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    mGluR metabotropic Glutamate Receptor [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43838, updated on 17-Dec-2024

    Summary

    Official Symbol
    mGluRprovided by FlyBase
    Official Full Name
    metabotropic Glutamate Receptorprovided by FlyBase
    Primary source
    FLYBASE:FBgn0019985
    Locus tag
    Dmel_CG11144
    See related
    AllianceGenome:FB:FBgn0019985
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CAA67993.1_Dr; CG11144; Dmel\CG11144; DmGlu-A; DmGlu-RA; DmGluA; DmGluAR; DmGluR; dmGluRA; DmGluRA; DmGluR[[A]]; DmGlu[[A]]R; FBgn0019985; Glu-RA; GluR; mGLuR; mGlurA; mGluRA
    Summary
    Enables cholesterol binding activity; glutamate binding activity; and group II metabotropic glutamate receptor activity. Involved in several processes, including G protein-coupled glutamate receptor signaling pathway; learning or memory; and synapse organization. Located in membrane raft and plasma membrane. Is expressed in several structures, including adult central brain intrinsic neurons; ellipsoid body layer; ganglia; neuromere; and synaptic neuropil domain. Orthologous to several human genes including GRM3 (glutamate metabotropic receptor 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    See mGluR in Genome Data Viewer
    Location:
    102F1-102F3; 4-0 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 4 NC_004353.4 (936819..949441)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 4 NC_004353.3 (957445..970067)

    Chromosome 4 - NC_004353.4Genomic Context describing neighboring genes Neighboring gene unc-13 Neighboring gene pseudo Neighboring gene eukaryotic translation initiation factor 4G1 Neighboring gene long non-coding RNA:CR45201 Neighboring gene eIF4E-Transporter

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    General gene information

    mobile_element

    • Loc: 937640-938062 mobile_element_type = transposon:INE-1{}2772
    • Loc: 938147-938265 mobile_element_type = transposon:INE-1{}2774
    • Loc: 939882-940079 mobile_element_type = transposon:INE-1{}5429
    • Loc: 947634-947690 mobile_element_type = transposon:INE-1{}2897

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity  
    enables G protein-coupled receptor activity PubMed 
    enables cholesterol binding PubMed 
    enables glutamate binding PubMed 
    enables glutamate receptor activity PubMed 
    enables group II metabotropic glutamate receptor activity  
    enables group II metabotropic glutamate receptor activity PubMed 
    Component Evidence Code Pubs
    part_of G protein-coupled receptor homodimeric complex  
    located_in membrane  
    located_in membrane PubMed 
    located_in membrane raft PubMed 
    is_active_in plasma membrane  
    located_in plasma membrane PubMed 

    General protein information

    Preferred Names
    metabotropic glutamate receptor
    Names
    CG11144-PA
    CG11144-PB
    CG11144-PC
    CG11144-PD
    mGluR-PA
    mGluR-PB
    mGluR-PC
    mGluR-PD
    mGluRA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004353.4 Reference assembly

      Range
      936819..949441
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001272147.1 → NP_001259076.1  metabotropic glutamate receptor, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259076.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P91685, Q9V485
      UniProtKB/TrEMBL
      L0MPZ9
      Conserved Domains (4) summary
      pfam00003
      Location:638 → 873
      7tm_3; 7 transmembrane sweet-taste receptor of 3 GCPR
      pfam01094
      Location:72 → 518
      ANF_receptor; Receptor family ligand binding region
      pfam07562
      Location:557 → 604
      NCD3G; Nine Cysteines Domain of family 3 GPCR
      cl10011
      Location:43 → 542
      Periplasmic_Binding_Protein_Type_1; Type 1 periplasmic binding fold superfamily
    2. NM_079900.3 → NP_524639.2  metabotropic glutamate receptor, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524639.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P91685, Q9V485
      UniProtKB/TrEMBL
      L0MPZ9
      Related
      FBpp0088248
      Conserved Domains (4) summary
      pfam00003
      Location:638 → 873
      7tm_3; 7 transmembrane sweet-taste receptor of 3 GCPR
      pfam01094
      Location:72 → 518
      ANF_receptor; Receptor family ligand binding region
      pfam07562
      Location:557 → 604
      NCD3G; Nine Cysteines Domain of family 3 GPCR
      cl10011
      Location:43 → 542
      Periplasmic_Binding_Protein_Type_1; Type 1 periplasmic binding fold superfamily
    3. NM_001297789.1 → NP_001284718.1  metabotropic glutamate receptor, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001284718.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      X2JBI2
      Conserved Domains (2) summary
      pfam01094
      Location:72 → 236
      ANF_receptor; Receptor family ligand binding region
      cl10011
      Location:43 → 229
      Periplasmic_Binding_Protein_Type_1; Type 1 periplasmic binding fold superfamily
    4. NM_001272148.1 → NP_001259077.1  metabotropic glutamate receptor, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259077.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C5WLT4
      Conserved Domains (2) summary
      pfam01094
      Location:72 → 518
      ANF_receptor; Receptor family ligand binding region
      cl10011
      Location:43 → 532
      Periplasmic_Binding_Protein_Type_1; Type 1 periplasmic binding fold superfamily
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