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    nclb no child left behind [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36150, updated on 9-Dec-2024

    Summary

    Official Symbol
    nclbprovided by FlyBase
    Official Full Name
    no child left behindprovided by FlyBase
    Primary source
    FLYBASE:FBgn0263510
    Locus tag
    Dmel_CG6751
    See related
    AllianceGenome:FB:FBgn0263510
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG6751; Dmel\CG6751; dPWP1; Nclb; PWP1
    Summary
    Enables chromatin DNA binding activity. Involved in several processes, including male germ-line stem cell population maintenance; oogenesis; and positive regulation of DNA-templated transcription. Located in nucleolus and nucleoplasm. Is expressed in several structures, including germline cell; gonad; head epidermis primordium; mesoderm; and visceral mesoderm derivative. Orthologous to human PWP1 (PWP1 homolog, endonuclein). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    See nclb in Genome Data Viewer
    Location:
    47C5-47C5; 2-63 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (10875748..10877296)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (6763253..6764801)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44302 Neighboring gene uncharacterized protein Neighboring gene TBP-associated factor 5 Neighboring gene Peroxin 6

    Genomic regions, transcripts, and products

    Interactions

    General gene information

    Gene Ontology Provided by FlyBase

    Component Evidence Code Pubs
    located_in nucleolus PubMed 
    located_in nucleoplasm PubMed 
    is_active_in nucleus  
    located_in nucleus PubMed 

    General protein information

    Preferred Names
    no child left behind
    Names
    CG6751-PA
    nclb-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      10875748..10877296
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_136779.4 → NP_610623.1  no child left behind [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610623.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A1Z8D0, B5X0K1, Q8SY06
      Related
      FBpp0087323
      Conserved Domains (2) summary
      sd00039
      Location:237 → 274
      7WD40; WD40 repeat [structural motif]
      cl25539
      Location:189 → 426
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
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