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    Uchl5 ubiquitin carboxyl-terminal esterase L5 [ Mus musculus (house mouse) ]

    Gene ID: 56207, updated on 4-Jan-2025

    Summary

    Official Symbol
    Uchl5provided by MGI
    Official Full Name
    ubiquitin carboxyl-terminal esterase L5provided by MGI
    Primary source
    MGI:MGI:1914848
    See related
    Ensembl:ENSMUSG00000018189 AllianceGenome:MGI:1914848
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Uch37; 5830413B11Rik
    Summary
    Predicted to enable cysteine-type deubiquitinase activity; endopeptidase inhibitor activity; and proteasome binding activity. Involved in several processes, including brain development; positive regulation of DNA metabolic process; and telomere maintenance. Predicted to be located in cytosol; nucleolus; and nucleoplasm. Predicted to be part of Ino80 complex and cytosolic proteasome complex. Predicted to be active in cytoplasm. Is expressed in several structures, including alimentary system; brain ventricular layer; genitourinary system; nose; and salivary gland primordium. Orthologous to human UCHL5 (ubiquitin C-terminal hydrolase L5). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Broad expression in liver E14 (RPKM 10.8), placenta adult (RPKM 8.5) and 22 other tissues See more
    Orthologs
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    Genomic context

    See Uchl5 in Genome Data Viewer
    Location:
    1 F; 1 62.54 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (143652993..143683204)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (143777234..143807466)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 46161 Neighboring gene glutaredoxin 2 Neighboring gene STARR-positive B cell enhancer ABC_E1564 Neighboring gene STARR-positive B cell enhancer ABC_E2564 Neighboring gene Ro60, Y RNA binding protein Neighboring gene predicted gene, 25663 Neighboring gene STARR-positive B cell enhancer ABC_E499 Neighboring gene STARR-seq mESC enhancer starr_02532 Neighboring gene STARR-positive B cell enhancer ABC_E5813 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:145766106-145766315 Neighboring gene predicted gene, 41964 Neighboring gene STARR-seq mESC enhancer starr_02533 Neighboring gene STARR-positive B cell enhancer ABC_E628 Neighboring gene regulator of G-protein signaling 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Gene trapped (2)  1 citation
    • Targeted (1) 

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cysteine-type deubiquitinase activity  
    enables cysteine-type deubiquitinase activity  
    enables cysteine-type deubiquitinase activity  
    enables cysteine-type deubiquitinase activity  
    enables endopeptidase inhibitor activity  
    enables endopeptidase inhibitor activity  
    enables proteasome binding  
    enables proteasome binding  
    Process Evidence Code Pubs
    involved_in DNA recombination  
    involved_in DNA repair  
    involved_in chromatin remodeling  
    involved_in forebrain morphogenesis PubMed 
    involved_in lateral ventricle development PubMed 
    involved_in midbrain development PubMed 
    involved_in negative regulation of proteasomal ubiquitin-dependent protein catabolic process  
    involved_in negative regulation of proteasomal ubiquitin-dependent protein catabolic process  
    involved_in positive regulation of DNA repair PubMed 
    involved_in positive regulation of DNA-templated transcription  
    involved_in positive regulation of smoothened signaling pathway  
    involved_in positive regulation of smoothened signaling pathway  
    involved_in positive regulation of telomere maintenance in response to DNA damage PubMed 
    involved_in protein deubiquitination  
    involved_in protein deubiquitination  
    involved_in regulation of DNA repair PubMed 
    involved_in regulation of DNA replication  
    involved_in regulation of DNA strand elongation  
    involved_in regulation of cell cycle  
    involved_in regulation of chromosome organization  
    involved_in regulation of chromosome organization  
    involved_in regulation of embryonic development PubMed 
    involved_in regulation of proteasomal protein catabolic process  
    involved_in telomere maintenance PubMed 
    involved_in ubiquitin-dependent protein catabolic process  
    Component Evidence Code Pubs
    part_of Ino80 complex  
    part_of Ino80 complex  
    is_active_in cytoplasm  
    located_in cytosol  
    located_in cytosol  
    located_in cytosol  
    part_of cytosolic proteasome complex  
    part_of cytosolic proteasome complex  
    located_in nucleolus  
    located_in nucleolus  
    located_in nucleoplasm  
    located_in nucleoplasm  
    located_in nucleus  
    located_in nucleus  

    General protein information

    Preferred Names
    ubiquitin carboxyl-terminal hydrolase isozyme L5
    Names
    UCH-L5
    ubiquitin C-terminal hydrolase 37
    ubiquitin C-terminal hydrolase UCH37
    ubiquitin thioesterase L5
    NP_001153338.1
    NP_062508.2
    XP_006529823.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001159866.1NP_001153338.1  ubiquitin carboxyl-terminal hydrolase isozyme L5 isoform 2

      See identical proteins and their annotated locations for NP_001153338.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice junction at the 5' end of an exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is 1 aa shorter compared to isoform 1.
      Source sequence(s)
      AK017925, BY279731
      Consensus CDS
      CCDS78699.1
      UniProtKB/Swiss-Prot
      Q9WUP7
      Related
      ENSMUSP00000018333.8, ENSMUST00000018333.13
      Conserved Domains (2) summary
      cd02255
      Location:8223
      Peptidase_C12; Cysteine peptidase C12 contains ubiquitin carboxyl-terminal hydrolase (UCH) families L1, L3, L5 and BAP1
      pfam18031
      Location:263308
      UCH_C; Ubiquitin carboxyl-terminal hydrolases
    2. NM_019562.2NP_062508.2  ubiquitin carboxyl-terminal hydrolase isozyme L5 isoform 1

      See identical proteins and their annotated locations for NP_062508.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AF148447, AL592403, BY279731
      Consensus CDS
      CCDS15346.1
      UniProtKB/Swiss-Prot
      Q9CVJ4, Q9CXZ3, Q9R107, Q9WUP7
      Related
      ENSMUSP00000140106.2, ENSMUST00000189936.7
      Conserved Domains (2) summary
      cd02255
      Location:8223
      Peptidase_C12; Cysteine peptidase C12 contains ubiquitin carboxyl-terminal hydrolase (UCH) families L1, L3, L5 and BAP1
      pfam18031
      Location:264309
      UCH_C; Ubiquitin carboxyl-terminal hydrolases

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      143652993..143683204
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006529760.5XP_006529823.1  ubiquitin carboxyl-terminal hydrolase isozyme L5 isoform X1

      Conserved Domains (2) summary
      cd02255
      Location:8223
      Peptidase_C12; Cysteine peptidase C12 contains ubiquitin carboxyl-terminal hydrolase (UCH) families L1, L3, L5 and BAP1
      pfam18031
      Location:264309
      UCH_C; Ubiquitin carboxyl-terminal hydrolases

    RNA

    1. XR_387185.5 RNA Sequence

    2. XR_001785184.3 RNA Sequence

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