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Conserved domains on  [gi|1938523070|ref|NP_113891|]
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aquaporin-3 [Rattus norvegicus]

Protein Classification

MIP/aquaporin family protein( domain architecture ID 10085424)

MIP (Major Intrinsic Protein)/aquaporin family protein similar to aquaporin that permits osmotically driven movement of water in both directions, and glycerol uptake facilitator protein that mediates glycerol diffusion across the cytoplasmic membrane via a pore-type mechanism

CATH:  1.20.1080.10
Gene Ontology:  GO:0055085|GO:0015267
PubMed:  11964478|8849412|11473620
SCOP:  3000508
TCDB:  1.A.8

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MIP cd00333
Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane ...
 23-264 1.78e-82

Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal cytosolic portion followed by six transmembrane helices, which might have arisen through gene duplication. On the basis of sequence similarity and functional characteristics, the superfamily can be subdivided into two major groups: water-selective channels called aquaporins (AQPs) and glycerol uptake facilitators (GlpFs). AQPs are found in all three kingdoms of life, while GlpFs have been characterized only within microorganisms.


:

Pssm-ID: 238204  Cd Length: 228  Bit Score: 247.94  E-value: 1.78e-82
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938523070  23 RQALAECLGTLILVMFGCGSVAQVVLSRGTHGGFLTINLAFGFAVTLAILVAGQVSGAHLNPAVTFAMCFLAREPWIKLP 102
Cdd:cd00333     1 RKYLAEFLGTFLLVFFGCGSVLAVKLAGGASGGLLGIALAWGFAIFVLVYAVGHISGGHINPAVTLALAVGGRFPLIRVI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938523070 103 IYTLAQTLGAFLGAGIVFGLYYDAIWAFAGnelvvsGPNGTAGIFATYPSGHLDMVNGFFDQFIGTAALIVCVLAIVDPY 182
Cdd:cd00333    81 PYIIAQLLGAILGAALLYGLYYGLYLEFLG------ANNIVAGIFGTYPSPGVSNGNAFFVEFIGTFILVLVVFATTDDP 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938523070 183 NNPVPRGLEAFTVGLVVLVIGTSMGFNSGYAVNPARDFGPRLFTALAgwgsevftTGQNWWWVPIVSPLLGSIGGVFVYQ 262
Cdd:cd00333   155 NGPPPGGLAPLAIGLLVAAIGLAGGPITGASMNPARSLGPALFTGLA--------RHWHYFWVYWVGPLIGAIAGALVYD 226


                  ..
gi 1938523070 263 LM 264
Cdd:cd00333   227 YV 228
 
Name Accession Description Interval E-value
MIP cd00333
Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane ...
 23-264 1.78e-82

Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal cytosolic portion followed by six transmembrane helices, which might have arisen through gene duplication. On the basis of sequence similarity and functional characteristics, the superfamily can be subdivided into two major groups: water-selective channels called aquaporins (AQPs) and glycerol uptake facilitators (GlpFs). AQPs are found in all three kingdoms of life, while GlpFs have been characterized only within microorganisms.


Pssm-ID: 238204  Cd Length: 228  Bit Score: 247.94  E-value: 1.78e-82
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938523070  23 RQALAECLGTLILVMFGCGSVAQVVLSRGTHGGFLTINLAFGFAVTLAILVAGQVSGAHLNPAVTFAMCFLAREPWIKLP 102
Cdd:cd00333     1 RKYLAEFLGTFLLVFFGCGSVLAVKLAGGASGGLLGIALAWGFAIFVLVYAVGHISGGHINPAVTLALAVGGRFPLIRVI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938523070 103 IYTLAQTLGAFLGAGIVFGLYYDAIWAFAGnelvvsGPNGTAGIFATYPSGHLDMVNGFFDQFIGTAALIVCVLAIVDPY 182
Cdd:cd00333    81 PYIIAQLLGAILGAALLYGLYYGLYLEFLG------ANNIVAGIFGTYPSPGVSNGNAFFVEFIGTFILVLVVFATTDDP 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938523070 183 NNPVPRGLEAFTVGLVVLVIGTSMGFNSGYAVNPARDFGPRLFTALAgwgsevftTGQNWWWVPIVSPLLGSIGGVFVYQ 262
Cdd:cd00333   155 NGPPPGGLAPLAIGLLVAAIGLAGGPITGASMNPARSLGPALFTGLA--------RHWHYFWVYWVGPLIGAIAGALVYD 226


