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30682728    47 RRIVcVTSGGTTVPLEQrcVRYIDNFSSGnrgaastenfvKAGYAV-IFLYRRGtcqpycrylpddpflecfefpdAKNI 125
Cdd:pfam04127   4 KRVL-VTAGPTREPIDP--VRFISNRSSG-----------KMGYALaRAAAARG----------------------AEVT 47
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30682728   126 QVHGSHSgavkmavmdqqaavaegrlLKLPF--------STiyeyLQMLrliATILKDVGPCSMFYLAAAVSDFYVPwlS 197
Cdd:pfam04127  48 LVSGPTS-------------------LPPPPgvevvdveSA----EEML---EAVLAAFPEADIVIMAAAVADYRPA--E 99
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 30682728   198 MTEHKI--ESGSGPLDIRLAQVPKMLSILRSNwAPKAFCISFKLETDSkiLLEKATKALQKYKVHAVVANEL 267
Cdd:pfam04127 100 VADGKIkkSSGGEELTLELVKNPDILAELGKR-KPGQLLVGFAAETED--LLENARAKLERKNLDLIVANDV 168
CoaBC COG0452
Phosphopantothenoylcysteine synthetase/decarboxylase CoaBC [Coenzyme transport and metabolism]; ...
26-267 2.80e-11

Phosphopantothenoylcysteine synthetase/decarboxylase CoaBC [Coenzyme transport and metabolism]; Phosphopantothenoylcysteine synthetase/decarboxylase CoaBC is part of the Pathway/BioSystem: Pantothenate/CoA biosynthesis


Pssm-ID: 440221 [Multi-domain]  Cd Length: 399  Bit Score: 63.51  E-value: 2.80e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30682728  26 EEIVANLNQFIELNSSCQGgmRRIVcVTSGGTTVPLEQrcVRYIDNFSSGnrgaastenfvKAGYAV-IFLYRRGtcqpy 104
Cdd:COG0452 169 EEIVEAIEALLAPKKDLAG--KKVL-ITAGPTREPIDP--VRFISNRSSG-----------KMGYALaEAAAARG----- 227
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30682728 105 crylpddpflecfefpdAKNIQVHGSHSgavkmavmdqqaavaegrlLKLPF--------STiyeyLQMLrliATILKDV 176
Cdd:COG0452 228 -----------------AEVTLVSGPVA-------------------LPTPAgveridveSA----EEML---EAVLAAF 264
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30682728 177 GPCSMFYLAAAVSDFYVpwLSMTEHKIESGSGPLDIRLAQVPKMLSILRSNWAPKAFCISFKLETDSkiLLEKATKALQK 256
Cdd:COG0452 265 PDADIVIMAAAVADYRP--AEVADQKIKKTDDPLTLELVKNPDILAELGARKKPGQFLVGFAAETEN--LLENARAKLAR 340
                       250
                ....*....|.
gi 30682728 257 YKVHAVVANEL 267
Cdd:COG0452 341 KNLDLIVANDV 351
 
Name Accession Description Interval E-value
PRK05579 PRK05579
bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated
26-267 2.80e-15

bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated


Pssm-ID: 235513 [Multi-domain]  Cd Length: 399  Bit Score: 75.56  E-value: 2.80e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30682728   26 EEIVANLNQFIElNSSCQGgmRRIVcVTSGGTTVPLEQrcVRYIDNFSSGNRGAASTENFVKAGYAVIfLYRRGTCQPyc 105
Cdd:PRK05579 171 EEIVAAAERALS-PKDLAG--KRVL-ITAGPTREPIDP--VRYITNRSSGKMGYALARAAARRGADVT-LVSGPVNLP-- 241
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30682728  106 rylpdDPflecfefPDAKNIQVHGShsgavkmavmdqqaavaegrllklpfstiyeyLQMLrliATILKDVGPCSMFYLA 185
Cdd:PRK05579 242 -----TP-------AGVKRIDVESA--------------------------------QEML---DAVLAALPQADIFIMA 274
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30682728  186 AAVSDFYVpwLSMTEHKIESGSGPLDIRLAQVPKMLSILRSNWAPKAFCISFKLETDskILLEKATKALQKYKVHAVVAN 265
Cdd:PRK05579 275 AAVADYRP--ATVAEGKIKKGEGELTLELVPNPDILAEVAALKDKRPFVVGFAAETG--DVLEYARAKLKRKGLDLIVAN 350

