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Conserved domains on  [gi|665389217|ref|NP_001284797|]
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Rabconnectin-3B, isoform B [Drosophila melanogaster]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 1000017)

WD40 repeat domain-containing protein folds into a beta-propeller structure and functions as a scaffold, providing a platform for the interaction and assembly of several proteins into a signalosome; similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
Gene Ontology:  GO:0005515
PubMed:  10322433|8090199|30069656|29026209
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 453-597 4.72e-15

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member cd00200:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 289  Bit Score: 77.38  E-value: 4.72e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389217  453 SHQILYGHRGRVNCLlcpsmiHSRYEKSHLLSGGIDFAVCLWDLYSGSLLHRFCVHAGEITQLLVPPEScsprilKCICS 532
Cdd:cd00200     1 LRRTLKGHTGGVTCV------AFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADG------TYLAS 68

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 665389217  533 VASDHSVTLVSLQERKCV-TLASrHLFPVVTIKWRPlDDFLIVGCS-DGSVYVWQMETGHLDRVLHG 597
Cdd:cd00200    69 GSSDKTIRLWDLETGECVrTLTG-HTSYVSSVAFSP-DGRILSSSSrDKTIKVWDVETGKCLTTLRG 133
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 22-202 1.77e-10

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member cd00200:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 289  Bit Score: 63.89  E-value: 1.77e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389217   22 ISSVFLSDDQFTLVTGCYDGQICLWQVEPTTLKMSprclLVGHSAPVLCLvraSLLPENNFLVSSSENGEMCTWDLTDGK 101
Cdd:cd00200    96 VSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTT----LRGHTDWVNSV---AFSPDGTFVASSSQDGTIKLWDLRTGK 168

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389217  102 CMeavklpQVHTQIQS--YHTANSEDVRLFCIGyyA---EIMVMDPFSLEVIYVLSSkvKPDWISAIHVLrpmrRKDDVV 176
Cdd:cd00200   169 CV------ATLTGHTGevNSVAFSPDGEKLLSS--SsdgTIKLWDLSTGKCLGTLRG--HENGVNSVAFS----PDGYLL 234

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 665389217  177 LAITTTGTVKVW---------TLTGnenkHAEPIY 202
Cdd:cd00200   235 ASGSEDGTIRVWdlrtgecvqTLSG----HTNSVT 265
WD40 COG2319
WD40 repeat [General function prediction only];
1408-1469 4.09e-08

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 57.23  E-value: 4.09e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 665389217 1408 RRIAVGANSGNLAIYELRQNKC-QMIPAHTHPITSLAFSPDGKYLVSYScAENRLSFWQTSTG 1469
Cdd:COG2319   217 KLLASGSADGTVRLWDLATGKLlRTLTGHSGSVRSVAFSPDGRLLASGS-ADGTVRLWDLATG 278
GvpP super family cl44178
Gas vesicle protein YhaH [General function prediction only];
735-816 2.64e-04

Gas vesicle protein YhaH [General function prediction only];


The actual alignment was detected with superfamily member COG4980:

Pssm-ID: 444004 [Multi-domain]  Cd Length: 106  Bit Score: 41.88  E-value: 2.64e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389217  735 PKDGKSMHldasKKIGDFFNKVKNKAVDVEKILKDKDKHgLVQKFKEKTEIVEKKVQAKVESLQKAVEPheEQQDLKSKI 814
Cdd:COG4980    26 PKSGKETR----KKLKDKADDLKDKAEDLKDELKEKASE-LSEEAKEKLDELIEEIKEKIEELKEEVEP--KIEELKEEA 98


                  ..
gi 665389217  815 AS 816
Cdd:COG4980    99 EK 100
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 453-597 4.72e-15

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 77.38  E-value: 4.72e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389217  453 SHQILYGHRGRVNCLlcpsmiHSRYEKSHLLSGGIDFAVCLWDLYSGSLLHRFCVHAGEITQLLVPPEScsprilKCICS 532
Cdd:cd00200     1 LRRTLKGHTGGVTCV------AFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADG------TYLAS 68

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 665389217  533 VASDHSVTLVSLQERKCV-TLASrHLFPVVTIKWRPlDDFLIVGCS-DGSVYVWQMETGHLDRVLHG 597
Cdd:cd00200    69 GSSDKTIRLWDLETGECVrTLTG-HTSYVSSVAFSP-DGRILSSSSrDKTIKVWDVETGKCLTTLRG 133
WD40 COG2319
WD40 repeat [General function prediction only];
413-597 7.88e-14

