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    PMCA plasma membrane calcium ATPase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43787, updated on 9-Dec-2024

    Summary

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    Official Symbol
    PMCAprovided by FlyBase
    Official Full Name
    plasma membrane calcium ATPaseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0259214
    Locus tag
    Dmel_CG42314
    See related
    AllianceGenome:FB:FBgn0259214
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BEST:CK; BEST:CK01140; BEST:CK02288; BP1021; CG2165; CG34036; CG42314; CK02288; Dmel\CG42314
    Old locus tag
    Dmel_CG2165; Dmel_CG34036
    Summary
    Predicted to enable P-type calcium transporter activity. Involved in intracellular calcium ion homeostasis. Located in plasma membrane. Is expressed in several structures, including adult head; adult heart; adult mushroom body; brain; and ellipsoid body. Human ortholog(s) of this gene implicated in X-linked spinocerebellar ataxia 1; autosomal dominant intellectual developmental disorder; autosomal dominant nonsyndromic deafness; and autosomal recessive nonsyndromic deafness 12. Orthologous to several human genes including ATP2B4 (ATPase plasma membrane Ca2+ transporting 4). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See PMCA in Genome Data Viewer
    Location:
    102B5-102B5; 4-0 cM
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 4 NC_004353.4 (328193..358917, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 4 NC_004353.3 (348819..379543, complement)

    Chromosome 4 - NC_004353.4Genomic Context describing neighboring genes Neighboring gene Rad23 Neighboring gene Zinc/iron regulated transporter-related protein 102B Neighboring gene Ring finger protein 11 Neighboring gene Host cell factor Neighboring gene long non-coding RNA:CR45125 Neighboring gene datilografo

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Ca2+ dynamics along identified synaptic terminals in Drosophila larvae. Lnenicka GA, et al. J Neurosci, 2006 Nov 22. PMID 17122054, Free PMC Article
    2. Ca²+ buffering at a drosophila larval synaptic terminal. He T, et al. Synapse, 2011 Jul. PMID 21218450
    3. Downregulation of Plasma Membrane Ca(2+) ATPase driven by tyrosine hydroxylase-Gal4 reduces Drosophila lifespan independently of effects in neurons. Erhardt B, et al. Fly (Austin), 2023 Dec. PMID 36949021, Free PMC Article
    4. Characterization of postsynaptic Ca2+ signals at the Drosophila larval NMJ. Desai SA, et al. J Neurophysiol, 2011 Aug. PMID 21593388
    5. Neuronal Glutamatergic Synaptic Clefts Alkalinize Rather Than Acidify during Neurotransmission. Stawarski M, et al. J Neurosci, 2020 Feb 19. PMID 31964719, Free PMC Article

    See all (95) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Separation of presynaptic Cav2 and Cav1 channel function in synaptic vesicle exo- and endocytosis by the membrane anchored Ca(2+) pump PMCA.
      Title: Separation of presynaptic Ca(v)2 and Ca(v)1 channel function in synaptic vesicle exo- and endocytosis by the membrane anchored Ca(2+) pump PMCA.
    2. Plasma membrane Ca2+-ATPase plays a role in extruding Ca2+ from the postsynaptic region of the neuromuscular junction.
      Title: Characterization of postsynaptic Ca2+ signals at the Drosophila larval NMJ.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    mobile_element

    • Loc: c332772-332341 mobile_element_type = transposon:INE-1{}5345
    • Loc: c333466-333282 mobile_element_type = transposon:INE-1{}5347
    • Loc: c339098-339043 mobile_element_type = transposon:INE-1{}5349
    • Loc: c343180-343136 mobile_element_type = transposon:INE-1{}5350
    • Loc: c347726-346641 mobile_element_type = transposon:Tc1-2{}5456
    • Loc: c353606-353513 mobile_element_type = transposon:BS3{}5390
    • Loc: c357789-357584 mobile_element_type = transposon:INE-1{}5363

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables P-type calcium transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables P-type calcium transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in calcium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in intracellular calcium ion homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of cytosolic calcium ion concentration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in intracellular membrane-bounded organelle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane HDA PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    plasma membrane calcium ATPase
    Names
    CG42314-PI
    CG42314-PJ
    CG42314-PK
    CG42314-PL
    CG42314-PM
    CG42314-PN
    CG42314-PO
    CG42314-PP
    CG42314-PQ
    CG42314-PR
    CG42314-PS
    PMCA-PI
    PMCA-PJ
    PMCA-PK
    PMCA-PL
    PMCA-PM
    PMCA-PN
    PMCA-PO
    PMCA-PP
    PMCA-PQ
    PMCA-PR
    PMCA-PS
    plasma membrane Ca2+ ATPase
    plasma membrane Ca[2+] ATPase
    NP_001014687.3
    NP_001014688.3
    NP_001014689.3
    NP_001033803.3
    NP_001188514.1
    NP_001188515.1
    NP_001188516.1
    NP_001188517.1
    NP_001188518.1
    NP_726564.5
    NP_726565.5

