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    Cd300lf Cd300 molecule-like family member F [ Rattus norvegicus (Norway rat) ]

    Gene ID: 287818, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Cd300lfprovided by RGD
    Official Full Name
    Cd300 molecule-like family member Fprovided by RGD
    Primary source
    RGD:1309733
    See related
    EnsemblRapid:ENSRNOG00000021424 AllianceGenome:RGD:1309733
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    CLM-1; CD300f; RGD1309733
    Summary
    Predicted to enable several functions, including interleukin-4 receptor binding activity; phosphatidylserine binding activity; and virus receptor activity. Predicted to be involved in several processes, including interleukin-13-mediated signaling pathway; regulation of apoptotic cell clearance; and regulation of innate immune response. Predicted to act upstream of or within osteoclast differentiation. Predicted to be active in plasma membrane. Orthologous to human CD300LF (CD300 molecule like family member f). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Liver (RPKM 27.8), Spleen (RPKM 22.8) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Cd300lf in Genome Data Viewer
    Location:
    10q32.1
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (100858924..100875111, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (100359942..100376130, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (103669781..103690584, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC103693477 Neighboring gene transfer RNA alanine (anticodon AGC) 73 Neighboring gene RAB37, member RAS oncogene family Neighboring gene NHERF family PDZ scaffold protein 1 Neighboring gene transmembrane protein 104 Neighboring gene N-acetyltransferase 9

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Cutting edge: mouse CD300f (CMRF-35-like molecule-1) recognizes outer membrane-exposed phosphatidylserine and can promote phagocytosis. Choi SC, et al. J Immunol, 2011 Oct 1. PMID 21865548, Free PMC Article
    2. Enhanced efferocytosis by dendritic cells underlies memory T-cell expansion and susceptibility to autoimmune disease in CD300f-deficient mice. Tian L, et al. Cell Death Differ, 2016 Jun. PMID 26768664, Free PMC Article
    3. The receptor LMIR3 negatively regulates mast cell activation and allergic responses by binding to extracellular ceramide. Izawa K, et al. Immunity, 2012 Nov 16. PMID 23123064
    4. Functional receptor molecules CD300lf and CD300ld within the CD300 family enable murine noroviruses to infect cells. Haga K, et al. Proc Natl Acad Sci U S A, 2016 Oct 11. PMID 27681626, Free PMC Article
    5. Sphingomyelin and ceramide are physiological ligands for human LMIR3/CD300f, inhibiting FcεRI-mediated mast cell activation. Izawa K, et al. J Allergy Clin Immunol, 2014 Jan. PMID 24035150

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ceramide binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ceramide binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables interleukin-4 receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables interleukin-4 receptor binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables phosphatidylserine binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphatidylserine binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables transmembrane signaling receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables virus receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in TRIF-dependent toll-like receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in TRIF-dependent toll-like receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in immune response-activating signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in interleukin-13-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in interleukin-13-mediated signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of MyD88-dependent toll-like receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of MyD88-dependent toll-like receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of apoptotic cell clearance ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of apoptotic cell clearance ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of mast cell activation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of mast cell activation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within osteoclast differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of apoptotic cell clearance ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of apoptotic cell clearance ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of interleukin-4-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of interleukin-4-mediated signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in symbiont entry into host cell IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    CMRF35-like molecule 1
    Names
    CD300 antigen-like family member F

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001025111.2 → NP_001020282.1  CMRF35-like molecule 1 isoform 2 precursor

      See identical proteins and their annotated locations for NP_001020282.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/Swiss-Prot
      Q566E6
      UniProtKB/TrEMBL
      D0VBM0
      Conserved Domains (3) summary
      cd05716
      Location:28 → 124
      Ig_pIgR; Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR)
      smart00410
      Location:26 → 126
      IG_like; Immunoglobulin like
      pfam15330
      Location:203 → 298
      SIT; SHP2-interacting transmembrane adaptor protein, SIT

