Zinc-finger double domain;

                          10        20
                  ....*....|....*....|....*
gi 528470362  510 LKSHLRIHTGEKPYHCENCDLRFRH 534
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528470362 368 VHNTFtEESSMGSTNSAERERVYCNECESEAEKPQWLQ-DGKPYKCDRCQAMFHYkGNPL----SSHKSVHTGEKPYRCN 442
Cdd:COG5189  276 SAELF-EESSLGFDYEFIHKSVGNKEIRGGISTGEMIDvRKLPCTNSSSNGKLAH-GGERnidtPSRMLKVKDGKPYKCP 353

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 528470362 443 V--CGAQFNRPANLKTHsRIHSGEKPYKCETCSSRfvqvahlrAHVLIHTGEKPYPCDICGTRFRHLQTLKSH 513
Cdd:COG5189  354 VegCNKKYKNQNGLKYH-MLHGHQNQKLHENPSPE--------KMNIFSAKDKPYRCEVCDKRYKNLNGLKYH 417

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528470362   22 FNRLRSRNLLTDVTIMVGGQQFRAHKTVLMACSGLFYSMFADNP-KSNLSLISLDpKVDPDGFAILLEFMYTSCLTLKDN 100
Cdd:pfam00651   1 LNELREQGELCDVTLVVGDKEFRAHKAVLAACSPYFKALFSGQEsESSVSEITLD-DVSPEDFEALLEFMYTGKLISEEN 79

                          90       100
                  ....*....|....*....|....*..
gi 528470362  101 fIIATLNTATYLQMDHVMETCQRFIDS 127
Cdd:pfam00651  80 -VDDLLAAADKLQIPSLVDKCEEFLIK 105

kelch-like protein; Provisional

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528470362  34 VTIMVGGQQFRAHKTVLMACSGLFYSMFADNPKSNLSLISLDPkvdpDGFAILLEFMYTSCLTLKDNFIIATLNTATYLQ 113
Cdd:PHA03098  14 IIIVNGGGIIKVHKIILSSSSEYFKKMFKNNFKENEINLNIDY----DSFNEVIKYIYTGKINITSNNVKDILSIANYLI 89

                         90
                 ....*....|..
gi 528470362 114 MDHVMETCQRFI 125
Cdd:PHA03098  90 IDFLINLCINYI 101

Zinc-finger double domain;

                          10        20
                  ....*....|....*....|....*.
gi 528470362  453 NLKTHSRIHSGEKPYKCETCSSRFVQ 478
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26

Zinc-finger double domain;

                          10        20
                  ....*....|....*....|....*.
gi 528470362  481 HLRAHVLIHTGEKPYPCDICGTRFRH 506
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell lymphoma 6 proteins, BCL-6 and BCL-6B; This family includes B-cell lymphoma 6 proteins, BCL-6 and BCL-6B. BCL-6 is a transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation, which have different mechanisms of action specific to the lineage and biological functions. BCL-6B is a sequence-specific transcriptional repressor in association with BCL-6. It may function in a narrow stage or be related to some events in the early B-cell development. Family members contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528470362  13 RHAGDVLFNFNRLRSRNLLTDVTIMVGGQQFRAHKTVLMACSGLFYSMFADNPKSNLSLISLDPKVDPDGFAILLEFMYT 92
Cdd:cd18215    1 RHASDVLLNLNRLRSRDILTDVVLVVGREQFRAHKTVLMACSGLFYSIFTDQLKNNVSVINLDPEIEPEGFRILLDFMYT 80

                         90       100       110
                 ....*....|....*....|....*....|...
gi 528470362  93 SCLTLKDNFIIATLNTATYLQMDHVMETCQRFI 125
Cdd:cd18215   81 SRLNLREGNIMAVMATAMYLQMEHVVDTCRKFI 113

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528470362   22 FNRLRSRNLLTDVTIMVGGQQFRAHKTVLMACSGLFYSMFADNP-KSNLSLISLDpKVDPDGFAILLEFMYTSCLTLKDN 100
Cdd:pfam00651   1 LNELREQGELCDVTLVVGDKEFRAHKAVLAACSPYFKALFSGQEsESSVSEITLD-DVSPEDFEALLEFMYTGKLISEEN 79

