Stau1 staufen double-stranded RNA binding protein 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Stau1provided by RGD
Official Full Name: staufen double-stranded RNA binding protein 1provided by RGD
Primary source: RGD:621778
See related: EnsemblRapid:ENSRNOG00000007781 AllianceGenome:RGD:621778
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Stau
Summary: Enables double-stranded RNA binding activity and protein phosphatase 1 binding activity. Involved in cellular response to oxidative stress; modification of postsynaptic structure; and positive regulation of long-term synaptic potentiation. Located in neuronal cell body. Is active in glutamatergic synapse. Orthologous to human STAU1 (staufen double-stranded RNA binding protein 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Kidney (RPKM 165.6), Lung (RPKM 131.4) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 3q42

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (176099053..176144947, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (155680000..155725969, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (163703204..163748996, complement)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Activity of Arhgef4 is modulated through Staufen1 in neurons.
Title: Activity of Arhgef4 is modulated through Staufen1 in neurons.
These findings clarify the role of Stau1-dependent mRNA regulation in physiological and morphological changes underlying long-term synaptic plasticity in pyramidal cells.
Title: mRNA binding protein staufen 1-dependent regulation of pyramidal cell spine morphology via NMDA receptor-mediated synaptic plasticity.
Stau1 is involved in recovery from stress by stabilizing polysomes, thus helping stress granule dissolution.
Title: Mammalian Staufen 1 is recruited to stress granules and impairs their assembly.
Stau1 is important for processing and/or transporting in dendrites mRNAs that are critical in regulation of synaptic strength and maintenance of functional connectivity changes underlying hippocampus-dependent learning and memory.
Title: Staufen1 regulation of protein synthesis-dependent long-term potentiation and synaptic function in hippocampal pyramidal cells.
Staufen 1 and Staufen 2 are novel and ubiquitous stress granules components that are involved in repositioning of most polysomal mRNAs, but not of recently synthesized transcripts, during the stress response
Title: Staufen recruitment into stress granules does not affect early mRNA transport in oligodendrocytes.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH128700 (e-PCR)
- UniSTS:212008

Stau1 (e-PCR), detects polymorphism
- UniSTS:547730

RH138783 (e-PCR)
- UniSTS:220870

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables RNA binding	ISO Inferred from Sequence Orthology more info
enables double-stranded RNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables double-stranded RNA binding	IDA Inferred from Direct Assay more info	PubMed
enables mRNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein phosphatase 1 binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in anterograde dendritic transport of messenger ribonucleoprotein complex	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to oxidative stress	IEP Inferred from Expression Pattern more info	PubMed
involved_in dendritic transport of messenger ribonucleoprotein complex	ISO Inferred from Sequence Orthology more info
involved_in germ cell development	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular mRNA localization	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within intracellular mRNA localization	ISO Inferred from Sequence Orthology more info
involved_in modification of postsynaptic structure	IDA Inferred from Direct Assay more info	PubMed
involved_in modification of postsynaptic structure	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in modulation of chemical synaptic transmission	IDA Inferred from Direct Assay more info	PubMed
involved_in modulation of chemical synaptic transmission	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation by virus of viral protein levels in host cell	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of long-term synaptic potentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of viral genome replication	ISO Inferred from Sequence Orthology more info
involved_in protein localization to synapse	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cell body	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic ribonucleoprotein granule	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasmic stress granule	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasmic stress granule	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in dendrite	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in neuron projection	IBA Inferred from Biological aspect of Ancestor more info
located_in neuron projection	ISO Inferred from Sequence Orthology more info
is_active_in neuronal cell body	IBA Inferred from Biological aspect of Ancestor more info
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
part_of ribonucleoprotein complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: double-stranded RNA-binding protein Staufen homolog 1

Names: staufen RNA binding protein homolog 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001109907.1 → NP_001103377.1 double-stranded RNA-binding protein Staufen homolog 1 isoform 2

See identical proteins and their annotated locations for NP_001103377.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate splice site in the coding region, compared to variant 1, resulting in a shorter protein (isoform 2).

Source sequence(s)

BC081755, DN932990

UniProtKB/TrEMBL

Q3T1L2, Q66HP4, Q9ESY8

Conserved Domains (4) summary

pfam16482
Location:360 → 469

Staufen_C; Staufen C-terminal domain

cd19883
Location:95 → 161

DSRM_STAU1_rpt3; third double-stranded RNA binding motif of double-stranded RNA-binding protein Staufen homolog 1 (Staufen 1) and similar proteins

cd19885
Location:188 → 273

DSRM_STAU1_rpt4; fourth double-stranded RNA binding motif of double-stranded RNA-binding protein Staufen homolog 1 (Staufen 1) and similar proteins

cl00054
Location:1 → 70

DSRM_SF; double-stranded RNA binding motif (DSRM) superfamily
NM_053436.2 → NP_445888.1 double-stranded RNA-binding protein Staufen homolog 1 isoform 1

See identical proteins and their annotated locations for NP_445888.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AF227200, BC081755, DN932990

UniProtKB/TrEMBL

Q66HP4, Q9ET50

Related

ENSRNOP00000010633.4, ENSRNOT00000010633.7

Conserved Domains (3) summary

pfam16482
Location:366 → 475

Staufen_C; Staufen C-terminal domain

cd19885
Location:194 → 279

DSRM_STAU1_rpt4; fourth double-stranded RNA binding motif of double-stranded RNA-binding protein Staufen homolog 1 (Staufen 1) and similar proteins

cl00054
Location:95 → 167

DSRM_SF; double-stranded RNA binding motif (DSRM) superfamily