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    Rfc3 replication factor C subunit 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 288414, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Rfc3provided by RGD
    Official Full Name
    replication factor C subunit 3provided by RGD
    Primary source
    RGD:1306832
    See related
    EnsemblRapid:ENSRNOG00000001088 AllianceGenome:RGD:1306832
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable ATP-dependent activity, acting on DNA. Predicted to contribute to DNA binding activity; DNA clamp loader activity; and single-stranded DNA helicase activity. Predicted to be involved in DNA metabolic process; positive regulation of DNA-directed DNA polymerase activity; and response to organophosphorus. Predicted to be part of Ctf18 RFC-like complex and DNA replication factor C complex. Predicted to be active in nucleus. Orthologous to human RFC3 (replication factor C subunit 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 184.3), Spleen (RPKM 121.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Rfc3 in Genome Data Viewer
    Location:
    12p12
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (5836546..5847331)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (1000987..1011778)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (1460581..1471344)

    Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene StAR-related lipid transfer domain containing 13 Neighboring gene uncharacterized LOC102549089 Neighboring gene uncharacterized LOC134481142 Neighboring gene uncharacterized LOC102554571 Neighboring gene vomeronasal 2 receptor, pseudogene 97

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Replication clamps and clamp loaders. Hedglin M, et al. Cold Spring Harb Perspect Biol, 2013 Apr 1. PMID 23545418, Free PMC Article
    2. Differential gene expression in normal human mammary epithelial cells treated with malathion monitored by DNA microarrays. Gwinn MR, et al. Environ Health Perspect, 2005 Aug. PMID 16079077, Free PMC Article
    3. Reconstitution of recombinant human replication factor C (RFC) and identification of an RFC subcomplex possessing DNA-dependent ATPase activity. Ellison V, et al. J Biol Chem, 1998 Mar 6. PMID 9488738
    4. The alternative Ctf18-Dcc1-Ctf8-replication factor C complex required for sister chromatid cohesion loads proliferating cell nuclear antigen onto DNA. Bermudez VP, et al. Proc Natl Acad Sci U S A, 2003 Sep 2. PMID 12930902, Free PMC Article
    5. Mechanisms and functions of DNA mismatch repair. Li GM. Cell Res, 2008 Jan. PMID 18157157

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Clone Names

    • MGC109141

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP-dependent activity, acting on DNA ISO
    Inferred from Sequence Orthology
    more info
    		  
    contributes_to DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    contributes_to DNA clamp loader activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to DNA clamp loader activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    contributes_to single-stranded DNA helicase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA duplex unwinding IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in DNA replication ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in DNA-templated DNA replication IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in DNA-templated DNA replication ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in positive regulation of DNA-directed DNA polymerase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to organophosphorus ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of Ctf18 RFC-like complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of DNA replication factor C complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of DNA replication factor C complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    replication factor C subunit 3
    Names
    replication factor C (activator 1) 3
    replication factor C 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001009629.1 → NP_001009629.1  replication factor C subunit 3

      See identical proteins and their annotated locations for NP_001009629.1

      Status: PROVISIONAL

      Source sequence(s)
      BC088281
      UniProtKB/TrEMBL
      F7F7G0, Q5M830
      Related
      ENSRNOP00000001444.4, ENSRNOT00000001444.8
      Conserved Domains (3) summary
      cd00009
      Location:21 → 187
      AAA; The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, ...
      PRK12402
      Location:3 → 339
      PRK12402; replication factor C small subunit 2; Reviewed
      pfam08542
      Location:250 → 337
      Rep_fac_C; Replication factor C C-terminal domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086030.1 Reference GRCr8

      Range
      5836546..5847331
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039089148.2 → XP_038945076.1  replication factor C subunit 3 isoform X1

      Conserved Domains (1) summary
      PRK12402
      Location:82 → 293
      PRK12402; replication factor C small subunit 2; Reviewed
    Nucleotide Protein Strain
    Heading Accession and Version

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