                          90       100
                  ....*....|....*....|....*..
gi 528470362  101 fIIATLNTATYLQMDHVMETCQRFIDS 127
Cdd:pfam00651  80 -VDDLLAAADKLQIPSLVDKCEEFLIK 105

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 44 (ZBTB44); ZBTB44, also called BTB/POZ domain-containing protein 15 (BTBD15) or zinc finger protein 851 (ZNF851), may be involved in transcriptional regulation. Single-nucleotide polymorphisms of ZBTB44 showed a suggestive association with disease progression of Crohn's disease. ZBTB44 has also preferentially been recognized by sera of patients with peripheral T-cell lymphoma (PTCL). It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528470362  14 HAGDVLFNFNRLRSRNLLTDVTIMVGGQQFRAHKTVLMACSGLFYSMFADNPKSNLSLISLDPK-------VDPDGFAIL 86
Cdd:cd18228    2 HSQELLGKLNSLRNEGHFCDVTIRVQDKIFRAHKVVLAACSDFFRSKLVGQASPRLVLVSPAGKcvldlhhVTVTGFAPL 81

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 528470362  87 LEFMYTSCLTLKDNFIIATLNTATYLQMDHVMETCQRFIDS 127
Cdd:cd18228   82 LEYAYTSTLSINTENIIDVLAAASYMQMFNVANTCSEFMKS 122

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing (ZBTB) proteins, Kelch-like (KLHL) proteins, and similar proteins; This family includes a variety of BTB/POZ domain-containing proteins, such as zinc finger and BTB domain-containing (ZBTB) proteins and Kelch-like (KLHL) proteins. They have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528470362  31 LTDVTIMVGGQQFRAHKTVLMACSGLFYSMFADNPK-SNLSLISLdPKVDPDGFAILLEFMYTSCLTLKDNFIIATLNTA 109
Cdd:cd18186    1 LCDVTLVVGGREFPAHRAVLAARSPYFRAMFSSGMKeSSSSEIEL-DDVSPEAFEALLDYIYTGELELSEENVEELLAAA 79

                 ...
gi 528470362 110 TYL 112
Cdd:cd18186   80 DKL 82

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like ECH-associated protein 1 (KEAP1); KEAP1, also called cytosolic inhibitor of Nrf2 (INrf2) or Kelch-like protein 19 (KLHL19), is a redox-regulated substrate adaptor protein for a Cullin3-dependent ubiquitin ligase complex that targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528470362  14 HAGDVLFNFNRLRSRNLLTDVTIMVGGQ----QFRAHKTVLMACSGLFYSMFADNPK-SNLSLISLDpKVDPDGFAILLE 88
Cdd:cd18248    4 HTKEAFQIMNELRLSQQLCDVTLKVKYQdpkeEFMAHKVVLASSSPYFKAMFTSGLReCGMEVVPIE-GVHPCVMSRLIE 82

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 528470362  89 FMYTSCLTLKDNFIIATLNTATYLQMDHVMETCQRFI 125
Cdd:cd18248   83 FAYTASISVGEKCVLHVLPGAVMYQMDSVVKACCDFL 119

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog 1 (BACH1); BACH1, also called BTB-basic leucine zipper transcription factor 1, belongs to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. It can act as repressor or activator. BACH1 is a heme-responsive transcriptional repressor of heme oxygenase (HO)-1. It represses genes involved in heme metabolism and oxidative stress response. It is also a negative regulator of nuclear factor erythroid 2-related factor 2 (Nrf2) that controls antioxidant response elements (ARE)-dependent gene expressions. BACH1 binds to NF-E2 binding sites in vitro, and plays important roles in coordinating transcription activation and repression by MafK. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528470362  14 HAGDVLFNFNRLRSRNLLTDVTIMVGGQQFRAHKTVLMACSGLFYSMFADNPKSNLSlISLDPKVDPDGFAILLEFMYTS 93
Cdd:cd18277   10 HSTNVLLSLNDQRKKDVLCDVTILVEGQRFRAHRSVLAACSSYFHSRIVGQADAELN-ITLPEEVTVKGFEPLIQFAYTA 88

