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Conserved domains on  [gi|320541585|ref|NP_001188514|]
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plasma membrane calcium ATPase, isoform O [Drosophila melanogaster]

Protein Classification

P-type_ATPase_Ca_PMCA-like and Cation_ATPase_C domain-containing protein( domain architecture ID 11550589)

protein containing domains P-type_ATPase_Ca_PMCA-like, Cation_ATPase_C, and ATP_Ca_trans_C

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
P-type_ATPase_Ca_PMCA-like cd02081
animal plasma membrane Ca2(+)-ATPases (PMCA), similar to human ATP2B1-4/PMCA1-4, and related ...
62-921 0e+00

animal plasma membrane Ca2(+)-ATPases (PMCA), similar to human ATP2B1-4/PMCA1-4, and related Ca2(+)-ATPases including Saccharomyces cerevisiae vacuolar PMC1; Animal PMCAs function to export Ca(2+) from cells and play a role in regulating Ca(2+) signals following stimulus induction and in preventing calcium toxicity. Many PMCA pump variants exist due to alternative splicing of transcripts. PMCAs are regulated by the binding of calmodulin or by kinase-mediated phosphorylation. Saccharomyces cerevisiae vacuolar transporter Pmc1p facilitates the accumulation of Ca2+ into vacuoles. Pmc1p is not regulated by direct calmodulin binding but responds to the calmodulin/calcineurin-signaling pathway and is controlled by the transcription factor complex Tcn1p/Crz1p. Similarly, the expression of the gene for Dictyostelium discoideum Ca(2+)-ATPase PAT1, patA, is under the control of a calcineurin-dependent transcription factor. Plant vacuolar Ca(2+)-ATPases, are regulated by direct-calmodulin binding. Plant Ca(2+)-ATPases are present at various cellular locations including the plasma membrane, endoplasmic reticulum, chloroplast and vacuole. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


:

Pssm-ID: 319776 [Multi-domain]  Cd Length: 721  Bit Score: 1261.35  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585   62 EHRRETFGSNVIPPKPPKTFLTLVWEALQDVTLIILEVAALVSLGLSFYKPADEdapvlqeEEEHHGWIEGLAILISVIV 141
Cdd:cd02081     2 EHRREVYGKNEIPPKPPKSFLQLVWEALQDPTLIILLIAAIVSLGLGFYTPFGE-------GEGKTGWIEGVAILVAVIL 74
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  142 VVIVTAFNDYSKERQFRGLQNRIEgEHKFSVIRGGEVCQISVGDILVGDIAQVKYGDLLPADGCLIQSNDLKVDESSLTG 221
Cdd:cd02081    75 VVLVTAGNDYQKEKQFRKLNSKKE-DQKVTVIRDGEVIQISVFDIVVGDIVQLKYGDLIPADGLLIEGNDLKIDESSLTG 153
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  222 ESDHVKKGPD---VDPMVLSGTHVMEGSGKMVVTAVGVNSQAGIIFTLLGAAvdeqeaeikkmkkeakrankqknltgen 298
Cdd:cd02081   154 ESDPIKKTPDnqiPDPFLLSGTKVLEGSGKMLVTAVGVNSQTGKIMTLLRAE---------------------------- 205
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  299 dgrsqikgsqapsqretvtseitksesegnhlpqssssgaaetghKKEKSVLQAKLTKLAIQIGYAGSTIAVLTVIILII 378
Cdd:cd02081   206 ---------------------------------------------NEEKTPLQEKLTKLAVQIGKVGLIVAALTFIVLII 240
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  379 QFCIKTFVIDEKPWKNTYANNLVKHLIIGVTVLVVAVPEGLPLAVTLSLAYSVKKMMKDNNLVRHLDACETMGNATAICS 458
Cdd:cd02081   241 RFIIDGFVNDGKSFSAEDLQEFVNFFIIAVTIIVVAVPEGLPLAVTLSLAYSVKKMMKDNNLVRHLDACETMGNATAICS 320
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  459 DKTGTLTTNRMTVVQSYIceklckvlptlsdipqhvgnlitmgisvnsaytsnimaghnpgdlpiqvGNKTECALLGFVQ 538
Cdd:cd02081   321 DKTGTLTQNRMTVVQGYI-------------------------------------------------GNKTECALLGFVL 351
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  539 GLGVKYQsIRDEITEDKFTRVYTFNSVRKSMGTVIPRPNGGYRLYTKGASEIIMKKCAFIYGHEGTlEKFTRDMQERLIR 618
Cdd:cd02081   352 ELGGDYR-YREKRPEEKVLKVYPFNSARKRMSTVVRLKDGGYRLYVKGASEIVLKKCSYILNSDGE-VVFLTSEKKEEIK 429
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  619 EVIEPMACDGLRTISVAYRDFVPGKAAINEVhidgepNWDDEENIMTNLTCLCVVGIEDPVRPEVPDAIRKCQRAGITVR 698
Cdd:cd02081   430 RVIEPMASDSLRTIGLAYRDFSPDEEPTAER------DWDDEEDIESDLTFIGIVGIKDPLRPEVPEAVAKCQRAGITVR 503
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  699 MVTGDNINTARSIASKCGILRPNDDFLILEGKEFNRRIRDSNGDIQQHLIDKVWPKLRVLARSSPTDKYTLVKGIIDStv 778
Cdd:cd02081   504 MVTGDNINTARAIARECGILTEGEDGLVLEGKEFRELIDEEVGEVCQEKFDKIWPKLRVLARSSPEDKYTLVKGLKDS-- 581
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  779 senREVVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFSSIVKAVMWGRNVYDSIAKFLQFQLTVNVV 858
Cdd:cd02081   582 ---GEVVAVTGDGTNDAPALKKADVGFAMGIAGTEVAKEASDIILLDDNFSSIVKAVMWGRNVYDSIRKFLQFQLTVNVV 658
                         810       820       830       840       850       860
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 320541585  859 AVIVAFIGACAVQDSPLKAVQMLWVNLIMDTLASLALATEFPTPDLLLRKPYGRTKPLISRTM 921
Cdd:cd02081   659 AVILAFIGAVVTKDSPLTAVQMLWVNLIMDTLAALALATEPPTEDLLKRKPYGRDKPLISRTM 721
Cation_ATPase_C pfam00689
Cation transporting ATPase, C-terminus; Members of this families are involved in Na+/K+, H+/K+, ...
873-1051 9.60e-49

Cation transporting ATPase, C-terminus; Members of this families are involved in Na+/K+, H+/K+, Ca++ and Mg++ transport. This family represents 5 transmembrane helices.


:

Pssm-ID: 376368 [Multi-domain]  Cd Length: 175  Bit Score: 170.88  E-value: 9.60e-49
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585   873 SPLKAVQMLWVNLIMDTLASLALATEFPTPDLLLRKPYGRTKPLISRTMMKNILGQALYQLIIIFGLLFVGDVILDIEsg 952
Cdd:pfam00689    2 LPLTPIQILWINLVTDGLPALALGFEPPEPDLMKRPPRKPKEPLFSRKMLRRILLQGLLIAILTLLVFFLGLLGFGIS-- 79
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585   953 rgqelnaGPTQHFTIIFNTFVMMTLFNEINARKIHGQRNVIeGLLTNPIFYTIWIFTMISQVLIIQYGKMA--FSTKALT 1030
Cdd:pfam00689   80 -------ESQNAQTMAFNTLVLSQLFNALNARSLRRSLFKI-GLFSNKLLLLAILLSLLLQLLIIYVPPLQavFGTTPLS 151
                          170       180
                   ....*....|....*....|.
gi 320541585  1031 LDQWLWCIFFGIGTLVWGQLI 1051
Cdd:pfam00689  152 LEQWLIVLLLALVVLLVVELR 172
ATP_Ca_trans_C pfam12424
Plasma membrane calcium transporter ATPase C terminal; This domain family is found in ...
1096-1142 2.40e-11

Plasma membrane calcium transporter ATPase C terminal; This domain family is found in eukaryotes, and is approximately 60 amino acids in length. The family is found in association with pfam00689, pfam00122, pfam00702, pfam00690. There is a conserved QTQ sequence motif. This family is the C terminal of a calcium transporting ATPase located in the plasma membrane.


:

Pssm-ID: 463575  Cd Length: 47  Bit Score: 59.73  E-value: 2.40e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 320541585  1096 GQILWIRGLTRLQTQV-IGGELQERL-IPVpySKSNTDQAIRVVNAFRQ 1142
Cdd:pfam12424    1 GQILWFRGLNRIQTQIrVVKAFQSSLrEGI--QKPYLRNSIHSFMSHPE 47
 
Name Accession Description Interval E-value
P-type_ATPase_Ca_PMCA-like cd02081
animal plasma membrane Ca2(+)-ATPases (PMCA), similar to human ATP2B1-4/PMCA1-4, and related ...
62-921 0e+00

animal plasma membrane Ca2(+)-ATPases (PMCA), similar to human ATP2B1-4/PMCA1-4, and related Ca2(+)-ATPases including Saccharomyces cerevisiae vacuolar PMC1; Animal PMCAs function to export Ca(2+) from cells and play a role in regulating Ca(2+) signals following stimulus induction and in preventing calcium toxicity. Many PMCA pump variants exist due to alternative splicing of transcripts. PMCAs are regulated by the binding of calmodulin or by kinase-mediated phosphorylation. Saccharomyces cerevisiae vacuolar transporter Pmc1p facilitates the accumulation of Ca2+ into vacuoles. Pmc1p is not regulated by direct calmodulin binding but responds to the calmodulin/calcineurin-signaling pathway and is controlled by the transcription factor complex Tcn1p/Crz1p. Similarly, the expression of the gene for Dictyostelium discoideum Ca(2+)-ATPase PAT1, patA, is under the control of a calcineurin-dependent transcription factor. Plant vacuolar Ca(2+)-ATPases, are regulated by direct-calmodulin binding. Plant Ca(2+)-ATPases are present at various cellular locations including the plasma membrane, endoplasmic reticulum, chloroplast and vacuole. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319776 [Multi-domain]  Cd Length: 721  Bit Score: 1261.35  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585   62 EHRRETFGSNVIPPKPPKTFLTLVWEALQDVTLIILEVAALVSLGLSFYKPADEdapvlqeEEEHHGWIEGLAILISVIV 141
Cdd:cd02081     2 EHRREVYGKNEIPPKPPKSFLQLVWEALQDPTLIILLIAAIVSLGLGFYTPFGE-------GEGKTGWIEGVAILVAVIL 74
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  142 VVIVTAFNDYSKERQFRGLQNRIEgEHKFSVIRGGEVCQISVGDILVGDIAQVKYGDLLPADGCLIQSNDLKVDESSLTG 221
Cdd:cd02081    75 VVLVTAGNDYQKEKQFRKLNSKKE-DQKVTVIRDGEVIQISVFDIVVGDIVQLKYGDLIPADGLLIEGNDLKIDESSLTG 153
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  222 ESDHVKKGPD---VDPMVLSGTHVMEGSGKMVVTAVGVNSQAGIIFTLLGAAvdeqeaeikkmkkeakrankqknltgen 298
Cdd:cd02081   154 ESDPIKKTPDnqiPDPFLLSGTKVLEGSGKMLVTAVGVNSQTGKIMTLLRAE---------------------------- 205
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  299 dgrsqikgsqapsqretvtseitksesegnhlpqssssgaaetghKKEKSVLQAKLTKLAIQIGYAGSTIAVLTVIILII 378
Cdd:cd02081   206 ---------------------------------------------NEEKTPLQEKLTKLAVQIGKVGLIVAALTFIVLII 240
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  379 QFCIKTFVIDEKPWKNTYANNLVKHLIIGVTVLVVAVPEGLPLAVTLSLAYSVKKMMKDNNLVRHLDACETMGNATAICS 458
Cdd:cd02081   241 RFIIDGFVNDGKSFSAEDLQEFVNFFIIAVTIIVVAVPEGLPLAVTLSLAYSVKKMMKDNNLVRHLDACETMGNATAICS 320
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  459 DKTGTLTTNRMTVVQSYIceklckvlptlsdipqhvgnlitmgisvnsaytsnimaghnpgdlpiqvGNKTECALLGFVQ 538
Cdd:cd02081   321 DKTGTLTQNRMTVVQGYI-------------------------------------------------GNKTECALLGFVL 351
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  539 GLGVKYQsIRDEITEDKFTRVYTFNSVRKSMGTVIPRPNGGYRLYTKGASEIIMKKCAFIYGHEGTlEKFTRDMQERLIR 618
Cdd:cd02081   352 ELGGDYR-YREKRPEEKVLKVYPFNSARKRMSTVVRLKDGGYRLYVKGASEIVLKKCSYILNSDGE-VVFLTSEKKEEIK 429
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  619 EVIEPMACDGLRTISVAYRDFVPGKAAINEVhidgepNWDDEENIMTNLTCLCVVGIEDPVRPEVPDAIRKCQRAGITVR 698
Cdd:cd02081   430 RVIEPMASDSLRTIGLAYRDFSPDEEPTAER------DWDDEEDIESDLTFIGIVGIKDPLRPEVPEAVAKCQRAGITVR 503
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  699 MVTGDNINTARSIASKCGILRPNDDFLILEGKEFNRRIRDSNGDIQQHLIDKVWPKLRVLARSSPTDKYTLVKGIIDStv 778
Cdd:cd02081   504 MVTGDNINTARAIARECGILTEGEDGLVLEGKEFRELIDEEVGEVCQEKFDKIWPKLRVLARSSPEDKYTLVKGLKDS-- 581
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  779 senREVVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFSSIVKAVMWGRNVYDSIAKFLQFQLTVNVV 858
Cdd:cd02081   582 ---GEVVAVTGDGTNDAPALKKADVGFAMGIAGTEVAKEASDIILLDDNFSSIVKAVMWGRNVYDSIRKFLQFQLTVNVV 658
                         810       820       830       840       850       860
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 320541585  859 AVIVAFIGACAVQDSPLKAVQMLWVNLIMDTLASLALATEFPTPDLLLRKPYGRTKPLISRTM 921
Cdd:cd02081   659 AVILAFIGAVVTKDSPLTAVQMLWVNLIMDTLAALALATEPPTEDLLKRKPYGRDKPLISRTM 721
ATPase-IIB_Ca TIGR01517
plasma-membrane calcium-translocating P-type ATPase; This model describes the P-type ATPase ...
1-1057 0e+00

plasma-membrane calcium-translocating P-type ATPase; This model describes the P-type ATPase responsible for translocating calcium ions across the plasma membrane of eukaryotes, out of the cell. In some organisms, this type of pump may also be found in vacuolar membranes. In humans and mice, at least, there are multiple isoforms of the PMCA pump with overlapping but not redundant functions. Accordingly, there are no human diseases linked to PMCA defects, although alterations of PMCA function do elicit physiological effects. The calcium P-type ATPases have been characterized as Type IIB based on a phylogenetic analysis which distinguishes this group from the Type IIA SERCA calcium pump. A separate analysis divides Type IIA into sub-types (SERCA and PMR1) which are represented by two corresponding models (TIGR01116 and TIGR01522). This model is well separated from those.


Pssm-ID: 273668 [Multi-domain]  Cd Length: 956  Bit Score: 1164.93  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585     1 MATIDGRPAQYGISLKQLRELMEHRGREGVMKI-AENGGIHELCKKLYTSPNEGLSGSKADEEHRRETFGSNVIPPKPPK 79
Cdd:TIGR01517    6 RRTSIRDNFTDGFDVGVSILTDLTDIFKKAMPLyEKLGGAEGIATKLKTDLNEGVRLSSSTLERREKVYGKNELPEKPPK 85
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585    80 TFLTLVWEALQDVTLIILEVAALVSLGLSFYKPADEDApvlqEEEEHHGWIEGLAILISVIVVVIVTAFNDYSKERQFRG 159
Cdd:TIGR01517   86 SFLQIVWAALSDQTLILLSVAAVVSLVLGLYVPSVGED----KADTETGWIEGVAILVSVILVVLVTAVNDYKKELQFRQ 161
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585   160 LqNRIEGEHKFSVIRGGEVCQISVGDILVGDIAQVKYGDLLPADGCLIQSNDLKVDESSLTGESDHVKKGPDVDPMVLSG 239
Cdd:TIGR01517  162 L-NREKSAQKIAVIRGGQEQQISIHDIVVGDIVSLSTGDVVPADGVFISGLSLEIDESSITGESDPIKKGPVQDPFLLSG 240
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585   240 THVMEGSGKMVVTAVGVNSQAGIIFTLLGAAvdeqeaeikkmkkeakrankqknltGEndgrsqikgsqapsqretvtse 319
Cdd:TIGR01517  241 TVVNEGSGRMLVTAVGVNSFGGKLMMELRQA-------------------------GE---------------------- 273
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585   320 itksesegnhlpqssssgaaetghkkEKSVLQAKLTKLAIQIGYAGSTIAVLTVIILIIQFCIKTFVIDEKP-WKNTYAN 398
Cdd:TIGR01517  274 --------------------------EETPLQEKLSELAGLIGKFGMGSAVLLFLVLSLRYVFRIIRGDGRFeDTEEDAQ 327
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585   399 NLVKHLIIGVTVLVVAVPEGLPLAVTLSLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTTNRMTVVQSYICE 478
Cdd:TIGR01517  328 TFLDHFIIAVTIVVVAVPEGLPLAVTIALAYSMKKMMKDNNLVRHLAACETMGSATAICSDKTGTLTQNVMSVVQGYIGE 407
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585   479 KLCKVLPT--LSDIPQHVGNLITMGISVNSaytsNIMAGHNPGDLPIQVGNKTECALLGFVQGLGVKYQSIRDEITEDKF 556
Cdd:TIGR01517  408 QRFNVRDEivLRNLPAAVRNILVEGISLNS----SSEEVVDRGGKRAFIGSKTECALLDFGLLLLLQSRDVQEVRAEEKV 483
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585   557 TRVYTFNSVRKSMGTVIPRPNGGYRLYTKGASEIIMKKCAFIYGHEGTLEKFTRDMQERlIREVIEPMACDGLRTISVAY 636
Cdd:TIGR01517  484 VKIYPFNSERKFMSVVVKHSGGKYREFRKGASEIVLKPCRKRLDSNGEATPISEDDKDR-CADVIEPLASDALRTICLAY 562
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585   637 RDFVPGKaainevhidgEPNWDDEENimtNLTCLCVVGIEDPVRPEVPDAIRKCQRAGITVRMVTGDNINTARSIASKCG 716
Cdd:TIGR01517  563 RDFAPEE----------FPRKDYPNK---GLTLIGVVGIKDPLRPGVREAVQECQRAGITVRMVTGDNIDTAKAIARNCG 629
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585   717 ILRPndDFLILEGKEFNRRIrdsngdiqQHLIDKVWPKLRVLARSSPTDKYTLVKgiidsTVSENREVVAVTGDGTNDGP 796
Cdd:TIGR01517  630 ILTF--GGLAMEGKEFRSLV--------YEEMDPILPKLRVLARSSPLDKQLLVL-----MLKDMGEVVAVTGDGTNDAP 694
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585   797 ALKKADVGFAMGIAGTDVAKEASDIILTDDNFSSIVKAVMWGRNVYDSIAKFLQFQLTVNVVAVIVAFIGACA--VQDSP 874
Cdd:TIGR01517  695 ALKLADVGFSMGISGTEVAKEASDIILLDDNFASIVRAVKWGRNVYDNIRKFLQFQLTVNVVAVILTFVGSCIssSHTSP 774
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585   875 LKAVQMLWVNLIMDTLASLALATEFPTPDLLLRKPYGRTKPLISRTMMKNILGQALYQLIIIFGLLFVGDVILDIESGRG 954
Cdd:TIGR01517  775 LTAVQLLWVNLIMDTLAALALATEPPTEALLDRKPIGRNAPLISRSMWKNILGQAGYQLVVTFILLFAGGSIFDVSGPDE 854
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585   955 QElNAGPTQHFTIIFNTFVMMTLFNEINARKIHGQRNVIEGLLTNPIFYTIWIFTMISQVLIIQYGKMAFSTKALTLDQW 1034
Cdd:TIGR01517  855 IT-SHQQGELNTIVFNTFVLLQLFNEINARKLYEGMNVFEGLFKNRIFVTIMGFTFGFQVIIVEFGGSFFSTVSLSIEQW 933
                         1050      1060
                   ....*....|....*....|...
gi 320541585  1035 LWCIFFGIGTLVWGQLITSVPTR 1057
Cdd:TIGR01517  934 IGCVLLGMLSLIFGVLLRLIPVE 956
MgtA COG0474
Magnesium-transporting ATPase (P-type) [Inorganic ion transport and metabolism];
39-1051 0e+00

Magnesium-transporting ATPase (P-type) [Inorganic ion transport and metabolism];


Pssm-ID: 440242 [Multi-domain]  Cd Length: 874  Bit Score: 659.88  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585   39 IHELCKKLYTSPnEGLSGSKADEehRRETFGSNVIPPKPPKTFLTLVWEALQDVTLIILEVAALVSLglsfykpadedap 118
Cdd:COG0474    13 AEEVLAELGTSE-EGLSSEEAAR--RLARYGPNELPEEKKRSLLRRFLEQFKNPLILILLAAAVISA------------- 76
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  119 VLQEeeehhgWIEGLAILISVIVVVIVTAFNDYSKERQFRGLQNRIEgeHKFSVIRGGEVCQISVGDILVGDIAQVKYGD 198
Cdd:COG0474    77 LLGD------WVDAIVILAVVLLNAIIGFVQEYRAEKALEALKKLLA--PTARVLRDGKWVEIPAEELVPGDIVLLEAGD 148
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  199 LLPADGCLIQSNDLKVDESSLTGESDHVKKGPDVDP----------MVLSGTHVMEGSGKMVVTAVGVNSQAGIIFTLLG 268
Cdd:COG0474   149 RVPADLRLLEAKDLQVDESALTGESVPVEKSADPLPedaplgdrgnMVFMGTLVTSGRGTAVVVATGMNTEFGKIAKLLQ 228
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  269 AAvdeqeaeikkmkkeakrankqknltgendgrsqikgsqapsqretvtseitksesegnhlpqssssgaaetghKKEKS 348
Cdd:COG0474   229 EA-------------------------------------------------------------------------EEEKT 235
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  349 VLQAKLTKLAIQIGYAGSTIAVLTVIILIIQfciktfvidEKPWKNTyannlvkhLIIGVTVLVVAVPEGLPLAVTLSLA 428
Cdd:COG0474   236 PLQKQLDRLGKLLAIIALVLAALVFLIGLLR---------GGPLLEA--------LLFAVALAVAAIPEGLPAVVTITLA 298
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  429 YSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTTNRMTVVQSYICEKLCKVLPTLSDIPQHvgnLITMGISVNSAY 508
Cdd:COG0474   299 LGAQRMAKRNAIVRRLPAVETLGSVTVICTDKTGTLTQNKMTVERVYTGGGTYEVTGEFDPALEE---LLRAAALCSDAQ 375
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  509 TSNIMAGHNPgdlpiqvgnkTECALLGFVQGLGVKYQSIRDEitedkFTRV--YTFNSVRKSMGTVIPRPNGGYRLYTKG 586
Cdd:COG0474   376 LEEETGLGDP----------TEGALLVAAAKAGLDVEELRKE-----YPRVdeIPFDSERKRMSTVHEDPDGKRLLIVKG 440
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  587 ASEIIMKKCAFIYgHEGTLEKFTRDMQERlIREVIEPMACDGLRTISVAYRDfvpgkaainevhIDGEPNWDDEEnIMTN 666
Cdd:COG0474   441 APEVVLALCTRVL-TGGGVVPLTEEDRAE-ILEAVEELAAQGLRVLAVAYKE------------LPADPELDSED-DESD 505
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  667 LTCLCVVGIEDPVRPEVPDAIRKCQRAGITVRMVTGDNINTARSIASKCGILRPNDDflILEGKEFNRrirDSNGDIQQh 746
Cdd:COG0474   506 LTFLGLVGMIDPPRPEAKEAIAECRRAGIRVKMITGDHPATARAIARQLGLGDDGDR--VLTGAELDA---MSDEELAE- 579
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  747 LIDKVwpklRVLARSSPTDKYTLVKgiidsTVSENREVVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDD 826
Cdd:COG0474   580 AVEDV----DVFARVSPEHKLRIVK-----ALQANGHVVAMTGDGVNDAPALKAADIGIAMGITGTDVAKEAADIVLLDD 650
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  827 NFSSIVKAVMWGRNVYDSIAKFLQFQLTVNVVAVIVAFIGACAVQDSPLKAVQMLWVNLIMDTLASLALATEFPTPDLLL 906
Cdd:COG0474   651 NFATIVAAVEEGRRIYDNIRKFIKYLLSSNFGEVLSVLLASLLGLPLPLTPIQILWINLVTDGLPALALGFEPVEPDVMK 730
                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  907 RKPYGRTKPLISRTMMKNILGQALYQLIIIFGLLFVGdvildIESGRGQELnagpTQhfTIIFNTFVMMTLFNEINARKI 986
Cdd:COG0474   731 RPPRWPDEPILSRFLLLRILLLGLLIAIFTLLTFALA-----LARGASLAL----AR--TMAFTTLVLSQLFNVFNCRSE 799
                         970       980       990      1000      1010      1020
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 320541585  987 HgqRNVIE-GLLTNPIFYTIWIFTMISQVLIIQYGKMA--FSTKALTLDQWLWCIFFGIGTLVWGQLI 1051
Cdd:COG0474   800 R--RSFFKsGLFPNRPLLLAVLLSLLLQLLLIYVPPLQalFGTVPLPLSDWLLILGLALLYLLLVELV 865
Cation_ATPase_C pfam00689
Cation transporting ATPase, C-terminus; Members of this families are involved in Na+/K+, H+/K+, ...
873-1051 9.60e-49

Cation transporting ATPase, C-terminus; Members of this families are involved in Na+/K+, H+/K+, Ca++ and Mg++ transport. This family represents 5 transmembrane helices.


