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Conserved domains on  [gi|28574497|ref|NP_788038|]
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rhomboid-6, isoform B [Drosophila melanogaster]

Protein Classification

rhomboid family protein( domain architecture ID 10483871)

rhomboid family protein may be an intramembrane serine protease that catalyzes regulated intramembrane proteolysis, resulting in the release of functional polypeptides from their membrane anchors, or an inactive rhomboid protein that lacks the conserved active sites and has no peptidase activity

CATH:  1.20.1540.10
Gene Ontology:  GO:0016020
MEROPS:  S54
PubMed:  24099005|22035660|26527717|12620104
SCOP:  4000471

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Rhomboid pfam01694
Rhomboid family; This family contains integral membrane proteins that are related to ...
 106-252 1.17e-22

Rhomboid family; This family contains integral membrane proteins that are related to Drosophila rhomboid protein. Members of this family are found in bacteria and eukaryotes. Rhomboid promotes the cleavage of the membrane-anchored TGF-alpha-like growth factor Spitz, allowing it to activate the Drosophila EGF receptor. Analysis has shown that Rhomboid-1 is an intramembrane serine protease (EC:3.4.21.105). Parasite-encoded rhomboid enzymes are also important for invasion of host cells by Toxoplasma and the malaria parasite.


:

Pssm-ID: 426384  Cd Length: 147  Bit Score: 90.36  E-value: 1.17e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574497   106 EYWRLLTYMLLHSDYWHLSLNICFQCFIGICLEVEQGHWRLAVVYMVGGVAGSLANAWLQPHLHLM-GASAGVYAMLGSH 184
Cdd:pfam01694   6 QLWRLITSMFLHAGWLHLLFNMLALLFFGGPLERILGSVRFLLLYLLSGIAGSLLSYLFSPLSTPSvGASGAIFGLLGAL 85

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 28574497   185 VPHLVLNFSQLSHRFARIASLLILLLSDVGFTTYhfchnhnRNPRTSLEAHIGGGVAGILCGFIVYRR 252
Cdd:pfam01694  86 LVLGPRNRILLFGLIGALLALLLFILLNLVLGLL-------PGNGVSNLAHLGGLLVGLLLGFILLRR 146
 
Name Accession Description Interval E-value
Rhomboid pfam01694
Rhomboid family; This family contains integral membrane proteins that are related to ...
 106-252 1.17e-22

Rhomboid family; This family contains integral membrane proteins that are related to Drosophila rhomboid protein. Members of this family are found in bacteria and eukaryotes. Rhomboid promotes the cleavage of the membrane-anchored TGF-alpha-like growth factor Spitz, allowing it to activate the Drosophila EGF receptor. Analysis has shown that Rhomboid-1 is an intramembrane serine protease (EC:3.4.21.105). Parasite-encoded rhomboid enzymes are also important for invasion of host cells by Toxoplasma and the malaria parasite.


Pssm-ID: 426384  Cd Length: 147  Bit Score: 90.36  E-value: 1.17e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574497   106 EYWRLLTYMLLHSDYWHLSLNICFQCFIGICLEVEQGHWRLAVVYMVGGVAGSLANAWLQPHLHLM-GASAGVYAMLGSH 184
Cdd:pfam01694   6 QLWRLITSMFLHAGWLHLLFNMLALLFFGGPLERILGSVRFLLLYLLSGIAGSLLSYLFSPLSTPSvGASGAIFGLLGAL 85

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 28574497   185 VPHLVLNFSQLSHRFARIASLLILLLSDVGFTTYhfchnhnRNPRTSLEAHIGGGVAGILCGFIVYRR 252
Cdd:pfam01694  86 LVLGPRNRILLFGLIGALLALLLFILLNLVLGLL-------PGNGVSNLAHLGGLLVGLLLGFILLRR 146
GlpG COG0705
Membrane-associated serine protease, rhomboid family [Posttranslational modification, protein ...
 106-252 3.39e-19