                         90       100       110
                 ....*....|....*....|....*....|..
gi 528470362  94 CLTLKDNFIIATLNTATYLQMDHVMETCQRFI 125
Cdd:cd18277   89 KLILSKDNVDEVCKCVEFLSVHNIEESCFQFL 120

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 17 (ZBTB17); ZBTB1 is also called c-Myc-interacting zinc finger protein 1 (Miz-1), zinc finger protein 151, or zinc finger protein 60. It is a poly-Cys2His2 zinc finger (ZF) transcription factor that can function as an activator or repressor depending on its binding partners, and by targeting negative regulators of cell cycle progression. ZBTB17 has been implicated in cardiomyopathy and is important in cardiac stress response. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528470362  11 FTRHAGDVLFNFNRLRSRNLLTDVTIMVGGQQFRAHKTVLMACSGLFYSMFADNPksnlSLISLDPKvDPDGFAILLEFM 90
Cdd:cd18206    2 FPQHSQHVLEQLNQQRQLGLLCDCTFVVDGVDFKAHKAVLAACSEYFRMLFVDQK----DVVHLDIS-NAAGLGQVLEFM 76

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 528470362  91 YTSCLTLKDNFIIATLNTATYLQMDHVMETCQRFID 126
Cdd:cd18206   77 YTAKLSLSPENVDDVLAVATFLQMQDIVTACHALKS 112

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 34 (KLHL34); KLHL34 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The methylation status of KLHL34 cg14232291 appears to be predictive of pathologic response to preoperative chemoradiation therapy in rectal cancer patients. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528470362  14 HAGDVLFNFNRLRSRNLLTDVTIMVGGQQFRAHKTVLMACSGLFYSMFADNPK-SNLSLISLdPKVDPDGFAILLEFMYT 92
Cdd:cd18264   11 HGEAVLSQYQSLRAEGFLCDVVLEAEGNEFPAHRSLLACSSDYFRALFKDYTQeSKARVIHL-PVVSAAGLQRVLDFIYT 89

                         90       100       110
                 ....*....|....*....|....*....|...
gi 528470362  93 SCLTLKDNFIIATLNTATYLQMDHVMETCQRFI 125
Cdd:cd18264   90 SWLSLSLDTLEDTLEAASYLQVTEAIGLCSQYL 122

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 10 (ZBTB10); ZBTB10, also called zinc finger protein RIN ZF, is an mRNA target of miR-27a and a transcriptional repressor of Specificity protein (Sp) expression. The microRNA-27a:ZBTB10-specificity protein pathway is involved in follicle stimulating hormone-induced VEGF, Cox2, and survivin expression in ovarian epithelial cancer cells. ZBTB10 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528470362  18 VLFNFNRLRSRNLLTDVTIMVGGQQFRAHKTVLMACSGLFYSMFADNPKSN---LSLISLDpKVDPDGFAILLEFMYTSC 94
Cdd:cd18201    8 LLQELNEQRKKGILCDVNIVVSGKVFRAHKNILVAGSRFFKTLYCFTNKEScdqTTVTHLD-VVAVQGFSVILDFMYSGN 86

                         90       100       110
                 ....*....|....*....|....*....|.
gi 528470362  95 LTLKDNFIIATLNTATYLQMDHVMETCQRFI 125
Cdd:cd18201   87 LVLTSQNAIEVMSVASYLQMTEVVQSCRNFI 117

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8A (ZBTB8A); ZBTB8A, also called BTB/POZ and zinc-finger domain-containing factor or BTB/POZ and zinc-finger domains factor on chromosome 1 (BOZ-F1), is a novel proto-oncoprotein that stimulates cell proliferation. It binds to all the proximal GC boxes to repress transcription, and it inhibits p53 acetylation without affecting p53 stability. It may be involved in gastric adenocarcinoma cell differentiation, cancer invasion, and metastasis. ZBTB8A contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528470362  11 FTRHAGDVLFNFNRLRSRNLLTDVTIMVGGQQFRAHKTVLMACSGLFYSMFADNPKSNLSLISLDPKV-DPDGFAILLEF 89
Cdd:cd18329    1 ISSHQSRLLQQLDEQRKQELFCDCSILVEGQVFKAHRNVLFASSGYFKMLLSQNAKETGQPTVATFDVfSPDTFTIILDF 80

