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Conserved domains on  [gi|672069690|ref|XP_008766561|]
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CMRF35-like molecule 1 isoform X4 [Rattus norvegicus]

Protein Classification

Ig_pIgR_like and SIT domain-containing protein( domain architecture ID 10146073)

Ig_pIgR_like and SIT domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
IgV_pIgR_like cd05716
Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The ...
 24-125 4.30e-29

Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The members here are composed of the immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins. pIgR delivers dimeric IgA and pentameric IgM to mucosal secretions. Polymeric immunoglobulin (pIgs) are the first defense against pathogens and toxins. IgA and IgM can form polymers via an 18-residue extension at their C-termini referred to as the tailpiece. pIgR transports pIgs across mucosal epithelia into mucosal secretions. Human pIgR is a glycosylated type I transmembrane protein, comprised of a 620-residue extracellular region, a 23-residue transmembrane region, and a 103-residue cytoplasmic tail. The extracellular region contains five domains that share sequence similarity with Ig variable (v) regions. This group also contains the Ig-like extracellular domains of other receptors such as NK cell receptor Nkp44 and myeloid receptors, among others.


:

Pssm-ID: 409381  Cd Length: 100  Bit Score: 107.48  E-value: 4.30e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672069690  24 TGPEEVSGYEQGSLTVWCRYGSWWKDYSKYWCRGPKRSsCEIRVETdasERLVKENHVSIRDDQTNFTFTVTMEDLRMSD 103
Cdd:cd05716    2 VGPEVVTGVEGGSVTIQCPYPPKYASSRKYWCKWGSEG-CQTLVSS---EGVVPGGRISLTDDPDNGVFTVTLNQLRKED 77

                         90       100
                 ....*....|....*....|...
gi 672069690 104 AGIYWCGITKAGY-DHMFKVHVS 125
Cdd:cd05716   78 AGWYWCGVGDDGDrGLTVQVKLV 100
SIT pfam15330
SHP2-interacting transmembrane adaptor protein, SIT; SIT, or SHP2-interacting transmembrane ...
 210-289 9.74e-28

SHP2-interacting transmembrane adaptor protein, SIT; SIT, or SHP2-interacting transmembrane adaptor protein, is a disulfide-linked dimer that regulates human T Cell activation.


:

Pssm-ID: 464650  Cd Length: 114  Bit Score: 104.39  E-value: 9.74e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672069690  210 WRMVRRQKKAAGPPSG---------QPLEDDLCYANLSLQQPRTSPLKK----GSSMSSSGKDHQEEVEYVTMAPFPREE 276
Cdd:pfam15330  22 WRMMKRQKKAAGYSPEqvipreyylQPIEGDLCYANLTLQQTGTSPGSSdekaYEQMSSSAQRSQNEVEYVTMAPFPREE 101

                          90
                  ....*....|...
gi 672069690  277 ISYAALSLASLGQ 289
Cdd:pfam15330 102 ISYASLSLDVLDQ 114
 
Name Accession Description Interval E-value
IgV_pIgR_like cd05716
Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The ...
 24-125 4.30e-29

Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The members here are composed of the immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins. pIgR delivers dimeric IgA and pentameric IgM to mucosal secretions. Polymeric immunoglobulin (pIgs) are the first defense against pathogens and toxins. IgA and IgM can form polymers via an 18-residue extension at their C-termini referred to as the tailpiece. pIgR transports pIgs across mucosal epithelia into mucosal secretions. Human pIgR is a glycosylated type I transmembrane protein, comprised of a 620-residue extracellular region, a 23-residue transmembrane region, and a 103-residue cytoplasmic tail. The extracellular region contains five domains that share sequence similarity with Ig variable (v) regions. This group also contains the Ig-like extracellular domains of other receptors such as NK cell receptor Nkp44 and myeloid receptors, among others.


Pssm-ID: 409381  Cd Length: 100  Bit Score: 107.48  E-value: 4.30e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672069690  24 TGPEEVSGYEQGSLTVWCRYGSWWKDYSKYWCRGPKRSsCEIRVETdasERLVKENHVSIRDDQTNFTFTVTMEDLRMSD 103
Cdd:cd05716    2 VGPEVVTGVEGGSVTIQCPYPPKYASSRKYWCKWGSEG-CQTLVSS---EGVVPGGRISLTDDPDNGVFTVTLNQLRKED 77

                         90       100
                 ....*....|....*....|...
gi 672069690 104 AGIYWCGITKAGY-DHMFKVHVS 125
Cdd:cd05716   78 AGWYWCGVGDDGDrGLTVQVKLV 100
SIT pfam15330
SHP2-interacting transmembrane adaptor protein, SIT; SIT, or SHP2-interacting transmembrane ...
 210-289 9.74e-28

SHP2-interacting transmembrane adaptor protein, SIT; SIT, or SHP2-interacting transmembrane adaptor protein, is a disulfide-linked dimer that regulates human T Cell activation.


