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    bcl6ab BCL6A transcription repressor b [ Danio rerio (zebrafish) ]

    Gene ID: 100001936, updated on 9-Dec-2024

    Summary

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    Official Symbol
    bcl6abprovided by ZNC
    Official Full Name
    BCL6A transcription repressor bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-7523
    See related
    Ensembl:ENSDARG00000069295 AllianceGenome:ZFIN:ZDB-GENE-030131-7523
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fj23a05; wu:fj23a05; wu:fv66b06
    Summary
    Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II; regulation of cytokine production; and regulation of immune system process. Predicted to be located in nucleus. Predicted to be active in nucleoplasm. Is expressed in telencephalon. Human ortholog(s) of this gene implicated in B-cell lymphoma and diffuse large B-cell lymphoma. Orthologous to human BCL6 (BCL6 transcription repressor). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See bcl6ab in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 2 NC_007113.7 (10087334..10098191, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 2 NC_007113.6 (10289512..10300387, complement)

    Chromosome 2 - NC_007113.7Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 78 member Ba Neighboring gene cytidylate kinase Neighboring gene insulin-like 5b Neighboring gene alpha-2-HS-glycoprotein 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Transcriptome profiling reveals Th17-like immune responses induced in zebrafish bath-vaccinated with a live attenuated Vibrio anguillarum. Zhang H, et al. PLoS One, 2013. PMID 24023910, Free PMC Article
    2. Zebrafish Regulatory T Cells Mediate Organ-Specific Regenerative Programs. Hui SP, et al. Dev Cell, 2017 Dec 18. PMID 29257949
    3. Evolution of gene function and regulatory control after whole-genome duplication: comparative analyses in vertebrates. Kassahn KS, et al. Genome Res, 2009 Aug. PMID 19439512, Free PMC Article
    4. Comprehensive expression map of transcription regulators in the adult zebrafish telencephalon reveals distinct neurogenic niches. Diotel N, et al. J Comp Neurol, 2015 Jun 1. PMID 25556858, Free PMC Article
    5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    BCL6A transcription repressor b
    Names
    B cell CLL/lymphoma 6ab
    B-cell CLL/lymphoma 6a, genome duplicate b

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001100074.1 → NP_001093544.1  BCL6A transcription repressor b

      Status: PROVISIONAL

      Source sequence(s)
      CU104710
      UniProtKB/TrEMBL
      A0A8M1NFA1, A5WWI3
      Related
      ENSDARP00000116903.1, ENSDART00000138081.2
      Conserved Domains (4) summary
      smart00225
      Location:33 → 128
      BTB; Broad-Complex, Tramtrack and Bric a brac
      sd00017
      Location:440 → 460
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00651
      Location:22 → 126
      BTB; BTB/POZ domain
      pfam13465
      Location:452 → 477
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007113.7 Reference GRCz11 Primary Assembly

      Range
      10087334..10098191 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005171137.4 → XP_005171194.1  BCL6A transcription repressor b isoform X1

      UniProtKB/TrEMBL
      A0A8M2BIF1
      Conserved Domains (4) summary
      smart00225
      Location:33 → 128
      BTB; Broad-Complex, Tramtrack and Bric a brac
      sd00017
      Location:441 → 461
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00651
      Location:22 → 126
      BTB; BTB/POZ domain
      pfam13465
      Location:453 → 478
      zf-H2C2_2; Zinc-finger double domain
    Nucleotide Protein Strain
    Heading Accession and Version

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