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 528470362  90 MYTSCLTLKDNFIIATLNTATYLQMDHVMETCQRFI 125
Cdd:cd18329   81 VYSGKLSLTSQNVIEVMSAASYLQMTDVISVCKTFI 116

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 24 (ZBTB24); ZBTB24, also called zinc finger protein 450, functions as a transcription factor essentially involved in B-cell functions in humans. The loss-of-function mutations in ZBTB24 can cause ICF2 (immunodeficiency, centromeric instability and facial anomalies syndrome 2) with immunological characteristics of greatly reduced serum antibodies and circulating memory B cells. ZBTB24 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528470362  14 HAGDVLFNFNRLRSRNLLTDVTIMVGGQQFRAHKTVLMACSGLFYSMFADNPKSNLSLISLDPKVdPDGFAILLEFMYTS 93
Cdd:cd18212    6 HKDTVLTNFEEQRKKDFLCDITLIVENVQFRAHKALLAASSEYFSMMFADEGEVGQSIYMLEGMV-AETFGALLEFIYTG 84

                         90       100
                 ....*....|....*....|.
gi 528470362  94 CLTLKDNFIIATLNTATYLQM 114
Cdd:cd18212   85 CLQVGEKSLEQILATAQFLKV 105

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for the ubiquitination and degradation of rapsyn, a postsynaptic protein required for clustering of nicotinic acetylcholine receptors (nAChRs) at the neuromuscular junction. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528470362  21 NFNRLRSRNLLTDVTIMVGGQQFRAHKTVLMACSGLFYSMFADN-PKSNLSLISLDpKVDPDGFAILLEFMYTSCLTLKD 99
Cdd:cd18238    5 VLHQFYENGELCDVTLKVGEKSIHCHRLVLACVSPYFRAMFTSEmAESKQDSITIK-DIDEEAVELLVDFAYTGKLTLTV 83

                         90       100
                 ....*....|....*....|....*.
gi 528470362 100 NFIIATLNTATYLQMDHVMETCQRFI 125
Cdd:cd18238   84 DNVQSLLYAASLLQVEEVAKACCEFM 109

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7A (ZBTB7A); ZBTB7A is also called factor binding IST protein 1 (FBI-1), factor that binds to inducer of short transcripts protein 1, HIV-1 1st-binding protein 1, Leukemia/lymphoma-related factor (LRF), POZ and Krueppel erythroid myeloid ontogenic factor, POK erythroid myeloid ontogenic factor, Pokemon, TTF-I-interacting peptide 21 (TIP21), or zinc finger protein 857A (ZNF857A). It is a transcription repressor of key glycolytic genes, including GLUT3, PFKP, and PKM, and its downregulation in human cancer contributes to tumor metabolism. It has been implicated in carcinogenesis and cell differentiation and development. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528470362   9 IKFTRHAGDVLFNFNRLRSRNLLTDVTIMVGGQQFRAHKTVLMACSGLFYSMFADNPKSNLSLISLDPKVDPDGFAILLE 88
Cdd:cd18326    3 IPFPDHSSDILSSLNEQRTQGLLCDVVILVEGREFPTHRSVLAACSQYFKKLFTSGAVVDQQNVYEIDFVSAEALTALLD 82

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 528470362  89 FMYTSCLTLKDNFIIATLNTATYLQMDHVMETCQRFID 126
Cdd:cd18326   83 FAYTATLTVSTSNVGDILSAARLLEIPAVSHVCADLLD 120

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 12 (ZBTB12); ZBTB12, also called protein G10, may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528470362  14 HAGDVLFNFNRLRSRNLLTDVTIMVGGQQFRAHKTVLMACSGLFYSMFADNPKSNLSlISL--DPKVDPDgfaiLLEFMY 91
Cdd:cd18203    8 HEAATLRNMNQLRSEERFCDVTIVADSLKFRGHKVVLAACSPFLRDQFLLNPSSELQ-VSLmhSSRVVAD----LLLSCY 82

                         90       100       110
                 ....*....|....*....|....*....|.
gi 528470362  92 TSCLTLKDNFIIATLNTATYLQMDHVMETCQ 122
Cdd:cd18203   83 TGALEFSVRDIVNYLTAASYLQMEHVVEKCR 113

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog (BACH) proteins; This subfamily includes BACH1 (also called BTB-basic leucine zipper transcription factor 1), BACH2 (also called BTB-basic leucine zipper transcription factor 2), and similar proteins. They belong to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. BACH1 is a heme-responsive transcriptional repressor of heme oxygenase (HO)-1. It represses genes involved in heme metabolism and oxidative stress response. BACH2 is a lymphoid-specific transcription factor with a prominent role in B-cell development. It is transcriptionally regulated by the BCR/ABL oncogene. It represses the anti-apoptotic factor heme oxygenase-1 (HO-1). Subfamily members contain a BTB domain and a basic leucine zipper (bZIP) domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528470362  31 LTDVTIMVGGQQFRAHKTVLMACSGLFYSMFADNPKSNLsLISLDPKVDPDGFAILLEFMYTSCLTLKDNFIIATLNTAT 110
Cdd:cd18955    1 LCDVTIVVEDQRFRAHRAVLAACSDYFLSRVVGQTDGDL-VITLPEEVTVKGFEPLLQFAYTAKLLLSKENVLEVCRCAE 79

                         90
                 ....*....|....*
gi 528470362 111 YLQMDHVMETCQRFI 125
Cdd:cd18955   80 FLGVHNIEKACFDFL 94

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins KLHL1, KLHL4 and KLHL5; This family contains the Kelch-like proteins: KLHL1, KLHL4 and KLHL5, all of which share high identity and similarity with the Drosophila kelch protein, a component of ring canals. KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels. Family members contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528470362  31 LTDVTIMVGGQQFRAHKTVLMACSGLFYSMFADNPK-SNLSLISLDpKVDPDGFAILLEFMYTSCLTLKDNFIIATLNTA 109
Cdd:cd18234    1 LCDVILIAGDRRIPAHRLVLSAVSDYFAAMFTNDVReATEEEIKLK-DVDPDALWTLVQYCYTGRLELKEDNVESLLATA 79

                         90       100
                 ....*....|....*....|....*
gi 528470362 110 TYLQMDHVMETCQRFIdsrglcMKQ 134
Cdd:cd18234   80 CLLQLSEVVEACCGFL------MKQ 98

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 37 (ZBTB37); ZBTB37 may be involved in transcriptional regulation. It is differentially expressed in aryl hydrocarbon receptor (AhR)-KO mice compared with WT mice, and may potentially contribute to the aging phenotype of AhR-KO mice. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528470362  15 AGDVLFNFNRLRSRNLLTDVTIMVGGQQFRAHKTVLMACSGLFYSMFADNpksNLSLISLDPKVDPDGFAILLEFMYTS- 93
Cdd:cd18222    9 SNSVLSHLNQLRMQGRLCDIVVNVQGQSFRAHKVVLAASSPYFRDHMSLN---EMSTVSISVIKNPTVFEQLLSFCYTGr 85

                         90       100       110
                 ....*....|....*....|....*....|....
gi 528470362  94 -CLTLKDnfIIATLNTATYLQMDHVMETCQRFID 126
Cdd:cd18222   86 iCLQLAD--IISYLTAASFLQMQHIIDKCTQILE 117

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 30 (KLHL30); KLHL30 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528470362  14 HAGDVLFNFNRLRSRNLLTDVTIMVGGQQFRAHKTVLMACSGLFYSMFADNPKSNLSLISLDPKVDPDGFAILLEFMYTS 93
Cdd:cd18259   15 HPQSILDGLQTLRSNPKLSDVTLLVGGREFPCHRSVLALCSHYFNAMFTGDFVESISARVEIKDVDPAVMESLIDFAYTG 94