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 75.33  E-value: 7.88e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389217  413 PQQSRLVIGREDGSIVIVpatqtvmmqllvgikqNFSDWPSHQILYGHRGRVNCL-LCPSmihsryeKSHLLSGGIDFAV 491
Cdd:COG2319   130 PDGKTLASGSADGTVRLW----------------DLATGKLLRTLTGHSGAVTSVaFSPD-------GKLLASGSDDGTV 186

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389217  492 CLWDLYSGSLLHRFCVHAGEITQLlvppeSCSP--RILkciCSVASDHSVTLVSLQERKCVTLASRHLFPVVTIKWRPLD 569
Cdd:COG2319   187 RLWDLATGKLLRTLTGHTGAVRSV-----AFSPdgKLL---ASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDG 258

                         170       180
                  ....*....|....*....|....*...
gi 665389217  570 DFLIVGCSDGSVYVWQMETGHLDRVLHG 597
Cdd:COG2319   259 RLLASGSADGTVRLWDLATGELLRTLTG 286
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 22-202 1.77e-10

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 63.89  E-value: 1.77e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389217   22 ISSVFLSDDQFTLVTGCYDGQICLWQVEPTTLKMSprclLVGHSAPVLCLvraSLLPENNFLVSSSENGEMCTWDLTDGK 101
Cdd:cd00200    96 VSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTT----LRGHTDWVNSV---AFSPDGTFVASSSQDGTIKLWDLRTGK 168

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389217  102 CMeavklpQVHTQIQS--YHTANSEDVRLFCIGyyA---EIMVMDPFSLEVIYVLSSkvKPDWISAIHVLrpmrRKDDVV 176
Cdd:cd00200   169 CV------ATLTGHTGevNSVAFSPDGEKLLSS--SsdgTIKLWDLSTGKCLGTLRG--HENGVNSVAFS----PDGYLL 234

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 665389217  177 LAITTTGTVKVW---------TLTGnenkHAEPIY 202
Cdd:cd00200   235 ASGSEDGTIRVWdlrtgecvqTLSG----HTNSVT 265
WD40 COG2319
WD40 repeat [General function prediction only];
1408-1469 4.09e-08

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 57.23  E-value: 4.09e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 665389217 1408 RRIAVGANSGNLAIYELRQNKC-QMIPAHTHPITSLAFSPDGKYLVSYScAENRLSFWQTSTG 1469
Cdd:COG2319   217 KLLASGSADGTVRLWDLATGKLlRTLTGHSGSVRSVAFSPDGRLLASGS-ADGTVRLWDLATG 278
WD40 COG2319
WD40 repeat [General function prediction only];
9-194 6.61e-08

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 56.84  E-value: 6.61e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389217    9 PVVLWGPTAPthcISSVFLSDDQFTLVTGCYDGQICLWQVEpttlkmSPRCL--LVGHSAPVLCLvraSLLPENNFLVSS 86
Cdd:COG2319   113 LRTLTGHTGA---VRSVAFSPDGKTLASGSADGTVRLWDLA------TGKLLrtLTGHSGAVTSV---AFSPDGKLLASG 180

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389217   87 SENGEMCTWDLTDGKCMEAVKLpqvhtqiqsyHTANSEDV-------RLFCIGYYAEIMVMDPFSLEVIYVLSSkvKPDW 159
Cdd:COG2319   181 SDDGTVRLWDLATGKLLRTLTG----------HTGAVRSVafspdgkLLASGSADGTVRLWDLATGKLLRTLTG--HSGS 248

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 665389217  160 ISAIhVLRPmrrkDDVVLAITTT-GTVKVWTLTGNE 194
Cdd:COG2319   249 VRSV-AFSP----DGRLLASGSAdGTVRLWDLATGE 279
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 1399-1495 3.33e-06

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 50.80  E-value: 3.33e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389217 1399 NQISHCAQT---RRIAVGANSGNLAIYELRQNKC-QMIPAHTHPITSLAFSPDGKYLVSYScAENRLSFWQTSTG--MFG 1472
Cdd:cd00200   178 GEVNSVAFSpdgEKLLSSSSDGTIKLWDLSTGKClGTLRGHENGVNSVAFSPDGYLLASGS-EDGTIRVWDLRTGecVQT 256

                          90       100
                  ....*....|....*....|...
gi 665389217 1473 LGQSQTRCTkgySTAPIPDVSRL 1495
Cdd:cd00200   257 LSGHTNSVT---SLAWSPDGKRL 276
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 1427-1464 1.56e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 40.37  E-value: 1.56e-04
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 665389217   1427 NKCQMIPAHTHPITSLAFSPDGKYLVSySCAENRLSFW 1464
Cdd:smart00320    3 ELLKTLKGHTGPVTSVAFSPDGKYLAS-GSDDGTIKLW 39
GvpP COG4980
Gas vesicle protein YhaH [General function prediction only];
735-816 2.64e-04

Gas vesicle protein YhaH [General function prediction only];


Pssm-ID: 444004 [Multi-domain]  Cd Length: 106  Bit Score: 41.88  E-value: 2.64e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389217  735 PKDGKSMHldasKKIGDFFNKVKNKAVDVEKILKDKDKHgLVQKFKEKTEIVEKKVQAKVESLQKAVEPheEQQDLKSKI 814
Cdd:COG4980    26 PKSGKETR----KKLKDKADDLKDKAEDLKDELKEKASE-LSEEAKEKLDELIEEIKEKIEELKEEVEP--KIEELKEEA 98


                  ..
gi 665389217  815 AS 816
Cdd:COG4980    99 EK 100
WD40 pfam00400
WD domain, G-beta repeat;
1430-1464 1.31e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 37.71  E-value: 1.31e-03
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 665389217  1430 QMIPAHTHPITSLAFSPDGKYLVSySCAENRLSFW 1464
Cdd:pfam00400    5 KTLEGHTGSVTSLAFSPDGKLLAS-GSDDGTVKVW 38
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 547-584 3.42e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 36.52  E-value: 3.42e-03
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 665389217    547 RKCVTLASRHLFPVVTIKWRPLDDFLIVGCSDGSVYVW 584
Cdd:smart00320    2 GELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 16-46 9.36e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 35.37  E-value: 9.36e-03
                            10        20        30
                    ....*....|....*....|....*....|.
gi 665389217     16 TAPTHCISSVFLSDDQFTLVTGCYDGQICLW 46
Cdd:smart00320    9 KGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
547-584 9.86e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 35.40  E-value: 9.86e-03
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 665389217   547 RKCVTLASRHLFPVVTIKWRPLDDFLIVGCSDGSVYVW 584
Cdd:pfam00400    1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 453-597 4.72e-15

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 77.38  E-value: 4.72e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389217  453 SHQILYGHRGRVNCLlcpsmiHSRYEKSHLLSGGIDFAVCLWDLYSGSLLHRFCVHAGEITQLLVPPEScsprilKCICS 532
Cdd:cd00200     1 LRRTLKGHTGGVTCV------AFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADG------TYLAS 68

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 665389217  533 VASDHSVTLVSLQERKCV-TLASrHLFPVVTIKWRPlDDFLIVGCS-DGSVYVWQMETGHLDRVLHG 597
Cdd:cd00200    69 GSSDKTIRLWDLETGECVrTLTG-HTSYVSSVAFSP-DGRILSSSSrDKTIKVWDVETGKCLTTLRG 133
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 455-597 4.18e-14

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 74.68  E-value: 4.18e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389217  455 QILYGHRGRVNCL-LCPSmihsryeKSHLLSGGIDFAVCLWDLYSGSLLHRFCVHAGEITQLlvppeSCSPRiLKCICSV 533
Cdd:cd00200   129 TTLRGHTDWVNSVaFSPD-------GTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSV-----AFSPD-GEKLLSS 195

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 665389217  534 ASDHSVTLVSLQERKCVTLASRHLFPVVTIKWRPLDDFLIVGCSDGSVYVWQMETGHLDRVLHG 597
Cdd:cd00200   196 SSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSG 259
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 399-607 6.83e-14

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 73.91  E-value: 6.83e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389217  399 ITESPVKLTSSIYLPQQSRLVIGREDGSIVIVpatqtvmmqllvgikqNFSDWPSHQILYGHRGRVNCLLCPSmiHSRYe 478
Cdd:cd00200     5 LKGHTGGVTCVAFSPDGKLLATGSGDGTIKVW----------------DLETGELLRTLKGHTGPVRDVAASA--DGTY- 65

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389217  479 kshLLSGGIDFAVCLWDLYSGSLLHRFCVHAGEITQLlvppeSCSPrILKCICSVASDHSVTLVSLQERKCVTLASRHLF 558
Cdd:cd00200    66 ---LASGSSDKTIRLWDLETGECVRTLTGHTSYVSSV-----AFSP-DGRILSSSSRDKTIKVWDVETGKCLTTLRGHTD 136

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 665389217  559 PVVTIKWRPLDDFLIVGCSDGSVYVWQMETGHLDRVLHGMlAEEVLSAC 607
Cdd:cd00200   137 WVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGH-TGEVNSVA 184
WD40 COG2319
WD40 repeat [General function prediction only];
413-597 7.88e-14

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 75.33  E-value: 7.88e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389217  413 PQQSRLVIGREDGSIVIVpatqtvmmqllvgikqNFSDWPSHQILYGHRGRVNCL-LCPSmihsryeKSHLLSGGIDFAV 491
Cdd:COG2319   130 PDGKTLASGSADGTVRLW----------------DLATGKLLRTLTGHSGAVTSVaFSPD-------GKLLASGSDDGTV 186

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389217  492 CLWDLYSGSLLHRFCVHAGEITQLlvppeSCSP--RILkciCSVASDHSVTLVSLQERKCVTLASRHLFPVVTIKWRPLD 569
Cdd:COG2319   187 RLWDLATGKLLRTLTGHTGAVRSV-----AFSPdgKLL---ASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDG 258

                         170       180
                  ....*....|....*....|....*...
gi 665389217  570 DFLIVGCSDGSVYVWQMETGHLDRVLHG 597
Cdd:COG2319   259 RLLASGSADGTVRLWDLATGELLRTLTG 286
WD40 COG2319
WD40 repeat [General function prediction only];
413-597 5.10e-13

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 73.02  E-value: 5.10e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389217  413 PQQSRLVIGREDGSIVI--VPATQTVmmqllvgikqnfsdwpshQILYGHRGRVNCL-LCPSmihsryeKSHLLSGGIDF 489
Cdd:COG2319   214 PDGKLLASGSADGTVRLwdLATGKLL------------------RTLTGHSGSVRSVaFSPD-------GRLLASGSADG 268

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389217  490 AVCLWDLYSGSLLHRFCVHAGEITQLlvppeSCSP--RILkciCSVASDHSVTLVSLQERKCVTLASRHLFPVVTIKWRP 567
Cdd:COG2319   269 TVRLWDLATGELLRTLTGHSGGVNSV-----AFSPdgKLL---ASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSP 340

                         170       180       190
                  ....*....|....*....|....*....|
gi 665389217  568 LDDFLIVGCSDGSVYVWQMETGHLDRVLHG 597
Cdd:COG2319   341 DGKTLASGSDDGTVRLWDLATGELLRTLTG 370
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 22-202 1.77e-10

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 63.89  E-value: 1.77e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389217   22 ISSVFLSDDQFTLVTGCYDGQICLWQVEPTTLKMSprclLVGHSAPVLCLvraSLLPENNFLVSSSENGEMCTWDLTDGK 101
Cdd:cd00200    96 VSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTT----LRGHTDWVNSV---AFSPDGTFVASSSQDGTIKLWDLRTGK 168

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389217  102 CMeavklpQVHTQIQS--YHTANSEDVRLFCIGyyA---EIMVMDPFSLEVIYVLSSkvKPDWISAIHVLrpmrRKDDVV 176
Cdd:cd00200   169 CV------ATLTGHTGevNSVAFSPDGEKLLSS--SsdgTIKLWDLSTGKCLGTLRG--HENGVNSVAFS----PDGYLL 234

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 665389217  177 LAITTTGTVKVW---------TLTGnenkHAEPIY 202
Cdd:cd00200   235 ASGSEDGTIRVWdlrtgecvqTLSG----HTNSVT 265
WD40 COG2319
WD40 repeat [General function prediction only];
413-588 7.50e-10

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 63.01  E-value: 7.50e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389217  413 PQQSRLVIGREDGSIVIVpatqtvmmqllvgikqNFSDWPSHQILYGHRGRVNcllcpSMIHSRYEKsHLLSGGIDFAVC 492
Cdd:COG2319   256 PDGRLLASGSADGTVRLW----------------DLATGELLRTLTGHSGGVN-----SVAFSPDGK-LLASGSDDGTVR 313