Pssm-ID: 376368 [Multi-domain]  Cd Length: 175  Bit Score: 170.88  E-value: 9.60e-49
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585   873 SPLKAVQMLWVNLIMDTLASLALATEFPTPDLLLRKPYGRTKPLISRTMMKNILGQALYQLIIIFGLLFVGDVILDIEsg 952
Cdd:pfam00689    2 LPLTPIQILWINLVTDGLPALALGFEPPEPDLMKRPPRKPKEPLFSRKMLRRILLQGLLIAILTLLVFFLGLLGFGIS-- 79
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585   953 rgqelnaGPTQHFTIIFNTFVMMTLFNEINARKIHGQRNVIeGLLTNPIFYTIWIFTMISQVLIIQYGKMA--FSTKALT 1030
Cdd:pfam00689   80 -------ESQNAQTMAFNTLVLSQLFNALNARSLRRSLFKI-GLFSNKLLLLAILLSLLLQLLIIYVPPLQavFGTTPLS 151
                          170       180
                   ....*....|....*....|.
gi 320541585  1031 LDQWLWCIFFGIGTLVWGQLI 1051
Cdd:pfam00689  152 LEQWLIVLLLALVVLLVVELR 172
PRK10517 PRK10517
magnesium-transporting P-type ATPase MgtA;
180-888 8.24e-43

magnesium-transporting P-type ATPase MgtA;


Pssm-ID: 236705 [Multi-domain]  Cd Length: 902  Bit Score: 169.87  E-value: 8.24e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  180 QISVGDILVGDIAQVKYGDLLPADGCLIQSNDLKVDESSLTGESDHVKKGP-----------DVDPMVLSGTHVMEGSGK 248
Cdd:PRK10517  177 EIPIDQLVPGDIIKLAAGDMIPADLRILQARDLFVAQASLTGESLPVEKFAttrqpehsnplECDTLCFMGTNVVSGTAQ 256
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  249 MVVTAVGVNSQagiiFTLLGAAVDEQEAEikkmkkeakrankqknltgendgrsqikgsqapsqretvtseitksesegn 328
Cdd:PRK10517  257 AVVIATGANTW----FGQLAGRVSEQDSE--------------------------------------------------- 281
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  329 hlPQSSSSGAAetghkkeksvlqaKLTKLAIQIgyagstIAVLTVIILIIqfciktfvidekpwkNTYAN-NLVKHLIIG 407
Cdd:PRK10517  282 --PNAFQQGIS-------------RVSWLLIRF------MLVMAPVVLLI---------------NGYTKgDWWEAALFA 325
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  408 VTVLVVAVPEGLPLAVTLSLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTTNRMtvvqsyiceklckVLPTL 487
Cdd:PRK10517  326 LSVAVGLTPEMLPMIVTSTLARGAVKLSKQKVIVKRLDAIQNFGAMDILCTDKTGTLTQDKI-------------VLENH 392
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  488 SDIPQHVGNLITMGISVNSAYtsnimaghnpgdlpiQVGNKT-------ECALLGFVQGLGVKYQSIrDEITedkftrvy 560
Cdd:PRK10517  393 TDISGKTSERVLHSAWLNSHY---------------QTGLKNlldtavlEGVDEESARSLASRWQKI-DEIP-------- 448
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  561 tFNSVRKSMGTVIPRPNGGYRLYTKGASEIIMKKCAFIYgHEGTLEKFTRDMQERlIREVIEPMACDGLRTISVAYRDFV 640
Cdd:PRK10517  449 -FDFERRRMSVVVAENTEHHQLICKGALEEILNVCSQVR-HNGEIVPLDDIMLRR-IKRVTDTLNRQGLRVVAVATKYLP 525
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  641 PGKAAINEVhidgepnwdDEenimTNLTCLCVVGIEDPVRPEVPDAIRKCQRAGITVRMVTGDNINTARSIASKCGIlrP 720
Cdd:PRK10517  526 AREGDYQRA---------DE----SDLILEGYIAFLDPPKETTAPALKALKASGVTVKILTGDSELVAAKVCHEVGL--D 590
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  721 NDDFLIlegkefnrrirdsNGDIQ----QHLIDKVwPKLRVLARSSPTDKYTLVKgiidsTVSENREVVAVTGDGTNDGP 796
Cdd:PRK10517  591 AGEVLI-------------GSDIEtlsdDELANLA-ERTTLFARLTPMHKERIVT-----LLKREGHVVGFMGDGINDAP 651
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  797 ALKKADVGFAMGiAGTDVAKEASDIILTDDNFSSIVKAVMWGRNVYDSIAKFLqfQLTV-----NVVAVIV--AFIGACa 869
Cdd:PRK10517  652 ALRAADIGISVD-GAVDIAREAADIILLEKSLMVLEEGVIEGRRTFANMLKYI--KMTAssnfgNVFSVLVasAFLPFL- 727
                         730
                  ....*....|....*....
gi 320541585  870 vqdsPLKAVQMLWVNLIMD 888
Cdd:PRK10517  728 ----PMLPLHLLIQNLLYD 742
E1-E2_ATPase pfam00122
E1-E2 ATPase;
172-436 7.33e-27

E1-E2 ATPase;


Pssm-ID: 425475 [Multi-domain]  Cd Length: 181  Bit Score: 108.43  E-value: 7.33e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585   172 VIRGGEVCQISVGDILVGDIAQVKYGDLLPADGCLIQSNDLkVDESSLTGESDHVKKgpDVDPMVLSGTHVMEGSGKMVV 251
Cdd:pfam00122    9 VLRDGTEEEVPADELVPGDIVLLKPGERVPADGRIVEGSAS-VDESLLTGESLPVEK--KKGDMVYSGTVVVSGSAKAVV 85
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585   252 TAVGVNSQAGIIFTLLgaavdeqeaeikkmkKEAKRAnkqknltgendgrsqikgsqapsqretvtseitksesegnhlp 331
Cdd:pfam00122   86 TATGEDTELGRIARLV---------------EEAKSK------------------------------------------- 107
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585   332 qssssgaaetghkkeKSVLQAKLTKLAIQIGYAGSTIAVLTVIILIIQFciktfvidekpwkntyaNNLVKHLIIGVTVL 411
Cdd:pfam00122  108 ---------------KTPLQRLLDRLGKYFSPVVLLIALAVFLLWLFVG-----------------GPPLRALLRALAVL 155
                          250       260
                   ....*....|....*....|....*
gi 320541585   412 VVAVPEGLPLAVTLSLAYSVKKMMK 436
Cdd:pfam00122  156 VAACPCALPLATPLALAVGARRLAK 180
Cation_ATPase_N smart00831
Cation transporter/ATPase, N-terminus; This entry represents the conserved N-terminal region ...
39-107 3.24e-12

Cation transporter/ATPase, N-terminus; This entry represents the conserved N-terminal region found in several classes of cation-transporting P-type ATPases, including those that transport H+, Na+, Ca2+, Na+/K+, and H+/K+. In the H+/K+- and Na+/K+-exchange P-ATPases, this domain is found in the catalytic alpha chain. In gastric H+/K+-ATPases, this domain undergoes reversible sequential phosphorylation inducing conformational changes that may be important for regulating the function of these ATPases.


Pssm-ID: 214842 [Multi-domain]  Cd Length: 75  Bit Score: 62.99  E-value: 3.24e-12
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 320541585     39 IHELCKKLYTSPNEGLSGSKADEehRRETFGSNVIPPKPPKTFLTLVWEALQDVTLIILEVAALVSLGL 107
Cdd:smart00831    9 LEEVLERLQTDLEKGLSSEEAAR--RLERYGPNELPPPKKTSPLLRFLRQFHNPLIYILLAAAVLSALL 75
ATP_Ca_trans_C pfam12424
Plasma membrane calcium transporter ATPase C terminal; This domain family is found in ...
1096-1142 2.40e-11

Plasma membrane calcium transporter ATPase C terminal; This domain family is found in eukaryotes, and is approximately 60 amino acids in length. The family is found in association with pfam00689, pfam00122, pfam00702, pfam00690. There is a conserved QTQ sequence motif. This family is the C terminal of a calcium transporting ATPase located in the plasma membrane.


Pssm-ID: 463575  Cd Length: 47  Bit Score: 59.73  E-value: 2.40e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 320541585  1096 GQILWIRGLTRLQTQV-IGGELQERL-IPVpySKSNTDQAIRVVNAFRQ 1142
Cdd:pfam12424    1 GQILWFRGLNRIQTQIrVVKAFQSSLrEGI--QKPYLRNSIHSFMSHPE 47
 
Name Accession Description Interval E-value
P-type_ATPase_Ca_PMCA-like cd02081
animal plasma membrane Ca2(+)-ATPases (PMCA), similar to human ATP2B1-4/PMCA1-4, and related ...
62-921 0e+00

animal plasma membrane Ca2(+)-ATPases (PMCA), similar to human ATP2B1-4/PMCA1-4, and related Ca2(+)-ATPases including Saccharomyces cerevisiae vacuolar PMC1; Animal PMCAs function to export Ca(2+) from cells and play a role in regulating Ca(2+) signals following stimulus induction and in preventing calcium toxicity. Many PMCA pump variants exist due to alternative splicing of transcripts. PMCAs are regulated by the binding of calmodulin or by kinase-mediated phosphorylation. Saccharomyces cerevisiae vacuolar transporter Pmc1p facilitates the accumulation of Ca2+ into vacuoles. Pmc1p is not regulated by direct calmodulin binding but responds to the calmodulin/calcineurin-signaling pathway and is controlled by the transcription factor complex Tcn1p/Crz1p. Similarly, the expression of the gene for Dictyostelium discoideum Ca(2+)-ATPase PAT1, patA, is under the control of a calcineurin-dependent transcription factor. Plant vacuolar Ca(2+)-ATPases, are regulated by direct-calmodulin binding. Plant Ca(2+)-ATPases are present at various cellular locations including the plasma membrane, endoplasmic reticulum, chloroplast and vacuole. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319776 [Multi-domain]  Cd Length: 721  Bit Score: 1261.35  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585   62 EHRRETFGSNVIPPKPPKTFLTLVWEALQDVTLIILEVAALVSLGLSFYKPADEdapvlqeEEEHHGWIEGLAILISVIV 141
Cdd:cd02081     2 EHRREVYGKNEIPPKPPKSFLQLVWEALQDPTLIILLIAAIVSLGLGFYTPFGE-------GEGKTGWIEGVAILVAVIL 74
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  142 VVIVTAFNDYSKERQFRGLQNRIEgEHKFSVIRGGEVCQISVGDILVGDIAQVKYGDLLPADGCLIQSNDLKVDESSLTG 221
Cdd:cd02081    75 VVLVTAGNDYQKEKQFRKLNSKKE-DQKVTVIRDGEVIQISVFDIVVGDIVQLKYGDLIPADGLLIEGNDLKIDESSLTG 153
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  222 ESDHVKKGPD---VDPMVLSGTHVMEGSGKMVVTAVGVNSQAGIIFTLLGAAvdeqeaeikkmkkeakrankqknltgen 298
Cdd:cd02081   154 ESDPIKKTPDnqiPDPFLLSGTKVLEGSGKMLVTAVGVNSQTGKIMTLLRAE---------------------------- 205
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  299 dgrsqikgsqapsqretvtseitksesegnhlpqssssgaaetghKKEKSVLQAKLTKLAIQIGYAGSTIAVLTVIILII 378
Cdd:cd02081   206 ---------------------------------------------NEEKTPLQEKLTKLAVQIGKVGLIVAALTFIVLII 240
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  379 QFCIKTFVIDEKPWKNTYANNLVKHLIIGVTVLVVAVPEGLPLAVTLSLAYSVKKMMKDNNLVRHLDACETMGNATAICS 458
Cdd:cd02081   241 RFIIDGFVNDGKSFSAEDLQEFVNFFIIAVTIIVVAVPEGLPLAVTLSLAYSVKKMMKDNNLVRHLDACETMGNATAICS 320
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  459 DKTGTLTTNRMTVVQSYIceklckvlptlsdipqhvgnlitmgisvnsaytsnimaghnpgdlpiqvGNKTECALLGFVQ 538
Cdd:cd02081   321 DKTGTLTQNRMTVVQGYI-------------------------------------------------GNKTECALLGFVL 351
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  539 GLGVKYQsIRDEITEDKFTRVYTFNSVRKSMGTVIPRPNGGYRLYTKGASEIIMKKCAFIYGHEGTlEKFTRDMQERLIR 618
Cdd:cd02081   352 ELGGDYR-YREKRPEEKVLKVYPFNSARKRMSTVVRLKDGGYRLYVKGASEIVLKKCSYILNSDGE-VVFLTSEKKEEIK 429
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  619 EVIEPMACDGLRTISVAYRDFVPGKAAINEVhidgepNWDDEENIMTNLTCLCVVGIEDPVRPEVPDAIRKCQRAGITVR 698
Cdd:cd02081   430 RVIEPMASDSLRTIGLAYRDFSPDEEPTAER------DWDDEEDIESDLTFIGIVGIKDPLRPEVPEAVAKCQRAGITVR 503
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  699 MVTGDNINTARSIASKCGILRPNDDFLILEGKEFNRRIRDSNGDIQQHLIDKVWPKLRVLARSSPTDKYTLVKGIIDStv 778
Cdd:cd02081   504 MVTGDNINTARAIARECGILTEGEDGLVLEGKEFRELIDEEVGEVCQEKFDKIWPKLRVLARSSPEDKYTLVKGLKDS-- 581
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  779 senREVVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFSSIVKAVMWGRNVYDSIAKFLQFQLTVNVV 858
Cdd:cd02081   582 ---GEVVAVTGDGTNDAPALKKADVGFAMGIAGTEVAKEASDIILLDDNFSSIVKAVMWGRNVYDSIRKFLQFQLTVNVV 658
                         810       820       830       840       850       860
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 320541585  859 AVIVAFIGACAVQDSPLKAVQMLWVNLIMDTLASLALATEFPTPDLLLRKPYGRTKPLISRTM 921
Cdd:cd02081   659 AVILAFIGAVVTKDSPLTAVQMLWVNLIMDTLAALALATEPPTEDLLKRKPYGRDKPLISRTM 721
ATPase-IIB_Ca TIGR01517
plasma-membrane calcium-translocating P-type ATPase; This model describes the P-type ATPase ...
1-1057 0e+00

plasma-membrane calcium-translocating P-type ATPase; This model describes the P-type ATPase responsible for translocating calcium ions across the plasma membrane of eukaryotes, out of the cell. In some organisms, this type of pump may also be found in vacuolar membranes. In humans and mice, at least, there are multiple isoforms of the PMCA pump with overlapping but not redundant functions. Accordingly, there are no human diseases linked to PMCA defects, although alterations of PMCA function do elicit physiological effects. The calcium P-type ATPases have been characterized as Type IIB based on a phylogenetic analysis which distinguishes this group from the Type IIA SERCA calcium pump. A separate analysis divides Type IIA into sub-types (SERCA and PMR1) which are represented by two corresponding models (TIGR01116 and TIGR01522). This model is well separated from those.


Pssm-ID: 273668 [Multi-domain]  Cd Length: 956  Bit Score: 1164.93  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585     1 MATIDGRPAQYGISLKQLRELMEHRGREGVMKI-AENGGIHELCKKLYTSPNEGLSGSKADEEHRRETFGSNVIPPKPPK 79
Cdd:TIGR01517    6 RRTSIRDNFTDGFDVGVSILTDLTDIFKKAMPLyEKLGGAEGIATKLKTDLNEGVRLSSSTLERREKVYGKNELPEKPPK 85
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585    80 TFLTLVWEALQDVTLIILEVAALVSLGLSFYKPADEDApvlqEEEEHHGWIEGLAILISVIVVVIVTAFNDYSKERQFRG 159
Cdd:TIGR01517   86 SFLQIVWAALSDQTLILLSVAAVVSLVLGLYVPSVGED----KADTETGWIEGVAILVSVILVVLVTAVNDYKKELQFRQ 161
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585   160 LqNRIEGEHKFSVIRGGEVCQISVGDILVGDIAQVKYGDLLPADGCLIQSNDLKVDESSLTGESDHVKKGPDVDPMVLSG 239
Cdd:TIGR01517  162 L-NREKSAQKIAVIRGGQEQQISIHDIVVGDIVSLSTGDVVPADGVFISGLSLEIDESSITGESDPIKKGPVQDPFLLSG 240
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585   240 THVMEGSGKMVVTAVGVNSQAGIIFTLLGAAvdeqeaeikkmkkeakrankqknltGEndgrsqikgsqapsqretvtse 319
Cdd:TIGR01517  241 TVVNEGSGRMLVTAVGVNSFGGKLMMELRQA-------------------------GE---------------------- 273
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585   320 itksesegnhlpqssssgaaetghkkEKSVLQAKLTKLAIQIGYAGSTIAVLTVIILIIQFCIKTFVIDEKP-WKNTYAN 398
Cdd:TIGR01517  274 --------------------------EETPLQEKLSELAGLIGKFGMGSAVLLFLVLSLRYVFRIIRGDGRFeDTEEDAQ 327
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585   399 NLVKHLIIGVTVLVVAVPEGLPLAVTLSLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTTNRMTVVQSYICE 478
Cdd:TIGR01517  328 TFLDHFIIAVTIVVVAVPEGLPLAVTIALAYSMKKMMKDNNLVRHLAACETMGSATAICSDKTGTLTQNVMSVVQGYIGE 407
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585   479 KLCKVLPT--LSDIPQHVGNLITMGISVNSaytsNIMAGHNPGDLPIQVGNKTECALLGFVQGLGVKYQSIRDEITEDKF 556
Cdd:TIGR01517  408 QRFNVRDEivLRNLPAAVRNILVEGISLNS----SSEEVVDRGGKRAFIGSKTECALLDFGLLLLLQSRDVQEVRAEEKV 483
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585   557 TRVYTFNSVRKSMGTVIPRPNGGYRLYTKGASEIIMKKCAFIYGHEGTLEKFTRDMQERlIREVIEPMACDGLRTISVAY 636
Cdd:TIGR01517  484 VKIYPFNSERKFMSVVVKHSGGKYREFRKGASEIVLKPCRKRLDSNGEATPISEDDKDR-CADVIEPLASDALRTICLAY 562
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585   637 RDFVPGKaainevhidgEPNWDDEENimtNLTCLCVVGIEDPVRPEVPDAIRKCQRAGITVRMVTGDNINTARSIASKCG 716
Cdd:TIGR01517  563 RDFAPEE----------FPRKDYPNK---GLTLIGVVGIKDPLRPGVREAVQECQRAGITVRMVTGDNIDTAKAIARNCG 629
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585   717 ILRPndDFLILEGKEFNRRIrdsngdiqQHLIDKVWPKLRVLARSSPTDKYTLVKgiidsTVSENREVVAVTGDGTNDGP 796
Cdd:TIGR01517  630 ILTF--GGLAMEGKEFRSLV--------YEEMDPILPKLRVLARSSPLDKQLLVL-----MLKDMGEVVAVTGDGTNDAP 694
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585   797 ALKKADVGFAMGIAGTDVAKEASDIILTDDNFSSIVKAVMWGRNVYDSIAKFLQFQLTVNVVAVIVAFIGACA--VQDSP 874
Cdd:TIGR01517  695 ALKLADVGFSMGISGTEVAKEASDIILLDDNFASIVRAVKWGRNVYDNIRKFLQFQLTVNVVAVILTFVGSCIssSHTSP 774
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585   875 LKAVQMLWVNLIMDTLASLALATEFPTPDLLLRKPYGRTKPLISRTMMKNILGQALYQLIIIFGLLFVGDVILDIESGRG 954
Cdd:TIGR01517  775 LTAVQLLWVNLIMDTLAALALATEPPTEALLDRKPIGRNAPLISRSMWKNILGQAGYQLVVTFILLFAGGSIFDVSGPDE 854
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585   955 QElNAGPTQHFTIIFNTFVMMTLFNEINARKIHGQRNVIEGLLTNPIFYTIWIFTMISQVLIIQYGKMAFSTKALTLDQW 1034
Cdd:TIGR01517  855 IT-SHQQGELNTIVFNTFVLLQLFNEINARKLYEGMNVFEGLFKNRIFVTIMGFTFGFQVIIVEFGGSFFSTVSLSIEQW 933
                         1050      1060
                   ....*....|....*....|...
gi 320541585  1035 LWCIFFGIGTLVWGQLITSVPTR 1057
Cdd:TIGR01517  934 IGCVLLGMLSLIFGVLLRLIPVE 956
MgtA COG0474
Magnesium-transporting ATPase (P-type) [Inorganic ion transport and metabolism];
39-1051 0e+00

Magnesium-transporting ATPase (P-type) [Inorganic ion transport and metabolism];


Pssm-ID: 440242 [Multi-domain]  Cd Length: 874  Bit Score: 659.88  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585   39 IHELCKKLYTSPnEGLSGSKADEehRRETFGSNVIPPKPPKTFLTLVWEALQDVTLIILEVAALVSLglsfykpadedap 118
Cdd:COG0474    13 AEEVLAELGTSE-EGLSSEEAAR--RLARYGPNELPEEKKRSLLRRFLEQFKNPLILILLAAAVISA------------- 76
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  119 VLQEeeehhgWIEGLAILISVIVVVIVTAFNDYSKERQFRGLQNRIEgeHKFSVIRGGEVCQISVGDILVGDIAQVKYGD 198
Cdd:COG0474    77 LLGD------WVDAIVILAVVLLNAIIGFVQEYRAEKALEALKKLLA--PTARVLRDGKWVEIPAEELVPGDIVLLEAGD 148
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  199 LLPADGCLIQSNDLKVDESSLTGESDHVKKGPDVDP----------MVLSGTHVMEGSGKMVVTAVGVNSQAGIIFTLLG 268
Cdd:COG0474   149 RVPADLRLLEAKDLQVDESALTGESVPVEKSADPLPedaplgdrgnMVFMGTLVTSGRGTAVVVATGMNTEFGKIAKLLQ 228
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  269 AAvdeqeaeikkmkkeakrankqknltgendgrsqikgsqapsqretvtseitksesegnhlpqssssgaaetghKKEKS 348
Cdd:COG0474   229 EA-------------------------------------------------------------------------EEEKT 235
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  349 VLQAKLTKLAIQIGYAGSTIAVLTVIILIIQfciktfvidEKPWKNTyannlvkhLIIGVTVLVVAVPEGLPLAVTLSLA 428
Cdd:COG0474   236 PLQKQLDRLGKLLAIIALVLAALVFLIGLLR---------GGPLLEA--------LLFAVALAVAAIPEGLPAVVTITLA 298
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  429 YSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTTNRMTVVQSYICEKLCKVLPTLSDIPQHvgnLITMGISVNSAY 508
Cdd:COG0474   299 LGAQRMAKRNAIVRRLPAVETLGSVTVICTDKTGTLTQNKMTVERVYTGGGTYEVTGEFDPALEE---LLRAAALCSDAQ 375
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  509 TSNIMAGHNPgdlpiqvgnkTECALLGFVQGLGVKYQSIRDEitedkFTRV--YTFNSVRKSMGTVIPRPNGGYRLYTKG 586
Cdd:COG0474   376 LEEETGLGDP----------TEGALLVAAAKAGLDVEELRKE-----YPRVdeIPFDSERKRMSTVHEDPDGKRLLIVKG 440
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  587 ASEIIMKKCAFIYgHEGTLEKFTRDMQERlIREVIEPMACDGLRTISVAYRDfvpgkaainevhIDGEPNWDDEEnIMTN 666
Cdd:COG0474   441 APEVVLALCTRVL-TGGGVVPLTEEDRAE-ILEAVEELAAQGLRVLAVAYKE------------LPADPELDSED-DESD 505
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  667 LTCLCVVGIEDPVRPEVPDAIRKCQRAGITVRMVTGDNINTARSIASKCGILRPNDDflILEGKEFNRrirDSNGDIQQh 746
Cdd:COG0474   506 LTFLGLVGMIDPPRPEAKEAIAECRRAGIRVKMITGDHPATARAIARQLGLGDDGDR--VLTGAELDA---MSDEELAE- 579
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  747 LIDKVwpklRVLARSSPTDKYTLVKgiidsTVSENREVVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDD 826
Cdd:COG0474   580 AVEDV----DVFARVSPEHKLRIVK-----ALQANGHVVAMTGDGVNDAPALKAADIGIAMGITGTDVAKEAADIVLLDD 650
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  827 NFSSIVKAVMWGRNVYDSIAKFLQFQLTVNVVAVIVAFIGACAVQDSPLKAVQMLWVNLIMDTLASLALATEFPTPDLLL 906
Cdd:COG0474   651 NFATIVAAVEEGRRIYDNIRKFIKYLLSSNFGEVLSVLLASLLGLPLPLTPIQILWINLVTDGLPALALGFEPVEPDVMK 730
                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  907 RKPYGRTKPLISRTMMKNILGQALYQLIIIFGLLFVGdvildIESGRGQELnagpTQhfTIIFNTFVMMTLFNEINARKI 986
Cdd:COG0474   731 RPPRWPDEPILSRFLLLRILLLGLLIAIFTLLTFALA-----LARGASLAL----AR--TMAFTTLVLSQLFNVFNCRSE 799
                         970       980       990      1000      1010      1020
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 320541585  987 HgqRNVIE-GLLTNPIFYTIWIFTMISQVLIIQYGKMA--FSTKALTLDQWLWCIFFGIGTLVWGQLI 1051
Cdd:COG0474   800 R--RSFFKsGLFPNRPLLLAVLLSLLLQLLLIYVPPLQalFGTVPLPLSDWLLILGLALLYLLLVELV 865
P-type_ATPase_Ca_prok cd02089
prokaryotic P-type Ca(2+)-ATPase similar to Synechococcus elongatus sp. strain PCC 7942 PacL ...
53-909 6.36e-160

prokaryotic P-type Ca(2+)-ATPase similar to Synechococcus elongatus sp. strain PCC 7942 PacL and Listeria monocytogenes LMCA1; Ca(2+) transport ATPase is a plasma membrane protein which pumps Ca(2+) ion out of the cytoplasm. This prokaryotic subfamily includes the Ca(2+)-ATPase Synechococcus elongatus PacL, Listeria monocytogenes Ca(2+)-ATPase 1 (LMCA1) which has a low Ca(2+) affinity and a high pH optimum (pH about 9) and may remove Ca(2+) from the microorganism in environmental conditions when e.g. stressed by high Ca(2+) and alkaline pH, and the Bacillus subtilis putative P-type Ca(2+)-transport ATPase encoded by the yloB gene, which is expressed during sporulation. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319781 [Multi-domain]  Cd Length: 674  Bit Score: 492.51  E-value: 6.36e-160
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585   53 GLSGSKAdeEHRRETFGSNVIPPKPPKTFLTLVWEALQDVTLIILEVAALVSLglsfykpadedapVLQEeeehhgWIEG 132
Cdd:cd02089     1 GLSEEEA--ERRLAKYGPNELVEKKKRSPWKKFLEQFKDFMVIVLLAAAVISG-------------VLGE------YVDA 59
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  133 LAILISVIVVVIVTAFNDYSKERQFRGLQNRieGEHKFSVIRGGEVCQISVGDILVGDIAQVKYGDLLPADGCLIQSNDL 212
Cdd:cd02089    60 IVIIAIVILNAVLGFVQEYKAEKALAALKKM--SAPTAKVLRDGKKQEIPARELVPGDIVLLEAGDYVPADGRLIESASL 137
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  213 KVDESSLTGESDHVKKGPDVDP-----------MVLSGTHVMEGSGKMVVTAVGVNSQAGIIFTLLGAAvdeqeaeikkm 281
Cdd:cd02089   138 RVEESSLTGESEPVEKDADTLLeedvplgdrknMVFSGTLVTYGRGRAVVTATGMNTEMGKIATLLEET----------- 206
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  282 kkeakrankqknltgendgrsqikgsqapsqretvtseitksesegnhlpqssssgaaetghKKEKSVLQAKLTKLAIQI 361
Cdd:cd02089   207 --------------------------------------------------------------EEEKTPLQKRLDQLGKRL 224
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  362 GYAgstIAVLTVIILIIQFCIKTFVIDEkpwkntyannlvkhLIIGVTVLVVAVPEGLPLAVTLSLAYSVKKMMKDNNLV 441
Cdd:cd02089   225 AIA---ALIICALVFALGLLRGEDLLDM--------------LLTAVSLAVAAIPEGLPAIVTIVLALGVQRMAKRNAII 287
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  442 RHLDACETMGNATAICSDKTGTLTTNRMTVVQSYIceklckvlptlsdipqhvgnlitmgisvnsaytsnimaghnpgdl 521
Cdd:cd02089   288 RKLPAVETLGSVSVICSDKTGTLTQNKMTVEKIYT--------------------------------------------- 322
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  522 piqVGNKTECALLGFVQGLGVKYQSIrdeitEDKFTRVYT--FNSVRKSMgTVIPRPNGGYRLYTKGASEIIMKKCAFIY 599
Cdd:cd02089   323 ---IGDPTETALIRAARKAGLDKEEL-----EKKYPRIAEipFDSERKLM-TTVHKDAGKYIVFTKGAPDVLLPRCTYIY 393
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  600 GHEGTLEKFTRDMQErlIREVIEPMACDGLRTISVAYRDFvpgkaainevhidGEPNWDDEENIMTNLTCLCVVGIEDPV 679
Cdd:cd02089   394 INGQVRPLTEEDRAK--ILAVNEEFSEEALRVLAVAYKPL-------------DEDPTESSEDLENDLIFLGLVGMIDPP 458
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  680 RPEVPDAIRKCQRAGITVRMVTGDNINTARSIASKCGILRPNDdfLILEGKEFNRrirdsngdIQQHLIDKVWPKLRVLA 759
Cdd:cd02089   459 RPEVKDAVAECKKAGIKTVMITGDHKLTARAIAKELGILEDGD--KALTGEELDK--------MSDEELEKKVEQISVYA 528
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  760 RSSPTDKYTLVKGIidstvSENREVVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFSSIVKAVMWGR 839
Cdd:cd02089   529 RVSPEHKLRIVKAL-----QRKGKIVAMTGDGVNDAPALKAADIGVAMGITGTDVAKEAADMILTDDNFATIVAAVEEGR 603
                         810       820       830       840       850       860       870
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  840 NVYDSIAKFLQFQLTVNVVAVIVAFIGACAVQDSPLKAVQMLWVNLIMDTLASLALATEFPTPDLLLRKP 909
Cdd:cd02089   604 TIYDNIRKFIRYLLSGNVGEILTMLLAPLLGWPVPLLPIQLLWINLLTDGLPALALGVEPAEPDIMDRKP 673
P-type_ATPase_cation cd02080
P-type cation-transporting ATPase similar to Exiguobacterium aurantiacum Mna, an Na(+)-ATPase, ...
53-1042 2.03e-138