                  ..
gi 1938523070 263 LM 264
Cdd:cd00333   227 YV 228
PTZ00016 PTZ00016
aquaglyceroporin; Provisional
 18-266 1.68e-76

aquaglyceroporin; Provisional


Pssm-ID: 240230 [Multi-domain]  Cd Length: 294  Bit Score: 235.02  E-value: 1.68e-76
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938523070  18 RYRL-LRQALAECLGTLILVMFGCGSVAQVVLSrGTHGGFLTINLAFGFAVTLAILVAGQVSGAHLNPAVTFAMCFLARE 96
Cdd:PTZ00016   45 EYRPnVREYVAEFLGTFVLLFFGEGVVATTHTV-GNNGDYLAITIGWGLGVTFGLLVSAGISGGHLNPAVTLGNAVFGKF 123

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938523070  97 PWIKLPIYTLAQTLGAFLGAGIVFGLYYDAIWAFAGNELVVSGP-NGTAGIFATYPSGHLdmVNGFFDQFIGTAALIVCV 175
Cdd:PTZ00016  124 PWKKLPGYFVAQLLGAFVGAACVYGLYYGFFKDHGIPELPWETMaNGFAGVFATYPREGN--FYAIFSELILTAILLLVI 201

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938523070 176 LAIVDPYNNPvPRGLEAFTVGLVVLVIGTSMGFNSGYAVNPARDFGPRLFTALAgWGSEVFTTGQNWWWVPIVSPLLGSI 255
Cdd:PTZ00016  202 LAITDPNNCP-AFNYLPVAVGLLVFVIGISFGGNTGYALNPARDLGPRLFSAIL-WGSEVFTKDNYYFWVPLVAPFVGAV 279

                         250
                  ....*....|.
gi 1938523070 256 GGVFVYQLMIG 266
Cdd:PTZ00016  280 LGMFLYDKFIP 290
GlpF COG0580
Glycerol uptake facilitator or related aquaporin (Major Intrinsic protein Family) ...
 21-266 1.63e-73

Glycerol uptake facilitator or related aquaporin (Major Intrinsic protein Family) [Carbohydrate transport and metabolism];


Pssm-ID: 440345 [Multi-domain]  Cd Length: 232  Bit Score: 225.01  E-value: 1.63e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938523070  21 LLRQALAECLGTLILVMFGCGSVAQVVLSRGThGGFLTINLAFGFAVTLAILVAGQVSGAHLNPAVTFAMCFLAREPWIK 100
Cdd:COG0580     2 LMKRLLAEFLGTFILVLLGCGVVAVLAGTKGG-IGWLGIALAWGLAVLAGVYAFGHISGAHLNPAVTLALAVAGRFPWKD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938523070 101 LPIYTLAQTLGAFLGAGIVFGLYYDAIWAFAgnelvvsGPNGTAGIFATYPSGHLDMVNGFFDQFIGTAALIVCVLAIVD 180
Cdd:COG0580    81 VLPYIIAQLLGAFLGAALVYLIYGGHFDATE-------DGGAKLGVFATSPAIGYSLGAAFLTEIIGTFVLVFVILGITD 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938523070 181 PYNNpvPRGLEAFTVGLVVLVIGTSMGFNSGYAVNPARDFGPRLFTALAGWGSEVfttgqNWWWVPIVSPLLGSIGGVFV 260
Cdd:COG0580   154 KRAA--PGGLAPLAIGLLVAAIGLSLGPLTGYAINPARDLGPRLFHALGKGGSDW-----GYLWVPIVAPILGAALAALL 226


                  ....*.
gi 1938523070 261 YQLMIG 266
Cdd:COG0580   227 YRALFG 232
MIP TIGR00861
MIP family channel proteins; 1.A.8 The Major Intrinsic Protein (MIP) FamilyThe MIP family is ...
 27-261 3.23e-68