Membrane-associated serine protease, rhomboid family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440469 [Multi-domain]  Cd Length: 189  Bit Score: 82.60  E-value: 3.39e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574497 106 EYWRLLTYMLLHSDYWHLSLNICFQCFIGICLEVEQGHWRLAVVYMVGGVAGSLANAWLQPHLH--LMGASAGVYAMLGS 183
Cdd:COG0705  42 ELWRLLTSMFLHGGFLHLLFNMLALWVFGPLLERRLGSKRFLLLYLLSGLGGGLLQLLFSPGSGypLVGASGAIFGLLGA 121

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 28574497 184 hvpHLVLNFSQLSHRFARIASLLILLlsdVGFTTYHFCHNHNRNPRTSLEAHIGGGVAGILCGFIVYRR 252
Cdd:COG0705 122 ---LLVLGPRRRVLLLFIPIPALLFL---LVWLLLGLLFGLLGGGGIAWEAHLGGLLAGLLLALLLRKL 184
PTZ00101 PTZ00101
rhomboid-1 protease; Provisional
 74-198 2.56e-06

rhomboid-1 protease; Provisional


Pssm-ID: 185445  Cd Length: 278  Bit Score: 47.54  E-value: 2.56e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574497   74 FILLMSFVQIsLHWIASECMQKVLIFKPEWNV---------------EYWRLLTYMLLHSDYWHLSLNICFQCFIGICLE 138
Cdd:PTZ00101  55 FIMAISIIQI-IVFIISVSIKPADFLTPSDSLlvtlganvasrikqgEIHRLILPIFLHANIFHTFFNVFFQLRMGFTLE 133

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574497  139 VEQGHWRLAVVYMVGGVAGSLANAWLQPHLHLMGASAGVYAMLGSHVPHLVLNFSQLSHR 198
Cdd:PTZ00101 134 KNYGIVKIIILYFLTGIYGNILSSSVTYCPIKVGASTSGMGLLGIVTSELILLWHVIRHR 193
rhom_GG_sort TIGR03902
rhomboid family GlyGly-CTERM serine protease; This model describes a rhomboid-like ...
 106-169 4.14e-04

rhomboid family GlyGly-CTERM serine protease; This model describes a rhomboid-like intramembrane serine protease. Its species distribution closely matches model TIGR03501, GlyGly-CTERM, which describes a protein targeting domain analogous to LPXTG and PEP-CTERM. In a number of species (Ralstonia eutropha ,R. metallidurans, R. solanacearum, Marinobacter aquaeolei, etc) with just one GlyGly-CTERM protein (i.e., a dedicated system), the rhombosortase and GlyGly-CTERM genes are adjacent.


Pssm-ID: 274845  Cd Length: 154  Bit Score: 39.86  E-value: 4.14e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 28574497   106 EYWRLLTYMLLHSDYWHLSLNICFQCFIGICLEVEQGHWRLAVVYMVGGVAGSLANAWLQPHLH 169
Cdd:TIGR03902  15 EWWRLLTGHFVHLNWWHLLMNLAGLLLLWALFGRHLRARRLLLLLLLLSLLISLGLLLFLPSLQ 78
 
Name Accession Description Interval E-value
Rhomboid pfam01694
Rhomboid family; This family contains integral membrane proteins that are related to ...
 106-252 1.17e-22

Rhomboid family; This family contains integral membrane proteins that are related to Drosophila rhomboid protein. Members of this family are found in bacteria and eukaryotes. Rhomboid promotes the cleavage of the membrane-anchored TGF-alpha-like growth factor Spitz, allowing it to activate the Drosophila EGF receptor. Analysis has shown that Rhomboid-1 is an intramembrane serine protease (EC:3.4.21.105). Parasite-encoded rhomboid enzymes are also important for invasion of host cells by Toxoplasma and the malaria parasite.


