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    Pif1A PFTAIRE-interacting factor 1A [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 8674049, updated on 17-Dec-2024

    Summary

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    Official Symbol
    Pif1Aprovided by FlyBase
    Official Full Name
    PFTAIRE-interacting factor 1Aprovided by FlyBase
    Primary source
    FLYBASE:FBgn0261015
    Locus tag
    Dmel_CG42599
    See related
    AllianceGenome:FB:FBgn0261015
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:GH12504; CG11773; CG11774; CG11776; CG32940; CG33719; CG42599; CG9808; DM22; Dmel\CG42599; IP06413p; PIF-1A; Pif1
    Old locus tag
    CG33719; Dmel_CG11776; Dmel_CG33719
    Summary
    Involved in sperm individualization. Located in investment cone and nucleus. Is expressed in several structures, including antennal primordium; central brain primordium; epithelium; gut section; and head epidermis primordium. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Pif1A in Genome Data Viewer
    Location:
    85B1-85B1; 3-48 cM
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (8774286..8801176, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (4600008..4626898, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene PFTAIRE-interacting factor 1B Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Ionotropic receptor 85a Neighboring gene Chaperonin containing TCP1 subunit 7 Neighboring gene uncharacterized protein Neighboring gene hinge2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Inversions and adaptation to the plant toxin ouabain shape DNA sequence variation within and between chromosomal inversions of Drosophila subobscura. Pegueroles C, et al. Sci Rep, 2016 Mar 31. PMID 27029337, Free PMC Article
    2. L63, the Drosophila PFTAIRE, interacts with two novel proteins unrelated to cyclins. Rascle A, et al. Mech Dev, 2003 May. PMID 12782278
    3. PFTAIRE Kinase L63 Interactor 1A (Pif1A Protein) Is Required for Actin Cone Movement during Spermatid Individualization in Drosophila melanogaster. Pravder HD, et al. Int J Mol Sci, 2022 Mar 10. PMID 35328431, Free PMC Article
    4. Proteomic analysis of individual fruit fly hemolymph. Zeng Q, et al. J Chromatogr B Analyt Technol Biomed Life Sci, 2015 Feb 15. PMID 25596379
    5. Drosophila Pif1A is essential for spermatogenesis and is the homolog of human CCDC157, a gene associated with idiopathic NOA. Yuan X, et al. Cell Death Dis, 2019 Feb 11. PMID 30741974, Free PMC Article

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. PFTAIRE Kinase L63 Interactor 1A (Pif1A Protein) Is Required for Actin Cone Movement during Spermatid Individualization in Drosophila melanogaster.
      Title: PFTAIRE Kinase L63 Interactor 1A (Pif1A Protein) Is Required for Actin Cone Movement during Spermatid Individualization in Drosophila melanogaster.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in sperm individualization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in investment cone IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    PFTAIRE-interacting factor 1A
    Names
    CG42599-PA
    CG42599-PG
    CG42599-PH
    CG42599-PI
    CG42599-PJ
    Pif1A-PA
    Pif1A-PG
    Pif1A-PH
    Pif1A-PI
    Pif1A-PJ

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      8774286..8801176 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001202266.2 → NP_001189195.2  PFTAIRE-interacting factor 1A, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001189195.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4JDD0
      Conserved Domains (1) summary
      pfam16034
      Location:516 → 595
      JAKMIP_CC3; JAKMIP CC3 domain

    2. NM_001316487.1 → NP_001303416.1  PFTAIRE-interacting factor 1A, isoform J [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4JDD0
      Conserved Domains (1) summary
      pfam16034
      Location:516 → 595
      JAKMIP_CC3; JAKMIP CC3 domain

    3. NM_001170085.2 → NP_001163556.2  PFTAIRE-interacting factor 1A, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163556.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      E1JIF4
      Conserved Domains (1) summary
      pfam16034
      Location:478 → 557
      JAKMIP_CC3; JAKMIP CC3 domain

    4. NM_001031987.1 → NP_001027158.1  PFTAIRE-interacting factor 1A, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001027158.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8WTI8
      Conserved Domains (1) summary
      pfam16034
      Location:131 → 210
      JAKMIP_CC3; JAKMIP CC3 domain

    5. NM_001031986.2 → NP_001027157.2  PFTAIRE-interacting factor 1A, isoform I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001027157.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q86BA7, Q8MRQ5
      Conserved Domains (1) summary
      pfam10267
      Location:147 → 260
      Tmemb_cc2; Predicted transmembrane and coiled-coil 2 protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4JDD0 A0A0B4JDD0
    E1JIF4 E1JIF4
    Q8MRQ5 Q8MRQ5
    Q8WTI8 Q8WTI8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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