NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1958784181|ref|XP_017449786|]
View 

doublecortin domain-containing protein 2C isoform X5 [Rattus norvegicus]

Protein Classification

ubiquitin family protein( domain architecture ID 1000087)

ubiquitin family protein belongs to an diverse class of protein modifier and gene expression regulatory proteins that participate in a number of cellular processes

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Ubl1_cv_Nsp3_N-like super family cl28922
first ubiquitin-like (Ubl) domain located at the N-terminus of coronavirus SARS-CoV ...
 16-94 4.89e-39

first ubiquitin-like (Ubl) domain located at the N-terminus of coronavirus SARS-CoV non-structural protein 3 (Nsp3) and related proteins; This ubiquitin-like (Ubl) domain (Ubl1) is found at the N-terminus of coronavirus Nsp3, a large multi-functional multi-domain protein which is an essential component of the replication/transcription complex (RTC). The functions of Ubl1 in CoVs are related to single-stranded RNA (ssRNA) binding and to interacting with the nucleocapsid (N) protein. SARS-CoV Ubl1 has been shown to bind ssRNA having AUA patterns, and since the 5'-UTR of the SARS-CoV genome has a number of AUA repeats, it may bind there. In mouse hepatitis virus (MHV), this Ubl1 domain binds the cognate N protein. Adjacent to Ubl1 is a Glu-rich acidic region (also referred to as hypervariable region, HVR); Ubl1 together with HVR has been called Nsp3a. Currently, the function of HVR in CoVs is unknown. This model corresponds to one of two Ubl domains in Nsp3; the other is located N-terminal to the papain-like protease (PLpro) and is not represented by this model.


The actual alignment was detected with superfamily member cd17151:

Pssm-ID: 475130  Cd Length: 79  Bit Score: 137.61  E-value: 4.89e-39
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1958784181  16 KTILVYRNGDQFYVGRKFVFSRRRVANFEALLEQLTEQVEVPFGVRRLYTPTYGHRVLELESLQTGGKYVAAGRERFKK 94
Cdd:cd17151     1 KTILVYRNGDPFYQAHKVVIHRRRVKTFDALLRQLTETVKVPFGVRCLYTPRNGHRVKGLDDLQGGGKYVAAGRERFKK 79
Ubl1_cv_Nsp3_N-like super family cl28922
first ubiquitin-like (Ubl) domain located at the N-terminus of coronavirus SARS-CoV ...
 135-213 8.36e-30

first ubiquitin-like (Ubl) domain located at the N-terminus of coronavirus SARS-CoV non-structural protein 3 (Nsp3) and related proteins; This ubiquitin-like (Ubl) domain (Ubl1) is found at the N-terminus of coronavirus Nsp3, a large multi-functional multi-domain protein which is an essential component of the replication/transcription complex (RTC). The functions of Ubl1 in CoVs are related to single-stranded RNA (ssRNA) binding and to interacting with the nucleocapsid (N) protein. SARS-CoV Ubl1 has been shown to bind ssRNA having AUA patterns, and since the 5'-UTR of the SARS-CoV genome has a number of AUA repeats, it may bind there. In mouse hepatitis virus (MHV), this Ubl1 domain binds the cognate N protein. Adjacent to Ubl1 is a Glu-rich acidic region (also referred to as hypervariable region, HVR); Ubl1 together with HVR has been called Nsp3a. Currently, the function of HVR in CoVs is unknown. This model corresponds to one of two Ubl domains in Nsp3; the other is located N-terminal to the papain-like protease (PLpro) and is not represented by this model.


The actual alignment was detected with superfamily member cd17154:

Pssm-ID: 475130  Cd Length: 80  Bit Score: 112.21  E-value: 8.36e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958784181 135 SRYINVFTNGRLFIPPIKIIIPKFSLSDWNSVLAMIGEKVFP-LGGVRKLFTMDGHLLDDSKNLQDNYFYVAAGLESFKS 213
Cdd:cd17154     1 SRTINVFTNGEVLVPPAKIIIPKFTLRSWENVLAMITEKAFLrTGGVFRLCTLNGHPVSDSTELEDNHYYVAVGSEKFKA 80
PRK10263 super family cl35903
DNA translocase FtsK; Provisional
 403-553 2.24e-06

DNA translocase FtsK; Provisional


The actual alignment was detected with superfamily member PRK10263:

Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 50.85  E-value: 2.24e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958784181  403 QTDPSVRQESLEKSSLTQDQRHEQQESfiksslGAPPPEQRPEMKESPRQLFLGPTPPEHQLEQQEIPEQSSFGPPSPEQ 482
Cdd:PRK10263   690 DADAAAEAELARQFAQTQQQRYSGEQP------AGANPFSLDDFEFSPMKALLDDGPHEPLFTPIVEPVQQPQQPVAPQQ 763

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1958784181  483 QLEQQEIPVqlslGPPSPEQQLEQPEIPVQSFLGP-------PSTEQQLEQGSPGQLFLGPSSPKPPEHQFEQQEIPA 553
Cdd:PRK10263   764 QYQQPQQPV----APQPQYQQPQQPVAPQPQYQQPqqpvapqPQYQQPQQPVAPQPQYQQPQQPVAPQPQYQQPQQPV 837
 
Name Accession Description Interval E-value
DCX1_DCDC2C cd17151
Dublecortin-like domain 1 found in doublecortin domain-containing protein 2C (DCDC2C); DCDC2 ...
 16-94 4.89e-39

Dublecortin-like domain 1 found in doublecortin domain-containing protein 2C (DCDC2C); DCDC2 is a member of doublecortin (DCX) family. It is a microtubule-associated protein (MAP) with stable double tandem DCX repeats of ubiquitin-like tertiary fold. Microtubules are key components of the cytoskeleton that are involved in cell movement, shape determination, division and transport. DCDC2 genetic variation in humans is associated with reading disability, attention deficit hyperactivity disorder (ADHD), and difficulties in mathematics. A genetic variant of DCDC2 associates with dyslexia, a common neurobehavioral disorder of reading. DCDC2 protein interacts with many of the same cytoskeleton related proteins that other members of the DCX family interact with.


Pssm-ID: 340671  Cd Length: 79  Bit Score: 137.61  E-value: 4.89e-39
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1958784181  16 KTILVYRNGDQFYVGRKFVFSRRRVANFEALLEQLTEQVEVPFGVRRLYTPTYGHRVLELESLQTGGKYVAAGRERFKK 94
Cdd:cd17151     1 KTILVYRNGDPFYQAHKVVIHRRRVKTFDALLRQLTETVKVPFGVRCLYTPRNGHRVKGLDDLQGGGKYVAAGRERFKK 79
DCX2_DCDC2C cd17154
Doublecortin-like domain 2 found in doublecortin domain-containing protein 2C (DCDC2C); DCDC2 ...
 135-213 8.36e-30

Doublecortin-like domain 2 found in doublecortin domain-containing protein 2C (DCDC2C); DCDC2 is a member of the doublecortin (DCX) family. It is a microtubule-associated protein (MAP) with stable double tandem DCX repeats of a ubiquitin-like tertiary fold. Microtubules are key components of cytoskeleton that are involved in cell movement, shape determination, division and transport. DCDC2 genetic variation in humans is associated with reading disability, attention deficit hyperactivity disorder (ADHD), and difficulties in mathematics. A genetic variant of DCDC2 associates with dyslexia, a common neurobehavioral disorder of reading. DCDC2 protein interacts with many of the same cytoskeleton related proteins that other members of the DCX family interact with.


Pssm-ID: 340674  Cd Length: 80  Bit Score: 112.21  E-value: 8.36e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958784181 135 SRYINVFTNGRLFIPPIKIIIPKFSLSDWNSVLAMIGEKVFP-LGGVRKLFTMDGHLLDDSKNLQDNYFYVAAGLESFKS 213
Cdd:cd17154     1 SRTINVFTNGEVLVPPAKIIIPKFTLRSWENVLAMITEKAFLrTGGVFRLCTLNGHPVSDSTELEDNHYYVAVGSEKFKA 80
DCX smart00537
Domain in the Doublecortin (DCX) gene product; Tandemly-repeated domain in doublin, the ...
 15-97 3.67e-25

Domain in the Doublecortin (DCX) gene product; Tandemly-repeated domain in doublin, the Doublecortin gene product. Proposed to bind tubulin. Doublecortin (DCX) is mutated in human X-linked neuronal migration defects.