                         90       100       110
                 ....*....|....*....|....*....|..
gi 528470362  94 CLTLKDNFIIATLNTATYLQMDHVMETCQRFI 125
Cdd:cd18259   95 KLTINQGNVEALIRTSNRLQFPTVRKVCSRYL 126

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 24 (KLHL24); KLHL24, also called kainate receptor-interacting protein for GluR6 (KRIP6) or protein DRE1, is necessary to maintain the balance between intermediate filament stability and degradation, a process that is essential for skin integrity. KLHL24 is a component of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that mediates ubiquitination of KRT14 and controls its levels during keratinocyte differentiation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528470362  14 HAGDVLFNFNRLRSRNLLTDVTIMVGGQQFRAHKTVLMACSGLFYSMFADNPKSNLSLISLDPKVDPDGFAILLEFMYTS 93
Cdd:cd18253    1 HSESILQVFNEFRDSRLFTDVIICVEGREFPCHRAILSACSSYFRAMFCNDHRESREMLVEINGILAEAMDCFLQYVYTG 80

                         90       100       110
                 ....*....|....*....|....*....|...
gi 528470362  94 CLTLKDNFIIATLNTATYLQMDHVMETCQRFID 126
Cdd:cd18253   81 KVKITTENVQYLFETSSLFQISPLRDACAKFLE 113

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster proteins bric-a-brac 1 (BAB1), bric-a-brac 2 (BAB2), modifier of mdg4 (doom), and similar proteins; BAB1 and BAB2 probably act as transcriptional regulators that are required for specification of the tarsal segment and are involved in antenna development. Doom is a product of the Drosophila mod(mdg4) gene. It induces apoptosis and binds to baculovirus inhibitor-of-apoptosis proteins. This subfamily also includes Drosophila melanogaster sex determination protein fruitless (FRU), protein jim lovell (LOV), zinc finger protein chinmo, transcription factor GAGA, transcription factor Ken, and longitudinals lacking proteins (LOLA). FRU probably acts as a transcriptional regulator that plays a role in male courtship behavior and sexual orientation, and enhances male-specific expression of takeout in brain-associated fat body. LOV, also called tyrosine kinase-related (TKR), has a regulatory role during midline cell development. Chinmo is a functional effector of the JAK/STAT pathway that regulates eye development, tumor formation, and stem cell self-renewal in Drosophila. GAGA is a transcriptional activator that functions by regulating chromatin structure. Ken, also termed protein Ken and Barbie, is a transcription factor required for Terminalia development. LOLA proteins are putative transcription factors required for axon growth and guidance in the central and peripheral nervous systems. Proteins in this subfamily contain a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528470362  31 LTDVTIMVGGQQFRAHKTVLMACSGLFYSMFADNPKSNLSLISLdPKVDPDGFAILLEFMYTSCLTLKDNFIIATLNTAT 110
Cdd:cd18315    1 LVDVTLACEGGSLKAHKLVLAAASPYFAALLKETPPDEHPVIIL-PDVPYSELKALLDFIYTGEVNVSQEQLESLLKLAE 79

                 ....*.
gi 528470362 111 YLQMDH 116
Cdd:cd18315   80 LLQIKG 85

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 31 (KLHL31); KLHL31 is also called BTB and kelch domain-containing protein 6 (BKLHD6), Kelch repeat and BTB domain-containing protein 1 (KBTBD1), or Kelch-like protein KLHL. It is a transcriptional repressor in the MAPK/JNK signaling pathway to regulate cellular functions. Overexpression inhibits the transcriptional activities of both the TPA-response element (TRE) and serum response element (SRE). It is also a novel modulator of canonical Wnt signaling, which is important for vertebrate myogenesis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528470362  14 HAGDVLFNFNRLRSRNLLTDVTIMVGGQQFRAHKTVLMACSGLFYSMFADNPksNLSLISLDpKVDPDGFAILLEFMYTS 93
Cdd:cd18260    1 YGANLLEGLNRMRQERFLCDLTIATKTKSFDVHKVVMASCSEYFRNILKKDP--SLQRVELN-DISPLGLATVITYAYTG 77