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    Dcdc2c doublecortin domain containing 2C [ Rattus norvegicus (Norway rat) ]

    Gene ID: 500637, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Dcdc2cprovided by RGD
    Official Full Name
    doublecortin domain containing 2Cprovided by RGD
    Primary source
    RGD:1559651
    See related
    EnsemblRapid:ENSRNOG00000067604 AllianceGenome:RGD:1559651
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1559651
    Summary
    Predicted to be involved in intracellular signal transduction. Predicted to be located in cytoplasm and sperm flagellum. Orthologous to human DCDC2C (doublecortin domain containing 2C). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward (RPKM 16.0) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Dcdc2c in Genome Data Viewer
    Location:
    6q16
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (50832407..50907437, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (45103838..45179040, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (47737814..47812219, complement)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene nucleophosmin 1, pseudogene 19 Neighboring gene aldo-keto reductase family 1, member B1 (aldose reductase), pseudogene 1 Neighboring gene allantoicase Neighboring gene U6 spliceosomal RNA Neighboring gene collectin sub-family member 11

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Defining the human sperm microtubulome: an integrated genomics approach. Jumeau F, et al. Biol Reprod, 2017 Jan 1. PMID 28395323
    2. The doublecortin gene family and disorders of neuronal structure. Dijkmans TF, et al. Cent Nerv Syst Agents Med Chem, 2010 Mar. PMID 20236041
    3. The evolving doublecortin (DCX) superfamily. Reiner O, et al. BMC Genomics, 2006 Jul 26. PMID 16869982, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in microtubule organizing center IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in sperm flagellum ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    doublecortin domain-containing protein 2C

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001195807.1 → NP_001182736.1  doublecortin domain-containing protein 2C

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/TrEMBL
      D3Z9D4
      Related
      ENSRNOP00000010942.6, ENSRNOT00000010942.8
      Conserved Domains (2) summary
      cd01617
      Location:16 → 94
      DCX; Ubiquitin-like domain of DCX
      pfam03607
      Location:160 → 207
      DCX; Doublecortin

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      50832407..50907437 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063262307.1 → XP_063118377.1  doublecortin domain-containing protein 2C isoform X15

    2. XM_039112713.2 → XP_038968641.1  doublecortin domain-containing protein 2C isoform X2

      Conserved Domains (2) summary
      PRK10263
      Location:504 → 671
      PRK10263; DNA translocase FtsK; Provisional
      cl28922
      Location:16 → 94
      Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

    3. XM_006239958.5 → XP_006240020.1  doublecortin domain-containing protein 2C isoform X14

      Conserved Domains (2) summary
      cd01617
      Location:16 → 94
      DCX; Ubiquitin-like domain of DCX
      pfam03607
      Location:160 → 207
      DCX; Doublecortin

    4. XM_017594297.3 → XP_017449786.2  doublecortin domain-containing protein 2C isoform X5

      Conserved Domains (2) summary
      PRK10263
      Location:403 → 553
      PRK10263; DNA translocase FtsK; Provisional
      cl28922
      Location:16 → 94
      Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

    5. XM_017594294.3 → XP_017449783.2  doublecortin domain-containing protein 2C isoform X3

      Related
      ENSRNOP00000080351.2, ENSRNOT00000099045.2
      Conserved Domains (2) summary
      PRK10263
      Location:491 → 658
      PRK10263; DNA translocase FtsK; Provisional
      cl28922
      Location:16 → 94
      Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

    6. XM_017594301.3 → XP_017449790.1  doublecortin domain-containing protein 2C isoform X11

      UniProtKB/TrEMBL
      A0A8I5ZV25
      Related
      ENSRNOP00000082312.1, ENSRNOT00000108156.2

    7. XM_039112714.2 → XP_038968642.1  doublecortin domain-containing protein 2C isoform X4

      Conserved Domains (2) summary
      PRK10263
      Location:417 → 567
      PRK10263; DNA translocase FtsK; Provisional
      cl28922
      Location:16 → 94
      Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

    8. XM_039112712.2 → XP_038968640.1  doublecortin domain-containing protein 2C isoform X1

      Conserved Domains (2) summary
      PRK10263
      Location:505 → 672
      PRK10263; DNA translocase FtsK; Provisional
      cl28922
      Location:16 → 94
      Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

    9. XM_039112715.2 → XP_038968643.1  doublecortin domain-containing protein 2C isoform X6

      Conserved Domains (2) summary
      PRK10263
      Location:398 → 548
      PRK10263; DNA translocase FtsK; Provisional
      cl28922
      Location:28 → 106
      Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

    10. XM_039112716.2 → XP_038968644.1  doublecortin domain-containing protein 2C isoform X6

      Conserved Domains (2) summary
      PRK10263
      Location:398 → 548
      PRK10263; DNA translocase FtsK; Provisional
      cl28922
      Location:28 → 106
      Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

    11. XM_006239956.5 → XP_006240018.1  doublecortin domain-containing protein 2C isoform X12

      UniProtKB/TrEMBL
      A0A8I5ZSW5
      Conserved Domains (2) summary
      cd01617
      Location:16 → 94
      DCX; Ubiquitin-like domain of DCX
      pfam03607
      Location:160 → 207
      DCX; Doublecortin

    12. XM_017594300.3 → XP_017449789.1  doublecortin domain-containing protein 2C isoform X10

    13. XM_039112719.2 → XP_038968647.1  doublecortin domain-containing protein 2C isoform X9

      Conserved Domains (1) summary
      cl28922
      Location:16 → 94
      Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

    14. XM_039112718.2 → XP_038968646.1  doublecortin domain-containing protein 2C isoform X8

      Conserved Domains (1) summary
      cl28922
      Location:16 → 94
      Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

    15. XM_039112717.2 → XP_038968645.1  doublecortin domain-containing protein 2C isoform X7

      Conserved Domains (1) summary
      cl28922
      Location:16 → 94
      Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

    16. XM_039112721.2 → XP_038968649.1  doublecortin domain-containing protein 2C isoform X16

      Conserved Domains (1) summary
      cl28922
      Location:16 → 94
      Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

    17. XM_006239957.5 → XP_006240019.1  doublecortin domain-containing protein 2C isoform X13

      Conserved Domains (2) summary
      cd01617
      Location:16 → 94
      DCX; Ubiquitin-like domain of DCX
      pfam03607
      Location:160 → 207
      DCX; Doublecortin
    Nucleotide Protein Strain
    Heading Accession and Version

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