Pssm-ID: 214711  Cd Length: 89  Bit Score: 99.25  E-value: 3.67e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958784181   15 AKTILVYRNGDQFYVGRKFVFSRRRVANFEALLEQLTEQV--EVPFGVRRLYTPTyGHRVLELESLQTGGKYVAAGRERF 92
Cdd:smart00537   5 PKRIRFYRNGDRFFKGVRLVVNRKRFKSFEALLQDLTEVVklDLPHGVRKLYTLD-GKKVTSLDELEDGGSYVASGTEAF 83


                   ....*
gi 1958784181   93 KKLDY 97
Cdd:smart00537  84 KKVDY 88
DCX pfam03607
Doublecortin;
34-92 9.87e-19

Doublecortin;


Pssm-ID: 460986  Cd Length: 60  Bit Score: 80.18  E-value: 9.87e-19
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1958784181  34 VFSRRRVANFEALLEQLTEQV-EVPFG-VRRLYTPTyGHRVLELESLQTGGKYVAAGRERF 92
Cdd:pfam03607   1 VVNKRRFRSFDALLDELTEKVvKLPFGaVRKLYTLD-GKRVTSLDELEDGGVYVAAGREKF 60
DCX pfam03607
Doublecortin;
159-211 1.03e-12

Doublecortin;


Pssm-ID: 460986  Cd Length: 60  Bit Score: 62.85  E-value: 1.03e-12
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1958784181 159 SLSDWNSVLAMIGEKV--FPLGGVRKLFTMDGHLLDDSKNLQDNYFYVAAGLESF 211
Cdd:pfam03607   6 RFRSFDALLDELTEKVvkLPFGAVRKLYTLDGKRVTSLDELEDGGVYVAAGREKF 60
DCX smart00537
Domain in the Doublecortin (DCX) gene product; Tandemly-repeated domain in doublin, the ...
 136-216 1.99e-07

Domain in the Doublecortin (DCX) gene product; Tandemly-repeated domain in doublin, the Doublecortin gene product. Proposed to bind tubulin. Doublecortin (DCX) is mutated in human X-linked neuronal migration defects.


Pssm-ID: 214711  Cd Length: 89  Bit Score: 48.79  E-value: 1.99e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958784181  136 RYINVFTNGRLFIPPIKIIIPKFSLSDWNSVLAMIGEKV-FPLG-GVRKLFTMDGHLLDDSKNLQDNYFYVAAGLESFKS 213
Cdd:smart00537   6 KRIRFYRNGDRFFKGVRLVVNRKRFKSFEALLQDLTEVVkLDLPhGVRKLYTLDGKKVTSLDELEDGGSYVASGTEAFKK 85


                   ...
gi 1958784181  214 IPY 216
Cdd:smart00537  86 VDY 88
PRK10263 PRK10263
DNA translocase FtsK; Provisional
 403-553 2.24e-06

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 50.85  E-value: 2.24e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958784181  403 QTDPSVRQESLEKSSLTQDQRHEQQESfiksslGAPPPEQRPEMKESPRQLFLGPTPPEHQLEQQEIPEQSSFGPPSPEQ 482
Cdd:PRK10263   690 DADAAAEAELARQFAQTQQQRYSGEQP------AGANPFSLDDFEFSPMKALLDDGPHEPLFTPIVEPVQQPQQPVAPQQ 763

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1958784181  483 QLEQQEIPVqlslGPPSPEQQLEQPEIPVQSFLGP-------PSTEQQLEQGSPGQLFLGPSSPKPPEHQFEQQEIPA 553
Cdd:PRK10263   764 QYQQPQQPV----APQPQYQQPQQPVAPQPQYQQPqqpvapqPQYQQPQQPVAPQPQYQQPQQPVAPQPQYQQPQQPV 837
PAT1 pfam09770
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ...
 391-531 2.56e-05

Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.


Pssm-ID: 401645 [Multi-domain]  Cd Length: 846  Bit Score: 47.34  E-value: 2.56e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958784181 391 LALPETQEKVEVQTDPSVRQESLEKSSLTQDQRHEQQESFIKSSLGAPPPEQRPEMKESPRQlFLGPTPPEHQLE-QQEI 469
Cdd:pfam09770 194 MSLEEVEAAMRAQAKKPAQQPAPAPAQPPAAPPAQQAQQQQQFPPQIQQQQQPQQQPQQPQQ-HPGQGHPVTILQrPQSP 272

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1958784181 470 PEQSSFGPPSPEQQLEQQEIPVQlslgPPSPEQQLEQPEIPVQSFLGPPSTEQQLEQGSPGQ 531
Cdd:pfam09770 273 QPDPAQPSIQPQAQQFHQQPPPV----PVQPTQILQNPNRLSAARVGYPQNPQPGVQPAPAH 330
 
Name Accession Description Interval E-value
DCX1_DCDC2C cd17151
Dublecortin-like domain 1 found in doublecortin domain-containing protein 2C (DCDC2C); DCDC2 ...
 16-94 4.89e-39

Dublecortin-like domain 1 found in doublecortin domain-containing protein 2C (DCDC2C); DCDC2 is a member of doublecortin (DCX) family. It is a microtubule-associated protein (MAP) with stable double tandem DCX repeats of ubiquitin-like tertiary fold. Microtubules are key components of the cytoskeleton that are involved in cell movement, shape determination, division and transport. DCDC2 genetic variation in humans is associated with reading disability, attention deficit hyperactivity disorder (ADHD), and difficulties in mathematics. A genetic variant of DCDC2 associates with dyslexia, a common neurobehavioral disorder of reading. DCDC2 protein interacts with many of the same cytoskeleton related proteins that other members of the DCX family interact with.


Pssm-ID: 340671  Cd Length: 79  Bit Score: 137.61  E-value: 4.89e-39
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1958784181  16 KTILVYRNGDQFYVGRKFVFSRRRVANFEALLEQLTEQVEVPFGVRRLYTPTYGHRVLELESLQTGGKYVAAGRERFKK 94
Cdd:cd17151     1 KTILVYRNGDPFYQAHKVVIHRRRVKTFDALLRQLTETVKVPFGVRCLYTPRNGHRVKGLDDLQGGGKYVAAGRERFKK 79
DCX1_DCDC2_like cd17071
Dublecortin-like domain 1 found in doublecortin domain-containing protein 2 (DCDC2) and ...
 16-94 3.44e-37

Dublecortin-like domain 1 found in doublecortin domain-containing protein 2 (DCDC2) and similar proteins; DCDC2 is a member of the doublecortin (DCX) family. It is a microtubule-associated protein (MAP) with stable double tandem DCX repeats of ubiquitin-like tertiary fold. Ubiquitin (Ub) is a protein modifier in eukaryotes that is involved in various cellular processes, including transcriptional regulation, cell cycle control, and DNA repair. Microtubules are key components of the cytoskeleton that are involved in cell movement, shape determination, division and transport. DCDC2 genetic variation in humans is associated with reading disability, attention deficit hyperactivity disorder (ADHD), and difficulties in mathematics. A genetic variant of DCDC2 associates with dyslexia, a common neurobehavioral disorder of reading. DCDC2 protein interacts with many of the same cytoskeleton related proteins that other members of the DCX family interact with.


Pssm-ID: 340591  Cd Length: 80  Bit Score: 132.73  E-value: 3.44e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958784181  16 KTILVYRNGDQFYVGRKFVFSRRRVANFEALLEQLTEQVEVPFG-VRRLYTPTYGHRVLELESLQTGGKYVAAGRERFKK 94
Cdd:cd17071     1 KIIVVYKNGDPFFPGKKFVVNERQVRTFDAFLNEVTSGIKAPFGaVRSIYTPTGGHRVKDLDSLQNGGVYVAAGSERFKK 80
DCX1_DCDC2 cd17149
Dublecortin-like domain 1 found in doublecortin domain-containing protein 2 (DCDC2); DCDC2 is ...
 16-94 3.73e-31

Dublecortin-like domain 1 found in doublecortin domain-containing protein 2 (DCDC2); DCDC2 is a member of doublecortin (DCX) family. It is a microtubule-associated protein (MAP) with a stable ubiquitin-like tertiary fold. Ubiquitin (Ub) is a protein modifier in eukaryotes that is involved in various cellular processes, including transcriptional regulation, cell cycle control, and DNA repair. Microtubules are key components of the cytoskeleton that are involved in cell movement, shape determination, division and transport. DCDC2 genetic variation in humans is associated with reading disability, attention deficit hyperactivity disorder (ADHD), and difficulties in mathematics. A genetic variant of DCDC2 associates with dyslexia, a common neurobehavioral disorder of reading. DCDC2 protein interacts with many of the same cytoskeleton related proteins that other members of the DCX family interact with.