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004353.4 Reference assembly

      Range
      328193..358917 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001201587.2 → NP_001188516.1  plasma membrane calcium ATPase, isoform Q [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001188516.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E6EK17
      Conserved Domains (7) summary
      cd01427
      Location:676 → 807
      HAD_like; Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others, ...
      TIGR01517
      Location:1 → 1057
      ATPase-IIB_Ca; plasma-membrane calcium-translocating P-type ATPase
      pfam00122
      Location:172 → 448
      E1-E2_ATPase; E1-E2 ATPase
      pfam00689
      Location:873 → 1051
      Cation_ATPase_C; Cation transporting ATPase, C-terminus
      pfam00690
      Location:36 → 104
      Cation_ATPase_N; Cation transporter/ATPase, N-terminus
      pfam12424
      Location:1096 → 1125
      ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal
      pfam13246
      Location:505 → 598
      Cation_ATPase; Cation transport ATPase (P-type)

    2. NM_001201585.2 → NP_001188514.1  plasma membrane calcium ATPase, isoform O [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001188514.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9V4C7
      Conserved Domains (7) summary
      cd01427
      Location:676 → 807
      HAD_like; Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others, ...
      TIGR01517
      Location:1 → 1057
      ATPase-IIB_Ca; plasma-membrane calcium-translocating P-type ATPase
      pfam00122
      Location:172 → 448
      E1-E2_ATPase; E1-E2 ATPase
      pfam00689
      Location:873 → 1051
      Cation_ATPase_C; Cation transporting ATPase, C-terminus
      pfam00690
      Location:36 → 104
      Cation_ATPase_N; Cation transporter/ATPase, N-terminus
      pfam12424
      Location:1096 → 1144
      ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal
      pfam13246
      Location:505 → 598
      Cation_ATPase; Cation transport ATPase (P-type)

    3. NM_001201586.2 → NP_001188515.1  plasma membrane calcium ATPase, isoform P [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001188515.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E6EK15
      Conserved Domains (7) summary
      cd01427
      Location:664 → 795
      HAD_like; Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others, ...
      TIGR01517
      Location:1 → 1045
      ATPase-IIB_Ca; plasma-membrane calcium-translocating P-type ATPase
      pfam00122
      Location:172 → 436
      E1-E2_ATPase; E1-E2 ATPase
      pfam00689
      Location:861 → 1039
      Cation_ATPase_C; Cation transporting ATPase, C-terminus
      pfam00690
      Location:36 → 104
      Cation_ATPase_N; Cation transporter/ATPase, N-terminus
      pfam12424
      Location:1084 → 1132
      ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal
      pfam13246
      Location:493 → 586
      Cation_ATPase; Cation transport ATPase (P-type)

    4. NM_166755.6 → NP_726565.5  plasma membrane calcium ATPase, isoform L [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_726565.5

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9V4C7
      Conserved Domains (7) summary
      cd01427
      Location:676 → 807
      HAD_like; Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others, ...
      TIGR01517
      Location:1 → 1057
      ATPase-IIB_Ca; plasma-membrane calcium-translocating P-type ATPase
      pfam00122
      Location:172 → 448
      E1-E2_ATPase; E1-E2 ATPase
      pfam00689
      Location:873 → 1051
      Cation_ATPase_C; Cation transporting ATPase, C-terminus
      pfam00690
      Location:36 → 104
      Cation_ATPase_N; Cation transporter/ATPase, N-terminus
      pfam12424
      Location:1096 → 1144
      ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal
      pfam13246
      Location:505 → 598
      Cation_ATPase; Cation transport ATPase (P-type)

    5. NM_001201588.2 → NP_001188517.1  plasma membrane calcium ATPase, isoform R [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001188517.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E6EK18
      Conserved Domains (7) summary
      cd01427
      Location:676 → 807
      HAD_like; Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others, ...
      TIGR01517
      Location:1 → 1057
      ATPase-IIB_Ca; plasma-membrane calcium-translocating P-type ATPase
      pfam00122
      Location:172 → 448
      E1-E2_ATPase; E1-E2 ATPase
      pfam00689
      Location:873 → 1051
      Cation_ATPase_C; Cation transporting ATPase, C-terminus
      pfam00690
      Location:36 → 104
      Cation_ATPase_N; Cation transporter/ATPase, N-terminus
      pfam12424
      Location:1096 → 1148
      ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal
      pfam13246
      Location:505 → 598
      Cation_ATPase; Cation transport ATPase (P-type)

    6. NM_001014688.4 → NP_001014688.3  plasma membrane calcium ATPase, isoform K [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001014688.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q59DQ0
      Conserved Domains (7) summary
      cd01427
      Location:676 → 807
      HAD_like; Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others, ...
      TIGR01517
      Location:1 → 1057
      ATPase-IIB_Ca; plasma-membrane calcium-translocating P-type ATPase
      pfam00122
      Location:172 → 448
      E1-E2_ATPase; E1-E2 ATPase
      pfam00689
      Location:873 → 1051
      Cation_ATPase_C; Cation transporting ATPase, C-terminus
      pfam00690
      Location:36 → 104
      Cation_ATPase_N; Cation transporter/ATPase, N-terminus
      pfam12424
      Location:1096 → 1121
      ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal
      pfam13246
      Location:505 → 598
      Cation_ATPase; Cation transport ATPase (P-type)