    2. NM_001394215.1 → NP_001381144.1  CMRF35-like molecule 1 isoform 1 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/TrEMBL
      D0V9T5, D0VBM0
      Conserved Domains (2) summary
      pfam15330
      Location:188 → 267
      SIT; SHP2-interacting transmembrane adaptor protein, SIT
      cd05716
      Location:24 → 125
      IgV_pIgR_like; Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      100858924..100875111 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008768338.3 → XP_008766560.1  CMRF35-like molecule 1 isoform X3

      UniProtKB/TrEMBL
      D0VBM0
      Conserved Domains (3) summary
      cd05716
      Location:28 → 124
      Ig_pIgR; Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR)
      smart00410
      Location:26 → 126
      IG_like; Immunoglobulin like
      pfam15330
      Location:188 → 295
      SIT; SHP2-interacting transmembrane adaptor protein, SIT

    2. XM_008768337.3 → XP_008766559.1  CMRF35-like molecule 1 isoform X2

      UniProtKB/TrEMBL
      D0VBM0
      Conserved Domains (3) summary
      cd05716
      Location:28 → 124
      Ig_pIgR; Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR)
      smart00410
      Location:26 → 126
      IG_like; Immunoglobulin like
      pfam15330
      Location:203 → 310
      SIT; SHP2-interacting transmembrane adaptor protein, SIT

    3. XM_017597155.2 → XP_017452644.1  CMRF35-like molecule 1 isoform X1

      UniProtKB/TrEMBL
      D0VBM0
      Related
      ENSRNOP00000033887.7, ENSRNOT00000039284.7
      Conserved Domains (3) summary
      cd05716
      Location:28 → 124
      Ig_pIgR; Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR)
      smart00410
      Location:26 → 126
      IG_like; Immunoglobulin like
      pfam15330
      Location:210 → 317
      SIT; SHP2-interacting transmembrane adaptor protein, SIT

    4. XM_008768340.4 → XP_008766562.1  CMRF35-like molecule 1 isoform X6

      UniProtKB/TrEMBL
      D0VBM0
      Conserved Domains (3) summary
      cd05716
      Location:28 → 124
      Ig_pIgR; Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR)
      smart00410
      Location:26 → 126
      IG_like; Immunoglobulin like
      pfam15330
      Location:169 → 276
      SIT; SHP2-interacting transmembrane adaptor protein, SIT

    5. XM_063268777.1 → XP_063124847.1  CMRF35-like molecule 1 isoform X5

      UniProtKB/TrEMBL
      A0A0H2UHU2, D0VBM0

    6. XM_008768339.4 → XP_008766561.1  CMRF35-like molecule 1 isoform X4

      UniProtKB/TrEMBL
      D0VBM0
      Conserved Domains (3) summary
      cd05716
      Location:28 → 124
      Ig_pIgR; Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR)
      smart00410
      Location:26 → 126
      IG_like; Immunoglobulin like
      pfam15330
      Location:210 → 289
      SIT; SHP2-interacting transmembrane adaptor protein, SIT

    7. XM_008768342.4 → XP_008766564.1  CMRF35-like molecule 1 isoform X7

      UniProtKB/TrEMBL
      D0VBM0, F1M5J1
      Conserved Domains (3) summary
      cd05716
      Location:28 → 124
      Ig_pIgR; Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR)
      smart00410
      Location:26 → 126
      IG_like; Immunoglobulin like
      pfam15330
      Location:169 → 248
      SIT; SHP2-interacting transmembrane adaptor protein, SIT

    8. XM_039085667.2 → XP_038941595.1  CMRF35-like molecule 1 isoform X8

      Conserved Domains (1) summary
      pfam15330
      Location:42 → 149
      SIT; SHP2-interacting transmembrane adaptor protein, SIT

    9. XM_063268778.1 → XP_063124848.1  CMRF35-like molecule 1 isoform X9

      UniProtKB/TrEMBL
      E9MW48

    RNA

    1. XR_005489765.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q566E6.1 GenPept UniProtKB/Swiss-Prot:Q566E6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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