MIP family channel proteins; 1.A.8 The Major Intrinsic Protein (MIP) FamilyThe MIP family is large and diverse, possessing over 100 members that all form transmembrane channels. These channel proteins function in water, smallcarbohydrate (e.g., glycerol), urea, NH3, CO2 and possibly ion transport by an energy independent mechanism. They are found ubiquitously in bacteria, archaeaand eukaryotes. The MIP family contains two major groups of channels: aquaporins and glycerol facilitators.The known aquaporins cluster loosely together as do the known glycerol facilitators. MIP family proteins are believed to form aqueous pores that selectively allow passive transport of their solute(s) across the membrane with minimal apparent recognition. Aquaporins selectively transport water (but not glycerol) while glycerol facilitators selectively transport glycerol but not water. Some aquaporins can transport NH3 and CO2. Glycerol facilitators function as solute nonspecific channels, and may transport glycerol, dihydroxyacetone, propanediol, urea and other small neutral molecules in physiologically importantprocesses. Some members of the family, including the yeast FPS protein (TC #1.A.8.5.1) and tobacco NtTIPA may transport both water and small solutes. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 273306 [Multi-domain]  Cd Length: 216  Bit Score: 211.00  E-value: 3.23e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938523070  27 AECLGTLILVMFGCGSVAQVVLSRGTH----GGFLTINLAFGFAVTLAILVAGQVSGAHLNPAVTFAMCFLAREPWIKLP 102
Cdd:TIGR00861   1 AEFLGTFLLVFFGVGSALGVNVAGAYGavggGQFLGVALAFGLAVATLVYCVGGISGAHLNPAVTIALLLGRRFPLKRVP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938523070 103 IYTLAQTLGAFLGAGIVFGLYYDaiwAFAGNELVVSGPngTAGIfatypsghlDMVNGFFDQFIGTAALIVCVLAIVDPY 182
Cdd:TIGR00861  81 VYIVAQLIGAILGAALLYGLTSG---LFPGNLAVNGSA--SAGV---------SSGQAFFVEFIGTAILVLVIFATTDDR 146

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1938523070 183 NNPVPRGLEAFTVGLVVLVIGTSMGFNSGYAVNPARDFGPRLFTALAGWGSevfttgqnwWWVPIVSPLLGSIGGVFVY 261
Cdd:TIGR00861 147 NRVPRGGFAPLAIGLLVFLIHLSMGPYTGTGMNPARSLGPALFAGLAGWGN---------HWVYWVGPIIGAILGALVY 216
MIP pfam00230
Major intrinsic protein; MIP (Major Intrinsic Protein) family proteins exhibit essentially two ...
 21-261 1.01e-44

Major intrinsic protein; MIP (Major Intrinsic Protein) family proteins exhibit essentially two distinct types of channel properties: (1) specific water transport by the aquaporins, and (2) small neutral solutes transport, such as glycerol by the glycerol facilitators.


Pssm-ID: 395174 [Multi-domain]  Cd Length: 223  Bit Score: 151.32  E-value: 1.01e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938523070  21 LLRQALAECLGTLILVMFGCGSVAQV--VLSRGTHGGFLTINLAFGFAVTLAILVAGQVSGAHLNPAVTFAMCFLAREPW 98
Cdd:pfam00230   7 FLRAVIAEFLATLLFVFFGVGSALGVkkLVSSLAVSGLLAVALAFGLALATLVYCAGHISGAHLNPAVTLALLVGRRFSL 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938523070  99 IKLPIYTLAQTLGAFLGAGIVFGLYYdaiwafagnelvvsgPNGTAGIFATYPSGHLDMVNGFFDQFIGTAALIVCVLAI 178
Cdd:pfam00230  87 LRAIFYIVAQLLGAIAGAALLYGVTV---------------GLQRAGLFANTLAPGVNAGQAFVVEIILTFQLVYCVFAT 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938523070 179 VDPYNNPVPRGLEAFTVGLVVLVIGTSMGFNSGYAVNPARDFGPRLFTalagWGSEVFttgqnwwWVPIVSPLLGSIGGV 258
Cdd:pfam00230 152 TDDRRNGSLGTVAPLAIGFAVFLNHLAGGPYTGASMNPARSFGPAVVL----WKWDDH-------WVYWVGPFIGAALGA 220


                  ...
gi 1938523070 259 FVY 261
Cdd:pfam00230 221 LVY 223
 
Name Accession Description Interval E-value
MIP cd00333
Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane ...
 23-264 1.78e-82

Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal cytosolic portion followed by six transmembrane helices, which might have arisen through gene duplication. On the basis of sequence similarity and functional characteristics, the superfamily can be subdivided into two major groups: water-selective channels called aquaporins (AQPs) and glycerol uptake facilitators (GlpFs). AQPs are found in all three kingdoms of life, while GlpFs have been characterized only within microorganisms.