P-type cation-transporting ATPase similar to Exiguobacterium aurantiacum Mna, an Na(+)-ATPase, and Synechocystis sp. PCC 6803 PMA1, a putative Ca(2+)-ATPase; This subfamily includes the P-type Na(+)-ATPase of an alkaliphilic bacterium Exiguobacterium aurantiacum Mna and cyanobacterium Synechocystis sp. PCC 6803 PMA1, a cation-transporting ATPase which may translocate calcium. The P-type ATPases, are a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319775 [Multi-domain]  Cd Length: 819  Bit Score: 440.55  E-value: 2.03e-138
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585   53 GLSGSKAdeEHRRETFGSNVIPPKPPKTFLTLVWEALQDVTLIILEVAALVSLGLSFYKpadeDAPVlqeeeehhgwIEG 132
Cdd:cd02080     1 GLTSEEA--AERLERYGPNRLPEKKTKSPLLRFLRQFNNPLIYILLAAAVVTAFLGHWV----DAIV----------IFG 64
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  133 LAILisvivvvivTAFNDYSKERQ----FRGLQNRIEGEHKfsVIRGGEVCQISVGDILVGDIAQVKYGDLLPADGCLIQ 208
Cdd:cd02080    65 VVLI---------NAIIGYIQEGKaekaLAAIKNMLSPEAT--VLRDGKKLTIDAEELVPGDIVLLEAGDKVPADLRLIE 133
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  209 SNDLKVDESSLTGESDHVKKGPDVDP----------MVLSGTHVMEGSGKMVVTAVGVNSQAGIIFTLLgaavdeqeaei 278
Cdd:cd02080   134 ARNLQIDESALTGESVPVEKQEGPLEedtplgdrknMAYSGTLVTAGSATGVVVATGADTEIGRINQLL----------- 202
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  279 kkmkkeakrankqknltgendgrSQIKGSQAPsqretvtseitksesegnhlpqssssgaaetghkkeksvLQAKLTKLA 358
Cdd:cd02080   203 -----------------------AEVEQLATP---------------------------------------LTRQIAKFS 220
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  359 IQIGYAgstIAVLTVIILIIqfcikTFVIDEKPWKNTyannlvkhLIIGVTVLVVAVPEGLPLAVTLSLAYSVKKMMKDN 438
Cdd:cd02080   221 KALLIV---ILVLAALTFVF-----GLLRGDYSLVEL--------FMAVVALAVAAIPEGLPAVITITLAIGVQRMAKRN 284
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  439 NLVRHLDACETMGNATAICSDKTGTLTTNRMTVVQSYIcekLCkvlptlsdipqhvgnlitmgisvNSAYTSnimagHNP 518
Cdd:cd02080   285 AIIRRLPAVETLGSVTVICSDKTGTLTRNEMTVQAIVT---LC-----------------------NDAQLH-----QED 333
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  519 GDLPIQvGNKTECALLGFVQGLGVKYQSIRDEITE-DKFTrvytFNSVRKSMGTVIPRpNGGYRLYTKGASEIIMKKCAF 597
Cdd:cd02080   334 GHWKIT-GDPTEGALLVLAAKAGLDPDRLASSYPRvDKIP----FDSAYRYMATLHRD-DGQRVIYVKGAPERLLDMCDQ 407
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  598 IYGhEGTLEKFTRDMqerlIREVIEPMACDGLRTISVAYRDFVPGKAAInevhidgepnwdDEENIMTNLTCLCVVGIED 677
Cdd:cd02080   408 ELL-DGGVSPLDRAY----WEAEAEDLAKQGLRVLAFAYREVDSEVEEI------------DHADLEGGLTFLGLQGMID 470
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  678 PVRPEVPDAIRKCQRAGITVRMVTGDNINTARSIASKCGILRPNDdflILEGKEFnrrirDSNGDIQ-QHLIDKVwpklR 756
Cdd:cd02080   471 PPRPEAIAAVAECQSAGIRVKMITGDHAETARAIGAQLGLGDGKK---VLTGAEL-----DALDDEElAEAVDEV----D 538
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  757 VLARSSPTDKYTLVKGIidstvSENREVVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFSSIVKAVM 836
Cdd:cd02080   539 VFARTSPEHKLRLVRAL-----QARGEVVAMTGDGVNDAPALKQADIGIAMGIKGTEVAKEAADMVLADDNFATIAAAVE 613
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  837 WGRNVYDSIAKFLQFQLTVNV---VAVIVAFIGACAVqdsPLKAVQMLWVNLIMDTLASLALATEFPTPDLLLRKPYGRT 913
Cdd:cd02080   614 EGRRVYDNLKKFILFTLPTNLgegLVIIVAILFGVTL---PLTPVQILWINMVTAITLGLALAFEPAEPGIMKRPPRDPS 690
                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  914 KPLISRTMMKNILGQALYQLIIIFGL-LFVGDVILDIESGRgqelnagptqhfTIIFNTFVMMTLFNEINARKIHgqRNV 992
Cdd:cd02080   691 EPLLSRELIWRILLVSLLMLGGAFGLfLWALDRGYSLETAR------------TMAVNTIVVAQIFYLFNCRSLH--RSI 756
                         970       980       990      1000      1010
                  ....*....|....*....|....*....|....*....|....*....|....
gi 320541585  993 IE-GLLTNPI-FYTIWIFTmISQVLIIQYGKM--AFSTKALTLDQWLWCIFFGI 1042
Cdd:cd02080   757 LKlGVFSNKIlFLGIGALI-LLQLAFTYLPFMnsLFGTAPIDLVDWAIILLVGI 809
ATPase_P-type TIGR01494
ATPase, P-type (transporting), HAD superfamily, subfamily IC; The P-type ATPases are a large ...
154-895 1.74e-130

ATPase, P-type (transporting), HAD superfamily, subfamily IC; The P-type ATPases are a large family of trans-membrane transporters acting on charged substances. The distinguishing feature of the family is the formation of a phosphorylated intermediate (aspartyl-phosphate) during the course of the reaction. Another common name for these enzymes is the E1-E2 ATPases based on the two isolable conformations: E1 (unphosphorylated) and E2 (phosphorylated). Generally, P-type ATPases consist of only a single subunit encompassing the ATPase and ion translocation pathway, however, in the case of the potassium (TIGR01497) and sodium/potassium (TIGR01106) varieties, these functions are split between two subunits. Additional small regulatory or stabilizing subunits may also exist in some forms. P-type ATPases are nearly ubiquitous in life and are found in numerous copies in higher organisms (at least 45 in Arabidopsis thaliana, for instance). Phylogenetic analyses have revealed that the P-type ATPase subfamily is divided up into groups based on substrate specificities and this is represented in the various subfamily and equivalog models that have been made: IA (K+) TIGR01497, IB (heavy metals) TIGR01525, IIA1 (SERCA-type Ca++) TIGR01116, IIA2 (PMR1-type Ca++) TIGR01522, IIB (PMCA-type Ca++) TIGR01517, IIC (Na+/K+, H+/K+ antiporters) TIGR01106, IID (fungal-type Na+ and K+) TIGR01523, IIIA (H+) TIGR01647, IIIB (Mg++) TIGR01524, IV (phospholipid, flippase) TIGR01652 and V (unknown specificity) TIGR01657. The crystal structure of one calcium-pumping ATPase and an analysis of the fold of the catalytic domain of the P-type ATPases have been published. These reveal that the catalytic core of these enzymes is a haloacid dehalogenase(HAD)-type aspartate-nucleophile hydrolase. The location of the ATP-binding loop in between the first and second HAD conserved catalytic motifs defines these enzymes as members of subfamily I of the HAD superfamily (see also TIGR01493, TIGR01509, TIGR01549, TIGR01544 and TIGR01545). Based on these classifications, the P-type ATPase _superfamily_ corresponds to the IC subfamily of the HAD superfamily.


Pssm-ID: 273656 [Multi-domain]  Cd Length: 545  Bit Score: 410.55  E-value: 1.74e-130
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585   154 ERQFRGLQNRIEGEHKFSVIRGGEVcQISVGDILVGDIAQVKYGDLLPADGCLIQSnDLKVDESSLTGESDHVKKGPDVD 233
Cdd:TIGR01494   21 EDALRSLKDSLVNTATVLVLRNGWK-EISSKDLVPGDVVLVKSGDTVPADGVLLSG-SAFVDESSLTGESLPVLKTALPD 98
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585   234 P-MVLSGTHVMEGSGKMVVTAVGVNSQAGIIftllGAAVdeqeaeikkmkkeakrankqknltgendgrsqikgsqapsq 312
Cdd:TIGR01494   99 GdAVFAGTINFGGTLIVKVTATGILTTVGKI----AVVV----------------------------------------- 133
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585   313 retvtseitksesegnhlpqssssgaaETGHKkEKSVLQAKLTKLAIQIG-YAGSTIAVLTVIILIIqfciktFVIDEKP 391
Cdd:TIGR01494  134 ---------------------------YTGFS-TKTPLQSKADKFENFIFiLFLLLLALAVFLLLPI------GGWDGNS 179
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585   392 WkntyannlVKHLIIGVTVLVVAVPEGLPLAVTLSLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTTNRMTV 471
Cdd:TIGR01494  180 I--------YKAILRALAVLVIAIPCALPLAVSVALAVGDARMAKKGILVKNLNALEELGKVDVICFDKTGTLTTNKMTL 251
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585   472 VQSYICEKlckvlptlsdipqhVGNLITMGISVNsaytsnimaghnpGDLPIQVGNKTECALLGFVQGLGVKYqsirDEI 551
Cdd:TIGR01494  252 QKVIIIGG--------------VEEASLALALLA-------------ASLEYLSGHPLERAIVKSAEGVIKSD----EIN 300
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585   552 TEDKFTRVYTFNSVRKSMGTVIPRPNGGYRLYTKGASEIIMKKCAfiyghegtlekftrdmQERLIREVIEPMACDGLRT 631
Cdd:TIGR01494  301 VEYKILDVFPFSSVLKRMGVIVEGANGSDLLFVKGAPEFVLERCN----------------NENDYDEKVDEYARQGLRV 364
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585   632 ISVAYRDfvpgkaainevhidgepnwddeenIMTNLTCLCVVGIEDPVRPEVPDAIRKCQRAGITVRMVTGDNINTARSI 711
Cdd:TIGR01494  365 LAFASKK------------------------LPDDLEFLGLLTFEDPLRPDAKETIEALRKAGIKVVMLTGDNVLTAKAI 420
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585   712 ASKCGILrpnddflilegkefnrrirdsngdiqqhlidkvwpklrVLARSSPTDKYTLVKGIIdstvsENREVVAVTGDG 791
Cdd:TIGR01494  421 AKELGID--------------------------------------VFARVKPEEKAAIVEALQ-----EKGRTVAMTGDG 457
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585   792 TNDGPALKKADVGFAMGIAgtDVAKEASDIILTDDNFSSIVKAVMWGRNVYDSIAKFLQFQLTVNVVAVIVAFIGACavq 871
Cdd:TIGR01494  458 VNDAPALKKADVGIAMGSG--DVAKAAADIVLLDDDLSTIVEAVKEGRKTFSNIKKNIFWAIAYNLILIPLALLLIV--- 532
                          730       740
                   ....*....|....*....|....
gi 320541585   872 dsplkavqmlwVNLIMDTLASLAL 895
Cdd:TIGR01494  533 -----------IILLPPLLAALAL 545
P-type_ATPase_SERCA cd02083
sarco/endoplasmic reticulum Ca(2+)-ATPase (SERCA), similar to mammalian ATP2A1-3/SERCA1-3; ...
41-918 5.27e-122

sarco/endoplasmic reticulum Ca(2+)-ATPase (SERCA), similar to mammalian ATP2A1-3/SERCA1-3; SERCA is a transmembrane (Ca2+)-ATPase and a major regulator of Ca(2+) homeostasis and contractility in cardiac and skeletal muscle. It re-sequesters cytoplasmic Ca(2+) to the sarco/endoplasmic reticulum store, thereby also terminating Ca(2+)-induced signaling such as in muscle contraction. Three genes (ATP2A1-3/SERCA1-3) encode SERCA pumps in mammals, further isoforms exist due to alternative splicing of transcripts. The activity of SERCA is regulated by two small membrane proteins called phospholamban and sarcolipin. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319778 [Multi-domain]  Cd Length: 979  Bit Score: 401.28  E-value: 5.27e-122
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585   41 ELCKKLYTSPNEGLSgsKADEEHRRETFGSNVIPPKPPKTFLTLVWEALQDVTLIILEVAALVSLGLSFYkpadedapvl 120
Cdd:cd02083     7 EVLAYFGVDPTRGLS--DEQVKRRREKYGPNELPAEEGKSLWELVLEQFDDLLVRILLLAAIISFVLALF---------- 74
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  121 qeEEEHHGWieglailisvivvvivTAF------------NDYSKERQFRGLQNRIEGEHKFS-----VIRGGEVCQ-IS 182
Cdd:cd02083    75 --EEGEEGV----------------TAFvepfvilliliaNAVVGVWQERNAEKAIEALKEYEpemakVLRNGKGVQrIR 136
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  183 VGDILVGDIAQVKYGDLLPADGCL--IQSNDLKVDESSLTGESDHVKKGPDVDP-----------MVLSGTHVMEGSGKM 249
Cdd:cd02083   137 ARELVPGDIVEVAVGDKVPADIRIieIKSTTLRVDQSILTGESVSVIKHTDVVPdpravnqdkknMLFSGTNVAAGKARG 216
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  250 VVTAVGVNSQAGIIftllgaavdeqeaeikkmkkeakrankqknltgendgRSQIkgsqapsqretvtseitksesegnh 329
Cdd:cd02083   217 VVVGTGLNTEIGKI-------------------------------------RDEM------------------------- 234
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  330 lpqssssgaAETGhkKEKSVLQAKLTKLAIQigyagstiavLTVIILIIqfCIKTFVIDEKPWKNT-YANNLVKHLI--- 405
Cdd:cd02083   235 ---------AETE--EEKTPLQQKLDEFGEQ----------LSKVISVI--CVAVWAINIGHFNDPaHGGSWIKGAIyyf 291
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  406 -IGVTVLVVAVPEGLPLAVTLSLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTTNRMTVVQSYICEKLC--- 481
Cdd:cd02083   292 kIAVALAVAAIPEGLPAVITTCLALGTRRMAKKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVSRMFILDKVEdds 371
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  482 -----------------------KVLPTLSDIPQHVGNLITMgisVNSAYTSnimagHNPGDLPIQ-VGNKTECALLGFV 537
Cdd:cd02083   372 slnefevtgstyapegevfkngkKVKAGQYDGLVELATICAL---CNDSSLD-----YNESKGVYEkVGEATETALTVLV 443
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  538 QGLGV------------KYQSIRDEItEDKFTRVYT--FNSVRKSMGTVI--PRPNGGYRLYTKGASEIIMKKCAFIYGH 601
Cdd:cd02083   444 EKMNVfntdksglskreRANACNDVI-EQLWKKEFTleFSRDRKSMSVYCspTKASGGNKLFVKGAPEGVLERCTHVRVG 522
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  602 EGTLEKFTRDMQERLIREVIEpMACDGLRTISVAYRDFVPGKaainEVHIDGEPNwdDEENIMTNLTCLCVVGIEDPVRP 681
Cdd:cd02083   523 GGKVVPLTAAIKILILKKVWG-YGTDTLRCLALATKDTPPKP----EDMDLEDST--KFYKYETDLTFVGVVGMLDPPRP 595
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  682 EVPDAIRKCQRAGITVRMVTGDNINTARSIASKCGILRPNDDFlilEGKEFNRRIRDSNGDIQQHLidkVWPKLRVLARS 761
Cdd:cd02083   596 EVRDSIEKCRDAGIRVIVITGDNKGTAEAICRRIGIFGEDEDT---TGKSYTGREFDDLSPEEQRE---ACRRARLFSRV 669
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  762 SPTDKYTLVKgiidsTVSENREVVAVTGDGTNDGPALKKADVGFAMGIaGTDVAKEASDIILTDDNFSSIVKAVMWGRNV 841
Cdd:cd02083   670 EPSHKSKIVE-----LLQSQGEITAMTGDGVNDAPALKKAEIGIAMGS-GTAVAKSASDMVLADDNFATIVAAVEEGRAI 743
                         890       900       910       920       930       940       950
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 320541585  842 YDSIAKFLQFQLTVNVVAVIVAFIGACAVQDSPLKAVQMLWVNLIMDTLASLALATEFPTPDLLLRKPYGRTKPLIS 918
Cdd:cd02083   744 YNNMKQFIRYLISSNIGEVVSIFLTAALGLPEALIPVQLLWVNLVTDGLPATALGFNPPDLDIMKKPPRKPDEPLIS 820
P-type_ATPase_Na_ENA cd02086
fungal-type Na(+)-ATPase, similar to the plasma membrane sodium transporters Saccharomyces ...
57-1062 4.69e-118

fungal-type Na(+)-ATPase, similar to the plasma membrane sodium transporters Saccharomyces cerevisiae Ena1p, Ena2p and Ustilago maydis Ena1, and the endoplasmic reticulum sodium transporter Ustilago maydis Ena2; Fungal-type Na(+)-ATPase (also called ENA ATPases). This subfamily includes the Saccharomyces cerevisiae plasma membrane transporters: Na(+)/Li(+)-exporting ATPase Ena1p which may also extrudes K(+), and Na(+)-exporting P-type ATPase Ena2p. It also includes Ustilago maydis plasma membrane Ena1, an K(+)/Na(+)-ATPase whose chief role is to pump Na(+) and K(+) out of the cytoplasm, especially at high pH values, and endoplasmic reticulum Ena2 ATPase which mediates Na(+) or K(+) fluxes in the ER or in other endomembranes. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319780 [Multi-domain]  Cd Length: 920  Bit Score: 389.12  E-value: 4.69e-118
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585   57 SKADEEHRRETFGSNVIPP----KPPKTFLTLVWEALqdvTLIILeVAALVSLGLSfykpadedapvlqeeeehhGWIEG 132
Cdd:cd02086     3 TNDEAERRLKEYGENELEGdtgvSAWKILLRQVANAM---TLVLI-IAMALSFAVK-------------------DWIEG 59
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  133 LAILISVIVVVIVTAFNDYSKERQFRGLQNRIEGEHKfsVIRGGEVCQISVGDILVGDIAQVKYGDLLPADGCLIQSNDL 212
Cdd:cd02086    60 GVIAAVIALNVIVGFIQEYKAEKTMDSLRNLSSPNAH--VIRSGKTETISSKDVVPGDIVLLKVGDTVPADLRLIETKNF 137
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  213 KVDESSLTGESDHVKK--------GPDVDP-----MVLSGTHVMEGSGKMVVTAVGVNSQAGIIFTLL---GAAVDEQEA 276
Cdd:cd02086   138 ETDEALLTGESLPVIKdaelvfgkEEDVSVgdrlnLAYSSSTVTKGRAKGIVVATGMNTEIGKIAKALrgkGGLISRDRV 217
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  277 EIKKMKKEAKRANKQKNLTGENDGrsqikgsqapsqretvtseitksesegnhlpqssssgaaetghkkekSVLQAKLTK 356
Cdd:cd02086   218 KSWLYGTLIVTWDAVGRFLGTNVG-----------------------------------------------TPLQRKLSK 250
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  357 LAIqigyagsTIAVLTVIILIIQFCIKTFVIdekpwkntyaNNLVkhLIIGVTVLVVAVPEGLPLAVTLSLAYSVKKMMK 436
Cdd:cd02086   251 LAY-------LLFFIAVILAIIVFAVNKFDV----------DNEV--IIYAIALAISMIPESLVAVLTITMAVGAKRMVK 311
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  437 DNNLVRHLDACETMGNATAICSDKTGTLTTNRMTVVQSYICEKLCkvlptlsdipqhvgNLITmgisVNSAYTSNIMAGH 516
Cdd:cd02086   312 RNVIVRKLDALEALGAVTDICSDKTGTLTQGKMVVRQVWIPAALC--------------NIAT----VFKDEETDCWKAH 373
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  517 npgdlpiqvGNKTECALLGFVQGLGV-KYQSIRDEITEDKFTRVYTFNSVRKSMGTVIPRP-NGGYRLYTKGASEIIMKK 594
Cdd:cd02086   374 ---------GDPTEIALQVFATKFDMgKNALTKGGSAQFQHVAEFPFDSTVKRMSVVYYNNqAGDYYAYMKGAVERVLEC 444
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  595 CAFIYGHEGTleKFTRDMQERLIREVIEPMACDGLRTISVAYRDFvpGKAAIN-EVHIDGEPNWDDEEnimTNLTCLCVV 673
Cdd:cd02086   445 CSSMYGKDGI--IPLDDEFRKTIIKNVESLASQGLRVLAFASRSF--TKAQFNdDQLKNITLSRADAE---SDLTFLGLV 517
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  674 GIEDPVRPEVPDAIRKCQRAGITVRMVTGDNINTARSIASKCGILRPND--------DFLILEGKEFnrrirDSNGDIQq 745
Cdd:cd02086   518 GIYDPPRNESAGAVEKCHQAGITVHMLTGDHPGTAKAIAREVGILPPNSyhysqeimDSMVMTASQF-----DGLSDEE- 591
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  746 hlIDKVwPKL-RVLARSSPTDKYTLVKGIidstvSENREVVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILT 824
Cdd:cd02086   592 --VDAL-PVLpLVIARCSPQTKVRMIEAL-----HRRKKFCAMTGDGVNDSPSLKMADVGIAMGLNGSDVAKDASDIVLT 663
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  825 DDNFSSIVKAVMWGRNVYDSIAKFLQFQLTVNVVAVIVAFIGaCAVQDS------PLKAVQMLWVNLIMDTLASLALATE 898
Cdd:cd02086   664 DDNFASIVNAIEEGRRMFDNIQKFVLHLLAENVAQVILLLIG-LAFKDEdglsvfPLSPVEILWINMVTSSFPAMGLGLE 742
                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  899 FPTPDLLLRKPYGRTKPLISRTMmknILGQALYQLII-IFGLL-FVGdVILDIESGR-GQELNAGPTQHFTIIFN----T 971
Cdd:cd02086   743 KASPDVMQRPPHDLKVGIFTREL---IIDTFVYGTFMgVLCLAsFTL-VIYGIGNGDlGSDCNESYNSSCEDVFRaraaV 818
                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  972 FVMMTLFNEINARKIHGQRNVieglltnpifytiwIFTM--ISQVLIIQYGKMAFSTKALtldqwLWCIFFGIgtlvwgq 1049
Cdd:cd02086   819 FATLTWCALILAWEVVDMRRS--------------FFNMhpDTDSPVKSFFKTLWKNKFL-----FWSVVLGF------- 872
                        1050
                  ....*....|...
gi 320541585 1050 lITSVPTRKLPKI 1062
Cdd:cd02086   873 -VSVFPTLYIPVI 884
P-type_ATPase_SPCA cd02085
golgi-associated secretory pathway Ca(2+) transport ATPases, similar to human ATPase secretory ...
150-1031 1.71e-116

golgi-associated secretory pathway Ca(2+) transport ATPases, similar to human ATPase secretory pathway Ca(2+) transporting 1/hSPCA1 and Saccharomyces cerevisiae Ca(2+)/Mn(2+)-transporting P-type ATPase, Pmr1p; SPCAs are Ca(2+) pumps important for the golgi-associated secretion pathway, in addition some function as Mn(2+) pumps in Mn(2+) detoxification. Saccharomyces cerevisiae Pmr1p is a high affinity Ca(2+)/Mn(2+) ATPase which transports Ca(2+) and Mn(2+) from the cytoplasm into the Golgi. Pmr1p also contributes to Cd(2+) detoxification. This subfamily includes human SPCA1 and SPCA2, encoded by the ATP2C1 and ATP2C2 genes; autosomal dominant Hailey-Hailey disease is caused by mutations in the human ATP2C1 gene. It also includes Strongylocentrotus purpuratus testis secretory pathway calcium transporting ATPase SPCA which plays an important role in fertilization. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319779 [Multi-domain]  Cd Length: 804  Bit Score: 381.36  E-value: 1.71e-116
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  150 DYSKERQFRGLQNRIEgeHKFSVIRGGEVCQISVGDILVGDIAQVKYGDLLPADGCLIQSNDLKVDESSLTGESDHVKKG 229
Cdd:cd02085    68 EYRSEKSLEALNKLVP--PECHCLRDGKLEHFLARELVPGDLVCLSIGDRIPADLRLFEATDLSIDESSLTGETEPCSKT 145
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  230 PDVDP------------MVLSGTHVMEGSGKMVVTAVGVNSQAGIIFtllgaavdeqeaeiKKMKKEakrankqknltge 297
Cdd:cd02085   146 TEVIPkasngdlttrsnIAFMGTLVRCGHGKGIVIGTGENSEFGEVF--------------KMMQAE------------- 198
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  298 ndgrsqikgsQAPsqretvtseitksesegnhlpqssssgaaetghkkeKSVLQAKLTKLAIQIGYAGSTIAVLTVIILI 377
Cdd:cd02085   199 ----------EAP------------------------------------KTPLQKSMDKLGKQLSLYSFIIIGVIMLIGW 232
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  378 IQfciktfvidekpwkntyANNLVKHLIIGVTVLVVAVPEGLPLAVTLSLAYSVKKMMKDNNLVRHLDACETMGNATAIC 457
Cdd:cd02085   233 LQ-----------------GKNLLEMFTIGVSLAVAAIPEGLPIVVTVTLALGVMRMAKRRAIVKKLPIVETLGCVNVIC 295
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  458 SDKTGTLTTNRMTVvQSYICEKLCkvlptlsdipqhvgnlitmgisvNSAYTSNimaghnpgdlPIQVGNKTECALLgfV 537
Cdd:cd02085   296 SDKTGTLTKNEMTV-TKIVTGCVC-----------------------NNAVIRN----------NTLMGQPTEGALI--A 339
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  538 QGLGVKYQSIRDEITEDKFtrvYTFNSVRKSMGT-VIPR--PNGGYRLYTKGASEIIMKKCAFIYGHEGTLEKFTrdMQE 614
Cdd:cd02085   340 LAMKMGLSDIRETYIRKQE---IPFSSEQKWMAVkCIPKynSDNEEIYFMKGALEQVLDYCTTYNSSDGSALPLT--QQQ 414
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  615 R-LIREVIEPMACDGLRTISVAyrdfvpgkaainevhiDGEpnwddeenIMTNLTCLCVVGIEDPVRPEVPDAIRKCQRA 693
Cdd:cd02085   415 RsEINEEEKEMGSKGLRVLALA----------------SGP--------ELGDLTFLGLVGINDPPRPGVREAIQILLES 470
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  694 GITVRMVTGDNINTARSIASKCGILRPNDdfLILEGKEFNrrirdsngDIQQHLIDKVWPKLRVLARSSPTDKYTLVKGI 773
Cdd:cd02085   471 GVRVKMITGDAQETAIAIGSSLGLYSPSL--QALSGEEVD--------QMSDSQLASVVRKVTVFYRASPRHKLKIVKAL 540
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  774 idstvSENREVVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFSSIVKAVMWGRNVYDSIAKFLQFQL 853
Cdd:cd02085   541 -----QKSGAVVAMTGDGVNDAVALKSADIGIAMGRTGTDVCKEAADMILVDDDFSTILAAIEEGKGIFYNIKNFVRFQL 615
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  854 TVNVVAVIVAFIGACAVQDSPLKAVQMLWVNLIMDTLASLALATEFPTPDLLLRKPYGRTKPLISRTMMKNILGQAlyqL 933
Cdd:cd02085   616 STSIAALSLIALSTLFNLPNPLNAMQILWINIIMDGPPAQSLGVEPVDKDVIRQPPRNVKDPILTRSLILNVLLSA---A 692
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  934 IIIFGLLFVGDVILdiesgrgQELNAGPtQHFTIIFNTFVMMTLFNEINARkiHGQRNVIE-GLLTNPIFYTIWIFTMIS 1012
Cdd:cd02085   693 IIVSGTLWVFWKEM-------SDDNVTP-RDTTMTFTCFVFFDMFNALSCR--SQTKSIFEiGFFSNRMFLYAVGGSLIG 762
                         890       900
                  ....*....|....*....|.
gi 320541585 1013 QVLIIQYG--KMAFSTKALTL 1031
Cdd:cd02085   763 QLLVIYFPplQRVFQTEALGL 783
ATPase-IIA1_Ca TIGR01116
sarco/endoplasmic reticulum calcium-translocating P-type ATPase; This model describes the ...
85-1035 5.02e-116