Pssm-ID: 340669  Cd Length: 80  Bit Score: 116.03  E-value: 3.73e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958784181  16 KTILVYRNGDQFYVGRKFVFSRRRVANFEALLEQLTEQVEVPFG-VRRLYTPTYGHRVLELESLQTGGKYVAAGRERFKK 94
Cdd:cd17149     1 KNVLVYRNGDPFYAGRRLVINEKRVSSFEVFLKEVTGGVQAPFGaVRNIYTPRGGHRVRSLEQLQSGEQYVAAGRERFKK 80
DCX1_DCDC2B cd17150
Dublecortin-like domain 1 found in doublecortin domain-containing protein 2B (DCDC2B); DCDC2 ...
 16-94 4.30e-30

Dublecortin-like domain 1 found in doublecortin domain-containing protein 2B (DCDC2B); DCDC2 is a member of doublecortin (DCX) family. It is a microtubule-associated protein (MAP) with stable double tandem DCX repeats of ubiquitin-like tertiary fold. Microtubules are key components of the cytoskeleton that are involved in cell movement, shape determination, division and transport. DCDC2 genetic variation in humans is associated with reading disability, attention deficit hyperactivity disorder (ADHD), and difficulties in mathematics. A genetic variant of DCDC2 associates with dyslexia, a common neurobehavioral disorder of reading. DCDC2 protein interacts with many of the same cytoskeleton related proteins that other members of the DCX family interact with.


Pssm-ID: 340670  Cd Length: 79  Bit Score: 112.97  E-value: 4.30e-30
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1958784181  16 KTILVYRNGDQFYVGRKFVFSRRRVANFEALLEQLTEQVEVPFGVRRLYTPTYGHRVLELESLQTGGKYVAAGRERFKK 94
Cdd:cd17150     1 KNVVVYRNGDPFFTGRKFVVNQRQFLTFEAFLNEVTSNIQAPVAVRNLYTPREGHRVTELGDLQNGGHYVAAGFERFKK 79
DCX2_DCDC2C cd17154
Doublecortin-like domain 2 found in doublecortin domain-containing protein 2C (DCDC2C); DCDC2 ...
 135-213 8.36e-30

Doublecortin-like domain 2 found in doublecortin domain-containing protein 2C (DCDC2C); DCDC2 is a member of the doublecortin (DCX) family. It is a microtubule-associated protein (MAP) with stable double tandem DCX repeats of a ubiquitin-like tertiary fold. Microtubules are key components of cytoskeleton that are involved in cell movement, shape determination, division and transport. DCDC2 genetic variation in humans is associated with reading disability, attention deficit hyperactivity disorder (ADHD), and difficulties in mathematics. A genetic variant of DCDC2 associates with dyslexia, a common neurobehavioral disorder of reading. DCDC2 protein interacts with many of the same cytoskeleton related proteins that other members of the DCX family interact with.


Pssm-ID: 340674  Cd Length: 80  Bit Score: 112.21  E-value: 8.36e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958784181 135 SRYINVFTNGRLFIPPIKIIIPKFSLSDWNSVLAMIGEKVFP-LGGVRKLFTMDGHLLDDSKNLQDNYFYVAAGLESFKS 213
Cdd:cd17154     1 SRTINVFTNGEVLVPPAKIIIPKFTLRSWENVLAMITEKAFLrTGGVFRLCTLNGHPVSDSTELEDNHYYVAVGSEKFKA 80
DCX smart00537
Domain in the Doublecortin (DCX) gene product; Tandemly-repeated domain in doublin, the ...
 15-97 3.67e-25

Domain in the Doublecortin (DCX) gene product; Tandemly-repeated domain in doublin, the Doublecortin gene product. Proposed to bind tubulin. Doublecortin (DCX) is mutated in human X-linked neuronal migration defects.


Pssm-ID: 214711  Cd Length: 89  Bit Score: 99.25  E-value: 3.67e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958784181   15 AKTILVYRNGDQFYVGRKFVFSRRRVANFEALLEQLTEQV--EVPFGVRRLYTPTyGHRVLELESLQTGGKYVAAGRERF 92
Cdd:smart00537   5 PKRIRFYRNGDRFFKGVRLVVNRKRFKSFEALLQDLTEVVklDLPHGVRKLYTLD-GKKVTSLDELEDGGSYVASGTEAF 83


                   ....*
gi 1958784181   93 KKLDY 97
Cdd:smart00537  84 KKVDY 88
DCX cd01617
Dublecortin-like domain structurally similar to a beta-grasp ubiquitin-like fold; Dublecortin ...
 16-88 5.28e-20

Dublecortin-like domain structurally similar to a beta-grasp ubiquitin-like fold; Dublecortin (DCX) is a microtubule-associated protein (MAP) with a stable ubiquitin-like tertiary fold. Ubiquitin (Ub) is a protein modifier in eukaryotes that is involved in various cellular processes, including transcriptional regulation, cell cycle control, and DNA repair. Microtubules are key components of the cytoskeleton that are involved in cell movement, shape determination, division and transport. The DCX gene family consists of eleven paralogs in human and mouse, and its DCX protein domains can occur in double tandem or as single DCX repeats. Proteins with DCX tandem domains in general have roles in microtubule (MT) regulation and signal transduction such as X-linked doublecortin (DCX), retinitis pigmentosa-1 (RP1) and doublecortin-like kinase (DCLK). Single DCX repeat proteins are normally localized to actin-rich subcellular structures, or the nucleus such as DCDC2. DCX is not only a unique MAP in terms of structure, it also interacts with multiple additional proteins. Mutations in human DCX genes are associated with abnormal neuronal migration, epilepsy, and mental retardation.


Pssm-ID: 340456  Cd Length: 73  Bit Score: 84.20  E-value: 5.28e-20
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1958784181  16 KTILVYRNGDQFYVGRKFVFSRRRVANFEALLEQLTEQVEV-PFGVRRLYTPTyGHRVLELESLQTGGKYVAAG 88
Cdd:cd01617     1 KRITVFRNGDKNFKGVKVLVKPRRFRTFDQLLDELTEKLGLpTGGVRKLYTPS-GKLVKSLSDLEDGESYVVCG 73
DCX pfam03607
Doublecortin;
34-92 9.87e-19

Doublecortin;


Pssm-ID: 460986  Cd Length: 60  Bit Score: 80.18  E-value: 9.87e-19
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1958784181  34 VFSRRRVANFEALLEQLTEQV-EVPFG-VRRLYTPTyGHRVLELESLQTGGKYVAAGRERF 92
Cdd:pfam03607   1 VVNKRRFRSFDALLDELTEKVvKLPFGaVRKLYTLD-GKRVTSLDELEDGGVYVAAGREKF 60
DCX2_DCDC2_like cd16113
Doublecortin-like domain 2 found in doublecortin domain-containing protein 2 (DCDC2); DCDC2 is ...
 135-207 1.25e-18

Doublecortin-like domain 2 found in doublecortin domain-containing protein 2 (DCDC2); DCDC2 is a member of the doublecortin (DCX) family. It is a microtubule-associated protein (MAP) with stable double tandem DCX repeats of a ubiquitin-like tertiary fold. Ubiquitin (Ub) is a protein modifier in eukaryotes that is involved in various cellular processes including transcriptional regulation, cell cycle control, and DNA repair. Microtubules are key components of cytoskeleton that are involved in cell movement, shape determination, division and transport. DCDC2 genetic variation in humans is associated with reading disability, attention deficit hyperactivity disorder (ADHD), and difficulties in mathematics. A genetic variant of DCDC2 associates with dyslexia, a common neurobehavioral disorder of reading. DCDC2 protein interacts with many of the same cytoskeleton related proteins that other members of the DCX family interact with.