Pssm-ID: 238204  Cd Length: 228  Bit Score: 247.94  E-value: 1.78e-82
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938523070  23 RQALAECLGTLILVMFGCGSVAQVVLSRGTHGGFLTINLAFGFAVTLAILVAGQVSGAHLNPAVTFAMCFLAREPWIKLP 102
Cdd:cd00333     1 RKYLAEFLGTFLLVFFGCGSVLAVKLAGGASGGLLGIALAWGFAIFVLVYAVGHISGGHINPAVTLALAVGGRFPLIRVI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938523070 103 IYTLAQTLGAFLGAGIVFGLYYDAIWAFAGnelvvsGPNGTAGIFATYPSGHLDMVNGFFDQFIGTAALIVCVLAIVDPY 182
Cdd:cd00333    81 PYIIAQLLGAILGAALLYGLYYGLYLEFLG------ANNIVAGIFGTYPSPGVSNGNAFFVEFIGTFILVLVVFATTDDP 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938523070 183 NNPVPRGLEAFTVGLVVLVIGTSMGFNSGYAVNPARDFGPRLFTALAgwgsevftTGQNWWWVPIVSPLLGSIGGVFVYQ 262
Cdd:cd00333   155 NGPPPGGLAPLAIGLLVAAIGLAGGPITGASMNPARSLGPALFTGLA--------RHWHYFWVYWVGPLIGAIAGALVYD 226


                  ..
gi 1938523070 263 LM 264
Cdd:cd00333   227 YV 228
PTZ00016 PTZ00016
aquaglyceroporin; Provisional
 18-266 1.68e-76

aquaglyceroporin; Provisional


Pssm-ID: 240230 [Multi-domain]  Cd Length: 294  Bit Score: 235.02  E-value: 1.68e-76
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938523070  18 RYRL-LRQALAECLGTLILVMFGCGSVAQVVLSrGTHGGFLTINLAFGFAVTLAILVAGQVSGAHLNPAVTFAMCFLARE 96
Cdd:PTZ00016   45 EYRPnVREYVAEFLGTFVLLFFGEGVVATTHTV-GNNGDYLAITIGWGLGVTFGLLVSAGISGGHLNPAVTLGNAVFGKF 123

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938523070  97 PWIKLPIYTLAQTLGAFLGAGIVFGLYYDAIWAFAGNELVVSGP-NGTAGIFATYPSGHLdmVNGFFDQFIGTAALIVCV 175
Cdd:PTZ00016  124 PWKKLPGYFVAQLLGAFVGAACVYGLYYGFFKDHGIPELPWETMaNGFAGVFATYPREGN--FYAIFSELILTAILLLVI 201

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938523070 176 LAIVDPYNNPvPRGLEAFTVGLVVLVIGTSMGFNSGYAVNPARDFGPRLFTALAgWGSEVFTTGQNWWWVPIVSPLLGSI 255
Cdd:PTZ00016  202 LAITDPNNCP-AFNYLPVAVGLLVFVIGISFGGNTGYALNPARDLGPRLFSAIL-WGSEVFTKDNYYFWVPLVAPFVGAV 279

                         250
                  ....*....|.
gi 1938523070 256 GGVFVYQLMIG 266
Cdd:PTZ00016  280 LGMFLYDKFIP 290
GlpF COG0580
Glycerol uptake facilitator or related aquaporin (Major Intrinsic protein Family) ...
 21-266 1.63e-73

Glycerol uptake facilitator or related aquaporin (Major Intrinsic protein Family) [Carbohydrate transport and metabolism];


Pssm-ID: 440345 [Multi-domain]  Cd Length: 232  Bit Score: 225.01  E-value: 1.63e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938523070  21 LLRQALAECLGTLILVMFGCGSVAQVVLSRGThGGFLTINLAFGFAVTLAILVAGQVSGAHLNPAVTFAMCFLAREPWIK 100
Cdd:COG0580     2 LMKRLLAEFLGTFILVLLGCGVVAVLAGTKGG-IGWLGIALAWGLAVLAGVYAFGHISGAHLNPAVTLALAVAGRFPWKD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938523070 101 LPIYTLAQTLGAFLGAGIVFGLYYDAIWAFAgnelvvsGPNGTAGIFATYPSGHLDMVNGFFDQFIGTAALIVCVLAIVD 180
Cdd:COG0580    81 VLPYIIAQLLGAFLGAALVYLIYGGHFDATE-------DGGAKLGVFATSPAIGYSLGAAFLTEIIGTFVLVFVILGITD 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938523070 181 PYNNpvPRGLEAFTVGLVVLVIGTSMGFNSGYAVNPARDFGPRLFTALAGWGSEVfttgqNWWWVPIVSPLLGSIGGVFV 260
Cdd:COG0580   154 KRAA--PGGLAPLAIGLLVAAIGLSLGPLTGYAINPARDLGPRLFHALGKGGSDW-----GYLWVPIVAPILGAALAALL 226


                  ....*.
gi 1938523070 261 YQLMIG 266
Cdd:COG0580   227 YRALFG 232
MIP TIGR00861
MIP family channel proteins; 1.A.8 The Major Intrinsic Protein (MIP) FamilyThe MIP family is ...
 27-261 3.23e-68

