Ormdl1 ORMDL sphingolipid biosynthesis regulator 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ormdl1provided by RGD
Official Full Name: ORMDL sphingolipid biosynthesis regulator 1provided by RGD
Primary source: RGD:2300146
See related: EnsemblRapid:ENSRNOG00000064999 AllianceGenome:RGD:2300146
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable several functions, including RNA-DNA hybrid ribonuclease activity; RNA-directed DNA polymerase activity; and zinc ion binding activity. Predicted to be involved in ceramide metabolic process; intracellular sphingolipid homeostasis; and sphingolipid biosynthetic process. Predicted to act upstream of or within negative regulation of ceramide biosynthetic process. Predicted to be located in endoplasmic reticulum membrane. Predicted to be part of serine palmitoyltransferase complex. Orthologous to human ORMDL1 (ORMDL sphingolipid biosynthesis regulator 1). [provided by Alliance of Genome Resources, Jan 2025]
Expression: Biased expression in Thymus (RPKM 40.0), Spleen (RPKM 21.3) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 9q22

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	9	NC_086027.1 (55735081..55745287, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	9	NC_051344.1 (48243365..48253316, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	9	NC_005108.4 (53110628..53120454, complement)

Chromosome 9 - NC_086027.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables RNA-DNA hybrid ribonuclease activity	IEA Inferred from Electronic Annotation more info
enables RNA-directed DNA polymerase activity	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in DNA integration	IEA Inferred from Electronic Annotation more info
involved_in RNA-templated DNA biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in ceramide metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in ceramide metabolic process	ISO Inferred from Sequence Orthology more info
involved_in intracellular sphingolipid homeostasis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of motor behavior	ISO Inferred from Sequence Orthology more info
acts_upstream_of myelination	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of ceramide biosynthetic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of regulation of ceramide biosynthetic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of regulation of sphingolipid biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in sphingolipid biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of sphingomyelin biosynthetic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
part_of serine palmitoyltransferase complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: ORM1-like protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.