Pssm-ID: 340530  Cd Length: 74  Bit Score: 80.31  E-value: 1.25e-18
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1958784181 135 SRYINVFTNGRLFIPPIKIIIPKFSLSDWNSVLAMIGEKVFP-LGGVRKLFTMDGHLLDDSKNLQDNYFYVAAG 207
Cdd:cd16113     1 PKTIHVFPNGDLLHPPSKVLLTKRRLPNWDTVLEEVTEKVKLqTGAVRKLYTLDGKRISDPDELVNGGQYVAVG 74
DCX1_RP_like cd16110
Doublecortin-like domain 1 found in retinitis pigmentosa (RP)-like protein; RP-like protein ...
 16-86 3.30e-16

Doublecortin-like domain 1 found in retinitis pigmentosa (RP)-like protein; RP-like protein family is part of doublecortin (DCX) family. It has double tandem DCX repeats that are associated with retinitis pigmentosa. DCX is a microtubule-associated protein (MAP) with a stable ubiquitin-like tertiary fold. Microtubules are key components of cytoskeleton that are involved in cell movement, shape determination, division and transport. RP-like proteins are colocalized to the photoreceptor and share a function in outer segment disc morphogenesis.


Pssm-ID: 340527  Cd Length: 75  Bit Score: 73.49  E-value: 3.30e-16
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1958784181  16 KTILVYRNGDQFYVGRKFVFSRRRVANFEALLEQLTEQVEVPFGVRRLYTPTYGHRVLELESLQTGGKYVA 86
Cdd:cd16110     1 KNVTFYKDGDVHFSGVRVAINPRRYRTFDALLDELSRKVPLPFGVRSITTPRGRHSITSLEQLEDGGKYVC 71
DCX1 cd16109
Dublecortin-like domain 1; Members of the doublecortin (DCX) gene family are ...
 15-94 5.87e-16

Dublecortin-like domain 1; Members of the doublecortin (DCX) gene family are microtubule-associated proteins (MAPs). Microtubules are key components of cytoskeleton that are involved in cell movement, shape determination, division and transport. The DCX gene family consists of eleven paralogs in human and mouse, and its protein domains can occur in double tandem or single repeats. The family represents the first repeat of the DCX domain which has a stable ubiquitin-like tertiary fold. Proteins with DCX double tandem domains in general have roles in microtubule (MT) regulation and signal transduction such as X-linked doublecortin (DCX), retinitis pigmentosa-1 (RP1) and doublecortin-like kinase (DCLK).


Pssm-ID: 340526  Cd Length: 85  Bit Score: 73.10  E-value: 5.87e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958784181  15 AKTILVYRNGDQFYVGRKFVFSRRRVANFEALLEQLT----EQVEVPFGVRRLYTPTYGHRVLELESLQTGGKYVAAGRE 90
Cdd:cd16109     2 AKKVRFYRNGDRFFKGIVYAVSSERFRSFEALLADLTrslsDNVNLPQGVRTIFTIDGSRKITSLDELEDGESYVCASTD 81


                  ....
gi 1958784181  91 RFKK 94
Cdd:cd16109    82 AFKK 85
DCX2_DCDC2_like cd16113
Doublecortin-like domain 2 found in doublecortin domain-containing protein 2 (DCDC2); DCDC2 is ...
 15-88 4.00e-15

Doublecortin-like domain 2 found in doublecortin domain-containing protein 2 (DCDC2); DCDC2 is a member of the doublecortin (DCX) family. It is a microtubule-associated protein (MAP) with stable double tandem DCX repeats of a ubiquitin-like tertiary fold. Ubiquitin (Ub) is a protein modifier in eukaryotes that is involved in various cellular processes including transcriptional regulation, cell cycle control, and DNA repair. Microtubules are key components of cytoskeleton that are involved in cell movement, shape determination, division and transport. DCDC2 genetic variation in humans is associated with reading disability, attention deficit hyperactivity disorder (ADHD), and difficulties in mathematics. A genetic variant of DCDC2 associates with dyslexia, a common neurobehavioral disorder of reading. DCDC2 protein interacts with many of the same cytoskeleton related proteins that other members of the DCX family interact with.


Pssm-ID: 340530  Cd Length: 74  Bit Score: 70.30  E-value: 4.00e-15
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1958784181  15 AKTILVYRNGDQFYVGRKFVFSRRRVANFEALLEQLTEQVEVPFG-VRRLYTPTyGHRVLELESLQTGGKYVAAG 88
Cdd:cd16113     1 PKTIHVFPNGDLLHPPSKVLLTKRRLPNWDTVLEEVTEKVKLQTGaVRKLYTLD-GKRISDPDELVNGGQYVAVG 74
DCX1_DCLK1 cd17140
Dublecortin-like domain 1 found in doublecortin-like kinase 1 (DCLK1); DCLK1 is a member of ...
 15-97 1.87e-14

Dublecortin-like domain 1 found in doublecortin-like kinase 1 (DCLK1); DCLK1 is a member of doublecortin (DCX) protein superfamily that functions as a microtubule-associated protein (MAP), and contains two conserved tubulin binding domains. The DCX domain has a stable ubiquitin-like tertiary fold. Ubiquitin (Ub) is a protein modifier in eukaryotes that is involved in various cellular processes, including transcriptional regulation, cell cycle control, and DNA repair. In addition to microtubule-binding domains, DCLK encodes a serine/threonine kinase domain that is similar to Ca/calmodulin-dependent (Cam) protein kinases. DCLK1 appears to regulate cyclic AMP signaling and is involved in neuronal migration, retrograde transport, neuronal apoptosis and neurogenesis. Unlike DCX, this DCLK has varying levels of expression throughout embryonic and adult life.


Pssm-ID: 340660  Cd Length: 89  Bit Score: 68.88  E-value: 1.87e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958784181  15 AKTILVYRNGDQFYVGRKFVFSRRRVANFEALLEQLT----EQVEVPFGVRRLYTPTYGHRVLELESLQTGGKYVAAGRE 90
Cdd:cd17140     2 AKKVRFYRNGDRYFKGIVYAISPDRFRSFEALLADLTrtlsDNVNLPQGVRTIYTIDGLKKISSLDQLVEGESYVCGSIE 81


                  ....*..
gi 1958784181  91 RFKKLDY 97
Cdd:cd17140    82 PFKKLEY 88
DCX1_DCLK2 cd17141
Dublecortin-like domain 1 found in doublecortin-like kinase 2 (DCLK2); DCLK2 is a member of ...
 15-94 4.97e-13

Dublecortin-like domain 1 found in doublecortin-like kinase 2 (DCLK2); DCLK2 is a member of doublecortin (DCX) protein superfamily that functions as a microtubule-associated protein (MAP), and contains two conserved tubulin binding domains, which typically occur in tandem. The DCX domain has a stable ubiquitin-like tertiary fold. Ubiquitin (Ub) is a protein modifier (Ubiquitination) in eukaryotes that is involved in various cellular processes including transcriptional regulation, cell cycle control, and DNA repair. In addition to microtubule binding domains, DCLK encodes a serine/threonine kinase-domain that is similar to Ca/calmodulin-dependent (Cam) protein kinases. Molecular actions of DCX members are less well characterized and it shows that DCLK2 members regulate cyclic AMP signaling. Unlike DCX, this DCLK has varying levels of expression throughout embryonic and adult life.