Pssm-ID: 426384  Cd Length: 147  Bit Score: 90.36  E-value: 1.17e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574497   106 EYWRLLTYMLLHSDYWHLSLNICFQCFIGICLEVEQGHWRLAVVYMVGGVAGSLANAWLQPHLHLM-GASAGVYAMLGSH 184
Cdd:pfam01694   6 QLWRLITSMFLHAGWLHLLFNMLALLFFGGPLERILGSVRFLLLYLLSGIAGSLLSYLFSPLSTPSvGASGAIFGLLGAL 85

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 28574497   185 VPHLVLNFSQLSHRFARIASLLILLLSDVGFTTYhfchnhnRNPRTSLEAHIGGGVAGILCGFIVYRR 252
Cdd:pfam01694  86 LVLGPRNRILLFGLIGALLALLLFILLNLVLGLL-------PGNGVSNLAHLGGLLVGLLLGFILLRR 146
GlpG COG0705
Membrane-associated serine protease, rhomboid family [Posttranslational modification, protein ...
 106-252 3.39e-19

Membrane-associated serine protease, rhomboid family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440469 [Multi-domain]  Cd Length: 189  Bit Score: 82.60  E-value: 3.39e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574497 106 EYWRLLTYMLLHSDYWHLSLNICFQCFIGICLEVEQGHWRLAVVYMVGGVAGSLANAWLQPHLH--LMGASAGVYAMLGS 183
Cdd:COG0705  42 ELWRLLTSMFLHGGFLHLLFNMLALWVFGPLLERRLGSKRFLLLYLLSGLGGGLLQLLFSPGSGypLVGASGAIFGLLGA 121

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 28574497 184 hvpHLVLNFSQLSHRFARIASLLILLlsdVGFTTYHFCHNHNRNPRTSLEAHIGGGVAGILCGFIVYRR 252
Cdd:COG0705 122 ---LLVLGPRRRVLLLFIPIPALLFL---LVWLLLGLLFGLLGGGGIAWEAHLGGLLAGLLLALLLRKL 184
PTZ00101 PTZ00101
rhomboid-1 protease; Provisional
 74-198 2.56e-06

rhomboid-1 protease; Provisional


Pssm-ID: 185445  Cd Length: 278  Bit Score: 47.54  E-value: 2.56e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574497   74 FILLMSFVQIsLHWIASECMQKVLIFKPEWNV---------------EYWRLLTYMLLHSDYWHLSLNICFQCFIGICLE 138
Cdd:PTZ00101  55 FIMAISIIQI-IVFIISVSIKPADFLTPSDSLlvtlganvasrikqgEIHRLILPIFLHANIFHTFFNVFFQLRMGFTLE 133

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574497  139 VEQGHWRLAVVYMVGGVAGSLANAWLQPHLHLMGASAGVYAMLGSHVPHLVLNFSQLSHR 198
Cdd:PTZ00101 134 KNYGIVKIIILYFLTGIYGNILSSSVTYCPIKVGASTSGMGLLGIVTSELILLWHVIRHR 193
rhom_GG_sort TIGR03902
rhomboid family GlyGly-CTERM serine protease; This model describes a rhomboid-like ...
 106-169 4.14e-04

rhomboid family GlyGly-CTERM serine protease; This model describes a rhomboid-like intramembrane serine protease. Its species distribution closely matches model TIGR03501, GlyGly-CTERM, which describes a protein targeting domain analogous to LPXTG and PEP-CTERM. In a number of species (Ralstonia eutropha ,R. metallidurans, R. solanacearum, Marinobacter aquaeolei, etc) with just one GlyGly-CTERM protein (i.e., a dedicated system), the rhombosortase and GlyGly-CTERM genes are adjacent.


Pssm-ID: 274845  Cd Length: 154  Bit Score: 39.86  E-value: 4.14e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 28574497   106 EYWRLLTYMLLHSDYWHLSLNICFQCFIGICLEVEQGHWRLAVVYMVGGVAGSLANAWLQPHLH 169
Cdd:TIGR03902  15 EWWRLLTGHFVHLNWWHLLMNLAGLLLLWALFGRHLRARRLLLLLLLLSLLISLGLLLFLPSLQ 78
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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