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    mbt mushroom bodies tiny [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32631, updated on 17-Dec-2024

    Summary

    Official Symbol
    mbtprovided by FlyBase
    Official Full Name
    mushroom bodies tinyprovided by FlyBase
    Primary source
    FLYBASE:FBgn0025743
    Locus tag
    Dmel_CG18582
    See related
    AllianceGenome:FB:FBgn0025743
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-EST:fe1G7; CG18582; Dmel\CG18582; DmMBT; DmPAK2; dPAK2; Mbt; PAK; Pak2; PAK2; Ste20; STE20
    Summary
    Enables ATP binding activity; protein serine/threonine kinase activity; and small GTPase binding activity. Involved in several processes, including negative regulation of cell size; nervous system development; and positive regulation of compound eye photoreceptor development. Located in adherens junction and cytoplasm. Colocalizes with plasma membrane. Is expressed in adult head; neuroblasts; organism; and ovary. Used to study Parkinson's disease. Human ortholog(s) of this gene implicated in clear cell renal cell carcinoma. Orthologous to several human genes including PAK4 (p21 (RAC1) activated kinase 4). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    See mbt in Genome Data Viewer
    Location:
    14F2-14F2; 1-54 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (16610685..16614856)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (16504718..16508889)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Ubiquitin conjugating enzyme 7 Neighboring gene uncharacterized protein Neighboring gene Nucleoporin 153kD Neighboring gene mir-4965 stem loop Neighboring gene stable intronic sequence RNA 2 Neighboring gene uncharacterized protein Neighboring gene Rho kinase Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    General gene information

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding  
    enables ATP binding PubMed 
    enables protein binding PubMed 
    enables protein kinase activity PubMed 
    enables protein serine/threonine kinase activity  
    enables protein serine/threonine kinase activity PubMed 
    enables protein serine/threonine kinase activity  
    enables protein serine/threonine kinase activity PubMed 
    enables small GTPase binding PubMed 
    Process Evidence Code Pubs
    involved_in Golgi organization PubMed 
    involved_in cellular response to starvation  
    involved_in compound eye development PubMed 
    involved_in compound eye photoreceptor cell differentiation PubMed 
    involved_in cytoskeleton organization PubMed 
    involved_in intracellular signal transduction  
    involved_in mushroom body development PubMed 
    involved_in negative regulation of cell size PubMed 
    involved_in positive regulation of compound eye photoreceptor development PubMed 
    involved_in positive regulation of developmental growth PubMed 
    involved_in protein phosphorylation  
    involved_in protein phosphorylation PubMed 
    involved_in regulation of MAPK cascade  
    involved_in regulation of MAPK cascade PubMed 
    involved_in regulation of cell-cell adhesion mediated by cadherin PubMed 
    Component Evidence Code Pubs
    located_in adherens junction PubMed 
    is_active_in cytoplasm  
    located_in cytoplasm PubMed 
    colocalizes_with plasma membrane PubMed 

    General protein information

    Preferred Names
    mushroom bodies tiny
    Names
    CG18582-PA
    anon-fast-evolving-1G7
    mbt-PA
    NP_523375.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      16610685..16614856
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_078651.4 → NP_523375.2  mushroom bodies tiny [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523375.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O96372, Q960J8, Q9TYH2, Q9VXE5
      UniProtKB/TrEMBL
      B5RIT0
      Related
      FBpp0074060
      Conserved Domains (3) summary
      smart00220
      Location:372 → 619
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd01093
      Location:9 → 54
      CRIB_PAK_like; PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the ...
      cd06648
      Location:360 → 620
      STKc_PAK_II; Catalytic domain of the Serine/Threonine Kinase, Group II p21-activated kinase
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