MIP family channel proteins; 1.A.8 The Major Intrinsic Protein (MIP) FamilyThe MIP family is large and diverse, possessing over 100 members that all form transmembrane channels. These channel proteins function in water, smallcarbohydrate (e.g., glycerol), urea, NH3, CO2 and possibly ion transport by an energy independent mechanism. They are found ubiquitously in bacteria, archaeaand eukaryotes. The MIP family contains two major groups of channels: aquaporins and glycerol facilitators.The known aquaporins cluster loosely together as do the known glycerol facilitators. MIP family proteins are believed to form aqueous pores that selectively allow passive transport of their solute(s) across the membrane with minimal apparent recognition. Aquaporins selectively transport water (but not glycerol) while glycerol facilitators selectively transport glycerol but not water. Some aquaporins can transport NH3 and CO2. Glycerol facilitators function as solute nonspecific channels, and may transport glycerol, dihydroxyacetone, propanediol, urea and other small neutral molecules in physiologically importantprocesses. Some members of the family, including the yeast FPS protein (TC #1.A.8.5.1) and tobacco NtTIPA may transport both water and small solutes. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 273306 [Multi-domain]  Cd Length: 216  Bit Score: 211.00  E-value: 3.23e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938523070  27 AECLGTLILVMFGCGSVAQVVLSRGTH----GGFLTINLAFGFAVTLAILVAGQVSGAHLNPAVTFAMCFLAREPWIKLP 102
Cdd:TIGR00861   1 AEFLGTFLLVFFGVGSALGVNVAGAYGavggGQFLGVALAFGLAVATLVYCVGGISGAHLNPAVTIALLLGRRFPLKRVP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938523070 103 IYTLAQTLGAFLGAGIVFGLYYDaiwAFAGNELVVSGPngTAGIfatypsghlDMVNGFFDQFIGTAALIVCVLAIVDPY 182
Cdd:TIGR00861  81 VYIVAQLIGAILGAALLYGLTSG---LFPGNLAVNGSA--SAGV---------SSGQAFFVEFIGTAILVLVIFATTDDR 146

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1938523070 183 NNPVPRGLEAFTVGLVVLVIGTSMGFNSGYAVNPARDFGPRLFTALAGWGSevfttgqnwWWVPIVSPLLGSIGGVFVY 261
Cdd:TIGR00861 147 NRVPRGGFAPLAIGLLVFLIHLSMGPYTGTGMNPARSLGPALFAGLAGWGN---------HWVYWVGPIIGAILGALVY 216
MIP pfam00230
Major intrinsic protein; MIP (Major Intrinsic Protein) family proteins exhibit essentially two ...
 21-261 1.01e-44

Major intrinsic protein; MIP (Major Intrinsic Protein) family proteins exhibit essentially two distinct types of channel properties: (1) specific water transport by the aquaporins, and (2) small neutral solutes transport, such as glycerol by the glycerol facilitators.


Pssm-ID: 395174 [Multi-domain]  Cd Length: 223  Bit Score: 151.32  E-value: 1.01e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938523070  21 LLRQALAECLGTLILVMFGCGSVAQV--VLSRGTHGGFLTINLAFGFAVTLAILVAGQVSGAHLNPAVTFAMCFLAREPW 98
Cdd:pfam00230   7 FLRAVIAEFLATLLFVFFGVGSALGVkkLVSSLAVSGLLAVALAFGLALATLVYCAGHISGAHLNPAVTLALLVGRRFSL 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938523070  99 IKLPIYTLAQTLGAFLGAGIVFGLYYdaiwafagnelvvsgPNGTAGIFATYPSGHLDMVNGFFDQFIGTAALIVCVLAI 178
Cdd:pfam00230  87 LRAIFYIVAQLLGAIAGAALLYGVTV---------------GLQRAGLFANTLAPGVNAGQAFVVEIILTFQLVYCVFAT 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938523070 179 VDPYNNPVPRGLEAFTVGLVVLVIGTSMGFNSGYAVNPARDFGPRLFTalagWGSEVFttgqnwwWVPIVSPLLGSIGGV 258
Cdd:pfam00230 152 TDDRRNGSLGTVAPLAIGFAVFLNHLAGGPYTGASMNPARSFGPAVVL----WKWDDH-------WVYWVGPFIGAALGA 220