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389217  493 LWDLYSGSLLHRFCVHAGEITQLLVPPEScsprilKCICSVASDHSVTLVSLQERKCVTLASRHLFPVVTIKWRPLDDFL 572
Cdd:COG2319   314 LWDLATGKLLRTLTGHTGAVRSVAFSPDG------KTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTL 387

                         170
                  ....*....|....*.
gi 665389217  573 IVGCSDGSVYVWQMET 588
Cdd:COG2319   388 ASGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 455-585 1.42e-09

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 60.81  E-value: 1.42e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389217  455 QILYGHRGRVNCLlCPSmihsrYEKSHLLSGGIDFAVCLWDLYSGSLLHRFCVHAGEITQLLVPPescSPRILkciCSVA 534
Cdd:cd00200   171 ATLTGHTGEVNSV-AFS-----PDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSP---DGYLL---ASGS 238

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 665389217  535 SDHSVTLVSLQERKCVTLASRHLFPVVTIKWRPLDDFLIVGCSDGSVYVWQ 585
Cdd:cd00200   239 EDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 16-102 2.95e-08

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 56.96  E-value: 2.95e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389217   16 TAPTHCISSVFLSDDQFTLVTGCYDGQICLWQVEpttlkmSPRCL--LVGHSAPVLCLvraSLLPENNFLVSSSENGEMC 93
Cdd:cd00200    48 KGHTGPVRDVAASADGTYLASGSSDKTIRLWDLE------TGECVrtLTGHTSYVSSV---AFSPDGRILSSSSRDKTIK 118


                  ....*....
gi 665389217   94 TWDLTDGKC 102
Cdd:cd00200   119 VWDVETGKC 127
WD40 COG2319
WD40 repeat [General function prediction only];
1408-1469 4.09e-08

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 57.23  E-value: 4.09e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 665389217 1408 RRIAVGANSGNLAIYELRQNKC-QMIPAHTHPITSLAFSPDGKYLVSYScAENRLSFWQTSTG 1469
Cdd:COG2319   217 KLLASGSADGTVRLWDLATGKLlRTLTGHSGSVRSVAFSPDGRLLASGS-ADGTVRLWDLATG 278
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 16-103 5.70e-08

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 56.19  E-value: 5.70e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389217   16 TAPTHCISSVFLSDDQFTLVTGCYDGQICLWqvEPTTLKMSprCLLVGHSAPVLCLVRaslLPENNFLVSSSENGEMCTW 95
Cdd:cd00200   174 TGHTGEVNSVAFSPDGEKLLSSSSDGTIKLW--DLSTGKCL--GTLRGHENGVNSVAF---SPDGYLLASGSEDGTIRVW 246


                  ....*...
gi 665389217   96 DLTDGKCM 103
Cdd:cd00200   247 DLRTGECV 254
WD40 COG2319
WD40 repeat [General function prediction only];
9-194 6.61e-08

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 56.84  E-value: 6.61e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389217    9 PVVLWGPTAPthcISSVFLSDDQFTLVTGCYDGQICLWQVEpttlkmSPRCL--LVGHSAPVLCLvraSLLPENNFLVSS 86
Cdd:COG2319   113 LRTLTGHTGA---VRSVAFSPDGKTLASGSADGTVRLWDLA------TGKLLrtLTGHSGAVTSV---AFSPDGKLLASG 180

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389217   87 SENGEMCTWDLTDGKCMEAVKLpqvhtqiqsyHTANSEDV-------RLFCIGYYAEIMVMDPFSLEVIYVLSSkvKPDW 159
Cdd:COG2319   181 SDDGTVRLWDLATGKLLRTLTG----------HTGAVRSVafspdgkLLASGSADGTVRLWDLATGKLLRTLTG--HSGS 248

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 665389217  160 ISAIhVLRPmrrkDDVVLAITTT-GTVKVWTLTGNE 194
Cdd:COG2319   249 VRSV-AFSP----DGRLLASGSAdGTVRLWDLATGE 279
WD40 COG2319
WD40 repeat [General function prediction only];
1408-1469 8.97e-08

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 56.46  E-value: 8.97e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 665389217 1408 RRIAVGANSGNLAIYELRQNKC-QMIPAHTHPITSLAFSPDGKYLVSySCAENRLSFWQTSTG 1469
Cdd:COG2319   259 RLLASGSADGTVRLWDLATGELlRTLTGHSGGVNSVAFSPDGKLLAS-GSDDGTVRLWDLATG 320
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 22-195 1.26e-07

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 55.03  E-value: 1.26e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389217   22 ISSVFLSDDQFTLVTGCYDGQICLWQVEPTTLKMSprclLVGHSAPVLCLvraSLLPENNFLVSSSENGEMCTWDLTDGK 101
Cdd:cd00200    12 VTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRT----LKGHTGPVRDV---AASADGTYLASGSSDKTIRLWDLETGE 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389217  102 CmeavklpqVHTQIQsyHTAN------SEDVRLFCIGYY-AEIMVMDPFSLEVIYVLSSkvKPDWISAIHVLRPmrrkDD 174
Cdd:cd00200    85 C--------VRTLTG--HTSYvssvafSPDGRILSSSSRdKTIKVWDVETGKCLTTLRG--HTDWVNSVAFSPD----GT 148

                         170       180       190
                  ....*....|....*....|....*....|
gi 665389217  175 VVLAITTTGTVKVW---------TLTGNEN 195
Cdd:cd00200   149 FVASSSQDGTIKLWdlrtgkcvaTLTGHTG 178
WD40 COG2319
WD40 repeat [General function prediction only];
1408-1469 1.75e-07

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 55.30  E-value: 1.75e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 665389217 1408 RRIAVGANSGNLAIYELRQNKC-QMIPAHTHPITSLAFSPDGKYLVSySCAENRLSFWQTSTG 1469
Cdd:COG2319   133 KTLASGSADGTVRLWDLATGKLlRTLTGHSGAVTSVAFSPDGKLLAS-GSDDGTVRLWDLATG 194
WD40 COG2319
WD40 repeat [General function prediction only];
16-194 2.34e-07

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 54.92  E-value: 2.34e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389217   16 TAPTHCISSVFLSDDQFTLVTGCYDGQICLWQVEPTTLkmspRCLLVGHSAPVLCLvraSLLPENNFLVSSSENGEMCTW 95
Cdd:COG2319   201 TGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKL----LRTLTGHSGSVRSV---AFSPDGRLLASGSADGTVRLW 273

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389217   96 DLTDGKCmeaVKLPQVHTQiQSYHTANSED-VRLFCIGYYAEIMVMDPFSLEVIYVLSSKVkpDWISAIhVLRPmrrkDD 174
Cdd:COG2319   274 DLATGEL---LRTLTGHSG-GVNSVAFSPDgKLLASGSDDGTVRLWDLATGKLLRTLTGHT--GAVRSV-AFSP----DG 342

                         170       180
                  ....*....|....*....|.
gi 665389217  175 VVLAITTT-GTVKVWTLTGNE 194
Cdd:COG2319   343 KTLASGSDdGTVRLWDLATGE 363
WD40 COG2319
WD40 repeat [General function prediction only];
480-597 4.15e-07

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 54.15  E-value: 4.15e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389217  480 SHLLSGGIDFAVCLWDLYSGSLLHRFCVHAGEITQLLVPPEScsprilKCICSVASDHSVTLVSLQERKCVTLASRHLFP 559
Cdd:COG2319    49 ARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDG------RLLASASADGTVRLWDLATGLLLRTLTGHTGA 122

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 665389217  560 VVTIKWRPLDDFLIVGCSDGSVYVWQMETGHLDRVLHG 597
Cdd:COG2319   123 VRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTG 160
WD40 COG2319
WD40 repeat [General function prediction only];
1408-1469 4.53e-07

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 54.15  E-value: 4.53e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 665389217 1408 RRIAVGANSGNLAIYELRQNKC-QMIPAHTHPITSLAFSPDGKYLVSySCAENRLSFWQTSTG 1469
Cdd:COG2319   175 KLLASGSDDGTVRLWDLATGKLlRTLTGHTGAVRSVAFSPDGKLLAS-GSADGTVRLWDLATG 236
WD40 COG2319
WD40 repeat [General function prediction only];
1408-1469 1.57e-06

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 52.22  E-value: 1.57e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 665389217 1408 RRIAVGANSGNLAIYELRQNKC-QMIPAHTHPITSLAFSPDGKYLVSYScAENRLSFWQTSTG 1469
Cdd:COG2319   301 KLLASGSDDGTVRLWDLATGKLlRTLTGHTGAVRSVAFSPDGKTLASGS-DDGTVRLWDLATG 362
WD40 COG2319
WD40 repeat [General function prediction only];
16-102 2.30e-06

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 51.84  E-value: 2.30e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389217   16 TAPTHCISSVFLSDDQFTLVTGCYDGQICLWQVEpttlkmSPRCL--LVGHSAPVLCLVrasLLPENNFLVSSSENGEMC 93
Cdd:COG2319   285 TGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLA------TGKLLrtLTGHTGAVRSVA---FSPDGKTLASGSDDGTVR 355


                  ....*....
gi 665389217   94 TWDLTDGKC 102
Cdd:COG2319   356 LWDLATGEL 364
WD40 COG2319
WD40 repeat [General function prediction only];
11-99 2.71e-06

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 51.45  E-value: 2.71e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389217   11 VLWGPTAPTHCISSVFLSDDQFTLVTGCYDGQICLWQVEPTTLkmspRCLLVGHSAPVLCLvraSLLPENNFLVSSSENG 90
Cdd:COG2319   322 LLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGEL----LRTLTGHTGAVTSV---AFSPDGRTLASGSADG 394


                  ....*....
gi 665389217   91 EMCTWDLTD 99
Cdd:COG2319   395 TVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 1399-1495 3.33e-06

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 50.80  E-value: 3.33e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389217 1399 NQISHCAQT---RRIAVGANSGNLAIYELRQNKC-QMIPAHTHPITSLAFSPDGKYLVSYScAENRLSFWQTSTG--MFG 1472
Cdd:cd00200   178 GEVNSVAFSpdgEKLLSSSSDGTIKLWDLSTGKClGTLRGHENGVNSVAFSPDGYLLASGS-EDGTIRVWDLRTGecVQT 256

                          90       100
                  ....*....|....*....|...
gi 665389217 1473 LGQSQTRCTkgySTAPIPDVSRL 1495
Cdd:cd00200   257 LSGHTNSVT---SLAWSPDGKRL 276
WD40 COG2319
WD40 repeat [General function prediction only];
1408-1469 4.61e-06

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 50.68  E-value: 4.61e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 665389217 1408 RRIAVGANSGNLAIYELRQNKCQMIP-AHTHPITSLAFSPDGKYLVSySCAENRLSFWQTSTG 1469
Cdd:COG2319    91 RLLASASADGTVRLWDLATGLLLRTLtGHTGAVRSVAFSPDGKTLAS-GSADGTVRLWDLATG 152
WD40 COG2319
WD40 repeat [General function prediction only];
1408-1468 4.77e-06

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 50.68  E-value: 4.77e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 665389217 1408 RRIAVGANSGNLAIYELRQNKC-QMIPAHTHPITSLAFSPDGKYLVSySCAENRLSFWQTST 1468
Cdd:COG2319   343 KTLASGSDDGTVRLWDLATGELlRTLTGHTGAVTSVAFSPDGRTLAS-GSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 1399-1465 7.85e-06

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 49.64  E-value: 7.85e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 665389217 1399 NQISHCA--QTRRIAVGANS-GNLAIYELRQNKC-QMIPAHTHPITSLAFSPDGKYLVSYScAENRLSFWQ 1465
Cdd:cd00200   220 NGVNSVAfsPDGYLLASGSEdGTIRVWDLRTGECvQTLSGHTNSVTSLAWSPDGKRLASGS-ADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 1399-1469 1.94e-05

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 48.10  E-value: 1.94e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 665389217 1399 NQISHCA--QTRRIAVGANS-GNLAIYELRQNKCQM-IPAHTHPITSLAFSPDGKYLVSySCAENRLSFWQTSTG 1469
Cdd:cd00200    94 SYVSSVAfsPDGRILSSSSRdKTIKVWDVETGKCLTtLRGHTDWVNSVAFSPDGTFVAS-SSQDGTIKLWDLRTG 167
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 407-539 8.26e-05

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 46.17  E-value: 8.26e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389217  407 TSSIYLPQQSRLVIGREDGSIVIVpatqtvmmqllvgikqNFSDWPSHQILYGHRGRVNCLlcpSMIHSRYeksHLLSGG 486
Cdd:cd00200   181 NSVAFSPDGEKLLSSSSDGTIKLW----------------DLSTGKCLGTLRGHENGVNSV---AFSPDGY---LLASGS 238

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 665389217  487 IDFAVCLWDLYSGSLLHRFCVHAGEITQLLVPPESCsprilkCICSVASDHSV 539
Cdd:cd00200   239 EDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGK------RLASGSADGTI 285
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 1404-1471 1.51e-04

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 45.40  E-value: 1.51e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 665389217 1404 CAQTRRIAVGANSGNLAIYELRQNKC-QMIPAHTHPITSLAFSPDGKYLVSySCAENRLSFWQTSTGMF 1471
Cdd:cd00200    60 SADGTYLASGSSDKTIRLWDLETGECvRTLTGHTSYVSSVAFSPDGRILSS-SSRDKTIKVWDVETGKC 127
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 1427-1464 1.56e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 40.37  E-value: 1.56e-04
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 665389217   1427 NKCQMIPAHTHPITSLAFSPDGKYLVSySCAENRLSFW 1464
Cdd:smart00320    3 ELLKTLKGHTGPVTSVAFSPDGKYLAS-GSDDGTIKLW 39
GvpP COG4980
Gas vesicle protein YhaH [General function prediction only];
735-816 2.64e-04

Gas vesicle protein YhaH [General function prediction only];


Pssm-ID: 444004 [Multi-domain]  Cd Length: 106  Bit Score: 41.88  E-value: 2.64e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389217  735 PKDGKSMHldasKKIGDFFNKVKNKAVDVEKILKDKDKHgLVQKFKEKTEIVEKKVQAKVESLQKAVEPheEQQDLKSKI 814
Cdd:COG4980    26 PKSGKETR----KKLKDKADDLKDKAEDLKDELKEKASE-LSEEAKEKLDELIEEIKEKIEELKEEVEP--KIEELKEEA 98


                  ..
gi 665389217  815 AS 816
Cdd:COG4980    99 EK 100
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 1410-1470 7.65e-04

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 43.48  E-value: 7.65e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 665389217 1410 IAVGANSGNLAIYELRQNKC-QMIPAHTHPITSLAFSPDGKYLVSySCAENRLSFWQTSTGM 1470
Cdd:cd00200   150 VASSSQDGTIKLWDLRTGKCvATLTGHTGEVNSVAFSPDGEKLLS-SSSDGTIKLWDLSTGK 210
WD40 pfam00400
WD domain, G-beta repeat;
1430-1464 1.31e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 37.71  E-value: 1.31e-03
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 665389217  1430 QMIPAHTHPITSLAFSPDGKYLVSySCAENRLSFW 1464
Cdd:pfam00400    5 KTLEGHTGSVTSLAFSPDGKLLAS-GSDDGTVKVW 38
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 547-584 3.42e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 36.52  E-value: 3.42e-03
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 665389217    547 RKCVTLASRHLFPVVTIKWRPLDDFLIVGCSDGSVYVW 584
Cdd:smart00320    2 GELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 22-96 6.83e-03

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 40.40  E-value: 6.83e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 665389217   22 ISSVFLSDDQFTLVTGCYDGQICLWQVEPTTLKMSprclLVGHSAPVLCLvraSLLPENNFLVSSSENGEMCTWD 96
Cdd:cd00200   222 VNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQT----LSGHTNSVTSL---AWSPDGKRLASGSADGTIRIWD 289
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 16-46 9.36e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 35.37  E-value: 9.36e-03
                            10        20        30
                    ....*....|....*....|....*....|.
gi 665389217     16 TAPTHCISSVFLSDDQFTLVTGCYDGQICLW 46
Cdd:smart00320    9 KGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 1432-1469 9.62e-03

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 40.01  E-value: 9.62e-03
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 665389217 1432 IPAHTHPITSLAFSPDGKYLVSySCAENRLSFWQTSTG 1469
Cdd:cd00200     5 LKGHTGGVTCVAFSPDGKLLAT-GSGDGTIKVWDLETG 41
WD40 pfam00400
WD domain, G-beta repeat;
547-584 9.86e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 35.40  E-value: 9.86e-03
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 665389217   547 RKCVTLASRHLFPVVTIKWRPLDDFLIVGCSDGSVYVW 584
Cdd:pfam00400    1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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