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    Ppp1cb protein phosphatase 1 catalytic subunit beta [ Rattus norvegicus (Norway rat) ]

    Gene ID: 25594, updated on 4-Jan-2025

    Summary

    Official Symbol
    Ppp1cbprovided by RGD
    Official Full Name
    protein phosphatase 1 catalytic subunit betaprovided by RGD
    Primary source
    RGD:3376
    See related
    EnsemblRapid:ENSRNOG00000004612 AllianceGenome:RGD:3376
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    PP1B; PP1beta
    Summary
    Enables phosphoprotein phosphatase activity. Involved in protein dephosphorylation; regulation of glycogen biosynthetic process; and regulation of glycogen catabolic process. Located in glycogen granule. Part of protein phosphatase type 1 complex. Human ortholog(s) of this gene implicated in Noonan syndrome-like disorder with loose anagen hair 2. Orthologous to human PPP1CB (protein phosphatase 1 catalytic subunit beta). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Biased expression in Muscle (RPKM 1634.0), Heart (RPKM 1018.2) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Ppp1cb in Genome Data Viewer
    Location:
    6q14
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (29681099..29712835, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (23958813..23992841, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (23548507..23581136, complement)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene transfer RNA cysteine (anticodon GCA) 30 Neighboring gene speedy/RINGO cell cycle regulator family member A Neighboring gene uncharacterized LOC134479110 Neighboring gene uncharacterized LOC120103485 Neighboring gene phospholipase B1 Neighboring gene PYM homolog 1, exon junction complex associated factor, pseudogene 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables MAP kinase serine/threonine phosphatase activity  
    enables RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity  
    enables RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity  
    enables RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity  
    enables RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity  
    enables RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity  
    enables calmodulin-dependent protein phosphatase activity  
    enables histone H2AXS140 phosphatase activity  
    enables metal ion binding  
    enables myosin phosphatase activity  
    enables myosin-light-chain-phosphatase activity  
    enables myosin-light-chain-phosphatase activity  
    enables phosphatase activity  
    enables phosphatase activity  
    enables phosphoprotein phosphatase activity PubMed 
    enables phosphoprotein phosphatase activity  
    enables protein binding PubMed 
    enables protein kinase binding  
    enables protein serine/threonine phosphatase activity  
    enables protein serine/threonine phosphatase activity  
    enables protein serine/threonine phosphatase activity  
    Process Evidence Code Pubs
    involved_in cell division  
    involved_in chromatin remodeling  
    involved_in circadian regulation of gene expression  
    involved_in circadian regulation of gene expression  
    involved_in circadian regulation of gene expression  
    involved_in entrainment of circadian clock by photoperiod  
    involved_in entrainment of circadian clock by photoperiod  
    involved_in glycogen metabolic process  
    involved_in protein dephosphorylation PubMed 
    acts_upstream_of_or_within protein dephosphorylation  
    involved_in protein dephosphorylation  
    involved_in regulation of cell adhesion  
    involved_in regulation of cell adhesion  
    involved_in regulation of circadian rhythm  
    involved_in regulation of circadian rhythm  
    involved_in regulation of circadian rhythm  
    involved_in regulation of glycogen biosynthetic process PubMed 
    involved_in regulation of glycogen catabolic process PubMed 
    involved_in regulation of transcription by RNA polymerase II  
    involved_in rhythmic process  
    Component Evidence Code Pubs
    part_of PTW/PP1 phosphatase complex  
    part_of PTW/PP1 phosphatase complex  
    located_in chromosome, telomeric region  
    is_active_in cytoplasm  
    located_in cytoplasm  
    located_in cytosol  
    located_in cytosol  
    located_in glycogen granule PubMed 
    located_in nucleolus  
    located_in nucleoplasm  
    located_in nucleoplasm  
    is_active_in nucleus  
    part_of protein phosphatase type 1 complex PubMed 

    General protein information

    Preferred Names
    serine/threonine-protein phosphatase PP1-beta catalytic subunit
    Names
    PP-1B
    protein phosphatase 1, catalytic subunit, beta isozyme
    protein phosphatase-1a
    NP_037197.1
    XP_038967740.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_013065.2NP_037197.1  serine/threonine-protein phosphatase PP1-beta catalytic subunit

      See identical proteins and their annotated locations for NP_037197.1

      Status: PROVISIONAL

      Source sequence(s)
      BC062033
      UniProtKB/Swiss-Prot
      P62142
      UniProtKB/TrEMBL
      A0A8I6ABP0, A6HA24
      Related
      ENSRNOP00000006190.3, ENSRNOT00000006190.6
      Conserved Domains (1) summary
      cd07414
      Location:7297
      MPP_PP1_PPKL; PP1, PPKL (PP1 and kelch-like) enzymes, and related proteins, metallophosphatase domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      29681099..29712835 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039111812.2XP_038967740.1  serine/threonine-protein phosphatase PP1-beta catalytic subunit isoform X1

      Conserved Domains (1) summary
      cl13995
      Location:7197
      MPP_superfamily; metallophosphatase superfamily, metallophosphatase domain
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