                  ...
gi 1938523070 259 FVY 261
Cdd:pfam00230 221 LVY 223
PLN00183 PLN00183
putative aquaporin NIP7; Provisional
 22-283 2.07e-24

putative aquaporin NIP7; Provisional


Pssm-ID: 215092  Cd Length: 274  Bit Score: 99.16  E-value: 2.07e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938523070  22 LRQALAECLGTLILVMFGCGSVAQVVLSRGtHGGFLTINLAFGFAVTLAILVAGQVSGAHLNPAVTFAMCFLAREPWIKL 101
Cdd:PLN00183   45 ARMVLAEMVGTFILMFCVCGIIASTQLSGG-EVGLLEYAATAGLTVVVVVFSIGSISGAHVNPSVTIAFATFGHFPWSKV 123

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938523070 102 PIYTLAQTLGAFLGAGIVFGLYydaiwafagnelvvsGPNgtAGIFATYPSghLDMVNGFFDQFIGTaaLIVCVLAIVDP 181
Cdd:PLN00183  124 PLYITAQTVGSVLATYVGVSVY---------------GVK--ADLMTTKPA--QGCSSAFWVEFIAT--FIVMFLAASLT 182

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938523070 182 YNNPVPRGLEAFTVGLVVLVIGTSMGFNSGYAVNPARDFGPrlftALAGWGSEVFttgqnwwWVPIVSPLLGSIGGVFVY 261
Cdd:PLN00183  183 SQPQSLGHLSGFVIGIAIGLAVLITGPVSGGSMNPARSLGP----AIVSWDFKDI-------WIYITAPTIGAVAGALMF 251

                         250       260
                  ....*....|....*....|..
gi 1938523070 262 QLMIGCHleQPLPSTEAENVKL 283
Cdd:PLN00183  252 HLLRLRT--QPCSPNSSPNTSL 271
PLN00184 PLN00184
aquaporin NIP1; Provisional
 8-264 2.80e-20

aquaporin NIP1; Provisional


Pssm-ID: 177778  Cd Length: 296  Bit Score: 88.54  E-value: 2.80e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938523070   8 MNRCGEMLHIRYRLLRQALAECLGTLILVMFGCGSVAqVVLSRGTHGGFLTINLAFGFAVTLAILVAGQVSGAHLNPAVT 87
Cdd:PLN00184   40 LKKQDSLLSVSVPFLQKLIAEVLGTYFLVFTGCASVV-VNMQNDNVVTLPGIAIVWGLTIMVLIYSLGHISGAHINPAVT 118

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938523070  88 FAMCFLAREPWIKLPIYTLAQTLGAFLGAG---IVFGLYYDaiwafagnelVVSGPNGTagIFATYPSGhlDMVNGFFDQ 164
Cdd:PLN00184  119 IAFASCGRFPLKQVPAYVISQVIGSTLAAAtlrLLFGLDHD----------VCSGKHDV--FIGSSPVG--SDLQAFVME 184

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938523070 165 FIGTAALIVCVLAIVDpyNNPVPRGLEAFTVGLVVLVIGTSMGFNSGYAVNPARDFGPRL-FTALAGwgsevfttgqnwW 243
Cdd:PLN00184  185 FIVTFYLMFIISGVAT--DNRAIGELAGLAIGSTVLLNVLIAAPVSSASMNPGRSLGPAMvYGCYKG------------I 250

                         250       260
                  ....*....|....*....|.
gi 1938523070 244 WVPIVSPLLGSIGGVFVYQLM 264
Cdd:PLN00184  251 WIYIVAPTLGAIAGAWVYNTV 271
PLN00182 PLN00182
putative aquaporin NIP4; Provisional
 21-264 1.92e-19

putative aquaporin NIP4; Provisional


Pssm-ID: 165748  Cd Length: 283  Bit Score: 85.73  E-value: 1.92e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938523070  21 LLRQALAECLGTLILVMFGCGSVAQVVLSRGTHGgFLTINLAFGFAVTLAILVAGQVSGAHLNPAVTFAMCFLAREPWIK 100
Cdd:PLN00182   41 LTQKLIAEMIGTYFIIFSGCGVVVVNVLYGGTIT-FPGICVTWGLIVMVMIYSTGHISGAHFNPAVTVTFAIFRRFPWYQ 119

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938523070 101 LPIYTLAQTLGAFLGAGIVFGLYYDAIWAFAGNelVVSGPNGTAGIfatypsghLDMVNGFfdqfigtaaLIVCVLAIVD 180
Cdd:PLN00182  120 VPLYIGAQLTGSLLASLTLRLMFNVTPEAFFGT--TPTDSSGQALV--------AEIIISF---------LLMFVISGVA 180

