Aqp3 aquaporin 3 (Gill blood group) [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Aqp3provided by RGD
Official Full Name: aquaporin 3 (Gill blood group)provided by RGD
Primary source: RGD:68428
See related: EnsemblRapid:ENSRNOG00000009797 AllianceGenome:RGD:68428
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables glycerol channel activity and water channel activity. Involved in glycerol transmembrane transport and water transport. Located in basolateral plasma membrane. Biomarker of brain ischemia and hypothyroidism. Orthologous to human AQP3 (aquaporin 3 (Gill blood group)). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Kidney (RPKM 212.3), Spleen (RPKM 48.1) and 1 other tissue See more
Orthologs: human mouse all
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Genomic context

Location:: 5q22

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (61035165..61040683, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (56239200..56244718, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (57423735..57429252, complement)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The role of AQP3 and AQP4 channels in cisplatin-induced cardiovascular edema and the protective effect of melatonin.
Title: The role of AQP3 and AQP4 channels in cisplatin-induced cardiovascular edema and the protective effect of melatonin.
Unexpected localization of AQP3 and AQP4 induced by migration of primary cultured IMCD cells.
Title: Unexpected localization of AQP3 and AQP4 induced by migration of primary cultured IMCD cells.
Negative relationship between AQP-3 expression and activity of the p38 MAPK pathway in nucleus pulposus cells under oxidative damage showed that AQP-3 overexpression partly decreases the pathway's activity in nucleus pulposus cells of the same condition.
Title: Aquaporin-3 Attenuates Oxidative Stress-Induced Nucleus Pulposus Cell Apoptosis Through Regulating the P38 MAPK Pathway.
liquid water metabolic abnormalities and intestine permeability might be the mechanism of IBS by regulating AQP1, AQP3 and AQP8 via NF-kappaB pathway.
Title: Aquaporins 1, 3 and 8 expression in irritable bowel syndrome rats' colon via NF-κB pathway.
The findings indicate that mRNA expression of AQP3 varies with age.
Title: Age-related changes in renal AQP3 and AQP4 expression in Sprague Dawley rats.
Larger expression of AQP3 may confer to the cell a more tumor like phenotype and contributes to explain the presence of this protein in many different tumors.
Title: Overexpression of AQP3 Modifies the Cell Cycle and the Proliferation Rate of Mammalian Cells in Culture.
one of the functional mechanisms of intense pulsed light might be related to the regulation of AQP3 protein expression
Title: Effect of intense pulsed light on the expression of aquaporin 3 in rat skin.
The results suggest that morphine increases the AQP3 expression level in the colon, which promotes water absorption from the luminal side to the vascular side and causes constipation.
Title: Morphine-Induced Constipation Develops With Increased Aquaporin-3 Expression in the Colon via Increased Serotonin Secretion.
Reciprocity in the developmental regulation of aquaporins 1, 3 and 5 during pregnancy and lactation
Title: Reciprocity in the developmental regulation of aquaporins 1, 3 and 5 during pregnancy and lactation in the rat.
The results obtained here implied that both AQP3 and AQP8 may be involved in the pathogenesis of inflammatory bowel disease.
Title: Aquaporin 3 and 8 are down-regulated in TNBS-induced rat colitis.

Submit: New GeneRIF Correction See all GeneRIFs (29)

General gene information

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Markers

D5Wox32 (e-PCR)
- UniSTS:239936

MARC_26051-26052:1032543524:1 (e-PCR)
- UniSTS:268923

Aqp3 (e-PCR), detects polymorphism
- UniSTS:186492

Aqp3 (e-PCR), detects polymorphism
- UniSTS:209564

RH130911 (e-PCR)
- UniSTS:214195

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables glycerol channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables glycerol channel activity	IDA Inferred from Direct Assay more info	PubMed
enables glycerol channel activity	IEA Inferred from Electronic Annotation more info
enables glycerol channel activity	ISO Inferred from Sequence Orthology more info
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables polyol transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables urea transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables water channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables water channel activity	IDA Inferred from Direct Assay more info	PubMed
enables water channel activity	IEA Inferred from Electronic Annotation more info
enables water channel activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cellular response to hypoxia	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cellular response to hypoxia	ISO Inferred from Sequence Orthology more info
involved_in establishment of localization in cell	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within establishment of localization in cell	ISO Inferred from Sequence Orthology more info
involved_in glycerol transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in glycerol transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in glycerol transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in glycerol transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in odontogenesis	IEA Inferred from Electronic Annotation more info
involved_in odontogenesis	ISO Inferred from Sequence Orthology more info
involved_in polyol transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of immune system process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of immune system process	ISO Inferred from Sequence Orthology more info
involved_in renal water absorption	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within renal water absorption	ISO Inferred from Sequence Orthology more info
involved_in response to ischemia	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to ischemia	ISO Inferred from Sequence Orthology more info
involved_in response to retinoic acid	IEA Inferred from Electronic Annotation more info
involved_in response to retinoic acid	ISO Inferred from Sequence Orthology more info
involved_in urea transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in urea transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within urea transport	ISO Inferred from Sequence Orthology more info
involved_in water transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in water transport	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within water transport	ISO Inferred from Sequence Orthology more info
involved_in water transport	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in basolateral plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in basolateral plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in basolateral plasma membrane	IEA Inferred from Electronic Annotation more info
located_in basolateral plasma membrane	ISO Inferred from Sequence Orthology more info
located_in cell-cell junction	IEA Inferred from Electronic Annotation more info
located_in cell-cell junction	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: aquaporin-3

Names: 31.4 kDa water channel protein; AQP-3; aquaglyceroporin-3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_031703.2 → NP_113891.2 aquaporin-3

Status: VALIDATED

Source sequence(s)

JAXUCZ010000005

UniProtKB/TrEMBL

A0A0G2JSK0, A6IIT6

Related

ENSRNOP00000013803.1, ENSRNOT00000013803.5

Conserved Domains (1) summary

cd00333
Location:23 → 264

MIP; Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal ...