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    Rbcn-3B Rabconnectin-3B [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31155, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Rbcn-3Bprovided by FlyBase
    Official Full Name
    Rabconnectin-3Bprovided by FlyBase
    Primary source
    FLYBASE:FBgn0023510
    Locus tag
    Dmel_CG17766
    See related
    AllianceGenome:FB:FBgn0023510
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG17766; Dmel\CG17766; EG:86E4.3; FK39
    Summary
    Involved in lumen formation, open tracheal system and vacuolar acidification. Predicted to be active in cytoplasm. Is expressed in adult head. Orthologous to human WDR7 (WD repeat domain 7). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Rbcn-3B in Genome Data Viewer
    Location:
    2B15-2B15; 1-0.2 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (1908920..1916825)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (1802953..1810858)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR43864 Neighboring gene uncharacterized protein Neighboring gene ER degradation enhancer, mannosidase alpha-like 1 Neighboring gene Myb-interacting protein 130 Neighboring gene eukaryotic translation initiation factor 2B subunit epsilon Neighboring gene Oculocerebrorenal syndrome of Lowe

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Intracellular lumen formation in Drosophila proceeds via a novel subcellular compartment. Nikolova LS, et al. Development, 2015 Nov 15. PMID 26428009, Free PMC Article
    2. The vacuolar proton pump, V-ATPase, is required for notch signaling and endosomal trafficking in Drosophila. Yan Y, et al. Dev Cell, 2009 Sep. PMID 19758563, Free PMC Article
    3. The Drosophila MSL complex activates the transcription of target genes. Straub T, et al. Genes Dev, 2005 Oct 1. PMID 16204179, Free PMC Article
    4. Profiling early infection responses: Pseudomonas aeruginosa eludes host defenses by suppressing antimicrobial peptide gene expression. Apidianakis Y, et al. Proc Natl Acad Sci U S A, 2005 Feb 15. PMID 15695583, Free PMC Article
    5. A Genetic Screen for Genes That Impact Peroxisomes in Drosophila Identifies Candidate Genes for Human Disease. Graves HK, et al. G3 (Bethesda), 2020 Jan 7. PMID 31767637, Free PMC Article

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Rabconnectin-3alpha and beta (Rbcn-3A, CG3585 and Rbcn-3B, CG17766) affects Notch signaling and trafficking through regulating V-ATPase function
      Title: The vacuolar proton pump, V-ATPase, is required for notch signaling and endosomal trafficking in Drosophila.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in lumen formation, open tracheal system IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in vacuolar acidification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Rabconnectin-3B
    Names
    CG17766-PA
    CG17766-PB
    Rabconnectin-3beta
    Rbcn-3B-PA
    Rbcn-3B-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      1908920..1916825
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001297868.1 → NP_001284797.1  Rabconnectin-3B, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001284797.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q2XXU2, Q9W543
      Conserved Domains (3) summary
      COG2319
      Location:449 → 607
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:20 → 63
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:453 → 597
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    2. NM_130604.4 → NP_569960.2  Rabconnectin-3B, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_569960.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q2XXU2, Q9W543
      Related
      FBpp0070303
      Conserved Domains (3) summary
      COG2319
      Location:449 → 607
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:20 → 63
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:453 → 597
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O46092 O46092
    Q2XXU2 Q2XXU2
    Q960M9 Q960M9
    Q9W543 Q9W543

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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