                 ..
gi 30682728  266 EL 267
Cdd:PRK05579 351 DV 352
coaBC_dfp TIGR00521
phosphopantothenoylcysteine decarboxylase / phosphopantothenate--cysteine ligase; This model ...
22-267 1.02e-14

phosphopantothenoylcysteine decarboxylase / phosphopantothenate--cysteine ligase; This model represents a bifunctional enzyme that catalyzes the second and third steps (cysteine ligation, EC 6.3.2.5, and decarboxylation, EC 4.1.1.36) in the biosynthesis of coenzyme A (CoA) from pantothenate in bacteria. In early descriptions of this flavoprotein, a ts mutation in one region of the protein appeared to cause a defect in DNA metaobolism rather than an increased need for the pantothenate precursor beta-alanine. This protein was then called dfp, for DNA/pantothenate metabolism flavoprotein. The authors responsible for detecting phosphopantothenate--cysteine ligase activity suggest renaming this bifunctional protein coaBC for its role in CoA biosynthesis. This enzyme contains the FMN cofactor, but no FAD or pyruvoyl group. The amino-terminal region contains the phosphopantothenoylcysteine decarboxylase activity. [Biosynthesis of cofactors, prosthetic groups, and carriers, Pantothenate and coenzyme A]


Pssm-ID: 273116 [Multi-domain]  Cd Length: 391  Bit Score: 73.94  E-value: 1.02e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30682728    22 LKNKEEIVANLNQFIELNSSCQGgmRRIVcVTSGGTTVPLEQrcVRYIDNFSSGNRGAASTENFVKAGYAVIFLYrrGTC 101
Cdd:TIGR00521 163 LAEPETIVKAAEREFSPKEDLEG--KRVL-ITAGPTREPIDP--VRFISNLSSGKMGLALAEAAYKRGADVTLIT--GPV 235
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30682728   102 QpycryLPDDPFLecfefpdaKNIQVhgshSGAVKMAvmdqQAAVAEgrllklpfstiyeylqmlrliatILKDvgpCSM 181
Cdd:TIGR00521 236 S-----LLTPPGV--------KSIKV----STAEEML----EAALNE-----------------------LAKD---FDI 268
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30682728   182 FYLAAAVSDFYVpwLSMTEHKIESGSGPLDIRLAQVPKMLSILRSNWaPKAFCISFKLETDsKILLEKATKALQKYKVHA 261
Cdd:TIGR00521 269 FISAAAVADFKP--KTVFEGKIKKQGEELSLKLVKNPDIIAEVRKIK-KHQVIVGFKAETN-DDLIKYAKEKLKKKNLDM 344

                  ....*.
gi 30682728   262 VVANEL 267
Cdd:TIGR00521 345 IVANDV 350
DFP pfam04127
DNA / pantothenate metabolism flavoprotein; The DNA/pantothenate metabolism flavoprotein (EC:4. ...
47-267 3.69e-14

DNA / pantothenate metabolism flavoprotein; The DNA/pantothenate metabolism flavoprotein (EC:4.1.1.36) affects synthesis of DNA, and pantothenate metabolism.


Pssm-ID: 461186 [Multi-domain]  Cd Length: 183  Bit Score: 69.36  E-value: 3.69e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30682728    47 RRIVcVTSGGTTVPLEQrcVRYIDNFSSGnrgaastenfvKAGYAV-IFLYRRGtcqpycrylpddpflecfefpdAKNI 125
Cdd:pfam04127   4 KRVL-VTAGPTREPIDP--VRFISNRSSG-----------KMGYALaRAAAARG----------------------AEVT 47
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30682728   126 QVHGSHSgavkmavmdqqaavaegrlLKLPF--------STiyeyLQMLrliATILKDVGPCSMFYLAAAVSDFYVPwlS 197
Cdd:pfam04127  48 LVSGPTS-------------------LPPPPgvevvdveSA----EEML---EAVLAAFPEADIVIMAAAVADYRPA--E 99
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 30682728   198 MTEHKI--ESGSGPLDIRLAQVPKMLSILRSNwAPKAFCISFKLETDSkiLLEKATKALQKYKVHAVVANEL 267
Cdd:pfam04127 100 VADGKIkkSSGGEELTLELVKNPDILAELGKR-KPGQLLVGFAAETED--LLENARAKLERKNLDLIVANDV 168
CoaBC COG0452
Phosphopantothenoylcysteine synthetase/decarboxylase CoaBC [Coenzyme transport and metabolism]; ...
26-267 2.80e-11