Pssm-ID: 340661  Cd Length: 85  Bit Score: 64.93  E-value: 4.97e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958784181  15 AKTILVYRNGDQFYVGRKFVFSRRRVANFEALLEQLT----EQVEVPFGVRRLYTPTYGHRVLELESLQTGGKYVAAGRE 90
Cdd:cd17141     2 AKKVRFYRNGDRYFKGLVYAVSSDRFRSFDALLMELTrslsDNVNLPQGVRTIYTIDGSKKITSLDELLEGESYVCASNE 81


                  ....
gi 1958784181  91 RFKK 94
Cdd:cd17141    82 PFRK 85
DCX2_RP1 cd17147
Dublecortin-like domain 2 found in retinitis pigmentosa 1 (RP1)-like protein; RP1, also termed ...
 16-93 9.20e-13

Dublecortin-like domain 2 found in retinitis pigmentosa 1 (RP1)-like protein; RP1, also termed oxygen-regulated protein 1, is a member of doublecortin (DCX) superfamily that contains double tandem repeats of the DCX domains. RP1 is associated with retinitis pigmentosa, which is a type of inherited blindness. DCX is a microtubule-associated protein (MAP) with a stable ubiquitin-like tertiary fold. Microtubules are key components of cytoskeleton that are involved in cell movement, shape determination, division and transport. The RP1 protein is expressed in photoreceptors that is required for correct stacking of outer segment discs. RP1 protein interacts with many of the same cytoskeleton related proteins that other members of the DCX family interact with.


Pssm-ID: 340667  Cd Length: 76  Bit Score: 63.62  E-value: 9.20e-13
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1958784181  16 KTILVYRNGDQfYVGRKFVFSRRRVANFEALLEQLTEQVEVPfgVRRLYTPTyGHRVLELESL-QTGGKYVAAGRERFK 93
Cdd:cd17147     1 RKLIVFKNGDP-GFKHTLILNKKTTQSFEALLDHVSELMQFP--VVKLYTTD-GRRVDSLQALiLSSGAVVAAGREPFK 75
DCX pfam03607
Doublecortin;
159-211 1.03e-12

Doublecortin;


Pssm-ID: 460986  Cd Length: 60  Bit Score: 62.85  E-value: 1.03e-12
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1958784181 159 SLSDWNSVLAMIGEKV--FPLGGVRKLFTMDGHLLDDSKNLQDNYFYVAAGLESF 211
Cdd:pfam03607   6 RFRSFDALLDELTEKVvkLPFGAVRKLYTLDGKRVTSLDELEDGGVYVAAGREKF 60
DCX1_DCX cd16112
Dublecortin-like domain 1 found in neuronal migration protein doublecortin (DCX); DCX, also ...
 15-97 1.07e-12

Dublecortin-like domain 1 found in neuronal migration protein doublecortin (DCX); DCX, also termed doublin or lissencephalin-X (Lis-XDCX), is a microtubule-associated protein (MAP). It belongs to the doublecortin (DCX) family, has double tandem DCX repeats, and is expressed in migrating neurons. Structure studies show that the N-terminal DCX domain has a stable ubiquitin-like fold. DCX is not only a unique MAP in terms of structure, it also interacts with multiple additional proteins. Mutations in the human DCX genes are associated with abnormal neuronal migration, epilepsy, and mental retardation.


Pssm-ID: 340529  Cd Length: 89  Bit Score: 63.78  E-value: 1.07e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958784181  15 AKTILVYRNGDQFYVGRKFVFSRRRVANFEALLEQLT----EQVEVPFGVRRLYTPTYGHRVLELESLQTGGKYVAAGRE 90
Cdd:cd16112     2 AKKVRFYRNGDRYFKGIVYAVSSDRFRSFDALLADLTrslsDNINLPQGVRYIYTIDGSRKIGSMDELEEGESYVCSSDN 81


                  ....*..
gi 1958784181  91 RFKKLDY 97
Cdd:cd16112    82 FFKKVEY 88
DCX2_DCDC2B cd17153
Doublecortin-like domain 2 found in doublecortin domain-containing protein 2B (DCDC2B); DCDC2 ...
 137-212 5.19e-12

Doublecortin-like domain 2 found in doublecortin domain-containing protein 2B (DCDC2B); DCDC2 is a member of the doublecortin (DCX) family. It is a microtubule-associated protein (MAP) with stable double tandem DCX repeats of a ubiquitin-like tertiary fold. Microtubules are key components of cytoskeleton that are involved in cell movement, shape determination, division and transport. DCDC2 genetic variation in humans is associated with reading disability, attention deficit hyperactivity disorder (ADHD), and difficulties in mathematics. A genetic variant of DCDC2 associates with dyslexia, a common neurobehavioral disorder of reading. DCDC2 protein interacts with many of the same cytoskeleton related proteins that other members of the DCX family interact with.


Pssm-ID: 340673  Cd Length: 80  Bit Score: 61.69  E-value: 5.19e-12
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1958784181 137 YINVFTNGRLFIPPIKIIIPKFSLSDWNSVLAMIGEKV-FPLGGVRKLFTMDGHLLDDSKNLQDNYFYVAAGLESFK 212
Cdd:cd17153     3 IIHVFRNGDLLSPPFRLLIPKHMLQDWETILSLLTEKAnLRTGAVRKLCTLDGVPLSSGKELVSGQYYVAVGSEKFK 79
DCX1_RP1 cd17145
Doublecortin-like domain 1 found in retinitis pigmentosa 1 (RP1)-like protein; RP1, also ...
 16-93 5.92e-12

Doublecortin-like domain 1 found in retinitis pigmentosa 1 (RP1)-like protein; RP1, also termed oxygen-regulated protein 1, is a member of the doublecortin (DCX) family. Its DCX domains occur in double tandem repeats. RP1 is associated with retinitis pigmentosa, which is a type of inherited blindness. DCX is a microtubule-associated protein (MAP) with a stable ubiquitin-like tertiary fold. Microtubules are key components of cytoskeleton that are involved in cell movement, shape determination, division and transport. The RP1 protein is expressed in photoreceptors and is required for correct stacking of outer segment discs. It interacts with many of the same cytoskeleton related proteins that other members of the DCX family interact with.


Pssm-ID: 340665  Cd Length: 79  Bit Score: 61.37  E-value: 5.92e-12
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1958784181  16 KTILVYRNGDQFYVGRKFVFSRRRVANFEALLEQLTEQVEVPFGVRRLYTPTYGHRVLELESLQTGGKYVAAGRERFK 93
Cdd:cd17145     1 KRVCFYKSGDPQFGGLRMVVNSRSFKTFDALLDNLSKKVPLPFGVRNITTPRGVHHITSLEDLEDGKSYICSHQKKVK 78
DCX1_RP1L1 cd17146
Doublecortin-like domain 1 found in retinitis pigmentosa 1-like 1 (RP1L1) protein; RP1L1 is a ...
 16-93 8.58e-12

Doublecortin-like domain 1 found in retinitis pigmentosa 1-like 1 (RP1L1) protein; RP1L1 is a member of the doublecortin (DCX) family. Its DCX domains occur in double tandem repeats. DCX is a microtubule-associated protein (MAP) with a stable ubiquitin-like tertiary fold. Microtubules are key components of cytoskeleton that are involved in cell movement, shape determination, division and transport. The DCX-domain of RP1L1 localizes to the photoreceptor and is genetically associated with retinitis pigmentosa.


Pssm-ID: 340666  Cd Length: 79  Bit Score: 61.00  E-value: 8.58e-12
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1958784181  16 KTILVYRNGDQFYVGRKFVFSRRRVANFEALLEQLTEQVEVPFGVRRLYTPTYGHRVLELESLQTGGKYVAAGRERFK 93
Cdd:cd17146     1 KKITFYKSGDPQFGGVKMAVNKRTFKSFSALLDDLSQRVPLPFGVRTITTPRGTHSISRLEQLEDGGCYLCSDKKYVK 78
DCX cd01617
Dublecortin-like domain structurally similar to a beta-grasp ubiquitin-like fold; Dublecortin ...
 136-207 4.44e-11

Dublecortin-like domain structurally similar to a beta-grasp ubiquitin-like fold; Dublecortin (DCX) is a microtubule-associated protein (MAP) with a stable ubiquitin-like tertiary fold. Ubiquitin (Ub) is a protein modifier in eukaryotes that is involved in various cellular processes, including transcriptional regulation, cell cycle control, and DNA repair. Microtubules are key components of the cytoskeleton that are involved in cell movement, shape determination, division and transport. The DCX gene family consists of eleven paralogs in human and mouse, and its DCX protein domains can occur in double tandem or as single DCX repeats. Proteins with DCX tandem domains in general have roles in microtubule (MT) regulation and signal transduction such as X-linked doublecortin (DCX), retinitis pigmentosa-1 (RP1) and doublecortin-like kinase (DCLK). Single DCX repeat proteins are normally localized to actin-rich subcellular structures, or the nucleus such as DCDC2. DCX is not only a unique MAP in terms of structure, it also interacts with multiple additional proteins. Mutations in human DCX genes are associated with abnormal neuronal migration, epilepsy, and mental retardation.