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938523070 181 PYNNPVPRgLEAFTVGLVVLVIGTSMGFNSGYAVNPARDFGPRLFTALAgwgsevfttgqNWWWVPIVSPLLGSIGGVFV 260
Cdd:PLN00182  181 TDSRAVGE-LAGIAVGMTIILNVFVAGPISGASMNPARSLGPAIVMGRY-----------KGIWVYIVGPFVGIIAGGFV 248


                  ....
gi 1938523070 261 YQLM 264
Cdd:PLN00182  249 YNLI 252
PRK05420 PRK05420
aquaporin Z; Provisional
 21-266 3.00e-19

aquaporin Z; Provisional


Pssm-ID: 235453 [Multi-domain]  Cd Length: 231  Bit Score: 84.25  E-value: 3.00e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938523070  21 LLRQALAECLGTLILVMFGCGSVaqvVLSRGTHG---GFLTINLAFGFAVTLAILVAGQVSGAHLNPAVTFAMCFLAREP 97
Cdd:PRK05420    1 MFKKLAAEFFGTFWLVFGGCGSA---VLAAAFPElgiGFLGVALAFGLTVLTMAYAVGHISGGHFNPAVSVGLWAGGRFP 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938523070  98 WIKLPIYTLAQTLGAFLGAGIvfgLYYDAIWAfAGNELVVSG--PNGtagiFATYPSGHLDMVNGFFDQFIGTAALIVCV 175
Cdd:PRK05420   78 AKELVPYIIAQVVGGIAAAAV---LYLIASGK-AGFDLAGSGfaSNG----YGEHSPGGYSLLAALVCEVVLTAFFLLVI 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938523070 176 LAIVDpynNPVPRGLEAFTVGLVVLVIGTSMGFNSGYAVNPARDFGPRLFtaLAGWGsevftTGQNW-WWvpiVSPLLGS 254
Cdd:PRK05420  150 LGATD---KRAPAGFAPIAIGLALTLIHLISIPVTNTSVNPARSTGVALF--VGGWA-----LEQLWlFW---VAPIVGA 216

                         250
                  ....*....|..
gi 1938523070 255 IGGVFVYQLMIG 266
Cdd:PRK05420  217 IIGGLIYRLLLE 228
PLN00026 PLN00026
aquaporin NIP; Provisional
 21-261 2.74e-16

aquaporin NIP; Provisional


Pssm-ID: 177663 [Multi-domain]  Cd Length: 298  Bit Score: 77.21  E-value: 2.74e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938523070  21 LLRQALAECLGTLILVMFGcgsVAQVVLSRGTHGGFLTINLAF--GFAVTLAILVAGQVSGAHLNPAVTFAMCFLAREPW 98
Cdd:PLN00026   70 LTRKLGAEFVGTFILIFAA---TAGPIVNQKYDGAETLIGNAAcaGLAVMIVILSTGHISGAHLNPSLTIAFAALRHFPW 146

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938523070  99 IKLPIYTLAQTLGAFLGAGIVFGLYYdaiwafagnelvvsgPNGTAGIfaTYPSGHLDmvNGFFDQFIGTAALIVCVLAI 178
Cdd:PLN00026  147 KHVPAYIAAQVSASICASFALKGVFH---------------PFMSGGV--TVPSVSTG--QAFALEFIITFNLLFVVTAV 207

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938523070 179 VDpyNNPVPRGLEAFTVGLVVLVIGTSMGFNSGYAVNPARDFGPrlftALAGWGSEVFttgqnwwWVPIVSPLLGSIGGV 258
Cdd:PLN00026  208 AT--DTRAVGELAGIAVGATVMLNILVAGPSTGGSMNPVRTLGP----AVAAGNYRAI-------WIYLVAPTLGALAGA 274


                  ...
gi 1938523070 259 FVY 261
Cdd:PLN00026  275 GTY 277
PLN00027 PLN00027
aquaporin TIP; Provisional
 22-277 1.19e-11

aquaporin TIP; Provisional


Pssm-ID: 177664  Cd Length: 252  Bit Score: 63.27  E-value: 1.19e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938523070  22 LRQALAECLGTLILVMFGCGS-VAQVVLSRG---THGGFLTINLAFGFAVTLAILVAGQVSGAHLNPAVTFAMCFLAREP 97
Cdd:PLN00027   20 LKAALAEFISTLIFVFAGEGSgMAFNKLTDNgstTPAGLVAAALAHAFALFVAVSVGANISGGHVNPAVTFGAFIGGNIT 99

