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    cdc27 cell division cycle 27 [ Danio rerio (zebrafish) ]

    Gene ID: 30450, updated on 4-Jan-2025

    Summary

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    Official Symbol
    cdc27provided by ZNC
    Official Full Name
    cell division cycle 27provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-990706-2
    See related
    Ensembl:ENSDARG00000056258 AllianceGenome:ZFIN:ZDB-GENE-990706-2
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    wu:fb54g06; wu:fc88c12
    Summary
    Predicted to be involved in several processes, including anaphase-promoting complex-dependent catabolic process; metaphase/anaphase transition of mitotic cell cycle; and protein ubiquitination. Predicted to be part of anaphase-promoting complex. Predicted to be active in cytoplasm. Orthologous to human CDC27 (cell division cycle 27). [provided by Alliance of Genome Resources, Jan 2025]
    Orthologs
    human mouse all
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    Genomic context

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    See cdc27 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 3 NC_007114.7 (22036091..22054823)
    105 previous assembly GRCz10 (GCF_000002035.5) 3 NC_007114.6 (21905532..21924921)

    Chromosome 3 - NC_007114.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC137490542 Neighboring gene uncharacterized LOC107988034 Neighboring gene KAT8 regulatory NSL complex subunit 1b Neighboring gene microtubule-associated protein tau b

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Zebrafish stat3 is expressed in restricted tissues during embryogenesis and stat1 rescues cytokine signaling in a STAT1-deficient human cell line. Oates AC, et al. Dev Dyn, 1999 Aug. PMID 10417824
    2. Radiographic analysis of zebrafish skeletal defects. Fisher S, et al. Dev Biol, 2003 Dec 1. PMID 14623232
    3. Functional and Genetic Analyses Unveil the Implication of CDC27 in Hemifacial Microsomia. Song W, et al. Int J Mol Sci, 2024 Apr 26. PMID 38731925, Free PMC Article
    4. Tissue factor pathway inhibitor-2: a novel gene involved in zebrafish central nervous system development. Zhang Y, et al. Dev Biol, 2013 Sep 1. PMID 23796905
    5. Rapid identification and isolation of zebrafish cDNA clones. Gong Z, et al. Gene, 1997 Nov 12. PMID 9409775

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Functional and Genetic Analyses Unveil the Implication of CDC27 in Hemifacial Microsomia.
      Title: Functional and Genetic Analyses Unveil the Implication of CDC27 in Hemifacial Microsomia.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Process Evidence Code Pubs
    involved_in anaphase-promoting complex-dependent catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell division IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in metaphase/anaphase transition of mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of anaphase-promoting complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    cell division cycle protein 27 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_201449.1 → NP_958857.1  cell division cycle protein 27 homolog

      See identical proteins and their annotated locations for NP_958857.1

      Status: PROVISIONAL

      Source sequence(s)
      BC049466
      UniProtKB/TrEMBL
      Q7ZWD5
      Conserved Domains (4) summary
      COG0457
      Location:463 → 724
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      sd00006
      Location:529 → 557
      TPR; TPR repeat [structural motif]
      pfam00515
      Location:597 → 629
      TPR_1; Tetratricopeptide repeat
      pfam12895
      Location:17 → 92
      ANAPC3; Anaphase-promoting complex, cyclosome, subunit 3

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007114.7 Reference GRCz11 Primary Assembly

      Range
      22036091..22054823
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005171566.5 → XP_005171623.1  cell division cycle protein 27 homolog isoform X1

      UniProtKB/TrEMBL
      A0A8M2BIV7, F1Q5X3
      Related
      ENSDARP00000113979.1, ENSDART00000132190.3
      Conserved Domains (4) summary
      COG0457
      Location:487 → 767
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      sd00006
      Location:572 → 600
      TPR; TPR repeat [structural motif]
      pfam00515
      Location:640 → 672
      TPR_1; Tetratricopeptide repeat
      pfam12895
      Location:17 → 92
      ANAPC3; Anaphase-promoting complex, cyclosome, subunit 3
    Nucleotide Protein Strain
    Heading Accession and Version

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