Pssm-ID: 340456  Cd Length: 73  Bit Score: 58.78  E-value: 4.44e-11
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1958784181 136 RYINVFTNGRLFIPPIKIIIPKFSLSDWNSVLAMIGEKVFPL-GGVRKLFTMDGHLLDDSKNLQDNYFYVAAG 207
Cdd:cd01617     1 KRITVFRNGDKNFKGVKVLVKPRRFRTFDQLLDELTEKLGLPtGGVRKLYTPSGKLVKSLSDLEDGESYVVCG 73
DCX2_DCDC2 cd17152
Doublecortin-like domain 2 found in doublecortin domain-containing protein 2 (DCDC2); DCDC2 is ...
 160-212 2.71e-10

Doublecortin-like domain 2 found in doublecortin domain-containing protein 2 (DCDC2); DCDC2 is a member of the doublecortin (DCX) family. It is a microtubule-associated protein (MAP) with a stable ubiquitin-like tertiary fold. Ubiquitin (Ub) is a protein modifier in eukaryotes that is involved in various cellular processes, including transcriptional regulation, cell cycle control, and DNA repair. Microtubules are key components of cytoskeleton that are involved in cell movement, shape determination, division and transport. DCDC2 genetic variation in humans is associated with reading disability, attention deficit hyperactivity disorder (ADHD), and difficulties in mathematics. A genetic variant of DCDC2 associates with dyslexia, a common neurobehavioral disorder of reading. DCDC2 protein interacts with many of the same cytoskeleton related proteins that other members of the DCX family interact with.


Pssm-ID: 340672  Cd Length: 80  Bit Score: 56.73  E-value: 2.71e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1958784181 160 LSDWNSVLAMIGEKV-FPLGGVRKLFTMDGHLLDDSKNLQDNYFYVAAGLESFK 212
Cdd:cd17152    26 LNQWEKILEMITEKVtLRTGAVRRLYTLDGKLINDGSELENGQFYVAVGREKFK 79
DCX2_DCDC2 cd17152
Doublecortin-like domain 2 found in doublecortin domain-containing protein 2 (DCDC2); DCDC2 is ...
 17-94 1.10e-09

Doublecortin-like domain 2 found in doublecortin domain-containing protein 2 (DCDC2); DCDC2 is a member of the doublecortin (DCX) family. It is a microtubule-associated protein (MAP) with a stable ubiquitin-like tertiary fold. Ubiquitin (Ub) is a protein modifier in eukaryotes that is involved in various cellular processes, including transcriptional regulation, cell cycle control, and DNA repair. Microtubules are key components of cytoskeleton that are involved in cell movement, shape determination, division and transport. DCDC2 genetic variation in humans is associated with reading disability, attention deficit hyperactivity disorder (ADHD), and difficulties in mathematics. A genetic variant of DCDC2 associates with dyslexia, a common neurobehavioral disorder of reading. DCDC2 protein interacts with many of the same cytoskeleton related proteins that other members of the DCX family interact with.


Pssm-ID: 340672  Cd Length: 80  Bit Score: 55.19  E-value: 1.10e-09
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1958784181  17 TILVYRNGDQFYVGRKFVFSRRRVANFEALLEQLTEQVEVPFG-VRRLYTpTYGHRVLELESLQTGGKYVAAGRERFKK 94
Cdd:cd17152     3 TIFVVANGDLLNPAVRLLIPRKTLNQWEKILEMITEKVTLRTGaVRRLYT-LDGKLINDGSELENGQFYVAVGREKFKK 80
DCX2_RP_like cd17070
Dublecortin-like domain 2 found in retinitis pigmentosa (RP)-like protein; RP-like protein ...
 16-87 1.41e-07

Dublecortin-like domain 2 found in retinitis pigmentosa (RP)-like protein; RP-like protein family is part of doublecortin (DCX) superfamily with double tandem DCX repeats that are associated with retinitis pigmentosa. DCX is a microtubule-associated protein (MAP) with a stable ubiquitin-like tertiary fold. Microtubules are key components of cytoskeleton that are involved in cell movement, shape determination, division and transport. RP-like proteins are colocalized to the photoreceptor and share a function in outer segment disc morphogenesis.


Pssm-ID: 340590  Cd Length: 69  Bit Score: 48.78  E-value: 1.41e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1958784181  16 KTILVYRNGDQFyVGRKFVFSRRRVANFEALLEQLTEQVEVPfgVRRLYTpTYGHRVLELESLQTG-GKYVAA 87
Cdd:cd17070     1 KVITVISNGDPH-SRHTILLNRRTTQSFEQVLQDLSELLKGP--VRKLYT-TDGKKVESLSALFHGpDEYVAA 69
DCX smart00537
Domain in the Doublecortin (DCX) gene product; Tandemly-repeated domain in doublin, the ...
 136-216 1.99e-07

Domain in the Doublecortin (DCX) gene product; Tandemly-repeated domain in doublin, the Doublecortin gene product. Proposed to bind tubulin. Doublecortin (DCX) is mutated in human X-linked neuronal migration defects.


Pssm-ID: 214711  Cd Length: 89  Bit Score: 48.79  E-value: 1.99e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958784181  136 RYINVFTNGRLFIPPIKIIIPKFSLSDWNSVLAMIGEKV-FPLG-GVRKLFTMDGHLLDDSKNLQDNYFYVAAGLESFKS 213
Cdd:smart00537   6 KRIRFYRNGDRFFKGVRLVVNRKRFKSFEALLQDLTEVVkLDLPhGVRKLYTLDGKKVTSLDELEDGGSYVASGTEAFKK 85


                   ...
gi 1958784181  214 IPY 216
Cdd:smart00537  86 VDY 88
DCX2_DCDC2B cd17153
Doublecortin-like domain 2 found in doublecortin domain-containing protein 2B (DCDC2B); DCDC2 ...
 18-94 5.59e-07

Doublecortin-like domain 2 found in doublecortin domain-containing protein 2B (DCDC2B); DCDC2 is a member of the doublecortin (DCX) family. It is a microtubule-associated protein (MAP) with stable double tandem DCX repeats of a ubiquitin-like tertiary fold. Microtubules are key components of cytoskeleton that are involved in cell movement, shape determination, division and transport. DCDC2 genetic variation in humans is associated with reading disability, attention deficit hyperactivity disorder (ADHD), and difficulties in mathematics. A genetic variant of DCDC2 associates with dyslexia, a common neurobehavioral disorder of reading. DCDC2 protein interacts with many of the same cytoskeleton related proteins that other members of the DCX family interact with.


Pssm-ID: 340673  Cd Length: 80  Bit Score: 47.44  E-value: 5.59e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1958784181  18 ILVYRNGDQFYVGRKFVFSRRRVANFEALLEQLTEQVEVPFG-VRRLYTpTYGHRVLELESLQTGGKYVAAGRERFKK 94
Cdd:cd17153     4 IHVFRNGDLLSPPFRLLIPKHMLQDWETILSLLTEKANLRTGaVRKLCT-LDGVPLSSGKELVSGQYYVAVGSEKFKD 80
PRK10263 PRK10263
DNA translocase FtsK; Provisional
 403-553 2.24e-06

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 50.85  E-value: 2.24e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958784181  403 QTDPSVRQESLEKSSLTQDQRHEQQESfiksslGAPPPEQRPEMKESPRQLFLGPTPPEHQLEQQEIPEQSSFGPPSPEQ 482
Cdd:PRK10263   690 DADAAAEAELARQFAQTQQQRYSGEQP------AGANPFSLDDFEFSPMKALLDDGPHEPLFTPIVEPVQQPQQPVAPQQ 763

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1958784181  483 QLEQQEIPVqlslGPPSPEQQLEQPEIPVQSFLGP-------PSTEQQLEQGSPGQLFLGPSSPKPPEHQFEQQEIPA 553
Cdd:PRK10263   764 QYQQPQQPV----APQPQYQQPQQPVAPQPQYQQPqqpvapqPQYQQPQQPVAPQPQYQQPQQPVAPQPQYQQPQQPV 837
DCX2_RP1L1 cd17148
Dublecortin-like domain 2 found in retinitis pigmentosa 1-like 1 (RP1L1) protein; RP1L1 is a ...
 16-93 5.48e-06

Dublecortin-like domain 2 found in retinitis pigmentosa 1-like 1 (RP1L1) protein; RP1L1 is a member of doublecortin (DCX) family. Its protein domains occur in tandem repeats. DCX is a microtubule-associated protein (MAP) with a stable ubiquitin-like tertiary fold. Microtubules are key components of cytoskeleton that are involved in cell movement, shape determination, division and transport. The DCX-domain of RP1L1 localizes to the photoreceptor and is genetically associated with retinitis pigmentosa.