Phosphopantothenoylcysteine synthetase/decarboxylase CoaBC [Coenzyme transport and metabolism]; Phosphopantothenoylcysteine synthetase/decarboxylase CoaBC is part of the Pathway/BioSystem: Pantothenate/CoA biosynthesis


Pssm-ID: 440221 [Multi-domain]  Cd Length: 399  Bit Score: 63.51  E-value: 2.80e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30682728  26 EEIVANLNQFIELNSSCQGgmRRIVcVTSGGTTVPLEQrcVRYIDNFSSGnrgaastenfvKAGYAV-IFLYRRGtcqpy 104
Cdd:COG0452 169 EEIVEAIEALLAPKKDLAG--KKVL-ITAGPTREPIDP--VRFISNRSSG-----------KMGYALaEAAAARG----- 227
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30682728 105 crylpddpflecfefpdAKNIQVHGSHSgavkmavmdqqaavaegrlLKLPF--------STiyeyLQMLrliATILKDV 176
Cdd:COG0452 228 -----------------AEVTLVSGPVA-------------------LPTPAgveridveSA----EEML---EAVLAAF 264
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30682728 177 GPCSMFYLAAAVSDFYVpwLSMTEHKIESGSGPLDIRLAQVPKMLSILRSNWAPKAFCISFKLETDSkiLLEKATKALQK 256
Cdd:COG0452 265 PDADIVIMAAAVADYRP--AEVADQKIKKTDDPLTLELVKNPDILAELGARKKPGQFLVGFAAETEN--LLENARAKLAR 340
                       250
                ....*....|.
gi 30682728 257 YKVHAVVANEL 267
Cdd:COG0452 341 KNLDLIVANDV 351
PRK06732 PRK06732
phosphopantothenate--cysteine ligase; Validated
50-267 9.10e-09

phosphopantothenate--cysteine ligase; Validated


Pssm-ID: 235856 [Multi-domain]  Cd Length: 229  Bit Score: 54.99  E-value: 9.10e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30682728   50 VCVTSGGTTVPLEQrcVRYIDNFSSGNRGAASTENFVKAGYAVIFLyrrgtcqpycrylpddpflecfefpdakniqvhg 129
Cdd:PRK06732   3 ILITSGGTTEPIDS--VRGITNHSTGQLGKIIAETFLAAGHEVTLV---------------------------------- 46
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30682728  130 shsgAVKMAVMDQQAAvaegrllKLpfsTIYEYLQMLRLIAT---ILK--DVGPCSMfylaaAVSDF---YVPWL----- 196
Cdd:PRK06732  47 ----TTKTAVKPEPHP-------NL---SIIEIENVDDLLETlepLVKdhDVLIHSM-----AVSDYtpvYMTDLeevsa 107
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30682728  197 ----------SMTEHKIESGSGPLDIRLAQVPKMLSILRsNWAPKAFCISFKLETD-SK-ILLEKATKALQKYKVHAVVA 264
Cdd:PRK06732 108 sdnlnefltkQNTEAKISSASDYQVLFLKKTPKVISYVK-KWNPNITLVGFKLLVNvSKeELIKVARASLIKNQADYILA 186

                 ...
gi 30682728  265 NEL 267
Cdd:PRK06732 187 NDL 189
PRK09620 PRK09620
hypothetical protein; Provisional
50-265 2.40e-03

hypothetical protein; Provisional


Pssm-ID: 181997  Cd Length: 229  Bit Score: 38.72  E-value: 2.40e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30682728   50 VCVTSGGTTVPLEQrcVRYIDNFSSGNRGAASTENFVKAGYAVIFLYRrgtcqpycrYLPDDPflecfefpdakniqvhg 129
Cdd:PRK09620   6 VLITSGGCLEKWDQ--VRGHTNMAKGTIGRIIAEELISKGAHVIYLHG---------YFAEKP----------------- 57
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30682728  130 shsgavkMAVMDQqaavaegrlLKL-PFSTIYEYLQMLRLIATILKdvgpCSMFYLAAAVSDFYVPWLSMTEH------- 201
Cdd:PRK09620  58 -------NDINNQ---------LELhPFEGIIDLQDKMKSIITHEK----VDAVIMAAAGSDWVVDKICDQEGnvldmng 117
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 30682728  202 KIESGSGPLdIRLAQVPKMLSILRSnWAPKAFCISFKLETD--SKILLEKATKALQKYKVHAVVAN 265
Cdd:PRK09620 118 KISSDIAPI-IHFQKAPKVLKQIKQ-WDPETVLVGFKLESDvnEEELFERAKNRMEEAKASVMIAN 181
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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