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mir-252 mir-252 stem loop [ Drosophila melanogaster (fruit fly) ]

Gene ID: 12797897, updated on 17-Dec-2024

Summary

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Official Symbol
mir-252provided by FlyBase
Official Full Name
mir-252 stem loopprovided by FlyBase
Primary source
FLYBASE:FBgn0262323
Locus tag
Dmel_CR43030
See related
miRBase:MI0005858; AllianceGenome:FB:FBgn0262323
Gene type
ncRNA
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
252; CR43030; dme-mir-252; dme-miR-252; dme-miR-252-5p; Dmel\CR43030; miR-252; MIR-252; miR-252-5p; miRNA-252
Summary
Enables mRNA 3'-UTR binding activity and mRNA base-pairing translational repressor activity. Involved in several processes, including negative regulation of G2/M transition of mitotic cell cycle; negative regulation of activin receptor signaling pathway; and negative regulation of macromolecule metabolic process. Is expressed in embryonic/larval optic lobe; eye disc; larval brain; and larval ventral nerve cord. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See mir-252 in Genome Data Viewer
Location:
87E12-87E12; 3-53 cM
Exon count:
1
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (13464219..13464311, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (9289941..9290033, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR45679 Neighboring gene sidestep IV Neighboring gene antisense RNA:CR17025 Neighboring gene antisense RNA:CR46354 Neighboring gene long non-coding RNA:CR45914 Neighboring gene long non-coding RNA:CR45589

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. MicroRNA miR-252 targets mbt to control the developmental growth of Drosophila. Lim DH, et al. Insect Mol Biol, 2019 Jun. PMID 30582233
  2. MicroRNA miR-252-5p regulates the Notch signaling pathway by targeting Rab6 in Drosophila wing development. Lim DH, et al. Insect Sci, 2023 Oct. PMID 36847222
  3. Orthopedia expression during Drosophila melanogaster nervous system development and its regulation by microRNA-252. Hildebrandt K, et al. Dev Biol, 2022 Dec. PMID 36179878
  4. Modulation of Ago2 Loading by Cyclophilin 40 Endows a Unique Repertoire of Functional miRNAs during Sperm Maturation in Drosophila. Iki T, et al. Cell Rep, 2020 Nov 10. PMID 33176138
  5. The conserved microRNA miR-8-3p coordinates the expression of V-ATPase subunits to regulate ecdysone biosynthesis for Drosophila metamorphosis. Lim DH, et al. FASEB J, 2020 May. PMID 32196731

See all (60) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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  • mir-252-RA; Dmel\mir-252-RA; CR43030-RA; Dmel\CR43030-RA
  • mir-252-RB; Dmel\mir-252-RB; CR43030-RB; Dmel\CR43030-RB
  • mir-252-RM; Dmel\mir-252-RM; CR43030-RM; Dmel\CR43030-RM

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables mRNA 3'-UTR binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables mRNA base-pairing translational repressor activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in miRNA-mediated gene silencing by mRNA destabilization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in miRNA-mediated post-transcriptional gene silencing IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in miRNA-mediated post-transcriptional gene silencing IEA
Inferred from Electronic Annotation
more info
  
involved_in muscle organ development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of G2/M transition of mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of activin receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of developmental growth IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of negative regulation of innate immune response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of receptor recycling IMP
Inferred from Mutant Phenotype
more info
 PubMed 

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    13464219..13464311 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. NR_048381.1 RNA Sequence

    Status: REVIEWED

Gene LinkOut

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Molecular Biology Databases
Research Materials