sarco/endoplasmic reticulum calcium-translocating P-type ATPase; This model describes the P-type ATPase responsible for translocating calcium ions across the endoplasmic reticulum membrane of eukaryotes, and is of particular importance in the sarcoplasmic reticulum of skeletal and cardiac muscle in vertebrates. These pumps transfer Ca2+ from the cytoplasm to the lumen of the endoplasmic reticulum. In humans and mice, at least, there are multiple isoforms of the SERCA pump with overlapping but not redundant functions. Defects in SERCA isoforms are associated with diseases in humans. The calcium P-type ATPases have been characterized as Type IIA based on a phylogenetic analysis which distinguishes this group from the Type IIB PMCA calcium pump modelled by TIGR01517. A separate analysis divides Type IIA into sub-types, SERCA and PMR1, the latter of which is modelled by TIGR01522. [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273452 [Multi-domain]  Cd Length: 917  Bit Score: 383.36  E-value: 5.02e-116
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585    85 VWEALQDVTLIILEVAALVSLGLSFYKPADEDAPvlqeeeehhGWIEGLAILISVIVVVIVTAFNDYSKERQFRGLQNrI 164
Cdd:TIGR01116    1 VLEQFEDLLVRILLLAACVSFVLAWFEEGEETVT---------AFVEPFVILLILVANAIVGVWQERNAEKAIEALKE-Y 70
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585   165 EGEHKfSVIRGGEVCQISVGDILVGDIAQVKYGDLLPADGCLIQSNDLKVDESSLTGESDHVKKGPDVDP---------- 234
Cdd:TIGR01116   71 ESEHA-KVLRDGRWSVIKAKDLVPGDIVELAVGDKVPADIRVLSLKTLRVDQSILTGESVSVNKHTESVPderavnqdkk 149
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585   235 -MVLSGTHVMEGSGKMVVTAVGVNSQAGIIftllgaavdeqeaeikkmkkeakrankqknltgendgrsqikgsqapsQR 313
Cdd:TIGR01116  150 nMLFSGTLVVAGKARGVVVRTGMSTEIGKI------------------------------------------------RD 181
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585   314 ETVTSEitksesegnhlpqssssgaaetghkKEKSVLQAKLTKLAIQigyagstiavLTVIILIIqfCIKTFVIDEKPWK 393
Cdd:TIGR01116  182 EMRAAE-------------------------QEDTPLQKKLDEFGEL----------LSKVIGLI--CILVWVINIGHFN 224
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585   394 NT-----YANNLVKHLIIGVTVLVVAVPEGLPLAVTLSLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTTNR 468
Cdd:TIGR01116  225 DPalgggWIQGAIYYFKIAVALAVAAIPEGLPAVITTCLALGTRKMAKKNAIVRKLPSVETLGCTTVICSDKTGTLTTNQ 304
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585   469 MTVVQSYICEKL-CKV----LPTLSDIPQ----HVGNLITMGISVNSAYTSNIMAGHNPGDLPI--------QVGNKTEC 531
Cdd:TIGR01116  305 MSVCKVVALDPSsSSLnefcVTGTTYAPEggviKDDGPVAGGQDAGLEELATIAALCNDSSLDFnerkgvyeKVGEATEA 384
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585   532 ALLGFVQGLGV-----KYQSIRDEIT------EDKFTRVYT--FNSVRKSMGtVIPRPNGGYRLYTKGASEIIMKKCAFI 598
Cdd:TIGR01116  385 ALKVLVEKMGLpatknGVSSKRRPALgcnsvwNDKFKKLATleFSRDRKSMS-VLCKPSTGNKLFVKGAPEGVLERCTHI 463
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585   599 YGHEGTLEKFTRDMQERLIREVIEPMACDGLRTISVAYRDFVPGKAainEVHIDGEPNWddeENIMTNLTCLCVVGIEDP 678
Cdd:TIGR01116  464 LNGDGRAVPLTDKMKNTILSVIKEMGTTKALRCLALAFKDIPDPRE---EDLLSDPANF---EAIESDLTFIGVVGMLDP 537
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585   679 VRPEVPDAIRKCQRAGITVRMVTGDNINTARSIASKCGILRPNDD--FLILEGKEFnrrirDSNGDIQQHlidKVWPKLR 756
Cdd:TIGR01116  538 PRPEVADAIEKCRTAGIRVIMITGDNKETAEAICRRIGIFSPDEDvtFKSFTGREF-----DEMGPAKQR---AACRSAV 609
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585   757 VLARSSPTDKYTLVKgiidsTVSENREVVAVTGDGTNDGPALKKADVGFAMGiAGTDVAKEASDIILTDDNFSSIVKAVM 836
Cdd:TIGR01116  610 LFSRVEPSHKSELVE-----LLQEQGEIVAMTGDGVNDAPALKKADIGIAMG-SGTEVAKEASDMVLADDNFATIVAAVE 683
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585   837 WGRNVYDSIAKFLQFQLTVNVVAVIVAFIGACAVQDSPLKAVQMLWVNLIMDTLASLALATEFPTPDLLLRKPYGRTKPL 916
Cdd:TIGR01116  684 EGRAIYNNMKQFIRYMISSNIGEVVCIFLTAALGIPEGLIPVQLLWVNLVTDGLPATALGFNPPDKDIMWKPPRRPDEPL 763
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585   917 IS-----RTMMKNI-LGQALYQLIIIFGLLF-----VGDVILDIESGRGQ--ELNAGPTQHFTIIFNTFVMMTLFNEINA 983
Cdd:TIGR01116  764 ITgwlffRYLVVGVyVGLATVGGFVWWYLLThftgcDEDSFTTCPDFEDPdcYVFEGKQPARTISLSVLVVIEMFNALNA 843
                          970       980       990      1000      1010
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 320541585   984 RKIHGQrnviegLLTNPIFYTIW----IFTMISQVLIIQY---GKMAFSTKALTLDQWL 1035
Cdd:TIGR01116  844 LSEDQS------LLRMPPWVNKWligaICLSMALHFLILYvpfLSRIFGVTPLSLTDWL 896
P-type_ATPases cd01431
ATP-dependent membrane-bound cation and aminophospholipid transporters; The P-type ATPases, ...
456-895 1.98e-91

ATP-dependent membrane-bound cation and aminophospholipid transporters; The P-type ATPases, are a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids. They are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle. A general characteristic of P-type ATPases is a bundle of transmembrane helices which make up the transport path, and three domains on the cytoplasmic side of the membrane. Members include pumps that transport various light metal ions, such as H(+), Na(+), K(+), Ca(2+), and Mg(2+), pumps that transport indispensable trace elements, such as Zn(2+) and Cu(2+), pumps that remove toxic heavy metal ions, such as Cd(2+), and pumps such as aminophospholipid translocases which transport phosphatidylserine and phosphatidylethanolamine.


Pssm-ID: 319764 [Multi-domain]  Cd Length: 319  Bit Score: 297.06  E-value: 1.98e-91
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  456 ICSDKTGTLTTNRMTVVqsyiceklckvlptlsdipqhvgnlitmgisvnsaytsnimaghnpgdlpiqvgnktecallg 535
Cdd:cd01431     2 ICSDKTGTLTKNGMTVT--------------------------------------------------------------- 18
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  536 fvqglgvkyqsirdeiteDKFTRVYTFNSVRKSMGTVIpRPNGGYRLYTKGASEIIMKKCafiyghegtlEKFTRDMQER 615
Cdd:cd01431    19 ------------------KLFIEEIPFNSTRKRMSVVV-RLPGRYRAIVKGAPETILSRC----------SHALTEEDRN 69
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  616 LIREVIEPMACDGLRTISVAYRDFvpgkaainevhidgePNWDDEENIMTNLTCLCVVGIEDPVRPEVPDAIRKCQRAGI 695
Cdd:cd01431    70 KIEKAQEESAREGLRVLALAYREF---------------DPETSKEAVELNLVFLGLIGLQDPPRPEVKEAIAKCRTAGI 134
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  696 TVRMVTGDNINTARSIASKCGILRPNDDFLILEGKEfnrrirdsngDIQQHLIDKVWPKLRVLARSSPTDKYTLVKGIID 775
Cdd:cd01431   135 KVVMITGDNPLTAIAIAREIGIDTKASGVILGEEAD----------EMSEEELLDLIAKVAVFARVTPEQKLRIVKALQA 204
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  776 STvsenrEVVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFSSIVKAVMWGRNVYDSIAKFLQFQLTV 855
Cdd:cd01431   205 RG-----EVVAMTGDGVNDAPALKQADVGIAMGSTGTDVAKEAADIVLLDDNFATIVEAVEEGRAIYDNIKKNITYLLAN 279
                         410       420       430       440
                  ....*....|....*....|....*....|....*....|
gi 320541585  856 NVVAVIVAFIGACAVQDSPLKAVQMLWVNLIMDTLASLAL 895
Cdd:cd01431   280 NVAEVFAIALALFLGGPLPLLAFQILWINLVTDLIPALAL 319
P-type_ATPase cd07539
uncharacterized subfamily of P-type ATPase transporters; This subfamily contains P-type ATPase ...
154-898 4.22e-88

uncharacterized subfamily of P-type ATPase transporters; This subfamily contains P-type ATPase transporters of unknown function. The P-type ATPases, are a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids. They are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle. A general characteristic of P-type ATPases is a bundle of transmembrane helices which make up the transport path, and three domains on the cytoplasmic side of the membrane. Members include pumps that transport various light metal ions, such as H(+), Na(+), K(+), Ca(2+), and Mg(2+), pumps that transport indispensable trace elements, such as Zn(2+) and Cu(2+), pumps that remove toxic heavy metal ions, such as Cd2+, and pumps such as aminophospholipid translocases which transport phosphatidylserine and phosphatidylethanolamine.


Pssm-ID: 319840 [Multi-domain]  Cd Length: 634  Bit Score: 298.56  E-value: 4.22e-88
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  154 ERQFRGLqnRIEGEHKFSVIR--GGEVCQISVGDILVGDIAQVKYGDLLPADGCLIQSNDLKVDESSLTGESDHVKKgpD 231
Cdd:cd07539    82 ERALAAL--LAQQQQPARVVRapAGRTQTVPAESLVPGDVIELRAGEVVPADARLLEADDLEVDESALTGESLPVDK--Q 157
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  232 VDP-----------MVLSGTHVMEGSGKMVVTAVGVNSQAGIIFTLlgaaVDEQEAEikkmkkeakrankqknltgendg 300
Cdd:cd07539   158 VAPtpgapladracMLYEGTTVVSGQGRAVVVATGPHTEAGRAQSL----VAPVETA----------------------- 210
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  301 rsqikgsqAPSQRETvtSEITKSEsegnhLPQSSSSGAAETGhkkeksvlqakltkLAIQIGYAgstiavltviiliiqf 380
Cdd:cd07539   211 --------TGVQAQL--RELTSQL-----LPLSLGGGAAVTG--------------LGLLRGAP---------------- 245
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  381 ciktfvidekpwkntyannLVKHLIIGVTVLVVAVPEGLPLAVTLSLAYSVKKMMKDNNLVRHLDACETMGNATAICSDK 460
Cdd:cd07539   246 -------------------LRQAVADGVSLAVAAVPEGLPLVATLAQLAAARRLSRRGVLVRSPRTVEALGRVDTICFDK 306
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  461 TGTLTTNRMTVVQsyiceklckVLPTLSDIPqhvgnlitmgisvnsaytsnimaghnpgdlpiqvgnktecallgfvqgl 540
Cdd:cd07539   307 TGTLTENRLRVVQ---------VRPPLAELP------------------------------------------------- 328
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  541 gvkyqsirdeitedkftrvytFNSVRKSMGTVIPRPNGGYRLYTKGASEIIMKKCAFIYGHEGTLEkFTRDMQERlIREV 620
Cdd:cd07539   329 ---------------------FESSRGYAAAIGRTGGGIPLLAVKGAPEVVLPRCDRRMTGGQVVP-LTEADRQA-IEEV 385
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  621 IEPMACDGLRTISVAYRDFVPGKAAINEVHIDgepnwddeenimtNLTCLCVVGIEDPVRPEVPDAIRKCQRAGITVRMV 700
Cdd:cd07539   386 NELLAGQGLRVLAVAYRTLDAGTTHAVEAVVD-------------DLELLGLLGLADTARPGAAALIAALHDAGIDVVMI 452
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  701 TGDNINTARSIASKCGIlrpNDDFLILEGKEFNRRIRDSngdiQQHLIDKVwpklRVLARSSPTDKYTLVkgiidSTVSE 780
Cdd:cd07539   453 TGDHPITARAIAKELGL---PRDAEVVTGAELDALDEEA----LTGLVADI----DVFARVSPEQKLQIV-----QALQA 516
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  781 NREVVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFSSIVKAVMWGRNVYDSIAKFLQFQLTVNVVAV 860
Cdd:cd07539   517 AGRVVAMTGDGANDAAAIRAADVGIGVGARGSDAAREAADLVLTDDDLETLLDAVVEGRTMWQNVRDAVHVLLGGNLGEV 596
                         730       740       750
                  ....*....|....*....|....*....|....*...
gi 320541585  861 IVAFIGACAVQDSPLKAVQMLWVNLIMDTLASLALATE 898
Cdd:cd07539   597 MFTLIGTAIGGGAPLNTRQLLLVNLLTDMFPALALAVE 634
P-type_ATPase cd07538
uncharacterized subfamily of P-type ATPase transporters; This subfamily contains P-type ATPase ...
57-932 4.61e-88

uncharacterized subfamily of P-type ATPase transporters; This subfamily contains P-type ATPase transporters of unknown function. The P-type ATPases, are a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids. They are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle. A general characteristic of P-type ATPases is a bundle of transmembrane helices which make up the transport path, and three domains on the cytoplasmic side of the membrane. Members include pumps that transport various light metal ions, such as H(+), Na(+), K(+), Ca(2+), and Mg(2+), pumps that transport indispensable trace elements, such as Zn(2+) and Cu(2+), pumps that remove toxic heavy metal ions, such as Cd2+, and pumps such as aminophospholipid translocases which transport phosphatidylserine and phosphatidylethanolamine.


Pssm-ID: 319839 [Multi-domain]  Cd Length: 653  Bit Score: 299.36  E-value: 4.61e-88
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585   57 SKADEEHRRETFGSNVIPPKPPKTFLTLVWEALQDVTLIILEVAALVSLGLSfykpadedapvlqeeeEHHgwiEGLAIL 136
Cdd:cd07538     3 TEAEARRRLESGGKNELPQPKKRTLLASILDVLREPMFLLLLAAALIYFVLG----------------DPR---EGLILL 63
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  137 ISVIVVVIVTAFNDYSKERQFRGLQNRieGEHKFSVIRGGEVCQISVGDILVGDIAQVKYGDLLPADGCLIQSNDLKVDE 216
Cdd:cd07538    64 IFVVVIIAIEVVQEWRTERALEALKNL--SSPRATVIRDGRERRIPSRELVPGDLLILGEGERIPADGRLLENDDLGVDE 141
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  217 SSLTGESDHVKKGPDV----------DPMVLSGTHVMEGSGKMVVTAVGVNSQAGIIftllGAAVDEQEAEIKKMKKEAk 286
Cdd:cd07538   142 STLTGESVPVWKRIDGkamsapggwdKNFCYAGTLVVRGRGVAKVEATGSRTELGKI----GKSLAEMDDEPTPLQKQT- 216
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  287 rankqknltgendgrsqikgsqapsqretvtseitksesegnhlpqssssgaaetghkkeksvlqAKLTKLaiqIGYAGS 366
Cdd:cd07538   217 -----------------------------------------------------------------GRLVKL---CALAAL 228
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  367 TIAVLTVIIliiqfcikTFVidekpwkntYANNLVKHLIIGVTVLVVAVPEGLPLAVTLSLAYSVKKMMKDNNLVRHLDA 446
Cdd:cd07538   229 VFCALIVAV--------YGV---------TRGDWIQAILAGITLAMAMIPEEFPVILTVFMAMGAWRLAKKNVLVRRAAA 291
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  447 CETMGNATAICSDKTGTLTTNRMTVVQSYiceklckvlptlsdipqhvgnlitmgisvnsaytsnimaghnpgdLPIqvg 526
Cdd:cd07538   292 VETLGSITVLCVDKTGTLTKNQMEVVELT---------------------------------------------SLV--- 323
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  527 nktecallgfvqglgvkyqsirdeitedkftRVYTFNSVRKSMGTVIPRPNGgYRLYTKGASEIIMKKCafiyghegtle 606
Cdd:cd07538   324 -------------------------------REYPLRPELRMMGQVWKRPEG-AFAAAKGSPEAIIRLC----------- 360
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  607 KFTRDMQERLIREVIEpMACDGLRTISVAyrdfvpgkaainEVHIDGEPNWDDEENIMTNLTCLcvVGIEDPVRPEVPDA 686
Cdd:cd07538   361 RLNPDEKAAIEDAVSE-MAGEGLRVLAVA------------ACRIDESFLPDDLEDAVFIFVGL--IGLADPLREDVPEA 425
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  687 IRKCQRAGITVRMVTGDNINTARSIASKCGILRPNDdflILEGKEfnrriRDSNGDiqQHLIDKVwPKLRVLARSSPTDK 766
Cdd:cd07538   426 VRICCEAGIRVVMITGDNPATAKAIAKQIGLDNTDN---VITGQE-----LDAMSD--EELAEKV-RDVNIFARVVPEQK 494
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  767 YTLVKGIidstvSENREVVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFSSIVKAVMWGRNVYDSIA 846
Cdd:cd07538   495 LRIVQAF-----KANGEIVAMTGDGVNDAPALKAAHIGIAMGKRGTDVAREASDIVLLDDNFSSIVSTIRLGRRIYDNLK 569
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  847 KFLQFQLTVNVVAVIVAFIGACAVQDSPLKAVQMLWVNLIMDTLASLALATEFPTPDLLLRKPYGRTKPLISrtmmKNIL 926
Cdd:cd07538   570 KAITYVFAIHVPIAGLALLPPLLGLPPLLFPVHVVLLELIIDPTCSIVFEAEPAERDIMRRPPRPPDEPLFG----PRLV 645

                  ....*.
gi 320541585  927 GQALYQ 932
Cdd:cd07538   646 IKAILQ 651
ATPase-IID_K-Na TIGR01523
potassium and/or sodium efflux P-type ATPase, fungal-type; Initially described as a calcium ...
34-926 1.37e-86

potassium and/or sodium efflux P-type ATPase, fungal-type; Initially described as a calcium efflux ATPase, more recent work has shown that the S. pombe CTA3 gene is in fact a potassium ion efflux pump. This model describes the clade of fungal P-type ATPases responsible for potassium and sodium efflux. The degree to which these pumps show preference for sodium or potassium varies. This group of ATPases has been classified by phylogentic analysis as type IID. The Leishmania sequence (GP|3192903), which falls between trusted and noise in this model, may very well turn out to be an active potassium pump.


Pssm-ID: 130586 [Multi-domain]  Cd Length: 1053  Bit Score: 304.24  E-value: 1.37e-86
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585    34 AENGGIHELCKK-----LYTSPNEGLSGSKAdeEHRRETFGSNVIPPKPPKTFLTLVWEALQDVTLIILEVAALVSLGLs 108
Cdd:TIGR01523    2 AEFNAYFSDIADeaaefIGTSIPEGLTHDEA--QHRLKEVGENRLEADSGIDAKAMLLHQVCNAMCMVLIIAAAISFAM- 78
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585   109 fykpadedapvlqeeeehHGWIEGLAILISVIVVVIVTAFNDYSKERQFRGLQNRieGEHKFSVIRGGEVCQISVGDILV 188
Cdd:TIGR01523   79 ------------------HDWIEGGVISAIIALNILIGFIQEYKAEKTMDSLKNL--ASPMAHVIRNGKSDAIDSHDLVP 138
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585   189 GDIAQVKYGDLLPADGCLIQSNDLKVDESSLTGESDHVKKGP-------------DVDPMVLSGTHVMEGSGKMVVTAVG 255
Cdd:TIGR01523  139 GDICLLKTGDTIPADLRLIETKNFDTDEALLTGESLPVIKDAhatfgkeedtpigDRINLAFSSSAVTKGRAKGICIATA 218
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585   256 VNSQAGIIftllgaavdeqEAEIKKMKKEAKRANKQKnltgendgrsqikgsqaPSQRETVTSEITKSESEGNHLPQSSS 335
Cdd:TIGR01523  219 LNSEIGAI-----------AAGLQGDGGLFQRPEKDD-----------------PNKRRKLNKWILKVTKKVTGAFLGLN 270
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585   336 SGAAetghkkeksvLQAKLTKLAIQIGYagstIAVLTVIILIIQfciKTFVIDEKPwkntyannlvkhLIIGVTVLVVAV 415
Cdd:TIGR01523  271 VGTP----------LHRKLSKLAVILFC----IAIIFAIIVMAA---HKFDVDKEV------------AIYAICLAISII 321
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585   416 PEGLPLAVTLSLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTTNRMTVVQSYIcEKLCKVLPTLSDIPQH-- 493
Cdd:TIGR01523  322 PESLIAVLSITMAMGAANMSKRNVIVRKLDALEALGAVNDICSDKTGTITQGKMIARQIWI-PRFGTISIDNSDDAFNpn 400
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585   494 VGNLITMGISVNSAYTSNIMAGHN--------------PGDLPIQV----------------------------GNKTEC 531
Cdd:TIGR01523  401 EGNVSGIPRFSPYEYSHNEAADQDilkefkdelkeidlPEDIDMDLfiklletaalaniatvfkddatdcwkahGDPTEI 480
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585   532 ALLGFVQGLGVKYQSIRDE----------------------ITEDKFTRVYTFNSVRKSMGTVIPRPNG-GYRLYTKGAS 588
Cdd:TIGR01523  481 AIHVFAKKFDLPHNALTGEedllksnendqsslsqhnekpgSAQFEFIAEFPFDSEIKRMASIYEDNHGeTYNIYAKGAF 560
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585   589 EIIMKKCAFIYGHEGTLEKFTRDMQERLIREVIEPMACDGLRTISVAYRDFvpgkaainevhiDGEPNWDDEENIMT--- 665
Cdd:TIGR01523  561 ERIIECCSSSNGKDGVKISPLEDCDRELIIANMESLAAEGLRVLAFASKSF------------DKADNNDDQLKNETlnr 628
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585   666 -----NLTCLCVVGIEDPVRPEVPDAIRKCQRAGITVRMVTGDNINTARSIASKCGIL--------RPNDDFLILEGKEF 732
Cdd:TIGR01523  629 ataesDLEFLGLIGIYDPPRNESAGAVEKCHQAGINVHMLTGDFPETAKAIAQEVGIIppnfihdrDEIMDSMVMTGSQF 708
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585   733 NrrirdsngDIQQHLIDKVWPKLRVLARSSPTDKYTLVKGIidstvSENREVVAVTGDGTNDGPALKKADVGFAMGIAGT 812
Cdd:TIGR01523  709 D--------ALSDEEVDDLKALCLVIARCAPQTKVKMIEAL-----HRRKAFCAMTGDGVNDSPSLKMANVGIAMGINGS 775
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585   813 DVAKEASDIILTDDNFSSIVKAVMWGRNVYDSIAKFLQFQLTVNVVAVIVAFIGaCAVQDS------PLKAVQMLWVNLI 886
Cdd:TIGR01523  776 DVAKDASDIVLSDDNFASILNAIEEGRRMFDNIMKFVLHLLAENVAEAILLIIG-LAFRDEngksvfPLSPVEILWCIMI 854
                          970       980       990      1000
                   ....*....|....*....|....*....|....*....|....*
gi 320541585   887 MDTLASLALATEFPTPDLLLRKPYGR-----TKPLISRTMMKNIL 926
Cdd:TIGR01523  855 TSCFPAMGLGLEKAAPDLMDRLPHDNevgifQKELIIDMFAYGFF 899
P-type_ATPase_Na-K_like cd02608
alpha-subunit of Na(+)/K(+)-ATPases and of gastric H(+)/K(+)-ATPase, similar to the human Na(+) ...
172-909 9.02e-82

alpha-subunit of Na(+)/K(+)-ATPases and of gastric H(+)/K(+)-ATPase, similar to the human Na(+)/K(+)-ATPase alpha subunits 1-4; This subfamily includes the alpha subunit of Na(+)/K(+)-ATPase a heteromeric transmembrane protein composed of an alpha- and beta-subunit and an optional third subunit belonging to the FXYD proteins which are more tissue specific regulatory subunits of the enzyme. The alpha-subunit is the catalytic subunit responsible for transport activities of the enzyme. This subfamily includes all four isotopes of the human alpha subunit: (alpha1-alpha4, encoded by the ATP1A1- ATP1A4 genes). Na(+)/K(+)-ATPase functions chiefly as an ion pump, hydrolyzing one molecule of ATP to pump three Na(+) out of the cell in exchange for two K(+)entering the cell per pump cycle. In addition Na(+)/K(+)-ATPase acts as a signal transducer. This subfamily also includes Oreochromis mossambicus (tilapia) Na(+)/K(+)-ATPase alpha 1 and alpha 3 subunits, and gastric H(+)/K(+)-ATPase which exchanges hydronium ion with potassium and is responsible for gastric acid secretion. Gastric H(+)/K(+)-ATPase is an alpha,beta-heterodimeric enzyme. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319794 [Multi-domain]  Cd Length: 905  Bit Score: 287.71  E-value: 9.02e-82
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  172 VIRGGEVCQISVGDILVGDIAQVKYGDLLPADGCLIQSNDLKVDESSLTGESDHVKKGPDV---DPM-----VLSGTHVM 243
Cdd:cd02608   110 VIRDGEKMQINAEELVVGDLVEVKGGDRIPADIRIISAHGCKVDNSSLTGESEPQTRSPEFtheNPLetkniAFFSTNCV 189
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  244 EGSGKMVVTAVGVNSQAGIIFTLLgaavdeqeaeikkmkkeakrankqknlTGENDGRSQIkgsqapsqretvtseitks 323
Cdd:cd02608   190 EGTARGIVINTGDRTVMGRIATLA---------------------------SGLEVGKTPI------------------- 223
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  324 esegnhlpqssssgAAETGHkkeksvlqakltklAIQIgyagstIAVLTVIiLIIQFCIKTFVIdEKPWkntyannlVKH 403
Cdd:cd02608   224 --------------AREIEH--------------FIHI------ITGVAVF-LGVSFFILSLIL-GYTW--------LEA 259
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  404 LIIGVTVLVVAVPEGLPLAVTLSLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTTNRMTVVQSYICEKL--C 481
Cdd:cd02608   260 VIFLIGIIVANVPEGLLATVTVCLTLTAKRMARKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMWFDNQIheA 339
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  482 KVLPTLSDIPQHVGNLITMGISVNSAYTSNIMAGHNPGDLPIQ----VGNKTECALLGFVQ---GLGVKYQSIRDEITEd 554
Cdd:cd02608   340 DTTEDQSGASFDKSSATWLALSRIAGLCNRAEFKAGQENVPILkrdvNGDASESALLKCIElscGSVMEMRERNPKVAE- 418
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  555 kftrvYTFNSVRKSMGTVIPRPN---GGYRLYTKGASEIIMKKCAFIY--GHEGTLEKFTRD-----------MQERLIr 618
Cdd:cd02608   419 -----IPFNSTNKYQLSIHENEDpgdPRYLLVMKGAPERILDRCSTILinGKEQPLDEEMKEafqnaylelggLGERVL- 492
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  619 eviepmacdGLRTISVAYRDFVPGKAAINEvhidgEPNWDdeenimtnLTCLCVVGIE---DPVRPEVPDAIRKCQRAGI 695
Cdd:cd02608   493 ---------GFCHLYLPDDKFPEGFKFDTD-----EVNFP--------TENLCFVGLMsmiDPPRAAVPDAVGKCRSAGI 550
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  696 TVRMVTGDNINTARSIASKCGILrpnddflilegkefnrrirdsngdiqqhlidkvwpklrVLARSSPTDKYTLVKGiid 775
Cdd:cd02608   551 KVIMVTGDHPITAKAIAKGVGII--------------------------------------VFARTSPQQKLIIVEG--- 589
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  776 stVSENREVVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFSSIVKAVMWGRNVYDSIAKFLQFQLTV 855
Cdd:cd02608   590 --CQRQGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKKSIAYTLTS 667
                         730       740       750       760       770
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 320541585  856 NV--VAVIVAFIgaCAVQDSPLKAVQMLWVNLIMDTLASLALATEFPTPDLLLRKP 909
Cdd:cd02608   668 NIpeITPFLIFI--IANIPLPLGTITILCIDLGTDMVPAISLAYEKAESDIMKRQP 721
ATPase-IIC_X-K TIGR01106
sodium or proton efflux -- potassium uptake antiporter, P-type ATPase, alpha subunit; This ...
41-909 5.75e-78

sodium or proton efflux -- potassium uptake antiporter, P-type ATPase, alpha subunit; This model describes the P-type ATPases responsible for the exchange of either protons or sodium ions for potassium ions across the plasma membranes of eukaryotes. Unlike most other P-type ATPases, members of this subfamily require a beta subunit for activity. This model encompasses eukaryotes and consists of two functional types, a Na/K antiporter found widely distributed in eukaryotes and a H/K antiporter found only in vertebrates. The Na+ or H+/K+ antiporter P-type ATPases have been characterized as Type IIC based on a published phylogenetic analysis. Sequences from Blastocladiella emersonii (GP|6636502, GP|6636502 and PIR|T43025), C. elegans (GP|2315419, GP|6671808 and PIR|T31763) and Drosophila melanogaster (GP|7291424) score below trusted cutoff, apparently due to long branch length (excessive divergence from the last common ancestor) as evidenced by a phylogenetic tree. Experimental evidence is needed to determine whether these sequences represent ATPases with conserved function. Aside from fragments, other sequences between trusted and noise appear to be bacterial ATPases of unclear lineage, but most likely calcium pumps. [Energy metabolism, ATP-proton motive force interconversion]