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938523070  98 WIKLPIYTLAQTLGAFLGAGIVfglyydaiwAFAGNELVVSGPNGTAGIFAtypsghldmVNGFFDQFIGTAALIVCVLA 177
Cdd:PLN00027  100 LLRGILYWIAQLLGSVVACLLL---------KFSTGGLETSAFSLSSGVGV---------WNAFVFEIVMTFGLVYTVYA 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938523070 178 I-VDPYNNPVprGLEA-FTVGLVVLVIGTSMGFNSGYAVNPARDFGPrlftALAGWgsevfttgqNWW--WVPIVSPLLG 253
Cdd:PLN00027  162 TaVDPKKGDL--GIIApIAIGFIVGANILAGGAFDGASMNPAVSFGP----AVVSW---------TWTnhWVYWAGPLIG 226

                         250       260
                  ....*....|....*....|....*
gi 1938523070 254 SIGGVFVYQLM-IGCHLEQPLPSTE 277
Cdd:PLN00027  227 GGIAGLVYELIfIGSTTHEQLPTTD 251
PLN00166 PLN00166
aquaporin TIP2; Provisional
 22-277 5.40e-10

aquaporin TIP2; Provisional


Pssm-ID: 165733  Cd Length: 250  Bit Score: 58.41  E-value: 5.40e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938523070  22 LRQALAECLGTLILVMFGCGS-VAQVVLSRGTH---GGFLTINLAFGFAVTLAILVAGQVSGAHLNPAVTFAMCFLAREP 97
Cdd:PLN00166   18 LKAYLSEFIATLLFVFAGVGSaIAFAKLTSDAAldpAGLVAVAVAHAFALFVGVSIAANISGGHLNPAVTLGLAIGGNIT 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938523070  98 WIKLPIYTLAQTLGAFLGAGIVfglyydaiwAFAGNELVVSGPNGTAGIFAtypsghldmVNGFFDQFIGTAALIVCVLA 177
Cdd:PLN00166   98 IITGFFYWIAQCLGSIVACLLL---------VFVTNGESVPTHGVAAGLGA---------IEGVVMEIVVTFALVYTVYA 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938523070 178 I-VDPYNNPVPRgLEAFTVGLVVLVIGTSMGFNSGYAVNPARDFGPRLFTAlagwgsevfTTGQNW-WWV-PIVSpllGS 254
Cdd:PLN00166  160 TaADPKKGSLGT-IAPIAIGFIVGANILAAGPFSGGSMNPARSFGPAVVSG---------DFSQIWiYWVgPLVG---GA 226

                         250       260
                  ....*....|....*....|...
gi 1938523070 255 IGGVFVYQLMIGCHleQPLPSTE 277
Cdd:PLN00166  227 LAGLIYGDVFIGSY--AAAPTSE 247
PLN00167 PLN00167
aquaporin TIP5; Provisional
 22-114 1.03e-04

aquaporin TIP5; Provisional


Pssm-ID: 215085  Cd Length: 256  Bit Score: 42.97  E-value: 1.03e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938523070  22 LRQALAECLGTLILVMFGCGSV--AQVVLSRGTHG--GFLTINLAFGFAVTLAILVAGQVSGAHLNPAVTFAMCFLARep 97
Cdd:PLN00167   22 LRSYLAEFISTFFFVFAAVGSAmsSRKLMPDAASDpsSLLIVAIANAFALSSAVYIAANISGGHVNPAVTFGMAVGGH-- 99

                          90       100
                  ....*....|....*....|
gi 1938523070  98 wIKLP---IYTLAQTLGAFL 114
Cdd:PLN00167  100 -ISVPtamFYWISQMLASVM 118
GlpF COG0580
Glycerol uptake facilitator or related aquaporin (Major Intrinsic protein Family) ...
 17-123 6.43e-04

Glycerol uptake facilitator or related aquaporin (Major Intrinsic protein Family) [Carbohydrate transport and metabolism];


Pssm-ID: 440345 [Multi-domain]  Cd Length: 232  Bit Score: 40.11  E-value: 6.43e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938523070  17 IRYRLLRQALAECLGTLILVM--FGCGSvaqvvlSRGTHGGFLTinLAFGFAVTLAILVAGQVSGAHLNPAVTFA---MC 91
Cdd:COG0580   126 IGYSLGAAFLTEIIGTFVLVFviLGITD------KRAAPGGLAP--LAIGLLVAAIGLSLGPLTGYAINPARDLGprlFH 197

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1938523070  92 FLAR--EPWIKLPIYTLAQTLGAFLGAGIVFGLY 123
Cdd:COG0580   198 ALGKggSDWGYLWVPIVAPILGAALAALLYRALF 231
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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