Pssm-ID: 464650  Cd Length: 114  Bit Score: 104.39  E-value: 9.74e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672069690  210 WRMVRRQKKAAGPPSG---------QPLEDDLCYANLSLQQPRTSPLKK----GSSMSSSGKDHQEEVEYVTMAPFPREE 276
Cdd:pfam15330  22 WRMMKRQKKAAGYSPEqvipreyylQPIEGDLCYANLTLQQTGTSPGSSdekaYEQMSSSAQRSQNEVEYVTMAPFPREE 101

                          90
                  ....*....|...
gi 672069690  277 ISYAALSLASLGQ 289
Cdd:pfam15330 102 ISYASLSLDVLDQ 114
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 24-126 4.01e-17

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 75.57  E-value: 4.01e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672069690   24 TGPEEVSGYEQGSLTVWCRYGSWW--KDYSKYWCRGP--KRSSCEIRVETDASERLVKENHVSIRDDQTNFTFTVTMEDL 99
Cdd:pfam07686   1 QTPREVTVALGGSVTLPCTYSSSMseASTSVYWYRQPpgKGPTFLIAYYSNGSEEGVKKGRFSGRGDPSNGDGSLTIQNL 80

                          90       100
                  ....*....|....*....|....*...
gi 672069690  100 RMSDAGIYWCGITKAGYDHMFK-VHVSI 126
Cdd:pfam07686  81 TLSDSGTYTCAVIPSGEGVFGKgTRLTV 108
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 26-126 2.10e-03

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 36.71  E-value: 2.10e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672069690    26 PEEVSGYEQGSLTVWCRYGSWwKDYSKYWCRgpkrssceirvetDASERLVKENHVSIRDDQTNFTFTvtMEDLRMSDAG 105
Cdd:smart00410   1 PPSVTVKEGESVTLSCEASGS-PPPEVTWYK-------------QGGKLLAESGRFSVSRSGSTSTLT--ISNVTPEDSG 64

                           90       100
                   ....*....|....*....|.
gi 672069690   106 IYWCGITKAGYDHMFKVHVSI 126
Cdd:smart00410  65 TYTCAATNSSGSASSGTTLTV 85
 
Name Accession Description Interval E-value
IgV_pIgR_like cd05716
Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The ...
 24-125 4.30e-29

Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The members here are composed of the immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins. pIgR delivers dimeric IgA and pentameric IgM to mucosal secretions. Polymeric immunoglobulin (pIgs) are the first defense against pathogens and toxins. IgA and IgM can form polymers via an 18-residue extension at their C-termini referred to as the tailpiece. pIgR transports pIgs across mucosal epithelia into mucosal secretions. Human pIgR is a glycosylated type I transmembrane protein, comprised of a 620-residue extracellular region, a 23-residue transmembrane region, and a 103-residue cytoplasmic tail. The extracellular region contains five domains that share sequence similarity with Ig variable (v) regions. This group also contains the Ig-like extracellular domains of other receptors such as NK cell receptor Nkp44 and myeloid receptors, among others.


Pssm-ID: 409381  Cd Length: 100  Bit Score: 107.48  E-value: 4.30e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672069690  24 TGPEEVSGYEQGSLTVWCRYGSWWKDYSKYWCRGPKRSsCEIRVETdasERLVKENHVSIRDDQTNFTFTVTMEDLRMSD 103
Cdd:cd05716    2 VGPEVVTGVEGGSVTIQCPYPPKYASSRKYWCKWGSEG-CQTLVSS---EGVVPGGRISLTDDPDNGVFTVTLNQLRKED 77

                         90       100
                 ....*....|....*....|...
gi 672069690 104 AGIYWCGITKAGY-DHMFKVHVS 125
Cdd:cd05716   78 AGWYWCGVGDDGDrGLTVQVKLV 100
SIT pfam15330
SHP2-interacting transmembrane adaptor protein, SIT; SIT, or SHP2-interacting transmembrane ...
 210-289 9.74e-28

SHP2-interacting transmembrane adaptor protein, SIT; SIT, or SHP2-interacting transmembrane adaptor protein, is a disulfide-linked dimer that regulates human T Cell activation.


Pssm-ID: 464650  Cd Length: 114  Bit Score: 104.39  E-value: 9.74e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672069690  210 WRMVRRQKKAAGPPSG---------QPLEDDLCYANLSLQQPRTSPLKK----GSSMSSSGKDHQEEVEYVTMAPFPREE 276
Cdd:pfam15330  22 WRMMKRQKKAAGYSPEqvipreyylQPIEGDLCYANLTLQQTGTSPGSSdekaYEQMSSSAQRSQNEVEYVTMAPFPREE 101

                          90
                  ....*....|...
gi 672069690  277 ISYAALSLASLGQ 289
Cdd:pfam15330 102 ISYASLSLDVLDQ 114
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 24-126 4.01e-17

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 75.57  E-value: 4.01e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672069690   24 TGPEEVSGYEQGSLTVWCRYGSWW--KDYSKYWCRGP--KRSSCEIRVETDASERLVKENHVSIRDDQTNFTFTVTMEDL 99
Cdd:pfam07686   1 QTPREVTVALGGSVTLPCTYSSSMseASTSVYWYRQPpgKGPTFLIAYYSNGSEEGVKKGRFSGRGDPSNGDGSLTIQNL 80

                          90       100
                  ....*....|....*....|....*...
gi 672069690  100 RMSDAGIYWCGITKAGYDHMFK-VHVSI 126
Cdd:pfam07686  81 TLSDSGTYTCAVIPSGEGVFGKgTRLTV 108
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 26-126 2.10e-03

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 36.71  E-value: 2.10e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672069690    26 PEEVSGYEQGSLTVWCRYGSWwKDYSKYWCRgpkrssceirvetDASERLVKENHVSIRDDQTNFTFTvtMEDLRMSDAG 105
Cdd:smart00410   1 PPSVTVKEGESVTLSCEASGS-PPPEVTWYK-------------QGGKLLAESGRFSVSRSGSTSTLT--ISNVTPEDSG 64

                           90       100
                   ....*....|....*....|.
gi 672069690   106 IYWCGITKAGYDHMFKVHVSI 126
Cdd:smart00410  65 TYTCAATNSSGSASSGTTLTV 85
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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