Pssm-ID: 273445 [Multi-domain]  Cd Length: 997  Bit Score: 278.21  E-value: 5.75e-78
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585    41 ELCKKLYTSPNEGLSGSKADEEHRREtfGSNVIPPkPPKT-----FLTLVWEALQdvtlIILEVAALVSLGLSFYKPADE 115
Cdd:TIGR01106   24 ELERKYGTDLSKGLSAARAAEILARD--GPNALTP-PPTTpewvkFCRQLFGGFS----MLLWIGAILCFLAYGIQASTE 96
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585   116 DAPVLQEeeehhgWIEGLAILISVIVVVIVTAFNDYSKERQFRGLQNRIEGEHkfSVIRGGEVCQISVGDILVGDIAQVK 195
Cdd:TIGR01106   97 EEPQNDN------LYLGVVLSAVVIITGCFSYYQEAKSSKIMESFKNMVPQQA--LVIRDGEKMSINAEQVVVGDLVEVK 168
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585   196 YGDLLPADGCLIQSNDLKVDESSLTGESDHVKKGPDV---DPM-----VLSGTHVMEGSGKMVVTAVGVNSQAGIIFTLL 267
Cdd:TIGR01106  169 GGDRIPADLRIISAQGCKVDNSSLTGESEPQTRSPEFtheNPLetrniAFFSTNCVEGTARGIVVNTGDRTVMGRIASLA 248
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585   268 gaavdeqeaeikkmkkeakrankqknlTGENDGRSQIkgsqapsqretvtseitksesegnhlpqssssgAAETGHkkek 347
Cdd:TIGR01106  249 ---------------------------SGLENGKTPI---------------------------------AIEIEH---- 264
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585   348 svLQAKLTKLAIQIGyagstiavltVIILIIQFCIKTFVIDEkpwkntyannlvkhLIIGVTVLVVAVPEGLPLAVTLSL 427
Cdd:TIGR01106  265 --FIHIITGVAVFLG----------VSFFILSLILGYTWLEA--------------VIFLIGIIVANVPEGLLATVTVCL 318
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585   428 AYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTTNRMTVVQSYICEKLCKVLPT--LSDIPQHVGNLITMGISVN 505
Cdd:TIGR01106  319 TLTAKRMARKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMWFDNQIHEADTTedQSGVSFDKSSATWLALSRI 398
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585   506 SAYTSNIMAGHNPGDLPIQ----VGNKTECALLGFVQGLGVKYQSIRDeitedKFTRV--YTFNSVRKSMGTVIPRPNGG 579
Cdd:TIGR01106  399 AGLCNRAVFKAGQENVPILkravAGDASESALLKCIELCLGSVMEMRE-----RNPKVveIPFNSTNKYQLSIHENEDPR 473
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585   580 ---YRLYTKGASEIIMKKCA--FIYGHEGTLEKFTRD-----------MQERLIreviepmacdGLRTISVAYRDFVPGK 643
Cdd:TIGR01106  474 dprHLLVMKGAPERILERCSsiLIHGKEQPLDEELKEafqnaylelggLGERVL----------GFCHLYLPDEQFPEGF 543
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585   644 AAinevhidgepnwdDEENIMTNLTCLCVVGIE---DPVRPEVPDAIRKCQRAGITVRMVTGDNINTARSIASKCGILRP 720
Cdd:TIGR01106  544 QF-------------DTDDVNFPTDNLCFVGLIsmiDPPRAAVPDAVGKCRSAGIKVIMVTGDHPITAKAIAKGVGIISE 610
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585   721 NDDF-------LILEGKEFNRRIRDS---NG----DIQQHLIDKVwpkLR-----VLARSSPTDKYTLVKGiidstVSEN 781
Cdd:TIGR01106  611 GNETvediaarLNIPVSQVNPRDAKAcvvHGsdlkDMTSEQLDEI---LKyhteiVFARTSPQQKLIIVEG-----CQRQ 682
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585   782 REVVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFSSIVKAVMWGRNVYDSIAKFLQFQLTVNVVAVI 861
Cdd:TIGR01106  683 GAIVAVTGDGVNDSPALKKADIGVAMGIAGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKKSIAYTLTSNIPEIT 762
                          890       900       910       920
                   ....*....|....*....|....*....|....*....|....*...
gi 320541585   862 VAFIGACAVQDSPLKAVQMLWVNLIMDTLASLALATEFPTPDLLLRKP 909
Cdd:TIGR01106  763 PFLIFIIANIPLPLGTITILCIDLGTDMVPAISLAYEKAESDIMKRQP 810
P-type_ATPase_Mg cd02077
magnesium transporting ATPase (MgtA), similar to Escherichia coli MgtA and Salmonella ...
53-1018 1.19e-66

magnesium transporting ATPase (MgtA), similar to Escherichia coli MgtA and Salmonella typhimurium MgtA; MgtA is a membrane protein which actively transports Mg(2+) into the cytosol with its electro-chemical gradient rather than against the gradient as other cation transporters do. It may act both as a transporter and as a sensor for Mg(2+). In Salmonella typhimurium and Escherichia coli, the two-component system PhoQ/PhoP regulates the transcription of the mgtA gene by sensing Mg(2+) concentrations in the periplasm. MgtA is activated by cardiolipin and it highly sensitive to free magnesium in vitro. It consists of a transmembrane domain and three cytosolic domains: nucleotide-binding domain, phosphorylation domain and actuator domain, and belongs to the P-type ATPase type III subfamily. The P-type ATPases, are a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319772 [Multi-domain]  Cd Length: 768  Bit Score: 241.00  E-value: 1.19e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585   53 GLSGSKADEehRRETFGSNVIPPKPPKTFLTLVWEALQDVTLIILEVAALVSLGLSFYKPADEDAPVlqeeeehhgwieG 132
Cdd:cd02077     1 GLTNEEAEE--RLEKYGPNEISHEKFPSWFKLLLKAFINPFNIVLLVLALVSFFTDVLLAPGEFDLV------------G 66
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  133 LAILISVIVVVIVTAF-NDYSKERQFRGLQNRIEgeHKFSVIRGGEV-CQISVGDILVGDIAQVKYGDLLPADGCLIQSN 210
Cdd:cd02077    67 ALIILLMVLISGLLDFiQEIRSLKAAEKLKKMVK--NTATVIRDGSKyMEIPIDELVPGDIVYLSAGDMIPADVRIIQSK 144
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  211 DLKVDESSLTGESDHVKKGP-----------DVDPMVLSGTHVMEGSGKMVVTAVGVNsqagiifTLLGAAvdeqeaeik 279
Cdd:cd02077   145 DLFVSQSSLTGESEPVEKHAtakktkdesilELENICFMGTNVVSGSALAVVIATGND-------TYFGSI--------- 208
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  280 kmkkeAKRANKQKNLTgendgrsqikgsqapsqretvtseitksesegnhlpqssssgAAETGHKKeksvlqakLTKLAI 359
Cdd:cd02077   209 -----AKSITEKRPET------------------------------------------SFDKGINK--------VSKLLI 233
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  360 QIgyagstIAVLTVIILIIQFCIKtfvidekpwkntyaNNLVKHLIIGVTVLVVAVPEGLPLAVTLSLAYSVKKMMKDNN 439
Cdd:cd02077   234 RF------MLVMVPVVFLINGLTK--------------GDWLEALLFALAVAVGLTPEMLPMIVTSNLAKGAVRMSKRKV 293
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  440 LVRHLDACETMGNATAICSDKTGTLTTNRMTVVQSY--ICEKLCKVLptlsdipqHVGNLitmgisvNSAYTSNImagHN 517
Cdd:cd02077   294 IVKNLNAIQNFGAMDILCTDKTGTLTQDKIVLERHLdvNGKESERVL--------RLAYL-------NSYFQTGL---KN 355
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  518 PGDLPIqVGNKTECALLGFVQGlgvkYQSIrDEITedkftrvytFNSVRKSMGTVIPRPNGGYRLYTKGASEIIMKKCAF 597
Cdd:cd02077   356 LLDKAI-IDHAEEANANGLIQD----YTKI-DEIP---------FDFERRRMSVVVKDNDGKHLLITKGAVEEILNVCTH 420
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  598 IYgHEGTLEKFTRDMQERLIREVIEpMACDGLRTISVAYRDFVPGkaainevhiDGEPNWDDEENimtnLTCLCVVGIED 677
Cdd:cd02077   421 VE-VNGEVVPLTDTLREKILAQVEE-LNREGLRVLAIAYKKLPAP---------EGEYSVKDEKE----LILIGFLAFLD 485
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  678 PVRPEVPDAIRKCQRAGITVRMVTGDNINTARSIASKCGIlrPNDDFLIleGKEFNRRIRDSNGDIQQhlidkvwpKLRV 757
Cdd:cd02077   486 PPKESAAQAIKALKKNGVNVKILTGDNEIVTKAICKQVGL--DINRVLT--GSEIEALSDEELAKIVE--------ETNI 553
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  758 LARSSPTDKYTLVkgiidSTVSENREVVAVTGDGTNDGPALKKADVGFAMGIAgTDVAKEASDIILTDDNFSSIVKAVMW 837
Cdd:cd02077   554 FAKLSPLQKARII-----QALKKNGHVVGFMGDGINDAPALRQADVGISVDSA-VDIAKEAADIILLEKDLMVLEEGVIE 627
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  838 GRNVYDSIAKFLQFQLTVN---VVAVIVA-----FIgacavqdsPLKAVQMLWVNLIMDtLASLALATEFPTPDlLLRKP 909
Cdd:cd02077   628 GRKTFGNILKYIKMTASSNfgnVFSVLVAsaflpFL--------PMLPIQLLLQNLLYD-FSQLAIPFDNVDEE-FLKKP 697
                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  910 ygrtkpliSRTMMKNILgqalyQLIIIFGLLfvgDVILDIesgrgqelnagptqhftIIFntFVMMTLFNEINARKIHgq 989
Cdd:cd02077   698 --------QKWDIKNIG-----RFMIWIGPI---SSIFDI-----------------LTF--LVMWFVFKANTAASQA-- 740
                         970       980       990
                  ....*....|....*....|....*....|
gi 320541585  990 rnvieglltnpIFYTIW-IFTMISQVLIIQ 1018
Cdd:cd02077   741 -----------LFQTGWfIEGLLTQTLVVH 759
P-type_ATPase_H cd02076
plant and fungal plasma membrane H(+)-ATPases, and related bacterial and archaeal putative H(+) ...
53-978 4.25e-66

plant and fungal plasma membrane H(+)-ATPases, and related bacterial and archaeal putative H(+)-ATPases; This subfamily includes eukaryotic plasma membrane H(+)-ATPase which transports H(+) from the cytosol to the extracellular space, thus energizing the plasma membrane for the uptake of ions and nutrients, and is expressed in plants and fungi. This H(+)-ATPase consists of four domains: a transmembrane domain and three cytosolic domains: nucleotide-binding domain, phosphorylation domain and actuator domain, and belongs to the P-type ATPase type III subfamily. This subfamily also includes the putative P-type H(+)-ATPase, MJ1226p of the anaerobic hyperthermophilic archaea Methanococcus jannaschii. The P-type ATPases, are a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319771 [Multi-domain]  Cd Length: 781  Bit Score: 239.44  E-value: 4.25e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585   53 GLSGSKAdeEHRRETFGSNVIPPK---PPKTFLTLVWEALQdvtlIILEVAALVSLGLSfykpadedapvlqeeeehhGW 129
Cdd:cd02076     1 GLTSEEA--AKRLKEYGPNELPEKkenPILKFLSFFWGPIP----WMLEAAAILAAALG-------------------DW 55
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  130 IEGLailiSVIVVVIVTAFNDYSKERQFRG----LQNRieGEHKFSVIRGGEVCQISVGDILVGDIAQVKYGDLLPADGC 205
Cdd:cd02076    56 VDFA----IILLLLLINAGIGFIEERQAGNavaaLKKS--LAPKARVLRDGQWQEIDAKELVPGDIVSLKIGDIVPADAR 129
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  206 LIQSNDLKVDESSLTGESDHVKKGP-DvdpMVLSGTHVMEGSGKMVVTAVGVNSQAGiiftllgaavdeqeaeikkmkke 284
Cdd:cd02076   130 LLTGDALQVDQSALTGESLPVTKHPgD---EAYSGSIVKQGEMLAVVTATGSNTFFG----------------------- 183
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  285 akranKQKNLTGEndgrsqikgsqapsqretvtseitksesegnhlpqssssgAAETGHkkeksvlqakLTKLAIQIG-Y 363
Cdd:cd02076   184 -----KTAALVAS----------------------------------------AEEQGH----------LQKVLNKIGnF 208
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  364 AGSTIAVLTVIILIIQFciktfvIDEKPWKNTYANNLVkhliigvtVLVVAVPEGLPLAVTLSLAYSVKKMMKDNNLVRH 443
Cdd:cd02076   209 LILLALILVLIIVIVAL------YRHDPFLEILQFVLV--------LLIASIPVAMPAVLTVTMAVGALELAKKKAIVSR 274
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  444 LDACETMGNATAICSDKTGTLTTNRMTVVQSYICEklckvlptlSDIPQHVgnLITMGISvnsAYTSNImaghNPGDLPI 523
Cdd:cd02076   275 LSAIEELAGVDILCSDKTGTLTLNKLSLDEPYSLE---------GDGKDEL--LLLAALA---SDTENP----DAIDTAI 336
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  524 qvgnktecallgfVQGLGvKYQSIRDEITEDKFTrvyTFNSVRK-SMGTVIpRPNGGYRLYTKGASEIIMKKCAFiyghe 602
Cdd:cd02076   337 -------------LNALD-DYKPDLAGYKQLKFT---PFDPVDKrTEATVE-DPDGERFKVTKGAPQVILELVGN----- 393
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  603 gtlekfTRDMQERlIREVIEPMACDGLRTISVAYRDfvpgkaainevhidGEPNWDdeenIMTNLTCLcvvgieDPVRPE 682
Cdd:cd02076   394 ------DEAIRQA-VEEKIDELASRGYRSLGVARKE--------------DGGRWE----LLGLLPLF------DPPRPD 442
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  683 VPDAIRKCQRAGITVRMVTGDNINTARSIASKCGI---------LRPNDDFLILEGKEFNRRIRDSNGdiqqhlIDKVWP 753
Cdd:cd02076   443 SKATIARAKELGVRVKMITGDQLAIAKETARQLGMgtnilsaerLKLGGGGGGMPGSELIEFIEDADG------FAEVFP 516
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  754 KlrvlarssptDKYTLVKgiidsTVSENREVVAVTGDGTNDGPALKKADVGFAMGIAgTDVAKEASDIILTDDNFSSIVK 833
Cdd:cd02076   517 E----------HKYRIVE-----ALQQRGHLVGMTGDGVNDAPALKKADVGIAVSGA-TDAARAAADIVLTAPGLSVIID 580
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  834 AVMWGRNVYDSIAKFLQFQLTVNVVAVIVAFIGACAVQDSPLKAVQMLWVNLIMDtLASLALATEfptpdlllRKPYgRT 913
Cdd:cd02076   581 AIKTSRQIFQRMKSYVIYRIAETLRILVFFTLGILILNFYPLPLIMIVLIAILND-GATLTIAYD--------NVPP-SP 650
                         890       900       910       920       930       940       950
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 320541585  914 KPLISRtmMKNILGQA----LYQLIIIFGLLFVGDVILdieSGRGQELNAGPTQhfTIIFNTFV---MMTLF 978
Cdd:cd02076   651 RPVRWN--MPELLGIAtvlgVVLTISSFLLLWLLDDQG---WFEDIVLSAGELQ--TILYLQLSisgHLTIF 715
P-type_ATPase cd02609
uncharacterized subfamily of P-type ATPase transporter, similar to uncharacterized ...
169-898 3.79e-57

uncharacterized subfamily of P-type ATPase transporter, similar to uncharacterized Streptococcus pneumoniae exported protein 7, Exp7; This subfamily contains P-type ATPase transporters of unknown function, similar to Streptococcus pneumoniae Exp7. The P-type ATPases, are a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids. They are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle. A general characteristic of P-type ATPases is a bundle of transmembrane helices which make up the transport path, and three domains on the cytoplasmic side of the membrane. Members include pumps that transport various light metal ions, such as H(+), Na(+), K(+), Ca(2+), and Mg(2+), pumps that transport indispensable trace elements, such as Zn(2+) and Cu(2+), pumps that remove toxic heavy metal ions, such as Cd(2+), and pumps such as aminophospholipid translocases which transport phosphatidylserine and phosphatidylethanolamine.


Pssm-ID: 319795 [Multi-domain]  Cd Length: 661  Bit Score: 210.60  E-value: 3.79e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  169 KFSVIRGGEVCQISVGDILVGDIAQVKYGDLLPADGCLIQSNDLKVDESSLTGESDHVKKgpDVDPMVLSGTHVMEGSGK 248
Cdd:cd02609    93 KVTVIRDGQEVKIPPEELVLDDILILKPGEQIPADGEVVEGGGLEVDESLLTGESDLIPK--KAGDKLLSGSFVVSGAAY 170
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  249 MVVTAVGvnsqagiiftllgaavdeQEAEIKKMKKEAKRankqknltgendgrsqikgsqapsqretvtseitksesegn 328
Cdd:cd02609   171 ARVTAVG------------------AESYAAKLTLEAKK----------------------------------------- 191
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  329 hlpqssssgaaetgHKKEKSVLQAKLTKLAIQIGYagstIAVLTVIILIIQfcikTFVIDEKPWKNTyannlvkhLIIGV 408
Cdd:cd02609   192 --------------HKLINSELLNSINKILKFTSF----IIIPLGLLLFVE----ALFRRGGGWRQA--------VVSTV 241
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  409 TVLVVAVPEGLPLAVTLSLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTTNRMtvvqsyiceKLCKVLPTLS 488
Cdd:cd02609   242 AALLGMIPEGLVLLTSVALAVGAIRLAKKKVLVQELYSIETLARVDVLCLDKTGTITEGKM---------KVERVEPLDE 312
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  489 DIPQHVGNLItmgisvnSAYTSNIMAGhnpgdlpiqvgNKTECALLGFVQGlGVKYQSirdeitedkfTRVYTFNSVRKs 568
Cdd:cd02609   313 ANEAEAAAAL-------AAFVAASEDN-----------NATMQAIRAAFFG-NNRFEV----------TSIIPFSSARK- 362
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  569 MGTVIPRPNGGYRLytkGASEIIMkkcafiyghegtlekftRDMQERlIREVIEPMACDGLRTISVAYrdfvpGKAAIne 648
Cdd:cd02609   363 WSAVEFRDGGTWVL---GAPEVLL-----------------GDLPSE-VLSRVNELAAQGYRVLLLAR-----SAGAL-- 414
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  649 vhidgepnwdDEENIMTNLTCLCVVGIEDPVRPEVPDAIRKCQRAGITVRMVTGDNINTARSIASKCGIlrPNDDFLIle 728
Cdd:cd02609   415 ----------THEQLPVGLEPLALILLTDPIRPEAKETLAYFAEQGVAVKVISGDNPVTVSAIAKRAGL--EGAESYI-- 480
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  729 gkefnrrirDSNGDIQQHLIDKVWPKLRVLARSSPTDKYTLVKgiidsTVSENREVVAVTGDGTNDGPALKKADVGFAMG 808
Cdd:cd02609   481 ---------DASTLTTDEELAEAVENYTVFGRVTPEQKRQLVQ-----ALQALGHTVAMTGDGVNDVLALKEADCSIAMA 546
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  809 iAGTDVAKEASDIILTDDNFSSIVKAVMWGRNVYDSIAKFLQFQLTVNVVAVIVAFIGACAVQDSPLKAVQMLWVNLIMD 888
Cdd:cd02609   547 -SGSDATRQVAQVVLLDSDFSALPDVVFEGRRVVNNIERVASLFLVKTIYSVLLALICVITALPFPFLPIQITLISLFTI 625
                         730
                  ....*....|
gi 320541585  889 TLASLALATE 898
Cdd:cd02609   626 GIPSFFLALE 635
ZntA COG2217
Cation-transporting P-type ATPase [Inorganic ion transport and metabolism];
172-866 1.03e-49

Cation-transporting P-type ATPase [Inorganic ion transport and metabolism];


Pssm-ID: 441819 [Multi-domain]  Cd Length: 717  Bit Score: 189.20  E-value: 1.03e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  172 VIRGGEVCQISVGDILVGDIAQVKYGDLLPADGCLI--QSNdlkVDESSLTGESDHVKKGPDvDPmVLSGTHVMEGSGKM 249
Cdd:COG2217   217 VLRDGEEVEVPVEELRVGDRVLVRPGERIPVDGVVLegESS---VDESMLTGESLPVEKTPG-DE-VFAGTINLDGSLRV 291
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  250 VVTAVGVNSqagiifTLlgaavdeqeAEIKKMKKEAKrankqknltgendgrsqikGSQAPSQRetvtseitksesegnh 329
Cdd:COG2217   292 RVTKVGSDT------TL---------ARIIRLVEEAQ-------------------SSKAPIQR---------------- 321
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  330 lpqssssgaaetghkkeksvlqakltkLAIQIgyagSTIAVLTVIIL-IIqfcikTFVIdekpWKnTYANNLVKHLIIGV 408
Cdd:COG2217   322 ---------------------------LADRI----ARYFVPAVLAIaAL-----TFLV----WL-LFGGDFSTALYRAV 360
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  409 TVLVVAVPEGLPLAVTLSLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTTNRMTVVqsyiceklcKVLPTLS 488
Cdd:COG2217   361 AVLVIACPCALGLATPTAIMVGTGRAARRGILIKGGEALERLAKVDTVVFDKTGTLTEGKPEVT---------DVVPLDG 431
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  489 DIPQHVgnlITMGISVNSAytSN------IMAGHNPGDLPI-QVGNKTEcallgfVQGLGVKyqsirdeitedkftrvyt 561
Cdd:COG2217   432 LDEDEL---LALAAALEQG--SEhplaraIVAAAKERGLELpEVEDFEA------IPGKGVE------------------ 482
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  562 fnsvrksmGTViprpNGG-YRLytkgaseiimkkcafiyGHEGTLEKFTRDMQERLiREVIEPMACDGlRTISVayrdfv 640
Cdd:COG2217   483 --------ATV----DGKrVLV-----------------GSPRLLEEEGIDLPEAL-EERAEELEAEG-KTVVY------ 525
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  641 pgkaaineVHIDGEPnwddeenimtnltcLCVVGIEDPVRPEVPDAIRKCQRAGITVRMVTGDNINTARSIASKCGIlrp 720
Cdd:COG2217   526 --------VAVDGRL--------------LGLIALADTLRPEAAEAIAALKALGIRVVMLTGDNERTAEAVARELGI--- 580
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  721 nDDflilegkefnrrirdsngdiqqhlidkvwpklrVLARSSPTDKYTLVKGIidstvSENREVVAVTGDGTNDGPALKK 800
Cdd:COG2217   581 -DE---------------------------------VRAEVLPEDKAAAVREL-----QAQGKKVAMVGDGINDAPALAA 621
                         650       660       670       680       690       700
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 320541585  801 ADVGFAMGiAGTDVAKEASDIILTDDNFSSIVKAVMWGRNVYdSIAKF-LQFQLTVNVVAVIVAFIG 866
Cdd:COG2217   622 ADVGIAMG-SGTDVAIEAADIVLMRDDLRGVPDAIRLSRATM-RIIRQnLFWAFGYNVIGIPLAAGG 686
Cation_ATPase_C pfam00689
Cation transporting ATPase, C-terminus; Members of this families are involved in Na+/K+, H+/K+, ...
873-1051 9.60e-49

Cation transporting ATPase, C-terminus; Members of this families are involved in Na+/K+, H+/K+, Ca++ and Mg++ transport. This family represents 5 transmembrane helices.