Pssm-ID: 340668  Cd Length: 76  Bit Score: 44.38  E-value: 5.48e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1958784181  16 KTILVYRNGDQfYVGRKFVFSRRRVANFEALLEQLTEQVEVPfgVRRLYTpTYGHRVLELESL-QTGGKYVAAGRERFK 93
Cdd:cd17148     1 KKITLVKNGDP-DVRRSIILNRRNARNLRTFLDEISDLLQFP--VKKLYT-LEGRKIDSIQALlHCPSVLVCVGREPFK 75
DCX2_DCDC2C cd17154
Doublecortin-like domain 2 found in doublecortin domain-containing protein 2C (DCDC2C); DCDC2 ...
 15-93 1.35e-05

Doublecortin-like domain 2 found in doublecortin domain-containing protein 2C (DCDC2C); DCDC2 is a member of the doublecortin (DCX) family. It is a microtubule-associated protein (MAP) with stable double tandem DCX repeats of a ubiquitin-like tertiary fold. Microtubules are key components of cytoskeleton that are involved in cell movement, shape determination, division and transport. DCDC2 genetic variation in humans is associated with reading disability, attention deficit hyperactivity disorder (ADHD), and difficulties in mathematics. A genetic variant of DCDC2 associates with dyslexia, a common neurobehavioral disorder of reading. DCDC2 protein interacts with many of the same cytoskeleton related proteins that other members of the DCX family interact with.


Pssm-ID: 340674  Cd Length: 80  Bit Score: 43.65  E-value: 1.35e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958784181  15 AKTILVYRNGDQFYVGRKFVFSRRRVANFEALLEQLTEQVEVPFG-VRRLYTPTyGHRVLELESLQTGGKYVAAGRERFK 93
Cdd:cd17154     1 SRTINVFTNGEVLVPPAKIIIPKFTLRSWENVLAMITEKAFLRTGgVFRLCTLN-GHPVSDSTELEDNHYYVAVGSEKFK 79
PAT1 pfam09770
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ...
 391-531 2.56e-05

Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.


Pssm-ID: 401645 [Multi-domain]  Cd Length: 846  Bit Score: 47.34  E-value: 2.56e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958784181 391 LALPETQEKVEVQTDPSVRQESLEKSSLTQDQRHEQQESFIKSSLGAPPPEQRPEMKESPRQlFLGPTPPEHQLE-QQEI 469
Cdd:pfam09770 194 MSLEEVEAAMRAQAKKPAQQPAPAPAQPPAAPPAQQAQQQQQFPPQIQQQQQPQQQPQQPQQ-HPGQGHPVTILQrPQSP 272

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1958784181 470 PEQSSFGPPSPEQQLEQQEIPVQlslgPPSPEQQLEQPEIPVQSFLGPPSTEQQLEQGSPGQ 531
Cdd:pfam09770 273 QPDPAQPSIQPQAQQFHQQPPPV----PVQPTQILQNPNRLSAARVGYPQNPQPGVQPAPAH 330
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 406-586 5.10e-05

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 46.30  E-value: 5.10e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958784181 406 PSVRQESLEKSSLTQDQRHEQQESFIKSSLGAPPPEQRPEMKE----------SPRQLFLGPTPPEHQLEQQEIPEQSSF 475
Cdd:pfam03154 149 PSPQDNESDSDSSAQQQILQTQPPVLQAQSGAASPPSPPPPGTtqaatagptpSAPSVPPQGSPATSQPPNQTQSTAAPH 228

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958784181 476 -----GPPSPEQQLEQQEIPVQLSLGPPSPEQQLEQPeIPVQSFLGP-PSTEQQLEQGSPGQLFLGPSSPKPPEHQFEQQ 549
Cdd:pfam03154 229 tliqqTPTLHPQRLPSPHPPLQPMTQPPPPSQVSPQP-LPQPSLHGQmPPMPHSLQTGPSHMQHPVPPQPFPLTPQSSQS 307

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 1958784181 550 EIPAYSSFGPLSPVQQFEQESSKELSLGlfLEQPPEQ 586
Cdd:pfam03154 308 QVPPGPSPAAPGQSQQRIHTPPSQSQLQ--SQQPPRE 342
PRK10263 PRK10263
DNA translocase FtsK; Provisional
 440-553 9.92e-05

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 45.46  E-value: 9.92e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958784181  440 PEQRPEMKESPRQLFLGPTPPEHQLEQQEIPEQssfgPPSPEQQLEQQEIPVqlslgppSPEQQLEQPEIPVQsflgPPS 519
Cdd:PRK10263   751 PVQQPQQPVAPQQQYQQPQQPVAPQPQYQQPQQ----PVAPQPQYQQPQQPV-------APQPQYQQPQQPVA----PQP 815

                           90       100       110
                   ....*....|....*....|....*....|....
gi 1958784181  520 TEQQLEQgspgqlflgPSSPKPPEHQFEQQEIPA 553
Cdd:PRK10263   816 QYQQPQQ---------PVAPQPQYQQPQQPVAPQ 840
PRK10263 PRK10263
DNA translocase FtsK; Provisional
 468-568 6.06e-04

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 43.15  E-value: 6.06e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958784181  468 EIPEQSSFGPP-SPEQQLEQQEIP---VQLSLGPPSPEQQLEQPEipvQSFLGPPSTEQQLEQGSPGQLFLGPSSPKPPE 543
Cdd:PRK10263   738 DGPHEPLFTPIvEPVQQPQQPVAPqqqYQQPQQPVAPQPQYQQPQ---QPVAPQPQYQQPQQPVAPQPQYQQPQQPVAPQ 814

                           90       100
                   ....*....|....*....|....*
gi 1958784181  544 HQFEQQEIPAyssfgplSPVQQFEQ 568
Cdd:PRK10263   815 PQYQQPQQPV-------APQPQYQQ 832
DCX3_DCDC5 cd17158
Doublecortin-like domain 3 found in doublecortin domain-containing protein 5 (DCDC5); DCDC5 is ...
 18-65 1.14e-03

Doublecortin-like domain 3 found in doublecortin domain-containing protein 5 (DCDC5); DCDC5 is a member of doublecortin (DCX) family. It is a microtubule-associated protein (MAP) with stable double tandem DCX repeats of ubiquitin-like tertiary fold. Ubiquitin (Ub) is a protein modifier in eukaryotes that is involved in various cellular processes, including transcriptional regulation, cell cycle control, and DNA repair. Microtubules are key components of the cytoskeleton that are involved in cell movement, shape determination, division and transport. DCDC5 is expressed during mitosis and involved in coordinating late cytokinesis. DCDC5 interacts with cytoplasmic dynein and Rab8, as well as with the Rab8 nucleotide exchange factor Rabin8.


