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    Dnai7 dynein axonemal intermediate chain 7 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 297720, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Dnai7provided by RGD
    Official Full Name
    dynein axonemal intermediate chain 7provided by RGD
    Primary source
    RGD:1311213
    See related
    EnsemblRapid:ENSRNOG00000027630 AllianceGenome:RGD:1311213
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Las1; Casc1; Cfap94
    Summary
    Predicted to enable beta-tubulin binding activity and microtubule binding activity. Predicted to be located in cilium; cytoplasm; and microtubule cytoskeleton. Predicted to be part of axonemal dynein complex. Predicted to be active in axoneme and cytoplasmic microtubule. Orthologous to human DNAI7 (dynein axonemal intermediate chain 7). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Lung (RPKM 45.8), Testes (RPKM 39.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Dnai7 in Genome Data Viewer
    Location:
    4q44
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (179874338..179910716, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (178143499..178179871, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (179440984..179476965, complement)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene small ribosomal subunit protein uS10-like Neighboring gene branched chain amino acid transaminase 1 Neighboring gene inositol 1,4,5-triphosphate receptor associated 2 Neighboring gene uncharacterized LOC134486864 Neighboring gene electron transfer flavoprotein regulatory factor 1 Neighboring gene KRAS proto-oncogene, GTPase Neighboring gene uncharacterized LOC134486865

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Mechanisms promoting escape from mitotic stress-induced tumor cell death. Sinnott R, et al. Cancer Res, 2014 Jul 15. PMID 24860162, Free PMC Article
    2. Degradation of lung adenoma susceptibility 1, a major candidate mouse lung tumor modifier, is required for cell cycle progression. Liu Y, et al. Cancer Res, 2007 Nov 1. PMID 17974961
    3. Positional cloning of the major quantitative trait locus underlying lung tumor susceptibility in mice. Zhang Z, et al. Proc Natl Acad Sci U S A, 2003 Oct 28. PMID 14583591, Free PMC Article
    4. Candidate lung tumor susceptibility genes identified through whole-genome association analyses in inbred mice. Liu P, et al. Nat Genet, 2006 Aug. PMID 16862160
    5. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Identification of mouse Casc1 (Las1) as a candidate for lung cancer susceptibility, and comparison of the protein to the rat and human orthologs.
      Title: Positional cloning of the major quantitative trait locus underlying lung tumor susceptibility in mice.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables beta-tubulin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables beta-tubulin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables microtubule binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    part_of axonemal dynein complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in axoneme IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cilium ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasmic microtubule ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasmic microtubule ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in microtubule cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    dynein axonemal intermediate chain 7
    Names
    cancer susceptibility 1
    cancer susceptibility candidate 1
    cilia and flagella associated protein 94
    dynein intermediate chain CFAP94, axonemal
    lung adenoma susceptibility 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106627.3 → NP_001100097.2  dynein axonemal intermediate chain 7

      See identical proteins and their annotated locations for NP_001100097.2

      Status: PROVISIONAL

      Source sequence(s)
      BC160907
      UniProtKB/TrEMBL
      A0A8I6ACC4, B1H288
      Related
      ENSRNOP00000035058.6, ENSRNOT00000030680.7
      Conserved Domains (2) summary
      pfam12366
      Location:244 → 469
      Casc1; Cancer susceptibility candidate 1
      pfam15927
      Location:37 → 229
      Casc1_N; Cancer susceptibility candidate 1 N-terminus

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      179874338..179910716 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039107470.2 → XP_038963398.1  dynein axonemal intermediate chain 7 isoform X5

      UniProtKB/TrEMBL
      A0A8I6ACC4
      Conserved Domains (1) summary
      pfam15927
      Location:4 → 137
      Casc1_N; Cancer susceptibility candidate 1 N-terminus

    2. XM_039107474.2 → XP_038963402.1  dynein axonemal intermediate chain 7 isoform X6

      UniProtKB/TrEMBL
      A0A8I6ACC4
      Conserved Domains (1) summary
      pfam15927
      Location:1 → 136
      Casc1_N; Cancer susceptibility candidate 1 N-terminus

    3. XM_039107473.2 → XP_038963401.1  dynein axonemal intermediate chain 7 isoform X4

      UniProtKB/TrEMBL
      A0A8I6ACC4
      Conserved Domains (1) summary
      pfam15927
      Location:22 → 168
      Casc1_N; Cancer susceptibility candidate 1 N-terminus

    4. XM_039107467.2 → XP_038963395.1  dynein axonemal intermediate chain 7 isoform X2

      UniProtKB/TrEMBL
      A0A8I6ACC4
      Conserved Domains (1) summary
      pfam15927
      Location:37 → 256
      Casc1_N; Cancer susceptibility candidate 1 N-terminus

    5. XM_039107476.2 → XP_038963404.1  dynein axonemal intermediate chain 7 isoform X8

      Conserved Domains (1) summary
      pfam15927
      Location:37 → 266
      Casc1_N; Cancer susceptibility candidate 1 N-terminus

    6. XM_039107466.2 → XP_038963394.1  dynein axonemal intermediate chain 7 isoform X1

      UniProtKB/TrEMBL
      A0A8I6ACC4, F7FKY0
      Conserved Domains (1) summary
      pfam15927
      Location:37 → 266
      Casc1_N; Cancer susceptibility candidate 1 N-terminus

    7. XM_039107475.2 → XP_038963403.1  dynein axonemal intermediate chain 7 isoform X7

      Conserved Domains (1) summary
      pfam15927
      Location:37 → 266
      Casc1_N; Cancer susceptibility candidate 1 N-terminus

    8. XM_039107472.2 → XP_038963400.1  dynein axonemal intermediate chain 7 isoform X6

      UniProtKB/TrEMBL
      A0A8I6ACC4
      Conserved Domains (1) summary
      pfam15927
      Location:1 → 136
      Casc1_N; Cancer susceptibility candidate 1 N-terminus

    9. XM_039107469.2 → XP_038963397.1  dynein axonemal intermediate chain 7 isoform X4

      UniProtKB/TrEMBL
      A0A8I6ACC4
      Conserved Domains (1) summary
      pfam15927
      Location:22 → 168
      Casc1_N; Cancer susceptibility candidate 1 N-terminus

    10. XM_039107468.2 → XP_038963396.1  dynein axonemal intermediate chain 7 isoform X3

      UniProtKB/TrEMBL
      A0A8I6ACC4
      Conserved Domains (1) summary
      pfam15927
      Location:52 → 181
      Casc1_N; Cancer susceptibility candidate 1 N-terminus

    11. XM_039107477.2 → XP_038963405.1  dynein axonemal intermediate chain 7 isoform X9

      Conserved Domains (1) summary
      pfam15927
      Location:37 → 266
      Casc1_N; Cancer susceptibility candidate 1 N-terminus

    12. XM_039107479.2 → XP_038963407.1  dynein axonemal intermediate chain 7 isoform X11

      Conserved Domains (1) summary
      pfam15927
      Location:37 → 266
      Casc1_N; Cancer susceptibility candidate 1 N-terminus

    13. XM_039107478.2 → XP_038963406.1  dynein axonemal intermediate chain 7 isoform X10

      Conserved Domains (1) summary
      pfam15927
      Location:37 → 266
      Casc1_N; Cancer susceptibility candidate 1 N-terminus
    Nucleotide Protein Strain
    Heading Accession and Version

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