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Conserved domains on  [gi|1958800719|ref|XP_038938825|]
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ORM1-like protein 1 isoform X1 [Rattus norvegicus]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
ORMDL super family cl02117
ORMDL family; Evidence form suggests that ORMDLs are involved in protein folding in the ER. ...
11-60 6.73e-21

ORMDL family; Evidence form suggests that ORMDLs are involved in protein folding in the ER. Orm proteins have been identified as negative regulators of sphingolipid synthesis that form a conserved complex with serine palmitoyltransferase, the first and rate-limiting enzyme in sphingolipid production. This novel and conserved protein complex, has been termed the SPOTS complex (serine palmitoyltransferase, Orm1/2, Tsc3, and Sac1).


The actual alignment was detected with superfamily member pfam04061:

Pssm-ID: 470473  Cd Length: 135  Bit Score: 88.00  E-value: 6.73e-21
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1958800719  11 NPNTRVMNSRGMWLTYALGVGLLHIVFLSIPFCSVPVAWTLTNIIHNLVS 60
Cdd:pfam04061   1 NPNASWVNSKGAWLIYIVLILLLKLLLLSIPGFSVEVAWTLTNLIHNIGT 50
Gag_p24 pfam00607
gag protein p24 N-terminal domain; p24 forms inner protein layer of the nucleocapsid. ELISA ...
332-408 1.08e-16

gag protein p24 N-terminal domain; p24 forms inner protein layer of the nucleocapsid. ELISA tests for p24 is the most commonly used method to demonstrate virus replication both in vivo and in vitro.


:

Pssm-ID: 459864  Cd Length: 128  Bit Score: 75.78  E-value: 1.08e-16
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1958800719 332 VHAPVEYVQIMELAESVHNYGVSANFTIAQVERLATL-AMTPGDWQTTVKAALPNmGQYVEWKALWYDASQAQAKVNA 408
Cdd:pfam00607   1 VWEPLDFKLLKELKKAVKQYGPNSPYTMQLLEALASSnALTPYDWRTLAKAVLSP-GQYLLWKAEWQELAQEQARRNQ 77
 
Name Accession Description Interval E-value
ORMDL pfam04061
ORMDL family; Evidence form suggests that ORMDLs are involved in protein folding in the ER. ...
11-60 6.73e-21

ORMDL family; Evidence form suggests that ORMDLs are involved in protein folding in the ER. Orm proteins have been identified as negative regulators of sphingolipid synthesis that form a conserved complex with serine palmitoyltransferase, the first and rate-limiting enzyme in sphingolipid production. This novel and conserved protein complex, has been termed the SPOTS complex (serine palmitoyltransferase, Orm1/2, Tsc3, and Sac1).


Pssm-ID: 461151  Cd Length: 135  Bit Score: 88.00  E-value: 6.73e-21
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1958800719  11 NPNTRVMNSRGMWLTYALGVGLLHIVFLSIPFCSVPVAWTLTNIIHNLVS 60
Cdd:pfam04061   1 NPNASWVNSKGAWLIYIVLILLLKLLLLSIPGFSVEVAWTLTNLIHNIGT 50
Gag_p24 pfam00607
gag protein p24 N-terminal domain; p24 forms inner protein layer of the nucleocapsid. ELISA ...
332-408 1.08e-16

gag protein p24 N-terminal domain; p24 forms inner protein layer of the nucleocapsid. ELISA tests for p24 is the most commonly used method to demonstrate virus replication both in vivo and in vitro.


Pssm-ID: 459864  Cd Length: 128  Bit Score: 75.78  E-value: 1.08e-16
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1958800719 332 VHAPVEYVQIMELAESVHNYGVSANFTIAQVERLATL-AMTPGDWQTTVKAALPNmGQYVEWKALWYDASQAQAKVNA 408
Cdd:pfam00607   1 VWEPLDFKLLKELKKAVKQYGPNSPYTMQLLEALASSnALTPYDWRTLAKAVLSP-GQYLLWKAEWQELAQEQARRNQ 77
 
Name Accession Description Interval E-value
ORMDL pfam04061
ORMDL family; Evidence form suggests that ORMDLs are involved in protein folding in the ER. ...
11-60 6.73e-21

ORMDL family; Evidence form suggests that ORMDLs are involved in protein folding in the ER. Orm proteins have been identified as negative regulators of sphingolipid synthesis that form a conserved complex with serine palmitoyltransferase, the first and rate-limiting enzyme in sphingolipid production. This novel and conserved protein complex, has been termed the SPOTS complex (serine palmitoyltransferase, Orm1/2, Tsc3, and Sac1).


Pssm-ID: 461151  Cd Length: 135  Bit Score: 88.00  E-value: 6.73e-21
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1958800719  11 NPNTRVMNSRGMWLTYALGVGLLHIVFLSIPFCSVPVAWTLTNIIHNLVS 60
Cdd:pfam04061   1 NPNASWVNSKGAWLIYIVLILLLKLLLLSIPGFSVEVAWTLTNLIHNIGT 50
Gag_p24 pfam00607
gag protein p24 N-terminal domain; p24 forms inner protein layer of the nucleocapsid. ELISA ...
332-408 1.08e-16

gag protein p24 N-terminal domain; p24 forms inner protein layer of the nucleocapsid. ELISA tests for p24 is the most commonly used method to demonstrate virus replication both in vivo and in vitro.


Pssm-ID: 459864  Cd Length: 128  Bit Score: 75.78  E-value: 1.08e-16
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1958800719 332 VHAPVEYVQIMELAESVHNYGVSANFTIAQVERLATL-AMTPGDWQTTVKAALPNmGQYVEWKALWYDASQAQAKVNA 408
Cdd:pfam00607   1 VWEPLDFKLLKELKKAVKQYGPNSPYTMQLLEALASSnALTPYDWRTLAKAVLSP-GQYLLWKAEWQELAQEQARRNQ 77
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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