    7. NM_166754.6 → NP_726564.5  plasma membrane calcium ATPase, isoform I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_726564.5

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9V4C7
      Conserved Domains (7) summary
      cd01427
      Location:676 → 807
      HAD_like; Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others, ...
      TIGR01517
      Location:1 → 1057
      ATPase-IIB_Ca; plasma-membrane calcium-translocating P-type ATPase
      pfam00122
      Location:172 → 448
      E1-E2_ATPase; E1-E2 ATPase
      pfam00689
      Location:873 → 1051
      Cation_ATPase_C; Cation transporting ATPase, C-terminus
      pfam00690
      Location:36 → 104
      Cation_ATPase_N; Cation transporter/ATPase, N-terminus
      pfam12424
      Location:1096 → 1144
      ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal
      pfam13246
      Location:505 → 598
      Cation_ATPase; Cation transport ATPase (P-type)

    8. NM_001038714.4 → NP_001033803.3  plasma membrane calcium ATPase, isoform J [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001033803.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q2PDM1, Q59DP9
      Conserved Domains (7) summary
      cd01427
      Location:676 → 807
      HAD_like; Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others, ...
      TIGR01517
      Location:1 → 1057
      ATPase-IIB_Ca; plasma-membrane calcium-translocating P-type ATPase
      pfam00122
      Location:172 → 448
      E1-E2_ATPase; E1-E2 ATPase
      pfam00689
      Location:873 → 1051
      Cation_ATPase_C; Cation transporting ATPase, C-terminus
      pfam00690
      Location:36 → 104
      Cation_ATPase_N; Cation transporter/ATPase, N-terminus
      pfam12424
      Location:1096 → 1142
      ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal
      pfam13246
      Location:505 → 598
      Cation_ATPase; Cation transport ATPase (P-type)

    9. NM_001201589.2 → NP_001188518.1  plasma membrane calcium ATPase, isoform S [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001188518.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q2PDM1, Q59DP9
      Conserved Domains (7) summary
      cd01427
      Location:676 → 807
      HAD_like; Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others, ...
      TIGR01517
      Location:1 → 1057
      ATPase-IIB_Ca; plasma-membrane calcium-translocating P-type ATPase
      pfam00122
      Location:172 → 448
      E1-E2_ATPase; E1-E2 ATPase
      pfam00689
      Location:873 → 1051
      Cation_ATPase_C; Cation transporting ATPase, C-terminus
      pfam00690
      Location:36 → 104
      Cation_ATPase_N; Cation transporter/ATPase, N-terminus
      pfam12424
      Location:1096 → 1142
      ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal
      pfam13246
      Location:505 → 598
      Cation_ATPase; Cation transport ATPase (P-type)

    10. NM_001014689.5 → NP_001014689.3  plasma membrane calcium ATPase, isoform M [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001014689.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q2PDM1, Q59DP9
      Conserved Domains (7) summary
      cd01427
      Location:676 → 807
      HAD_like; Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others, ...
      TIGR01517
      Location:1 → 1057
      ATPase-IIB_Ca; plasma-membrane calcium-translocating P-type ATPase
      pfam00122
      Location:172 → 448
      E1-E2_ATPase; E1-E2 ATPase
      pfam00689
      Location:873 → 1051
      Cation_ATPase_C; Cation transporting ATPase, C-terminus
      pfam00690
      Location:36 → 104
      Cation_ATPase_N; Cation transporter/ATPase, N-terminus
      pfam12424
      Location:1096 → 1142
      ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal
      pfam13246
      Location:505 → 598
      Cation_ATPase; Cation transport ATPase (P-type)

    11. NM_001014687.4 → NP_001014687.3  plasma membrane calcium ATPase, isoform N [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001014687.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q59DP8
      Conserved Domains (7) summary
      cd01427
      Location:676 → 807
      HAD_like; Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others, ...
      TIGR01517
      Location:1 → 1057
      ATPase-IIB_Ca; plasma-membrane calcium-translocating P-type ATPase
      pfam00122
      Location:172 → 448
      E1-E2_ATPase; E1-E2 ATPase
      pfam00689
      Location:873 → 1051
      Cation_ATPase_C; Cation transporting ATPase, C-terminus
      pfam00690
      Location:36 → 104
      Cation_ATPase_N; Cation transporter/ATPase, N-terminus
      pfam12424
      Location:1096 → 1111
      ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal
      pfam13246
      Location:505 → 598
      Cation_ATPase; Cation transport ATPase (P-type)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    E6EK15 E6EK15
    E6EK17 E6EK17
    E6EK18 E6EK18
    Q59DP8 Q59DP8
    Q59DP9 Q59DP9
    Q59DQ0 Q59DQ0
    Q9V4C7 Q9V4C7

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