Pssm-ID: 376368 [Multi-domain]  Cd Length: 175  Bit Score: 170.88  E-value: 9.60e-49
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585   873 SPLKAVQMLWVNLIMDTLASLALATEFPTPDLLLRKPYGRTKPLISRTMMKNILGQALYQLIIIFGLLFVGDVILDIEsg 952
Cdd:pfam00689    2 LPLTPIQILWINLVTDGLPALALGFEPPEPDLMKRPPRKPKEPLFSRKMLRRILLQGLLIAILTLLVFFLGLLGFGIS-- 79
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585   953 rgqelnaGPTQHFTIIFNTFVMMTLFNEINARKIHGQRNVIeGLLTNPIFYTIWIFTMISQVLIIQYGKMA--FSTKALT 1030
Cdd:pfam00689   80 -------ESQNAQTMAFNTLVLSQLFNALNARSLRRSLFKI-GLFSNKLLLLAILLSLLLQLLIIYVPPLQavFGTTPLS 151
                          170       180
                   ....*....|....*....|.
gi 320541585  1031 LDQWLWCIFFGIGTLVWGQLI 1051
Cdd:pfam00689  152 LEQWLIVLLLALVVLLVVELR 172
P-type_ATPase_HM cd02079
P-type heavy metal-transporting ATPase; Heavy metal-transporting ATPases (Type IB ATPases) ...
172-866 7.85e-45

P-type heavy metal-transporting ATPase; Heavy metal-transporting ATPases (Type IB ATPases) transport heavy metal ions (Cu(+), Cu(2+), Zn(2+), Cd(2+), Co(2+), etc.) across biological membranes. These ATPases include mammalian copper-transporting ATPases, ATP7A and ATP7B, Bacillus subtilis CadA which transports cadmium, zinc and cobalt out of the cell, Bacillus subtilis ZosA/PfeT which transports copper, and perhaps also zinc and ferrous iron, Archaeoglobus fulgidus CopA and CopB, Staphylococcus aureus plasmid pI258 CadA, a cadmium-efflux ATPase, and Escherichia coli ZntA which is selective for Pb(2+), Zn(2+), and Cd(2+). The characteristic N-terminal heavy metal associated (HMA) domain of this group is essential for the binding of metal ions. This family belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319774 [Multi-domain]  Cd Length: 617  Bit Score: 172.78  E-value: 7.85e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  172 VIRGGEVCQISVGDILVGDIAQVKYGDLLPADGCLIQSNDLkVDESSLTGESDHVKKGPDvDPmVLSGTHVMEGSGKMVV 251
Cdd:cd02079   129 VLEDGSTEEVPVDDLKVGDVVLVKPGERIPVDGVVVSGESS-VDESSLTGESLPVEKGAG-DT-VFAGTINLNGPLTIEV 205
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  252 TAVGVNSqagiifTLlgaavdeqeAEIKKMKKEAkrankqknltgendgrsqikgsqapsqretvtseitksesegnhlp 331
Cdd:cd02079   206 TKTGEDT------TL---------AKIIRLVEEA---------------------------------------------- 224
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  332 QSSssgaaetghkkeKSVLQAKLTKLAiqigyagstiAVLTVIILIIQFCikTFVIdekPWknTYANNLVKHLIIGVTVL 411
Cdd:cd02079   225 QSS------------KPPLQRLADRFA----------RYFTPAVLVLAAL--VFLF---WP--LVGGPPSLALYRALAVL 275
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  412 VVAVPEGLPLAVTLSLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTTNRMTV--VQSYICEKLCKVLPTLSD 489
Cdd:cd02079   276 VVACPCALGLATPTAIVAGIGRAARKGILIKGGDVLETLAKVDTVAFDKTGTLTEGKPEVteIEPLEGFSEDELLALAAA 355
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  490 IPQHvgnlitmgisvnsaytsnimAGHnpgdlPIQvgnktecallgfvqglgvkyQSIRDEITEDkftrvytfNSVRKSM 569
Cdd:cd02079   356 LEQH--------------------SEH-----PLA--------------------RAIVEAAEEK--------GLPPLEV 382
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  570 GTVIPRPNGGyrlytkgaseiimkKCAFIYGHE---GTLEKFTRDMQERLIREVIEPmacDGLRTISVAyrdfvpgkaai 646
Cdd:cd02079   383 EDVEEIPGKG--------------ISGEVDGREvliGSLSFAEEEGLVEAADALSDA---GKTSAVYVG----------- 434
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  647 nevhIDGEPnwddeenimtnltcLCVVGIEDPVRPEVPDAIRKCQRAGITVRMVTGDNINTARSIASKCGILRpnddfli 726
Cdd:cd02079   435 ----RDGKL--------------VGLFALEDQLRPEAKEVIAELKSGGIKVVMLTGDNEAAAQAVAKELGIDE------- 489
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  727 legkefnrrirdsngdiqqhlidkvwpklrVLARSSPTDKYTLVKGiidstVSENREVVAVTGDGTNDGPALKKADVGFA 806
Cdd:cd02079   490 ------------------------------VHAGLLPEDKLAIVKA-----LQAEGGPVAMVGDGINDAPALAQADVGIA 534
                         650       660       670       680       690       700
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  807 MGiAGTDVAKEASDIILTDDNFSSIVKAVMWGRNVYDSIAKFLQFQLTVNVVAVIVAFIG 866
Cdd:cd02079   535 MG-SGTDVAIETADIVLLSNDLSKLPDAIRLARRTRRIIKQNLAWALGYNAIALPLAALG 593
P-type_ATPase_Cu-like cd02094
P-type heavy metal-transporting ATPase, similar to human copper-transporting ATPases, ATP7A ...
172-835 1.87e-44

P-type heavy metal-transporting ATPase, similar to human copper-transporting ATPases, ATP7A and ATP7B; The mammalian copper-transporting P-type ATPases, ATP7A and ATP7B are key molecules required for the regulation and maintenance of copper homeostasis. Menkes and Wilson diseases are caused by mutation in ATP7A and ATP7B respectively. This subfamily includes other copper-transporting ATPases such as: Bacillus subtilis CopA , Archeaoglobus fulgidus CopA, and Saccharomyces cerevisiae Ccc2p. This subclass of P-type ATPase is also referred to as CPx-type ATPases because their amino acid sequences contain a characteristic CPC or CPH motif associated with a stretch of hydrophobic amino acids and N-terminal ion-binding sequences. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319783 [Multi-domain]  Cd Length: 647  Bit Score: 171.89  E-value: 1.87e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  172 VIRGGEVCQISVGDILVGDIAQVKYGDLLPADGCLIQSNDLkVDESSLTGESDHVKKGPDvDPmVLSGTHVMEGSGKMVV 251
Cdd:cd02094   143 VIRDGKEVEVPIEEVQVGDIVRVRPGEKIPVDGVVVEGESS-VDESMLTGESLPVEKKPG-DK-VIGGTINGNGSLLVRA 219
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  252 TAVGVNsqagiifTLLgaavdeqeAEIKKMKKEAKrankqknltgendgrsqikGSQAPSQRetvtseitksesegnhlp 331
Cdd:cd02094   220 TRVGAD-------TTL--------AQIIRLVEEAQ-------------------GSKAPIQR------------------ 247
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  332 qssssgaaetghkkeksvlqakltkLAIQIgyagSTIAVLTVIIL-IIQFCIKTFVIDEKPWknTYAnnlvkhLIIGVTV 410
Cdd:cd02094   248 -------------------------LADRV----SGVFVPVVIAIaILTFLVWLLLGPEPAL--TFA------LVAAVAV 290
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  411 LVVAVPEGLPLAVTLSLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTTNRMTVV-----QSYICEKLCKVLP 485
Cdd:cd02094   291 LVIACPCALGLATPTAIMVGTGRAAELGILIKGGEALERAHKVDTVVFDKTGTLTEGKPEVTdvvplPGDDEDELLRLAA 370
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  486 TLSDIPQHVgnlITMGIsVNSAYTSNImaghnpgdlpiqvgnkTECALLGF--VQGLGVKyqsirdeitedkftrvytfn 563
Cdd:cd02094   371 SLEQGSEHP---LAKAI-VAAAKEKGL----------------ELPEVEDFeaIPGKGVR-------------------- 410
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  564 svrksmGTViprpnGGYRLYTkGASEIIMKKCAFIYGHEGTLEKFTRDmqerlireviepmacdglrtisvayrdfvpGK 643
Cdd:cd02094   411 ------GTV-----DGRRVLV-GNRRLMEENGIDLSALEAEALALEEE------------------------------GK 448
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  644 AAInEVHIDGEPnwddeenimtnltcLCVVGIEDPVRPEVPDAIRKCQRAGITVRMVTGDNINTARSIASKCGIlrpnDD 723
Cdd:cd02094   449 TVV-LVAVDGEL--------------AGLIAVADPLKPDAAEAIEALKKMGIKVVMLTGDNRRTARAIAKELGI----DE 509
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  724 flilegkefnrrirdsngdiqqhlidkvwpklrVLARSSPTDKYTLVKgiidsTVSENREVVAVTGDGTNDGPALKKADV 803
Cdd:cd02094   510 ---------------------------------VIAEVLPEDKAEKVK-----KLQAQGKKVAMVGDGINDAPALAQADV 551
                         650       660       670
                  ....*....|....*....|....*....|..
gi 320541585  804 GFAMGiAGTDVAKEASDIILTDDNFSSIVKAV 835
Cdd:cd02094   552 GIAIG-SGTDVAIESADIVLMRGDLRGVVTAI 582
ATPase-IB_hvy TIGR01525
heavy metal translocating P-type ATPase; This model encompasses two equivalog models for the ...
150-866 1.04e-43

heavy metal translocating P-type ATPase; This model encompasses two equivalog models for the copper and cadmium-type heavy metal transporting P-type ATPases (TIGR01511 and TIGR01512) as well as those species which score ambiguously between both models. For more comments and references, see the files on TIGR01511 and 01512.


Pssm-ID: 273669 [Multi-domain]  Cd Length: 558  Bit Score: 168.19  E-value: 1.04e-43
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585   150 DYSKERQFRGLQNRIE--GEHKFSVIRGGEVCQISVGDILVGDIAQVKYGDLLPADGCLIQSNDLkVDESSLTGESDHVK 227
Cdd:TIGR01525   36 ERAKSRASDALSALLAlaPSTARVLQGDGSEEEVPVEELQVGDIVIVRPGERIPVDGVVISGESE-VDESALTGESMPVE 114
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585   228 KGPDvDPmVLSGTHVMEGSGKMVVTAVGVNSQAgiiftllgaavdeqeAEIKKMKKEAKRankqknltgendgrsqikgS 307
Cdd:TIGR01525  115 KKEG-DE-VFAGTINGDGSLTIRVTKLGEDSTL---------------AQIVELVEEAQS-------------------S 158
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585   308 QAPSQRetvtseitksesegnhlpqssssgaaetghkkeksvlqakltkLAIQIGyagstiAVLTVIILIIQFCikTFVI 387
Cdd:TIGR01525  159 KAPIQR-------------------------------------------LADRIA------SYYVPAVLAIALL--TFVV 187
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585   388 dekpWKnTYANNLVKHLIIGVTVLVVAVPEGLPLAVTLSLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTTN 467
Cdd:TIGR01525  188 ----WL-ALGALWREALYRALTVLVVACPCALGLATPVAILVAIGAAARRGILIKGGDALEKLAKVKTVVFDKTGTLTTG 262
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585   468 RMTVVQSYICEKL--CKVLPTLSDIPQHVGNLITMGIsVNSAytsnimAGHNPGDLPIQVGNktecallgfVQGLGVKyq 545
Cdd:TIGR01525  263 KPTVVDIEPLDDAseEELLALAAALEQSSSHPLARAI-VRYA------KERGLELPPEDVEE---------VPGKGVE-- 324
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585   546 sirdeitedkftrvytfnsvrksmGTViprpNGGYrlytkgasEIIMKKCAFIYGHEGTLEKftrdmqerlIREVIEPMA 625
Cdd:TIGR01525  325 ------------------------ATV----DGGR--------EVRIGNPRFLGNRELAIEP---------ISASPDLLN 359
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585   626 CDGLRTISVAYrdfvpgkaaineVHIDGEpnwddeenimtnltCLCVVGIEDPVRPEVPDAIRKCQRAG-ITVRMVTGDN 704
Cdd:TIGR01525  360 EGESQGKTVVF------------VAVDGE--------------LLGVIALRDQLRPEAKEAIAALKRAGgIKLVMLTGDN 413
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585   705 INTARSIASKCGIlrpNDDflilegkefnrrirdsngdiqqhlidkvwpklrVLARSSPTDKYTLVKGIIDStvsenREV 784
Cdd:TIGR01525  414 RSAAEAVAAELGI---DDE---------------------------------VHAELLPEDKLAIVKKLQEE-----GGP 452
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585   785 VAVTGDGTNDGPALKKADVGFAMGiAGTDVAKEASDIILTDDNFSSIVKAVMWGRNVYDSIAKFLQFQLTVNVVAVIVAF 864
Cdd:TIGR01525  453 VAMVGDGINDAPALAAADVGIAMG-SGSDVAIEAADIVLLNDDLRSLPTAIDLSRKTRRIIKQNLAWALGYNLVAIPLAA 531

                   ..
gi 320541585   865 IG 866
Cdd:TIGR01525  532 GG 533
PRK10517 PRK10517
magnesium-transporting P-type ATPase MgtA;
180-888 8.24e-43

magnesium-transporting P-type ATPase MgtA;


Pssm-ID: 236705 [Multi-domain]  Cd Length: 902  Bit Score: 169.87  E-value: 8.24e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  180 QISVGDILVGDIAQVKYGDLLPADGCLIQSNDLKVDESSLTGESDHVKKGP-----------DVDPMVLSGTHVMEGSGK 248
Cdd:PRK10517  177 EIPIDQLVPGDIIKLAAGDMIPADLRILQARDLFVAQASLTGESLPVEKFAttrqpehsnplECDTLCFMGTNVVSGTAQ 256
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  249 MVVTAVGVNSQagiiFTLLGAAVDEQEAEikkmkkeakrankqknltgendgrsqikgsqapsqretvtseitksesegn 328
Cdd:PRK10517  257 AVVIATGANTW----FGQLAGRVSEQDSE--------------------------------------------------- 281
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  329 hlPQSSSSGAAetghkkeksvlqaKLTKLAIQIgyagstIAVLTVIILIIqfciktfvidekpwkNTYAN-NLVKHLIIG 407
Cdd:PRK10517  282 --PNAFQQGIS-------------RVSWLLIRF------MLVMAPVVLLI---------------NGYTKgDWWEAALFA 325
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  408 VTVLVVAVPEGLPLAVTLSLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTTNRMtvvqsyiceklckVLPTL 487
Cdd:PRK10517  326 LSVAVGLTPEMLPMIVTSTLARGAVKLSKQKVIVKRLDAIQNFGAMDILCTDKTGTLTQDKI-------------VLENH 392
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  488 SDIPQHVGNLITMGISVNSAYtsnimaghnpgdlpiQVGNKT-------ECALLGFVQGLGVKYQSIrDEITedkftrvy 560
Cdd:PRK10517  393 TDISGKTSERVLHSAWLNSHY---------------QTGLKNlldtavlEGVDEESARSLASRWQKI-DEIP-------- 448
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  561 tFNSVRKSMGTVIPRPNGGYRLYTKGASEIIMKKCAFIYgHEGTLEKFTRDMQERlIREVIEPMACDGLRTISVAYRDFV 640
Cdd:PRK10517  449 -FDFERRRMSVVVAENTEHHQLICKGALEEILNVCSQVR-HNGEIVPLDDIMLRR-IKRVTDTLNRQGLRVVAVATKYLP 525
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  641 PGKAAINEVhidgepnwdDEenimTNLTCLCVVGIEDPVRPEVPDAIRKCQRAGITVRMVTGDNINTARSIASKCGIlrP 720
Cdd:PRK10517  526 AREGDYQRA---------DE----SDLILEGYIAFLDPPKETTAPALKALKASGVTVKILTGDSELVAAKVCHEVGL--D 590
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  721 NDDFLIlegkefnrrirdsNGDIQ----QHLIDKVwPKLRVLARSSPTDKYTLVKgiidsTVSENREVVAVTGDGTNDGP 796
Cdd:PRK10517  591 AGEVLI-------------GSDIEtlsdDELANLA-ERTTLFARLTPMHKERIVT-----LLKREGHVVGFMGDGINDAP 651
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  797 ALKKADVGFAMGiAGTDVAKEASDIILTDDNFSSIVKAVMWGRNVYDSIAKFLqfQLTV-----NVVAVIV--AFIGACa 869
Cdd:PRK10517  652 ALRAADIGISVD-GAVDIAREAADIILLEKSLMVLEEGVIEGRRTFANMLKYI--KMTAssnfgNVFSVLVasAFLPFL- 727
                         730
                  ....*....|....*....
gi 320541585  870 vqdsPLKAVQMLWVNLIMD 888
Cdd:PRK10517  728 ----PMLPLHLLIQNLLYD 742
ATPase-IB1_Cu TIGR01511
copper-(or silver)-translocating P-type ATPase; This model describes the P-type ATPase ...
175-863 9.82e-41

copper-(or silver)-translocating P-type ATPase; This model describes the P-type ATPase primarily responsible for translocating copper ions accross biological membranes. These transporters are found in prokaryotes and eukaryotes. This model encompasses those species which pump copper ions out of cells or organelles (efflux pumps such as CopA of Escherichia coli) as well as those which pump the ion into cells or organelles either for the purpose of supporting life in extremely low-copper environments (for example CopA of Enterococcus hirae) or for the specific delivery of copper to a biological complex for which it is a necessary component (for example FixI of Bradyrhizobium japonicum, or CtaA and PacS of Synechocystis). The substrate specificity of these transporters may, to a varying degree, include silver ions (for example, CopA from Archaeoglobus fulgidus). Copper transporters from this family are well known as the genes which are mutated in two human disorders of copper metabolism, Wilson's and Menkes' diseases. The sequences contributing to the seed of this model are all experimentally characterized. The copper P-type ATPases have been characterized as Type IB based on a phylogenetic analysis which combines the copper-translocating ATPases with the cadmium-translocating species. This model and that describing the cadmium-ATPases (TIGR01512) are well separated, and thus we further type the copper-ATPases as IB1 (and the cadmium-ATPases as IB2). Several sequences which have not been characterized experimentally fall just below the cutoffs for both of these models (SP|Q9CCL1 from Mycobacterium leprae, GP|13816263 from Sulfolobus solfataricus, OMNI|NTL01CJ01098 from Campylobacter jejuni, OMNI|NTL01HS01687 from Halobacterium sp., GP|6899169 from Ureaplasma urealyticum and OMNI|HP1503 from Helicobacter pylori). Accession PIR|A29576 from Enterococcus faecalis scores very high against this model, but yet is annotated as an "H+/K+ exchanging ATPase". BLAST of this sequence does not hit anything else annotated in this way. This error may come from the characterization paper published in 1987. Accession GP|7415611 from Saccharomyces cerevisiae appears to be mis-annotated as a cadmium resistance protein. Accession OMNI|NTL01HS00542 from Halobacterium which scores above trusted for this model is annotated as "molybdenum-binding protein" although no evidence can be found for this classification. [Cellular processes, Detoxification, Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273664 [Multi-domain]  Cd Length: 562  Bit Score: 159.36  E-value: 9.82e-41
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585   175 GGEVCQISVGDILVGDIAQVKYGDLLPADGCLIQSNDlKVDESSLTGESDHVKKGPDvDPmVLSGTHVMEGSGKMVVTAV 254
Cdd:TIGR01511   99 DGSIEEVPVALLQPGDIVKVLPGEKIPVDGTVIEGES-EVDESLVTGESLPVPKKVG-DP-VIAGTVNGTGSLVVRATAT 175
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585   255 GVNSqagiifTLlgaavdeqeAEIKKMKKEAKrankqknltgendgrsqikGSQAPSQRetvtseitksesegnhlpqss 334
Cdd:TIGR01511  176 GEDT------TL---------AQIVRLVRQAQ-------------------QSKAPIQR--------------------- 200
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585   335 ssgaaetghkkeksvlqakltkLAIQIGyagstiAVLTVIILIIqfCIKTFVIdekpWkntyannlVKHLIIGVTVLVVA 414
Cdd:TIGR01511  201 ----------------------LADKVA------GYFVPVVIAI--ALITFVI----W--------LFALEFAVTVLIIA 238
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585   415 VPEGLPLAVTLSLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTTNRMTVVQ------SYICEklckVLPTLS 488
Cdd:TIGR01511  239 CPCALGLATPTVIAVATGLAAKNGVLIKDGDALERAANIDTVVFDKTGTLTQGKPTVTDvhvfgdRDRTE----LLALAA 314
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585   489 DIPQHVGNLITMGIsVNSAYTSNIMAghnpgdlpiqvgnkTECALLGFVQGLGVKyqsirdeitedkftrvytfnsvrks 568
Cdd:TIGR01511  315 ALEAGSEHPLAKAI-VSYAKEKGITL--------------VTVSDFKAIPGIGVE------------------------- 354
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585   569 mGTViprpNGGyrlytkgasEIIMKKCAFIyGHEGTLEKFTRDMQErlireviepmacdglrTISVAyrdFVPGKAAine 648
Cdd:TIGR01511  355 -GTV----EGT---------KIQLGNEKLL-GENAIKIDGKAGQGS----------------TVVLV---AVNGELA--- 397
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585   649 vhidgepnwddeenimtnltclCVVGIEDPVRPEVPDAIRKCQRAGITVRMVTGDNINTARSIASKCGIlrpnddflile 728
Cdd:TIGR01511  398 ----------------------GVFALEDQLRPEAKEVIQALKRRGIEPVMLTGDNRKTAKAVAKELGI----------- 444
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585   729 gkefnrrirdsngdiqqhlidkvwpklRVLARSSPTDKYTLVKGIidstvSENREVVAVTGDGTNDGPALKKADVGFAMG 808
Cdd:TIGR01511  445 ---------------------------DVRAEVLPDDKAALIKKL-----QEKGPVVAMVGDGINDAPALAQADVGIAIG 492
                          650       660       670       680       690
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 320541585   809 iAGTDVAKEASDIILTDDNFSSIVKAVMWGRNVYDSIAKFLQFQLTVNVVAVIVA 863
Cdd:TIGR01511  493 -AGTDVAIEAADVVLLRNDLNDVATAIDLSRKTLRRIKQNLLWAFGYNVIAIPIA 546
P-type_ATPase_Cu-like cd07552
P-type heavy metal-transporting ATPase, similar to Archaeoglobus fulgidus CopB, a Cu(2+) ...
172-866 6.90e-37

P-type heavy metal-transporting ATPase, similar to Archaeoglobus fulgidus CopB, a Cu(2+)-ATPase; Archaeoglobus fulgidus CopB transports Cu(2+) from the cytoplasm to the exterior of the cell using ATP as energy source, it transports preferentially Cu(2+) over Cu(+), it is activated by Cu(2+) with high affinity and partially by Cu(+) and Ag(+). This subclass of P-type ATPase is also referred to as CPx-type ATPases because their amino acid sequences contain a characteristic CPC or CPH motif associated with a stretch of hydrophobic amino acids and N-terminal ion-binding sequences. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319850 [Multi-domain]  Cd Length: 632  Bit Score: 148.61  E-value: 6.90e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  172 VIRGGEVCQISVGDILVGDIAQVKYGDLLPADGcLIQSNDLKVDESSLTGESDHVKKGPDVDpmVLSGTHVMEGSGKMVV 251
Cdd:cd07552   135 LVTDGSIEDVPVSELKVGDVVLVRAGEKIPADG-TILEGESSVNESMVTGESKPVEKKPGDE--VIGGSVNGNGTLEVKV 211
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  252 TAVGVNSQAGIIFTLLGAAvdeqeaeikkmkkeakrankqknltgendgrsqikgsqapsqretvtseitksesegnhlp 331
Cdd:cd07552   212 TKTGEDSYLSQVMELVAQA------------------------------------------------------------- 230
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  332 QSSssgaaetghkkeKSVLQAKLTKLAIQIGYAGSTIAVLTVIIliiqfciktfvidekpWknTYANNLVKHLIIGVTVL 411
Cdd:cd07552   231 QAS------------KSRAENLADKVAGWLFYIALGVGIIAFII----------------W--LILGDLAFALERAVTVL 280
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  412 VVAVPEGLPLAVTLSLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTTNRMTVVQSYICEKLckvlpTLSDIP 491
Cdd:cd07552   281 VIACPHALGLAIPLVVARSTSIAAKNGLLIRNREALERARDIDVVLFDKTGTLTEGKFGVTDVITFDEY-----DEDEIL 355
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  492 QHVGnlitmGISVNSAYtsnimaghnpgdlPIQVGnktecaLLGFVQGLGVKYQSIRDeitedkftrvytFNSV--RKSM 569
Cdd:cd07552   356 SLAA-----ALEAGSEH-------------PLAQA------IVSAAKEKGIRPVEVEN------------FENIpgVGVE 399
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  570 GTViprpNGG-YRLYTkgaseiimkkcafiyghegtlEKFTRDMQERLIREVIEPMACDGLrTISVAYRDfvpgkaaiNE 648
Cdd:cd07552   400 GTV----NGKrYQVVS---------------------PKYLKELGLKYDEELVKRLAQQGN-TVSFLIQD--------GE 445
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  649 VhidgepnwddeenimtnltcLCVVGIEDPVRPEVPDAIRKCQRAGITVRMVTGDNINTARSIASKCGILRpnddflile 728
Cdd:cd07552   446 V--------------------IGAIALGDEIKPESKEAIRALKAQGITPVMLTGDNEEVAQAVAEELGIDE--------- 496
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  729 gkefnrrirdsngdiqqhlidkvwpklrVLARSSPTDKYTLVKgiidsTVSENREVVAVTGDGTNDGPALKKADVGFAMG 808
Cdd:cd07552   497 ----------------------------YFAEVLPEDKAKKVK-----ELQAEGKKVAMVGDGVNDAPALAQADVGIAIG 543
                         650       660       670       680       690       700
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 320541585  809 iAGTDVAKEASDIILTDDNFSSIVKAVMWGRNVYDSIAKFLQFQLTVNVVAV-----IVAFIG 866
Cdd:cd07552   544 -AGTDVAIESADVVLVKSDPRDIVDFLELAKATYRKMKQNLWWGAGYNVIAIplaagVLAPIG 605
ATPase-IB2_Cd TIGR01512
heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; This model describes the P-type ...
172-866 1.15e-36

heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; This model describes the P-type ATPase primarily responsible for translocating cadmium ions (and other closely-related divalent heavy metals such as cobalt, mercury, lead and zinc) across biological membranes. These transporters are found in prokaryotes and plants. Experimentally characterized members of the seed alignment include: SP|P37617 from E. coli, SP|Q10866 from Mycobacterium tuberculosis and SP|Q59998 from Synechocystis PCC6803. The cadmium P-type ATPases have been characterized as Type IB based on a phylogenetic analysis which combines the copper-translocating ATPases with the cadmium-translocating species. This model and that describing the copper-ATPases (TIGR01511) are well separated, and thus we further type the copper-ATPases as IB1 and the cadmium-ATPases as IB2. Several sequences which have not been characterized experimentally fall just below trusted cutoff for both of these models (SP|Q9CCL1 from Mycobacterium leprae, GP|13816263 from Sulfolobus solfataricus, OMNI|NTL01CJ01098 from Campylobacter jejuni, OMNI|NTL01HS01687 from Halobacterium sp., GP|6899169 from Ureaplasma urealyticum and OMNI|HP1503 from Helicobacter pylori). [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273665 [Multi-domain]  Cd Length: 550  Bit Score: 146.70  E-value: 1.15e-36
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585   172 VIRGGEVCQISVGDILVGDIAQVKYGDLLPADGCLIQSNDLkVDESSLTGESDHVKKGPDVDpmVLSGTHVMEGSGKMVV 251
Cdd:TIGR01512   59 RLQGDSLEEVAVEELKVGDVVVVKPGERVPVDGEVLSGTSS-VDESALTGESVPVEKAPGDE--VFAGAINLDGVLTIEV 135
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585   252 TAVGVNSQAGIIFTLLgaavdeQEAEIKKmkkeakrankqknltgendgrsqikgsqapsqretvtseitksesegnhlp 331
Cdd:TIGR01512  136 TKLPADSTIAKIVNLV------EEAQSRK--------------------------------------------------- 158
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585   332 qssssgaaetghkkeksvlqAKLTKLAIQIGyagstiAVLTVIILIIQFCIKTFVIDEKPWKNTYAnnlvkhLIIGVTVL 411
Cdd:TIGR01512  159 --------------------APTQRFIDRFA------RYYTPAVLAIALAAALVPPLLGAGPFLEW------IYRALVLL 206
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585   412 VVAVPEGLPLAVTLSLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTTNRMTVVQsyiceklckvlptLSDIP 491
Cdd:TIGR01512  207 VVASPCALVISAPAAYLSAISAAARHGILIKGGAALEALAKIKTVAFDKTGTLTTGKPKVTD-------------VHPAD 273
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585   492 QHVGNLITMGISVNSAYTSNIMAghnpgdlpiqvgnktecallgfvqglgvkyQSIRDEITEDkfTRVYTFNSVRKSMGt 571
Cdd:TIGR01512  274 GHSESEVLRLAAAAEQGSTHPLA------------------------------RAIVDYARAR--ELAPPVEDVEEVPG- 320
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585   572 viprpnggyrlytKGASeiimkkcAFIYGHEGTLEKftrdmqerlireviepmacDGLRTISVAYRDFVPGKAAINEVHI 651
Cdd:TIGR01512  321 -------------EGVR-------AVVDGGEVRIGN-------------------PRSLSEAVGASIAVPESAGKTIVLV 361
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585   652 --DGepnwddeenimtnlTCLCVVGIEDPVRPEVPDAIRKCQRAGI-TVRMVTGDNINTARSIASKCGIlrpnDDflile 728
Cdd:TIGR01512  362 arDG--------------TLLGYIALSDELRPDAAEAIAELKALGIkRLVMLTGDRRAVAEAVARELGI----DE----- 418
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585   729 gkefnrrirdsngdiqqhlidkvwpklrVLARSSPTDKYTLVKGIIdstvsENREVVAVTGDGTNDGPALKKADVGFAMG 808
Cdd:TIGR01512  419 ----------------------------VHAELLPEDKLEIVKELR-----EKAGPVAMVGDGINDAPALAAADVGIAMG 465
                          650       660       670       680       690
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 320541585   809 IAGTDVAKEASDIILTDDNFSSIVKAVMWGRNVYDSIAKFLQFQLTVNVVAVIVAFIG 866
Cdd:TIGR01512  466 ASGSDVALETADVVLLNDDLSRLPQAIRLARRTRRIIKQNVVIALGIILVLILLALFG 523
P-type_ATPase_APLT_Dnf-like cd02073
Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, ...
440-937 3.73e-32

Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2, -10D, -11B, -11C; Aminophospholipid translocases (APLTs), also known as type 4 P-type ATPases, act as flippases, and translocate specific phospholipids from the exoplasmic leaflet to the cytoplasmic leaflet of biological membranes. Yeast Dnf1 and Dnf2 mediate the transport of phosphatidylethanolamine, phosphatidylserine, and phosphatidylcholine from the outer to the inner leaflet of the plasma membrane. This subfamily includes mammalian flippases such as ATP11C which may selectively transports PS and PE from the outer leaflet of the plasma membrane to the inner leaflet. It also includes Arabidopsis phospholipid flippases including ALA1, and Caenorhabditis elegans flippases, including TAT-1, the latter has been shown to facilitate the inward transport of phosphatidylserine. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319770 [Multi-domain]  Cd Length: 836  Bit Score: 135.38  E-value: 3.73e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  440 LVRHLDACETMGNATAICSDKTGTLTTNRMTVVQSYICE---------KLC-KVLPtlsDIPQHVGNLITMGISvnsayt 509
Cdd:cd02073   342 EARTSNLNEELGQVEYIFSDKTGTLTENIMEFKKCSINGvdygfflalALChTVVP---EKDDHPGQLVYQASS------ 412
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  510 snimaghnpgdlPIQVGNKTECALLGFVQgLGVKYQSIrdEITEDKFTRVYT------FNSVRKSMGTVIPRPNGGYRLY 583
Cdd:cd02073   413 ------------PDEAALVEAARDLGFVF-LSRTPDTV--TINALGEEEEYEilhileFNSDRKRMSVIVRDPDGRILLY 477
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  584 TKGASEIIMKKCafiygHEGTLEKFTRdmqerlIREVIEPMACDGLRTISVAYRDFVPGK-AAINEVHIDGEPNWDD-EE 661
Cdd:cd02073   478 CKGADSVIFERL-----SPSSLELVEK------TQEHLEDFASEGLRTLCLAYREISEEEyEEWNEKYDEASTALQNrEE 546
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  662 NIM-------TNLTCLCVVGIEDPVRPEVPDAIRKCQRAGITVRMVTGDNINTARSIASKCGILRPNDD--FLILEGKEF 732
Cdd:cd02073   547 LLDevaeeieKDLILLGATAIEDKLQDGVPETIEALQRAGIKIWVLTGDKQETAINIGYSCRLLSEDMEnlALVIDGKTL 626
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  733 NRRIRDSNGDIQQHLIDKVwpKLRVLARSSPTDKYTLVKgiidsTVSENREVVAVT-GDGTNDGPALKKADVGfaMGIAG 811
Cdd:cd02073   627 TYALDPELERLFLELALKC--KAVICCRVSPLQKALVVK-----LVKKSKKAVTLAiGDGANDVSMIQEAHVG--VGISG 697
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  812 tdvaKE------ASDIILTddNFSSIVKAVM-WGRNVYDSIAKFLQFQLTVNVVAVIVAFIGA--CAVQDSPLKAVQMLW 882
Cdd:cd02073   698 ----QEgmqaarASDYAIA--QFRFLRRLLLvHGRWSYQRLAKLILYFFYKNIAFYLTQFWYQffNGFSGQTLYDSWYLT 771
                         490       500       510       520       530       540
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 320541585  883 V-NLIMDTLASLALAT--EFPTPDLLLRKP--YgrtKPLISRTM--MKNILG---QALYQLIIIF 937
Cdd:cd02073   772 LyNVLFTSLPPLVIGIfdQDVSAETLLRYPelY---KPGQLNELfnWKVFLYwilDGIYQSLIIF 833
ATPase-Plipid TIGR01652
phospholipid-translocating P-type ATPase, flippase; This model describes the P-type ATPase ...
147-864 9.83e-32

phospholipid-translocating P-type ATPase, flippase; This model describes the P-type ATPase responsible for transporting phospholipids from one leaflet of bilayer membranes to the other. These ATPases are found only in eukaryotes.


Pssm-ID: 273734 [Multi-domain]  Cd Length: 1057  Bit Score: 134.82  E-value: 9.83e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585   147 AFNDYSKERQFRGLQNRiegehKFSVIRG-GEVCQISVGDILVGDIAQVKYGDLLPADGCLIQSNDLK----VDESSLTG 221
Cdd:TIGR01652   69 AIEDIRRRRRDKEVNNR-----LTEVLEGhGQFVEIPWKDLRVGDIVKVKKDERIPADLLLLSSSEPDgvcyVETANLDG 143
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585   222 ESD-HVKKGPDVDPMVLSGTHVMEGSGKmvVTAVGVNSQagiIFTLLGaavdeqEAEIKKMKKEAK-------RANKQKN 293
Cdd:TIGR01652  144 ETNlKLRQALEETQKMLDEDDIKNFSGE--IECEQPNAS---LYSFQG------NMTINGDRQYPLspdnillRGCTLRN 212
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585   294 ---------LTGeNDGRSQIKGSQAPSQRETVTSEITksesegnhlpqssssgaaetghkkeksvlqakltklaiQIGYA 364
Cdd:TIGR01652  213 tdwvigvvvYTG-HDTKLMRNATQAPSKRSRLEKELN--------------------------------------FLIII 253
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585   365 GSTIAVLTVIILIIQFCIKTFVIDEKPW---KNTYANNLVKHLIIGVTVLVVAVPEGLP--LAVTLSLAYSVKKMMKDNN 439
Cdd:TIGR01652  254 LFCLLFVLCLISSVGAGIWNDAHGKDLWyirLDVSERNAAANGFFSFLTFLILFSSLIPisLYVSLELVKSVQAYFINSD 333
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585   440 L------------VRHLDACETMGNATAICSDKTGTLTTNRMTVVQ------SYIC---EKLCKVLPTLSDIPQHVGNLI 498
Cdd:TIGR01652  334 LqmyhektdtpasVRTSNLNEELGQVEYIFSDKTGTLTQNIMEFKKcsiagvSYGDgftEIKDGIRERLGSYVENENSML 413
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585   499 TMGISVN--------SAYTSNIMAG------------HN---------PGDLPIQVGNKTECALLGFVQGLGVKY----- 544
Cdd:TIGR01652  414 VESKGFTfvdprlvdLLKTNKPNAKrinefflalalcHTvvpefnddgPEEITYQAASPDEAALVKAARDVGFVFfertp 493
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585   545 QSIRDEITEDKFTRVYT------FNSVRKSMGTVIPRPNGGYRLYTKGASEIIMKKcafiyghegtLEKFTRDMQERLIR 618
Cdd:TIGR01652  494 KSISLLIEMHGETKEYEilnvleFNSDRKRMSVIVRNPDGRIKLLCKGADTVIFKR----------LSSGGNQVNEETKE 563
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585   619 EvIEPMACDGLRTISVAYRDFVPGK-AAINEVHIDGEPNWDDE--------ENIMTNLTCLCVVGIEDPVRPEVPDAIRK 689
Cdd:TIGR01652  564 H-LENYASEGLRTLCIAYRELSEEEyEEWNEEYNEASTALTDReekldvvaESIEKDLILLGATAIEDKLQEGVPETIEL 642
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585   690 CQRAGITVRMVTGDNINTARSIASKCGILRPNDDFLIL---------EGKEFNRRIRDSNGDIQQHLIDK---------- 750
Cdd:TIGR01652  643 LRQAGIKIWVLTGDKVETAINIGYSCRLLSRNMEQIVItsdsldatrSVEAAIKFGLEGTSEEFNNLGDSgnvalvidgk 722
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585   751 -----VWPKLR------------VLA-RSSPTDKYTLVKGIIDSTvseNREVVAVtGDGTNDGPALKKADVGfaMGIAGT 812
Cdd:TIGR01652  723 slgyaLDEELEkeflqlalkckaVICcRVSPSQKADVVRLVKKST---GKTTLAI-GDGANDVSMIQEADVG--VGISGK 796
                          810       820       830       840       850
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 320541585   813 D--VAKEASDIILTddNFSSIVKAVMW-GRNVYDSIAKFLQFQLTVNVVAVIVAF 864
Cdd:TIGR01652  797 EgmQAVMASDFAIG--QFRFLTKLLLVhGRWSYKRISKMILYFFYKNLIFAIIQF 849
P-type_ATPase_HM cd07550
P-type heavy metal-transporting ATPase; uncharacterized subfamily; Uncharacterized subfamily ...
150-866 4.85e-29

P-type heavy metal-transporting ATPase; uncharacterized subfamily; Uncharacterized subfamily of the heavy metal-transporting ATPases (Type IB ATPases) which transport heavy metal ions (Cu(+), Cu(2+), Zn(2+), Cd(2+), Co(2+), etc.) across biological membranes. The characteristic N-terminal heavy metal associated (HMA) domain of this group is essential for the binding of metal ions. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319848 [Multi-domain]  Cd Length: 592  Bit Score: 123.92  E-value: 4.85e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  150 DYSKERQFRGLQNRIE-GEHKFSVIRGGEVCQISVGDILVGDIAQVKYGDLLPADGcLIQSNDLKVDESSLTGESDHVKK 228
Cdd:cd07550    81 DYTARKSEKALLDLLSpQERTVWVERDGVEVEVPADEVQPGDTVVVGAGDVIPVDG-TVLSGEALIDQASLTGESLPVEK 159
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  229 GpdVDPMVLSGTHVMEGSGKMVVTAVGVNSQAGIIFTLLgaavdeQEAEikkmkkeakrankqknltgENDGRSQIKgsq 308
Cdd:cd07550   160 R--EGDLVFASTVVEEGQLVIRAERVGRETRAARIAELI------EQSP-------------------SLKARIQNY--- 209
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  309 apsqretvtseitksesegnhlpqssssgAAETGHKkeksvlqakltklAIQIGYAGSTIAVLTviILIIQFCIKTFVID 388
Cdd:cd07550   210 -----------------------------AERLADR-------------LVPPTLGLAGLVYAL--TGDISRAAAVLLVD 245
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  389 ekpwkntyannlvkhliigvtvLVVAVPEGLPLAVTLSLAYSVKKMMkdnnLVRHLDACETMGNATAICSDKTGTLTTNR 468
Cdd:cd07550   246 ----------------------FSCGIRLSTPVAVLSALNHAARHGI----LVKGGRALELLAKVDTVVFDKTGTLTEGE 299
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  469 MTVVQSYICEKLC---KVLPTLSDIPQHVGNLITMGIsVNSAYTSNImaghnpgDLPiqvgnktECALLGFVQGLGVKyq 545
Cdd:cd07550   300 PEVTAIITFDGRLseeDLLYLAASAEEHFPHPVARAI-VREAEERGI-------EHP-------EHEEVEYIVGHGIA-- 362
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  546 sirdeitedkfTRVytfnsvrksmgtviprpnggyrlytkGASEIIMKKCAFIYGHEGTLekfTRDMQERLIREVIEpma 625
Cdd:cd07550   363 -----------STV--------------------------DGKRIRVGSRHFMEEEEIIL---IPEVDELIEDLHAE--- 399
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  626 cdglrtisvayrdfvpgKAAINEVHIDGEPnwddeenimtnltcLCVVGIEDPVRPEVPDAIRKCQRAG-ITVRMVTGDN 704
Cdd:cd07550   400 -----------------GKSLLYVAIDGRL--------------IGVIGLSDPLRPEAAEVIARLRALGgKRIIMLTGDH 448
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  705 INTARSIASKCGIlrpnddflilegkefnrrirdsngdiqqhliDkvwpklRVLARSSPTDKYTLVKGIIDSTvsenrEV 784
Cdd:cd07550   449 EQRARALAEQLGI-------------------------------D------RYHAEALPEDKAEIVEKLQAEG-----RT 486
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  785 VAVTGDGTNDGPALKKADVGFAMGiAGTDVAKEASDIILTDDNFSSIVKAVMWGRNVYDSIAKFLQFQLTVNVVAVIVAF 864
Cdd:cd07550   487 VAFVGDGINDSPALSYADVGISMR-GGTDIARETADVVLLEDDLRGLAEAIELARETMALIKRNIALVVGPNTAVLAGGV 565

                  ..
gi 320541585  865 IG 866
Cdd:cd07550   566 FG 567
P-type_ATPase_cation cd07542
P-type cation-transporting ATPases, similar to human ATPase type 13A2 (ATP13A2) protein and ...
368-942 2.91e-28

P-type cation-transporting ATPases, similar to human ATPase type 13A2 (ATP13A2) protein and Saccharomyces cerevisiae Ypk9p; Saccharomyces cerevisiae Yph9p localizes to the yeast vacuole and may play a role in sequestering heavy metal ions, its deletion confers sensitivity for growth for cadmium, manganese, nickel or selenium. Human ATP13A2 (PARK9/CLN12) is a lysosomal transporter with zinc as the possible substrate. Mutation in the ATP13A2 gene has been linked to Parkinson's disease and Kufor-Rakeb syndrome, and to neuronal ceroid lipofuscinoses. ATP13A3/AFURS1 is a candidate gene for oculo auriculo vertebral spectrum (OAVS), being one of nine genes included in a 3q29 microduplication in a patient with OAVS. Mutation in the human ATP13A4 may be involved in a speech-language disorder. This subfamily also includes zebrafish ATP13A2 a lysosome-specific transmembrane ATPase protein of unknown function which plays a crucial role during embryonic development, its deletion is lethal. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319842 [Multi-domain]  Cd Length: 760  Bit Score: 122.74  E-value: 2.91e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  368 IAVLtVIILIIQFCIkTFVIdekpwknTYANNLVKHLII--GVTVLVVAVPEGLPLAVTLSLAYSVKKmmkdnnLVRHLD 445
Cdd:cd07542   227 ILFL-AIIALIGFIY-TLII-------LILNGESLGEIIirALDIITIVVPPALPAALTVGIIYAQSR------LKKKGI 291
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  446 AC---ETMGNATAI---CSDKTGTLTTNRMTVVQSYICEKLCKVLPTLSDIPQHVGNLITMGISVNSAYTSN---IMAGH 516
Cdd:cd07542   292 FCispQRINICGKInlvCFDKTGTLTEDGLDLWGVRPVSGNNFGDLEVFSLDLDLDSSLPNGPLLRAMATCHsltLIDGE 371
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  517 NPGD-LPIQVGNKTECALlgfvqglgvkyqsirdEITedkftRVYTFNSVRKSMGTVIPRPNGGYR-LYTKGASEIIMKK 594
Cdd:cd07542   372 LVGDpLDLKMFEFTGWSL----------------EIL-----RQFPFSSALQRMSVIVKTPGDDSMmAFTKGAPEMIASL 430
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  595 CafiyghegTLEKFTRDMQErlireVIEPMACDGLRTISVAYRdfvpgkaainevHIDGEPNWDDE---ENIMTNLTCLC 671
Cdd:cd07542   431 C--------KPETVPSNFQE-----VLNEYTKQGFRVIALAYK------------ALESKTWLLQKlsrEEVESDLEFLG 485
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  672 VVGIEDPVRPEVPDAIRKCQRAGITVRMVTGDNINTARSIASKCGILRPNDD-FLIlegkEFNRRIRDSNGDIQQHLIdk 750
Cdd:cd07542   486 LIVMENRLKPETAPVINELNRANIRTVMVTGDNLLTAISVARECGMISPSKKvILI----EAVKPEDDDSASLTWTLL-- 559
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  751 vwPKLRVLARSSPTDKYTLVKGI--IDSTvsenrevVAVTGDGTNDGPALKKADVGFAMGIAGTDVakeASDIILTDDNF 828
Cdd:cd07542   560 --LKGTVFARMSPDQKSELVEELqkLDYT-------VGMCGDGANDCGALKAADVGISLSEAEASV---AAPFTSKVPDI 627
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  829 SSIVKAVMWGRNVYD---SIAKFLqfqltvnVVAVIVAFIGACAV--QDSPLKAVQMLWVNLIMDTLASLALATEFPTPD 903
Cdd:cd07542   628 SCVPTVIKEGRAALVtsfSCFKYM-------ALYSLIQFISVLILysINSNLGDFQFLFIDLVIITPIAVFMSRTGAYPK 700
                         570       580       590
                  ....*....|....*....|....*....|....*....
gi 320541585  904 LLLRKPYGRtkpLISRTMMKNILGQALYQLIIIFGLLFV 942
Cdd:cd07542   701 LSSKRPPAS---LVSPPVLVSLLGQIVLILLFQVIGFLI 736
PRK15122 PRK15122
magnesium-transporting ATPase; Provisional
174-909 7.50e-28

magnesium-transporting ATPase; Provisional


Pssm-ID: 237914 [Multi-domain]  Cd Length: 903  Bit Score: 122.06  E-value: 7.50e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  174 RGGEVCQISVGDILVGDIAQVKYGDLLPADGCLIQSNDLKVDESSLTGESDHVKK--------------GPDVDPMVLS- 238
Cdd:PRK15122  160 AEPVRREIPMRELVPGDIVHLSAGDMIPADVRLIESRDLFISQAVLTGEALPVEKydtlgavagksadaLADDEGSLLDl 239
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  239 ------GTHVMEGSGKMVVTAVGVNsqagiifTLLGAAVdeqeaeikkmkkeakrankqKNLTGEndgRSQIkgsqapsq 312
Cdd:PRK15122  240 pnicfmGTNVVSGTATAVVVATGSR-------TYFGSLA--------------------KSIVGT---RAQT-------- 281
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  313 retvtseitksesegnhlpqssssgAAETGhkkeksvlqakltklaiqigyagstiaVLTVIILIIQFcikTFVIdeKPw 392
Cdd:PRK15122  282 -------------------------AFDRG---------------------------VNSVSWLLIRF---MLVM--VP- 303
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  393 kntyannlVKHLIIGVT----------VLVVAV---PEGLPLAVTLSLAYSVKKMMKDNNLVRHLDACETMGNATAICSD 459
Cdd:PRK15122  304 --------VVLLINGFTkgdwleallfALAVAVgltPEMLPMIVSSNLAKGAIAMARRKVVVKRLNAIQNFGAMDVLCTD 375
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  460 KTGTLTTNRMTVVQSYiceklckvlptlsDIPQHVGNLITMGISVNSAYTS---NIMaghnpgdlpiqvgnktECALLGF 536
Cdd:PRK15122  376 KTGTLTQDRIILEHHL-------------DVSGRKDERVLQLAWLNSFHQSgmkNLM----------------DQAVVAF 426
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  537 VQGLG-----VKYQSIrDEITedkftrvytFNSVRKSMGTVIPRPNGGYRLYTKGASEIIMKKCAFIYGHEGT--LEKFT 609
Cdd:PRK15122  427 AEGNPeivkpAGYRKV-DELP---------FDFVRRRLSVVVEDAQGQHLLICKGAVEEMLAVATHVRDGDTVrpLDEAR 496
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  610 RDMQERLIREVIEpmacDGLRTISVAYRDfVPGKAAINEVHIDgepnwdDEENIMTN--LTCLcvvgieDPVRPEVPDAI 687
Cdd:PRK15122  497 RERLLALAEAYNA----DGFRVLLVATRE-IPGGESRAQYSTA------DERDLVIRgfLTFL------DPPKESAAPAI 559
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  688 RKCQRAGITVRMVTGDNINTARSIASKCGiLRPNDdflILEGKEFNRRirdsnGDIQqhLIDKVwpKLR-VLARSSPTDK 766
Cdd:PRK15122  560 AALRENGVAVKVLTGDNPIVTAKICREVG-LEPGE---PLLGTEIEAM-----DDAA--LAREV--EERtVFAKLTPLQK 626
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  767 YTLVKgiidsTVSENREVVAVTGDGTNDGPALKKADVGFAMGiAGTDVAKEASDIILTDDNFSSIVKAVMWGRNVYDSIA 846
Cdd:PRK15122  627 SRVLK-----ALQANGHTVGFLGDGINDAPALRDADVGISVD-SGADIAKESADIILLEKSLMVLEEGVIKGRETFGNII 700
                         730       740       750       760       770       780       790
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 320541585  847 KFLqfQLTV-----NVVAVIV--AFIGAcavqdSPLKAVQMLWVNLIMDtLASLALA-----TEFptpdllLRKP 909
Cdd:PRK15122  701 KYL--NMTAssnfgNVFSVLVasAFIPF-----LPMLAIHLLLQNLMYD-ISQLSLPwdkmdKEF------LRKP 761
P-type_ATPase_HM_ZosA_PfeT-like cd07551
P-type heavy metal-transporting ATPase, similar to Bacillus subtilis ZosA/PfeT which ...
174-866 2.65e-27

P-type heavy metal-transporting ATPase, similar to Bacillus subtilis ZosA/PfeT which transports copper, and perhaps zinc under oxidative stress, and perhaps ferrous iron; Bacillus subtilis ZosA/PfeT (previously known as YkvW) transports copper, it may also transport zinc under oxidative stress and may also be involved in ferrous iron efflux. ZosA/PfeT is expressed under the regulation of the peroxide-sensing repressor PerR. It is involved in competence development. Disruption of the zosA/pfeT gene results in low transformability. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319849 [Multi-domain]  Cd Length: 611  Bit Score: 118.89  E-value: 2.65e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  174 RGGEVCQISVGDILVGDIAQVKYGDLLPADGcLIQSNDLKVDESSLTGESDHVKKGPdVDPmVLSGThvMEGSGKMVVTA 253
Cdd:cd07551   119 RDGEIEEVPVEELQIGDRVQVRPGERVPADG-VILSGSSSIDEASITGESIPVEKTP-GDE-VFAGT--INGSGALTVRV 193
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  254 VGVNSQagiifTLLgaavdeqeAEIKKMKKEAKrankqknltgendgrsqikGSQAPSQREtvtseITKSESegnhlpqs 333
Cdd:cd07551   194 TKLSSD-----TVF--------AKIVQLVEEAQ-------------------SEKSPTQSF-----IERFER-------- 228
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  334 sssgaaetghkkeksvlqakltklaiqiGYAGSTIAVLTVIILIIQFciktfvIDEKPWKNTyannlvkhLIIGVTVLVV 413
Cdd:cd07551   229 ----------------------------IYVKGVLLAVLLLLLLPPF------LLGWTWADS--------FYRAMVFLVV 266
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  414 AVPEGLPLAV---TLS-LAYSVKKMMkdnnLVRHLDACETMGNATAICSDKTGTLTTNRMTVVQSYICEKLCK--VLPTL 487
Cdd:cd07551   267 ASPCALVASTppaTLSaIANAARQGV----LFKGGVHLENLGSVKAIAFDKTGTLTEGKPRVTDVIPAEGVDEeeLLQVA 342
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  488 SDIPQHVGNLITMGIsVNSAYTSNImaghnPGDLPIQVGNKTECALLGFVQGLGV---KYQSIRDEITEDKFTrvytfns 564
Cdd:cd07551   343 AAAESQSEHPLAQAI-VRYAEERGI-----PRLPAIEVEAVTGKGVTATVDGQTYrigKPGFFGEVGIPSEAA------- 409
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  565 vrksmgtviprpnggyrlytkgaseiimkkcafiyghegTLEKFTRDmqerlireviepmacDGLRTISVAYRDFVPGka 644
Cdd:cd07551   410 ---------------------------------------ALAAELES---------------EGKTVVYVARDDQVVG-- 433
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  645 ainevhidgepnwddeenimtnltclcVVGIEDPVRPEVPDAIRKCQRAGITVRMVTGDNINTARSIASKCGIlrpnddf 724
Cdd:cd07551   434 ---------------------------LIALMDTPRPEAKEAIAALRLGGIKTIMLTGDNERTAEAVAKELGI------- 479
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  725 lilegkefnrrirdsngdiqqhliDKVWPKLRvlarssPTDKYTLVKgiidsTVSENREVVAVTGDGTNDGPALKKADVG 804
Cdd:cd07551   480 ------------------------DEVVANLL------PEDKVAIIR-----ELQQEYGTVAMVGDGINDAPALANADVG 524
                         650       660       670       680       690       700
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 320541585  805 FAMGiAGTDVAKEASDIILTDDNFSSIVKAVMWGRNVYDSIAKFLQFQLTVNVVAVIVAFIG 866
Cdd:cd07551   525 IAMG-AGTDVALETADVVLMKDDLSKLPYAIRLSRKMRRIIKQNLIFALAVIALLIVANLFG 585
P-ATPase-V TIGR01657
P-type ATPase of unknown pump specificity (type V); These P-type ATPases form a distinct clade ...
373-943 3.85e-27

P-type ATPase of unknown pump specificity (type V); These P-type ATPases form a distinct clade but the substrate of their pumping activity has yet to be determined. This clade has been designated type V in.


