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    en1a engrailed homeobox 1a [ Danio rerio (zebrafish) ]

    Gene ID: 30244, updated on 9-Dec-2024

    Summary

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    Official Symbol
    en1aprovided by ZNC
    Official Full Name
    engrailed homeobox 1aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-980526-216
    See related
    Ensembl:ENSDARG00000014321 AllianceGenome:ZFIN:ZDB-GENE-980526-216
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    en1; en-1; eng1; ENG-1; eng1a; zgc:100771
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within axonogenesis involved in innervation. Predicted to be active in nucleus. Is expressed in several structures, including adaxial cell; midbrain hindbrain boundary neural rod; musculature system; pectoral fin bud; and somite. Human ortholog(s) of this gene implicated in Parkinson's disease. Orthologous to human EN1 (engrailed homeobox 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See en1a in Genome Data Viewer
    Location:
    chromosome: 9
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 9 NC_007120.7 (781049..785288, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 9 NC_007120.6 (781416..785448, complement)

    Chromosome 9 - NC_007120.7Genomic Context describing neighboring genes Neighboring gene insulin induced gene 2 Neighboring gene uncharacterized LOC101883921 Neighboring gene macrophage receptor with collagenous structure Neighboring gene complement component 1, q subcomponent-like 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Preservation of duplicate genes by complementary, degenerative mutations. Force A, et al. Genetics, 1999 Apr. PMID 10101175, Free PMC Article
    2. Diverse chemical scaffolds support direct inhibition of the membrane-bound O-acyltransferase porcupine. Dodge ME, et al. J Biol Chem, 2012 Jun 29. PMID 22593577, Free PMC Article
    3. Sequence and expression pattern of pax-6 are highly conserved between zebrafish and mice. Püschel AW, et al. Development, 1992 Mar. PMID 1352238
    4. Diversity of expression of engrailed-like antigens in zebrafish. Hatta K, et al. Development, 1991 Jul. PMID 1682127
    5. Transcriptional profiling of human neural precursors post alcohol exposure reveals impaired neurogenesis via dysregulation of ERK signaling and miR-145. Louis LK, et al. J Neurochem, 2017 Aug 21. PMID 28833141

    See all (44) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Engrailed plays an evolutionarily conserved role in the separate innervation of vertebrate epaxial-hypaxial muscle.
      Title: Engrailed controls epaxial-hypaxial muscle innervation and the establishment of vertebrate three-dimensional mobility.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within axonogenesis involved in innervation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in neuron differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    homeobox protein engrailed-1a
    Names
    engrailed 1a
    homeobox protein en-1a

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_131045.2 → NP_571120.2  homeobox protein engrailed-1a

      Status: VALIDATED

      Source sequence(s)
      CABZ01070420
      UniProtKB/Swiss-Prot
      Q04896
      UniProtKB/TrEMBL
      Q68EL7
      Related
      ENSDARP00000023487.5, ENSDART00000012506.9
      Conserved Domains (2) summary
      pfam00046
      Location:146 → 199
      Homeobox; Homeobox domain
      pfam10525
      Location:201 → 230
      Engrail_1_C_sig; Engrailed homeobox C-terminal signature domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007120.7 Reference GRCz11 Primary Assembly

      Range
      781049..785288 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q04896.1 GenPept UniProtKB/Swiss-Prot:Q04896

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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