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Conserved domains on  [gi|1376175676|ref|NP_571120|]
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homeobox protein engrailed-1a [Danio rerio]

Protein Classification

homeodomain and Engrail_1_C_sig domain-containing protein( domain architecture ID 11079054)

homeodomain and Engrail_1_C_sig domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Homeodomain pfam00046
Homeodomain;
144-200 1.16e-23

Homeodomain;


:

Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 89.48  E-value: 1.16e-23
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1376175676 144 KRPRTAFTAEQLQRLKAEFQTSRYITEQRRQALARELGLNESQIKIWFQNKRAKIKK 200
Cdd:pfam00046   1 RRKRTTFTPEQLEELEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNRRAKWKR 57
Engrail_1_C_sig pfam10525
Engrailed homeobox C-terminal signature domain; Engrailed homeobox proteins are characterized ...
 201-230 1.88e-15

Engrailed homeobox C-terminal signature domain; Engrailed homeobox proteins are characterized by the presence of a conserved region of some 20 amino-acid residues located at the C-terminal of the 'homeobox' domain. This domain of approximately 20 residues forms a kind of a signature pattern for this subfamily of proteins.


:

Pssm-ID: 431338  Cd Length: 31  Bit Score: 67.40  E-value: 1.88e-15
                          10        20        30
                  ....*....|....*....|....*....|
gi 1376175676 201 SSGFKNALAMQLMAQGLYNHSTTTIQEEED 230
Cdd:pfam10525   1 ASGQKNPLALHLMAQGLYNHSTVTKQDEED 30
 
Name Accession Description Interval E-value
Homeodomain pfam00046
Homeodomain;
144-200 1.16e-23

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 89.48  E-value: 1.16e-23
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1376175676 144 KRPRTAFTAEQLQRLKAEFQTSRYITEQRRQALARELGLNESQIKIWFQNKRAKIKK 200
Cdd:pfam00046   1 RRKRTTFTPEQLEELEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNRRAKWKR 57
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 144-199 2.80e-20

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 80.76  E-value: 2.80e-20
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1376175676  144 KRPRTAFTAEQLQRLKAEFQTSRYITEQRRQALARELGLNESQIKIWFQNKRAKIK 199
Cdd:smart00389   2 RRKRTSFTPEQLEELEKEFQKNPYPSREEREELAKKLGLSERQVKVWFQNRRAKWK 57
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 144-202 7.61e-20

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 79.59  E-value: 7.61e-20
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1376175676 144 KRPRTAFTAEQLQRLKAEFQTSRYITEQRRQALARELGLNESQIKIWFQNKRAKIKKSS 202
Cdd:cd00086     1 RRKRTRFTPEQLEELEKEFEKNPYPSREEREELAKELGLTERQVKIWFQNRRAKLKRSE 59
Engrail_1_C_sig pfam10525
Engrailed homeobox C-terminal signature domain; Engrailed homeobox proteins are characterized ...
 201-230 1.88e-15

Engrailed homeobox C-terminal signature domain; Engrailed homeobox proteins are characterized by the presence of a conserved region of some 20 amino-acid residues located at the C-terminal of the 'homeobox' domain. This domain of approximately 20 residues forms a kind of a signature pattern for this subfamily of proteins.


Pssm-ID: 431338  Cd Length: 31  Bit Score: 67.40  E-value: 1.88e-15
                          10        20        30
                  ....*....|....*....|....*....|
gi 1376175676 201 SSGFKNALAMQLMAQGLYNHSTTTIQEEED 230
Cdd:pfam10525   1 ASGQKNPLALHLMAQGLYNHSTVTKQDEED 30
COG5576 COG5576
Homeodomain-containing transcription factor [Transcription];
129-206 9.76e-12

Homeodomain-containing transcription factor [Transcription];


Pssm-ID: 227863 [Multi-domain]  Cd Length: 156  Bit Score: 60.91  E-value: 9.76e-12
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1376175676 129 TRKLKKKNNNTeSDDKRPRTAFTAEQLQRLKAEFQTSRYITEQRRQALARELGLNESQIKIWFQNKRAKIKKSSGFKN 206
Cdd:COG5576    38 EMKLERKQDGS-SPPKSKRRRTTDEQLMVLEREFEINPYPSSITRIKLSLLLNMPPKSVQIWFQNKRAKEKKKRSGKV 114
 
Name Accession Description Interval E-value
Homeodomain pfam00046
Homeodomain;
144-200 1.16e-23

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 89.48  E-value: 1.16e-23
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1376175676 144 KRPRTAFTAEQLQRLKAEFQTSRYITEQRRQALARELGLNESQIKIWFQNKRAKIKK 200
Cdd:pfam00046   1 RRKRTTFTPEQLEELEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNRRAKWKR 57
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 144-199 2.80e-20

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 80.76  E-value: 2.80e-20
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1376175676  144 KRPRTAFTAEQLQRLKAEFQTSRYITEQRRQALARELGLNESQIKIWFQNKRAKIK 199
Cdd:smart00389   2 RRKRTSFTPEQLEELEKEFQKNPYPSREEREELAKKLGLSERQVKVWFQNRRAKWK 57
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 144-202 7.61e-20

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 79.59  E-value: 7.61e-20
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1376175676 144 KRPRTAFTAEQLQRLKAEFQTSRYITEQRRQALARELGLNESQIKIWFQNKRAKIKKSS 202
Cdd:cd00086     1 RRKRTRFTPEQLEELEKEFEKNPYPSREEREELAKELGLTERQVKIWFQNRRAKLKRSE 59
Engrail_1_C_sig pfam10525
Engrailed homeobox C-terminal signature domain; Engrailed homeobox proteins are characterized ...
 201-230 1.88e-15

Engrailed homeobox C-terminal signature domain; Engrailed homeobox proteins are characterized by the presence of a conserved region of some 20 amino-acid residues located at the C-terminal of the 'homeobox' domain. This domain of approximately 20 residues forms a kind of a signature pattern for this subfamily of proteins.


Pssm-ID: 431338  Cd Length: 31  Bit Score: 67.40  E-value: 1.88e-15
                          10        20        30
                  ....*....|....*....|....*....|
gi 1376175676 201 SSGFKNALAMQLMAQGLYNHSTTTIQEEED 230
Cdd:pfam10525   1 ASGQKNPLALHLMAQGLYNHSTVTKQDEED 30
COG5576 COG5576
Homeodomain-containing transcription factor [Transcription];
129-206 9.76e-12

Homeodomain-containing transcription factor [Transcription];


Pssm-ID: 227863 [Multi-domain]  Cd Length: 156  Bit Score: 60.91  E-value: 9.76e-12
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1376175676 129 TRKLKKKNNNTeSDDKRPRTAFTAEQLQRLKAEFQTSRYITEQRRQALARELGLNESQIKIWFQNKRAKIKKSSGFKN 206
Cdd:COG5576    38 EMKLERKQDGS-SPPKSKRRRTTDEQLMVLEREFEINPYPSSITRIKLSLLLNMPPKSVQIWFQNKRAKEKKKRSGKV 114
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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