Pssm-ID: 340678  Cd Length: 73  Bit Score: 37.68  E-value: 1.14e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1958784181  18 ILVYRNGDQFYVGRKFVfsrrrVAN-FEALLEQLTEQVEVPFGVRRLYT 65
Cdd:cd17158     3 ILAYKNGEGRLRDGVLI-----IGStFPGLLDQCTHRLGLARAARRLYT 46
PRK10927 PRK10927
cell division protein FtsN;
375-541 1.41e-03

cell division protein FtsN;


Pssm-ID: 236797 [Multi-domain]  Cd Length: 319  Bit Score: 41.20  E-value: 1.41e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958784181 375 PTPEKIRHDILEekhtlaLPETQEKVEVQTDPSVRQESLEKSSLTQDQRH--EQQESFIKSS----LGAPPPEQRPEMke 448
Cdd:PRK10927   77 PKPEERWRYIKE------LESRQPGVRAPTEPSAGGEVKTPEQLTPEQRQllEQMQADMRQQptqlVEVPWNEQTPEQ-- 148

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958784181 449 spRQLFLGPTPPEHQLEQQEIPEQSSFGPPSPEQQLEQ--QEIPVQLSLGPPSPEQQLEqpeiPVQSFLGPP---STEQQ 523
Cdd:PRK10927  149 --RQQTLQRQRQAQQLAEQQRLAQQSRTTEQSWQQQTRtsQAAPVQAQPRQSKPASTQQ----PYQDLLQTPahtTAQSK 222

                         170
                  ....*....|....*...
gi 1958784181 524 LEQGSPgqLFLGPSSPKP 541
Cdd:PRK10927  223 PQQAAP--VTRAADAPKP 238
PRK10263 PRK10263
DNA translocase FtsK; Provisional
 374-550 1.47e-03

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 41.61  E-value: 1.47e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958784181  374 VPTPEKIRHDILEEKHTLALPETQEKVEVQTDPSVRQESLEKSSLTQDQRHEQQESFIKSSLGAPPPEQRPEMKESPRQL 453
Cdd:PRK10263   346 VASVDVPPAQPTVAWQPVPGPQTGEPVIAPAPEGYPQQSQYAQPAVQYNEPLQQPVQPQQPYYAPAAEQPAQQPYYAPAP 425

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958784181  454 FLGPTPPEHQLEQQEIPEQSSFGPPSPEQQLEQQeiPVQlslgppSPEQQLEQPEIPVQSFLGPPSTEQQ-LEQGSPGQL 532
Cdd:PRK10263   426 EQPAQQPYYAPAPEQPVAGNAWQAEEQQSTFAPQ--STY------QTEQTYQQPAAQEPLYQQPQPVEQQpVVEPEPVVE 497

                          170
                   ....*....|....*...
gi 1958784181  533 FLGPSspKPPEHQFEQQE 550
Cdd:PRK10263   498 ETKPA--RPPLYYFEEVE 513
DCX_DCDC5_like cd17072
Doublecortin-like domain found in doublecortin domain-containing protein 5 (DCDC5) and similar ...
 16-79 2.40e-03

Doublecortin-like domain found in doublecortin domain-containing protein 5 (DCDC5) and similar proteins; DCDC5 is a member of doublecortin (DCX) family. It is a microtubule-associated protein (MAP) with stable double tandem DCX repeats of ubiquitin-like tertiary fold. Ubiquitin (Ub) is a protein modifier in eukaryotes that is involved in various cellular processes, including transcriptional regulation, cell cycle control, and DNA repair. Microtubules are key components of the cytoskeleton that are involved in cell movement, shape determination, division and transport. DCDC5 is expressed during mitosis and involved in coordinating late cytokinesis. DCDC5 interacts with cytoplasmic dynein and Rab8 as well as with the Rab8 nucleotide exchange factor Rabin8. This family also includes DCDC1, which is a hydrophilic intracellular protein that contains only one DCX repeat. Therefore, DCDC1 might only bind to microtubules without microtubule polymerization properties. DCDC1 is mainly expressed in adult testis.


Pssm-ID: 340592  Cd Length: 71  Bit Score: 36.87  E-value: 2.40e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1958784181  16 KTILVYRNGDQFYvgRKFVFSRRRVANFEALLEQLTEQVEVPFGVRRLYTPTyGHRVLELESLQ 79
Cdd:cd17072     1 VRLRVLKNGERDL--ERAVYVVGPDLELQLFLDRCTERLNLPFAARRLFDEN-GKEIFTLRDLE 61
PHA03378 PHA03378
EBNA-3B; Provisional
 437-531 2.43e-03

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 40.82  E-value: 2.43e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958784181 437 APPPEQRPEMKESPrQLFLGPTPPEHQLEQQEIPEQSSFGPPSPEQQLEQQEIPVQLSLGPPSPEQQLEQPEIPVQSFLG 516
Cdd:PHA03378  724 ARPPAAAPGRARPP-AAAPGRARPPAAAPGRARPPAAAPGRARPPAAAPGAPTPQPPPQAPPAPQQRPRGAPTPQPPPQA 802

                          90
                  ....*....|....*
gi 1958784181 517 PPSTEQQLEQGSPGQ 531
Cdd:PHA03378  803 GPTSMQLMPRAAPGQ 817
PRK10263 PRK10263
DNA translocase FtsK; Provisional
 406-510 3.72e-03

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 40.45  E-value: 3.72e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958784181  406 PSVRQESLEKSSLTQDQRHEQQESfiksSLGAPPPEQRPEMKESPRQLFLGPTPPEHQLEQQEIPEQssfgPPSPEQQLE 485
Cdd:PRK10263   747 PIVEPVQQPQQPVAPQQQYQQPQQ----PVAPQPQYQQPQQPVAPQPQYQQPQQPVAPQPQYQQPQQ----PVAPQPQYQ 818

                           90       100
                   ....*....|....*....|....*
gi 1958784181  486 QQEIPVqlslGPPSPEQQLEQPEIP 510
Cdd:PRK10263   819 QPQQPV----APQPQYQQPQQPVAP 839
PHA03378 PHA03378
EBNA-3B; Provisional
 437-551 6.23e-03

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 39.67  E-value: 6.23e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958784181 437 APPPEQRPEMKESPRQLfLGPTPPEHQLEQQEIPEQSSFGPPSPEQQLEQQEIPVQLSLGP----------PSPEQQLEQ 506
Cdd:PHA03378  704 MRPPAAPPGRAQRPAAA-TGRARPPAAAPGRARPPAAAPGRARPPAAAPGRARPPAAAPGRarppaaapgaPTPQPPPQA 782

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1958784181 507 PEIPVQSFLGPPsTEQQLEQGSPGQLFLGPssPKPPEHQFEQQEI 551
Cdd:PHA03378  783 PPAPQQRPRGAP-TPQPPPQAGPTSMQLMP--RAAPGQQGPTKQI 824
PRK10263 PRK10263
DNA translocase FtsK; Provisional
 267-586 7.56e-03

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 39.30  E-value: 7.56e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958784181  267 AKEKKQMDT--EPLIESGAEGDVYKAQTPAKEAQEALEVKEDPDMK-VELPVDQA---------PAEIVKEIDEIGSGSP 334
Cdd:PRK10263   517 AREREQLAAwyQPIPEPVKEPEPIKSSLKAPSVAAVPPVEAAAAVSpLASGVKKAtlatgaaatVAAPVFSLANSGGPRP 596

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958784181  335 GLESGMGDHSRMSFKKRFPlrhRRKRKASFKSLFKNKEVvpTPEKIRHDILEEKHTLALPETQEKVEVQTDPSVRQesle 414
Cdd:PRK10263   597 QVKEGIGPQLPRPKRIRVP---TRRELASYGIKLPSQRA--AEEKAREAQRNQYDSGDQYNDDEIDAMQQDELARQ---- 667

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958784181  415 kssLTQDQRHEQQESFIKSSLGAPPPEQRPEMKESPRQLflgptppeHQLEQQEIP-EQSSFGPPSPEQQLEQQEIPVQL 493
Cdd:PRK10263   668 ---FAQTQQQRYGEQYQHDVPVNAEDADAAAEAELARQF--------AQTQQQRYSgEQPAGANPFSLDDFEFSPMKALL 736

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958784181  494 SLGPPSP--EQQLEQPEIPVQSFLGPPSTEQQLEQGSPGQLFLGPSSPKPPEHQFEQQEIPAYSSFGPLSPVQQFEQESS 571
Cdd:PRK10263   737 DDGPHEPlfTPIVEPVQQPQQPVAPQQQYQQPQQPVAPQPQYQQPQQPVAPQPQYQQPQQPVAPQPQYQQPQQPVAPQPQ 816

                          330
                   ....*....|....*
gi 1958784181  572 KELSLGLFLEQPPEQ 586
Cdd:PRK10263   817 YQQPQQPVAPQPQYQ 831
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH