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    rho-6 rhomboid-6 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34640, updated on 9-Dec-2024

    Summary

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    Official Symbol
    rho-6provided by FlyBase
    Official Full Name
    rhomboid-6provided by FlyBase
    Primary source
    FLYBASE:FBgn0032415
    Locus tag
    Dmel_CG17212
    See related
    AllianceGenome:FB:FBgn0032415
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG17212; Dmel\CG17212; rho 6; Rho-related [33C1]; rho6
    Summary
    Predicted to enable serine-type endopeptidase activity. Predicted to be located in membrane. Orthologous to human RHBDL1 (rhomboid like 1) and RHBDL3 (rhomboid like 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See rho-6 in Genome Data Viewer
    Location:
    33D2-33D2; 2-46 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (12130516..12133411, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (12130516..12133411, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Phaedra 2 Neighboring gene uncharacterized protein Neighboring gene Gustatory receptor 33a Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. brother of rhomboid, a rhomboid-related gene expressed during early Drosophila oogenesis, promotes EGF-R/MAPK signaling. Guichard A, et al. Dev Biol, 2000 Oct 15. PMID 11023685
    2. A family of Rhomboid intramembrane proteases activates all Drosophila membrane-tethered EGF ligands. Urban S, et al. EMBO J, 2002 Aug 15. PMID 12169630, Free PMC Article
    3. Human BOULE gene rescues meiotic defects in infertile flies. Xu EY, et al. Hum Mol Genet, 2003 Jan 15. PMID 12499397
    4. A family of rhomboid-like genes: Drosophila rhomboid-1 and roughoid/rhomboid-3 cooperate to activate EGF receptor signaling. Wasserman JD, et al. Genes Dev, 2000 Jul 1. PMID 10887159, Free PMC Article
    5. Rhomboid proteins: conserved membrane proteases with divergent biological functions. Urban S. Genes Dev, 2006 Nov 15. PMID 17114579

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables serine-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables serine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    rhomboid-6
    Names
    CG17212-PB
    CG17212-PC
    Rhomboid-6
    rho-6-PB
    rho-6-PC
    NP_001285872.1
    NP_788038.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      12130516..12133411 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001298943.1 → NP_001285872.1  rhomboid-6, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285872.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      X2J9K6
      Conserved Domains (1) summary
      cl21536
      Location:106 → 132
      Rhomboid; Rhomboid family

    2. NM_176024.3 → NP_788038.1  rhomboid-6, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_788038.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G2J602, Q86BL6
      Related
      FBpp0079942
      Conserved Domains (1) summary
      pfam01694
      Location:106 → 251
      Rhomboid; Rhomboid family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q86BL6 Q86BL6
    X2J9K6 X2J9K6

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