Pssm-ID: 273738 [Multi-domain]  Cd Length: 1054  Bit Score: 119.78  E-value: 3.85e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585   373 VIILIIQFCiktFVidekpWKNTYANNL-VKHLIIGVT-VLVVAVPEGLPLAVTLSLAYSVKKmmkdnnLVRHLDAC--- 447
Cdd:TIGR01657  374 AVLALIGFI---YT-----IIELIKDGRpLGKIILRSLdIITIVVPPALPAELSIGINNSLAR------LKKKGIFCtsp 439
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585   448 ETMGNATAI---CSDKTGTLTTNRMTVVQSYICEKLCKVLPTLSDIPQHVGNLITMGISVNSAYTS--NIMAGhNPGDLP 522
Cdd:TIGR01657  440 FRINFAGKIdvcCFDKTGTLTEDGLDLRGVQGLSGNQEFLKIVTEDSSLKPSITHKALATCHSLTKleGKLVG-DPLDKK 518
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585   523 I-QVGNKTECALLGFVQGLGVKYQSIRDEIT-EDKFTRVYTFNSVRKSMgTVIPRPNGGYR--LYTKGASEIIMKKCafi 598
Cdd:TIGR01657  519 MfEATGWTLEEDDESAEPTSILAVVRTDDPPqELSIIRRFQFSSALQRM-SVIVSTNDERSpdAFVKGAPETIQSLC--- 594
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585   599 ygHEGTLEKFTRDMQERLIREviepmacdGLRTISVAYRDFvpGKAAINEVHidgEPNWDDEENimtNLTCLCVVGIEDP 678
Cdd:TIGR01657  595 --SPETVPSDYQEVLKSYTRE--------GYRVLALAYKEL--PKLTLQKAQ---DLSRDAVES---NLTFLGFIVFENP 656
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585   679 VRPEVPDAIRKCQRAGITVRMVTGDNINTARSIASKCGILRPNdDFLIL---------EGKEFNRRIRDS---------- 739
Cdd:TIGR01657  657 LKPDTKEVIKELKRASIRTVMITGDNPLTAVHVARECGIVNPS-NTLILaeaeppesgKPNQIKFEVIDSipfastqvei 735
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585   740 ---------------------NGD----IQQH---LIDKVWPKLRVLARSSPTDKYTLVKgiidsTVSENREVVAVTGDG 791
Cdd:TIGR01657  736 pyplgqdsvedllasryhlamSGKafavLQAHspeLLLRLLSHTTVFARMAPDQKETLVE-----LLQKLDYTVGMCGDG 810
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585   792 TNDGPALKKADVGFAM-----GIAGTDVAKEAS-----DIILTddnfssivkavmwGR-NVYDSIAKF---LQFQLTVNV 857
Cdd:TIGR01657  811 ANDCGALKQADVGISLseaeaSVAAPFTSKLASiscvpNVIRE-------------GRcALVTSFQMFkymALYSLIQFY 877
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585   858 VAVIVAFIGacavqdSPLKAVQMLWVNLIMDTLASLALATEFPTPDLLLRKPYGRtkpLISRTMMKNILGqalyQLIIIF 937
Cdd:TIGR01657  878 SVSILYLIG------SNLGDGQFLTIDLLLIFPVALLMSRNKPLKKLSKERPPSN---LFSVYILTSVLI----QFVLHI 944

                   ....*.
gi 320541585   938 GLLFVG 943
Cdd:TIGR01657  945 LSQVYL 950
P-type_ATPase_HM cd07544
P-type heavy metal-transporting ATPase; uncharacterized subfamily; Uncharacterized subfamily ...
172-835 6.76e-27

P-type heavy metal-transporting ATPase; uncharacterized subfamily; Uncharacterized subfamily of the heavy metal-transporting ATPases (Type IB ATPases) which transport heavy metal ions (Cu(+), Cu(2+), Zn(2+), Cd(2+), Co(2+), etc.) across biological membranes. The characteristic N-terminal heavy metal associated (HMA) domain of this group is essential for the binding of metal ions. This subclass of P-type ATPase is also referred to as CPx-type ATPases because their amino acid sequences contain a characteristic CPC or CPH motif associated with a stretch of hydrophobic amino acids and N-terminal ion-binding sequences. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319844 [Multi-domain]  Cd Length: 596  Bit Score: 117.42  E-value: 6.76e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  172 VIRGGEVCQISVGDILVGDIAQVKYGDLLPADGCLIQSNDLkVDESSLTGESDHVKKGPdvdpmvlsGTHVMEGSgkmvv 251
Cdd:cd07544   114 RLVGGQLEEVPVEEVTVGDRLLVRPGEVVPVDGEVVSGTAT-LDESSLTGESKPVSKRP--------GDRVMSGA----- 179
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  252 tavgVNSQAGIIFTLLGAAVDEQEAEIKKMKKEAKRAnkqknltgendgrsqikgsqapsqretvtseitksesegnhlp 331
Cdd:cd07544   180 ----VNGDSALTMVATKLAADSQYAGIVRLVKEAQAN------------------------------------------- 212
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  332 qssssgaaetghkkeksvlQAKLTKLAIQigYAgstiAVLTVIILIIQfciktfvidekpwkntyannLVKHLIIG---- 407
Cdd:cd07544   213 -------------------PAPFVRLADR--YA----VPFTLLALAIA--------------------GVAWAVSGdpvr 247
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  408 -VTVLVVAVPEGLPLAVTLSLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTTNRMTVVQsyiceklckVLPT 486
Cdd:cd07544   248 fAAVLVVATPCPLILAAPVAIVSGMSRSSRRGILVKDGGVLEKLARAKTVAFDKTGTLTYGQPKVVD---------VVPA 318
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  487 LSDIPQHVgnlITMGISVNSaYTSNIMAghnpgdlpiqvgnktecallgfvqglgvkyQSIRDEITEDKftrvytfnsVR 566
Cdd:cd07544   319 PGVDADEV---LRLAASVEQ-YSSHVLA------------------------------RAIVAAARERE---------LQ 355
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  567 KSMGTVIPRPNGgyrlytKGASeiimkkcAFIYGHEgtlekftrdmqerlireviepmacdglrtISVAYRDFVPGKaai 646
Cdd:cd07544   356 LSAVTELTEVPG------AGVT-------GTVDGHE-----------------------------VKVGKLKFVLAR--- 390
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  647 nevhidgePNWDDEENIMTNLTCLCVVGIE----------DPVRPEVPDAIRKCQRAGIT-VRMVTGDNINTARSIASKC 715
Cdd:cd07544   391 --------GAWAPDIRNRPLGGTAVYVSVDgkyagaitlrDEVRPEAKETLAHLRKAGVErLVMLTGDRRSVAEYIASEV 462
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  716 GIlrpnDDflilegkefnrrirdsngdiqqhlidkvwpklrVLARSSPTDKYTLVKGIidstvsENREVVAVTGDGTNDG 795
Cdd:cd07544   463 GI----DE---------------------------------VRAELLPEDKLAAVKEA------PKAGPTIMVGDGVNDA 499
                         650       660       670       680
                  ....*....|....*....|....*....|....*....|
gi 320541585  796 PALKKADVGFAMGIAGTDVAKEASDIILTDDNFSSIVKAV 835
Cdd:cd07544   500 PALAAADVGIAMGARGSTAASEAADVVILVDDLDRVVDAV 539
E1-E2_ATPase pfam00122
E1-E2 ATPase;
172-436 7.33e-27

E1-E2 ATPase;


Pssm-ID: 425475 [Multi-domain]  Cd Length: 181  Bit Score: 108.43  E-value: 7.33e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585   172 VIRGGEVCQISVGDILVGDIAQVKYGDLLPADGCLIQSNDLkVDESSLTGESDHVKKgpDVDPMVLSGTHVMEGSGKMVV 251
Cdd:pfam00122    9 VLRDGTEEEVPADELVPGDIVLLKPGERVPADGRIVEGSAS-VDESLLTGESLPVEK--KKGDMVYSGTVVVSGSAKAVV 85
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585   252 TAVGVNSQAGIIFTLLgaavdeqeaeikkmkKEAKRAnkqknltgendgrsqikgsqapsqretvtseitksesegnhlp 331
Cdd:pfam00122   86 TATGEDTELGRIARLV---------------EEAKSK------------------------------------------- 107
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585   332 qssssgaaetghkkeKSVLQAKLTKLAIQIGYAGSTIAVLTVIILIIQFciktfvidekpwkntyaNNLVKHLIIGVTVL 411
Cdd:pfam00122  108 ---------------KTPLQRLLDRLGKYFSPVVLLIALAVFLLWLFVG-----------------GPPLRALLRALAVL 155
                          250       260
                   ....*....|....*....|....*
gi 320541585   412 VVAVPEGLPLAVTLSLAYSVKKMMK 436
Cdd:pfam00122  156 VAACPCALPLATPLALAVGARRLAK 180
P-type_ATPase_APLT cd07536
Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, ...
158-937 1.74e-24

Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, Neo1p, and human ATP8A2, -9B, -10D, -11B, and -11C; Aminophospholipid translocases (APLTs), also known as type 4 P-type ATPases, act as flippases, and translocate specific phospholipids from the exoplasmic leaflet to the cytoplasmic leaflet of biological membranes. Yeast Dnf1 and Dnf2 mediate the transport of phosphatidylethanolamine, phosphatidylserine, and phosphatidylcholine from the outer to the inner leaflet of the plasma membrane. Mammalian ATP11C may selectively transports PS and PE from the outer leaflet of the plasma membrane to the inner leaflet. The yeast Neo1p localizes to the endoplasmic reticulum and the Golgi complex and plays a role in membrane trafficking within the endomembrane system. Human putative ATPase phospholipid transporting 9B, ATP9B, localizes to the trans-golgi network in a CDC50 protein-independent manner. It also includes Arabidopsis phospholipid flippases including ALA1, and Caenorhabditis elegans flippases, including TAT-1, the latter has been shown to facilitate the inward transport of phosphatidylserine. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319838 [Multi-domain]  Cd Length: 805  Bit Score: 110.77  E-value: 1.74e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  158 RGLQNRIEGEHKFSVIRGGEVCQISVGDILVGDIAQVKYGDLLPADGCLIQSNDLK----VDESSLTGESD-HVKKGPDV 232
Cdd:cd07536    73 RFQRDKEVNKKQLYSKLTGRKVQIKSSDIQVGDIVIVEKNQRIPSDMVLLRTSEPQgscyVETAQLDGETDlKLRVAVSC 152
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  233 DPMVLSGTHVMEGSGkmVVTAVGVNSQagiIFTLLGaavdeqeaeikKMKKEAKRANKQKNLTGEND--GRSQIKGSQAP 310
Cdd:cd07536   153 TQQLPALGDLMKISA--YVECQKPQMD---IHSFEG-----------NFTLEDSDPPIHESLSIENTllRASTLRNTGWV 216
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  311 SQRETVTSEITKSesegnhlpqSSSSGAAETghkkeksvlqaKLTKLAIQIGYAGSTIAVLTVIILIIQFCIKTFVIDEK 390
Cdd:cd07536   217 IGVVVYTGKETKL---------VMNTSNAKN-----------KVGLLDLELNRLTKALFLALVVLSLVMVTLQGFWGPWY 276
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  391 PWKNTY-------ANNLVKHLIIGVTVLVVAVPegLPLAVTLSLAYSV--KKMMKDNNL----------VRHLDACETMG 451
Cdd:cd07536   277 GEKNWYikkmdttSDNFGRNLLRFLLLFSYIIP--ISLRVNLDMVKAVyaWFIMWDENMyyigndtgtvARTSTIPEELG 354
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  452 NATAICSDKTGTLTTNRMtvvqsyICEKLCkvlptlsdipqhvgnlitmgisvnsaytsnimaghnpgdlpiqvgnktec 531
Cdd:cd07536   355 QVVYLLTDKTGTLTQNEM------IFKRCH-------------------------------------------------- 378
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  532 alLGfvqglGVKY--QSIRDEITEdkftrVYTFNSVRKSMGTVIPRP-NGGYRLYTKGASEIImkkcafiyghegtLEKF 608
Cdd:cd07536   379 --IG-----GVSYggQVLSFCILQ-----LLEFTSDRKRMSVIVRDEsTGEITLYMKGADVAI-------------SPIV 433
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  609 TRDMQERLIREVIEPMACDGLRTISVAYRDF---------VPGKAAINEVHidgEPNWDDE---ENIMTNLTCLCVVGIE 676
Cdd:cd07536   434 SKDSYMEQYNDWLEEECGEGLRTLCVAKKALteneyqeweSRYTEASLSLH---DRSLRVAevvESLERELELLGLTAIE 510
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  677 DPVRPEVPDAIRKCQRAGITVRMVTGDNINTARSIASKCGILRPNDDFLILegKEFNRRIRDSNgdIQQHLIDK------ 750
Cdd:cd07536   511 DRLQAGVPETIETLRKAGIKIWMLTGDKQETAICIAKSCHLVSRTQDIHLL--RQDTSRGERAA--ITQHAHLElnafrr 586
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  751 ----------------------------VWPKLRVLARSSPTDKYTLVKgIIDSTVSenREVVAVtGDGTNDGPALKKAD 802
Cdd:cd07536   587 khdvalvidgdslevalkyyrhefvelaCQCPAVICCRVSPTQKARIVT-LLKQHTG--RRTLAI-GDGGNDVSMIQAAD 662
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  803 VGfaMGIAGTD--VAKEASDIILTddNFSSIVKAVM-WGRNVYDSIAKFLQFQLTVNVVAVIV----AFIGACAVQdSPL 875
Cdd:cd07536   663 CG--VGISGKEgkQASLAADYSIT--QFRHLGRLLLvHGRNSYNRSAALGQYVFYKGLIISTIqavfSFVFGFSGV-PLF 737
                         810       820       830       840       850       860
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 320541585  876 KAVQMLWVNLIMDTLASLALAT-EFPTPDLLLRKP----YGRTKPLISRTMMKNILGQALYQLIIIF 937
Cdd:cd07536   738 QGFLMVGYNVIYTMFPVFSLVIdQDVKPESAMLYPqlykDLQKGRSLNFKTFLGWVLISLYHGGILF 804
P-type_ATPase_Cd-like cd07545
P-type heavy metal-transporting ATPase, similar to Staphylococcus aureus plasmid pI258 CadA, a ...
172-893 1.45e-23

P-type heavy metal-transporting ATPase, similar to Staphylococcus aureus plasmid pI258 CadA, a cadmium-efflux ATPase; CadA from gram-positive Staphylococcus aureus plasmid pI258 is required for full Cd(2+) and Zn(2+) resistance. This subfamily also includes CadA, from the gram-negative bacilli, Stenotrophomonas maltophilia D457R, which is a cadmium efflux pump acquired as part of a cluster of antibiotic and heavy metal resistance genes from gram-positive bacteria. This subclass of P-type ATPase is also referred to as CPx-type ATPases because their amino acid sequences contain a characteristic CPC or CPH motif associated with a stretch of hydrophobic amino acids and N-terminal ion-binding sequences. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319845 [Multi-domain]  Cd Length: 599  Bit Score: 107.12  E-value: 1.45e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  172 VIRGGEVCQISVGDILVGDIAQVKYGDLLPADGCLIQSNDLkVDESSLTGESDHVKKGpdVDPMVLSGTHVMEGSGKMVV 251
Cdd:cd07545   100 VRRDGQEREVPVAEVAVGDRMIVRPGERIAMDGIIVRGESS-VNQAAITGESLPVEKG--VGDEVFAGTLNGEGALEVRV 176
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  252 TAvgvnsqagiiftllgAAVDEQEAEIKKMKKEAKrankqknltgendgrsqikGSQAPSQRetvtseitksesegnhlp 331
Cdd:cd07545   177 TK---------------PAEDSTIARIIHLVEEAQ-------------------AERAPTQA------------------ 204
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  332 qssssgaaetghkkeksvLQAKLTKLAIQIGYAgstIAVLTVIILIIQFCIKTFvidekPWkntyannlvkhLIIGVTVL 411
Cdd:cd07545   205 ------------------FVDRFARYYTPVVMA---IAALVAIVPPLFFGGAWF-----TW-----------IYRGLALL 247
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  412 VVAVPEGL----PLAVTLSLAYSVKKMMkdnnLVRHLDACETMGNATAICSDKTGTLTTNRMTVVQSYICEklckvlptl 487
Cdd:cd07545   248 VVACPCALvistPVSIVSAIGNAARKGV----LIKGGVYLEELGRLKTVAFDKTGTLTKGKPVVTDVVVLG--------- 314
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  488 sdiPQHVGNLITMGISVNSAYTSNIMAghnpgdlpiqvgnktecALLGFVQGLGVKYQSIRDeitedkftrvytFNSvrk 567
Cdd:cd07545   315 ---GQTEKELLAIAAALEYRSEHPLAS-----------------AIVKKAEQRGLTLSAVEE------------FTA--- 359
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  568 smgtviprpnggyrLYTKGASEIIMKKCAFIYGHEgtlekftrdMQERLIREVIEPMACDgLRTISVAyrdfvpGKAAIn 647
Cdd:cd07545   360 --------------LTGRGVRGVVNGTTYYIGSPR---------LFEELNLSESPALEAK-LDALQNQ------GKTVM- 408
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  648 eVHIDGEpnwddeenimtnlTCLCVVGIEDPVRPEVPDAIRKCQRAGI--TVrMVTGDNINTARSIASKCGIlrpnddfl 725
Cdd:cd07545   409 -ILGDGE-------------RILGVIAVADQVRPSSRNAIAALHQLGIkqTV-MLTGDNPQTAQAIAAQVGV-------- 465
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  726 ilegkefnrrirdsnGDIQQHLIdkvwpklrvlarssPTDKYTLVKGIidstvSENREVVAVTGDGTNDGPALKKADVGF 805
Cdd:cd07545   466 ---------------SDIRAELL--------------PQDKLDAIEAL-----QAEGGRVAMVGDGVNDAPALAAADVGI 511
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  806 AMGIAGTDVAKEASDIILTDDNFSSIVKAVMWGRNVYDSIAKFLQFQLTVNVVAVIVAFIGacavqdsplkaVQMLWVNL 885
Cdd:cd07545   512 AMGAAGTDTALETADIALMGDDLRKLPFAVRLSRKTLAIIKQNIAFALGIKLIALLLVIPG-----------WLTLWMAV 580

                  ....*...
gi 320541585  886 IMDTLASL 893
Cdd:cd07545   581 FADMGASL 588
P-type_ATPase_Pb_Zn_Cd2-like cd07546
P-type heavy metal-transporting ATPase, similar to Escherichia coli ZntA which is selective ...
172-897 1.72e-20

P-type heavy metal-transporting ATPase, similar to Escherichia coli ZntA which is selective for Pb(2+), Zn(2+), and Cd(2+); Escherichia coli ZntA mediates resistance to toxic levels of selected divalent metal ions. ZntA has the highest selectivity for Pb(2+), followed by Zn(2+) and Cd(2+); it also shows low levels of activity with Cu(2+), Ni(2+), and Co(2+). It is upregulated by the transcription factor ZntR at high zinc concentrations. This subclass of P-type ATPase is also referred to as CPx-type ATPases because their amino acid sequences contain a characteristic CPC or CPH motif associated with a stretch of hydrophobic amino acids and N-terminal ion-binding sequences. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319846 [Multi-domain]  Cd Length: 597  Bit Score: 97.09  E-value: 1.72e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  172 VIRGGEVCQISVGDILVGDIAQVKYGDLLPADGCLIQSNDlKVDESSLTGESDHVKKGPdvdpmvlsGTHVMEGSgkmvv 251
Cdd:cd07546   103 REENGERREVPADSLRPGDVIEVAPGGRLPADGELLSGFA-SFDESALTGESIPVEKAA--------GDKVFAGS----- 168
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  252 tavgVNSQAGIIFTLLGAAVDEQEAEIKKMKKEAKRankqknltgendgrsqikgSQAPSQRetvtseitksesegnhlp 331
Cdd:cd07546   169 ----INVDGVLRIRVTSAPGDNAIDRILHLIEEAEE-------------------RRAPIER------------------ 207
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  332 qssssgaaetghkkeksvLQAKLTKLaiqigYagsTIAVLTVIILIIQFCIKTFVIDEKPWkntyannlvkhLIIGVTVL 411
Cdd:cd07546   208 ------------------FIDRFSRW-----Y---TPAIMAVALLVIVVPPLLFGADWQTW-----------IYRGLALL 250
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  412 VVAVPEGL----PLAVTLSLAYSVKKMMkdnnLVRHLDACETMGNATAICSDKTGTLTTNRmtvvqsyiceklckvlPTL 487
Cdd:cd07546   251 LIGCPCALvistPAAITSGLAAAARRGA----LIKGGAALEQLGRVTTVAFDKTGTLTRGK----------------PVV 310
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  488 SDIpqhvgnlitmgisvnsaytsnimaghnpgdLPIQVGNKTECALLGFVQGLGVKY---QSIRDEITEDkftrvytfns 564
Cdd:cd07546   311 TDV------------------------------VPLTGISEAELLALAAAVEMGSSHplaQAIVARAQAA---------- 350
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  565 vrksmGTVIPRPNGGYRLYTKGASEIIMKKCAFIYGHEGTLEKFTRDMQERlirevIEPMACDGlRTISVAYRDFVPgka 644
Cdd:cd07546   351 -----GLTIPPAEEARALVGRGIEGQVDGERVLIGAPKFAADRGTLEVQGR-----IAALEQAG-KTVVVVLANGRV--- 416
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  645 ainevhidgepnwddeenimtnltcLCVVGIEDPVRPEVPDAIRKCQRAGITVRMVTGDNINTARSIASKCGIlrpnddf 724
Cdd:cd07546   417 -------------------------LGLIALRDELRPDAAEAVAELNALGIKALMLTGDNPRAAAAIAAELGL------- 464
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  725 lilegkefnrrirdsngDIQQHLIdkvwpklrvlarssPTDKYTLVKGIidstvsENREVVAVTGDGTNDGPALKKADVG 804
Cdd:cd07546   465 -----------------DFRAGLL--------------PEDKVKAVREL------AQHGPVAMVGDGINDAPAMKAASIG 507
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  805 FAMGiAGTDVAKEASDIILTDDNFSSIVKAVMWGRNVYDSIAKFLQFQLTVNVVAVIVAFIGacavqdsplkaVQMLWVN 884
Cdd:cd07546   508 IAMG-SGTDVALETADAALTHNRLGGVAAMIELSRATLANIRQNITIALGLKAVFLVTTLLG-----------ITGLWLA 575
                         730
                  ....*....|...
gi 320541585  885 LIMDTLASlALAT 897
Cdd:cd07546   576 VLADTGAT-VLVT 587
P-type_ATPase_APLT_Neo1-like cd07541
Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Neo1p and human ...
421-851 2.46e-19

Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Neo1p and human putative APLT, ATP9B; Aminophospholipid translocases (APLTs), also known as type 4 P-type ATPases, act as a flippases, and translocate specific phospholipids from the exoplasmic leaflet to the cytoplasmic leaflet of biological membranes. The yeast Neo1 gene is an essential gene; Neo1p localizes to the endoplasmic reticulum and the Golgi complex and plays a role in membrane trafficking within the endomembrane system. Also included in this sub family is human putative ATPase phospholipid transporting 9B, ATP9B, which localizes to the trans-golgi network in a CDC50 protein-independent manner. Levels of ATP9B, along with levels of other ATPase genes, may contribute to expressivity of and atypical presentations of Hailey-Hailey disease (HHD), and the ATP9B gene has recently been identified as a putative Alzheimer's disease loci. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319841 [Multi-domain]  Cd Length: 792  Bit Score: 94.01  E-value: 2.46e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  421 LAVTLSLAYSV--KKMMKDNNL----VRHLDACETMGNATAICSDKTGTLTTNRMTVvqsyiceklcKVLptlsdipqHV 494
Cdd:cd07541   288 LRVNLDMAKIVysWQIEHDKNIpgtvVRTSTIPEELGRIEYLLSDKTGTLTQNEMVF----------KKL--------HL 349
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  495 GnliTMGISVNSaytsnimaghnpgdlpiqvgnktecallgfvqglgVKYQSIRdeitedkftrVYTFNSVRKSMGTVIP 574
Cdd:cd07541   350 G---TVSYGGQN-----------------------------------LNYEILQ----------IFPFTSESKRMGIIVR 381
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  575 RP-NGGYRLYTKGAsEIIMKKcafIYGHEGTLEKFTRDmqerlireviepMACDGLRTISVAYRDFVPGK-AAINEVHID 652
Cdd:cd07541   382 EEkTGEITFYMKGA-DVVMSK---IVQYNDWLEEECGN------------MAREGLRTLVVAKKKLSEEEyQAFEKRYNA 445
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  653 GEPNWDDE--------ENIMTNLTCLCVVGIEDPVRPEVPDAIRKCQRAGITVRMVTGDNINTARSIASKCGILRPNDDF 724
Cdd:cd07541   446 AKLSIHDRdlkvaevvESLERELELLCLTGVEDKLQEDVKPTLELLRNAGIKIWMLTGDKLETATCIAKSSKLVSRGQYI 525
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  725 LILEG--------KEFN--RRIRDS----NGD--------IQQHLIDKVWPKLRVLA-RSSPTDKYTLVKGIIDSTvseN 781
Cdd:cd07541   526 HVFRKvttreeahLELNnlRRKHDCalviDGEslevclkyYEHEFIELACQLPAVVCcRCSPTQKAQIVRLIQKHT---G 602
                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 320541585  782 REVVAVtGDGTNDGPALKKADVGfaMGIAGTDvAKEAS---DIILTDdnFSSIVKAVMW-GRNVYDSIAKFLQF 851
Cdd:cd07541   603 KRTCAI-GDGGNDVSMIQAADVG--VGIEGKE-GKQASlaaDFSITQ--FSHIGRLLLWhGRNSYKRSAKLAQF 670
Cation_ATPase pfam13246
Cation transport ATPase (P-type); This domain is found in cation transport ATPases, including ...
517-598 3.12e-19

Cation transport ATPase (P-type); This domain is found in cation transport ATPases, including phospholipid-transporting ATPases, calcium-transporting ATPases, and sodium-potassium ATPases.


Pssm-ID: 463817 [Multi-domain]  Cd Length: 91  Bit Score: 83.42  E-value: 3.12e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585   517 NPGDLPIQVGNKTECALLGFVQGLGVKYQSIRDEitedkFTRVYT--FNSVRKSMGTVI-PRPNGGYRLYTKGASEIIMK 593
Cdd:pfam13246   12 EEKGKWEIVGDPTESALLVFAEKMGIDVEELRKD-----YPRVAEipFNSDRKRMSTVHkLPDDGKYRLFVKGAPEIILD 86

                   ....*
gi 320541585   594 KCAFI 598
Cdd:pfam13246   87 RCTTI 91
P-type_ATPase_cation cd02082
P-type cation-transporting ATPases, similar to human ATPase type 13A1-A4 (ATP13A1-A4) proteins ...
410-815 3.39e-19

P-type cation-transporting ATPases, similar to human ATPase type 13A1-A4 (ATP13A1-A4) proteins and Saccharomyces cerevisiae Ypk9p and Spf1p; Saccharomyces cerevisiae Yph9p localizes to the yeast vacuole and may play a role in sequestering heavy metal ions, its deletion confers sensitivity for growth for cadmium, manganese, nickel or selenium. Saccharomyces 1 Spf1p may mediate manganese transport into the endoplasmic reticulum. Human ATP13A2 (PARK9/CLN12) is a lysosomal transporter with zinc as the possible substrate. Mutation in the ATP13A2 gene has been linked to Parkinson's disease and Kufor-Rakeb syndrome, and to neuronal ceroid lipofuscinoses. ATP13A3/AFURS1 is a candidate gene for oculo auriculo vertebral spectrum (OAVS), being one of nine genes included in a 3q29 microduplication in a patient with OAVS. Mutation in the human ATP13A4 may be involved in a speech-language disorder. The expression of ATP13A1 has been followed during mouse development, ATP13A1 transcript expression showed an increase as development progressed, with the highest expression at the peak of neurogenesis. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319777 [Multi-domain]  Cd Length: 786  Bit Score: 93.81  E-value: 3.39e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  410 VLVVAVPEGLPLAVTLSLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTTNRMTVVQSYICEKLCKVLPTLSD 489
Cdd:cd02082   260 ILTYSVPPGLPMLIAITNFVGLKRLKKNQILCQDPNRISQAGRIQTLCFDKTGTLTEDKLDLIGYQLKGQNQTFDPIQCQ 339
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  490 IPQHVGNLITMGISVNSAYTSNimaghnpGDLpiqVGNKTECALLGFVqGLGVKYQSIRDEITED------KFTRVYTFN 563
Cdd:cd02082   340 DPNNISIEHKLFAICHSLTKIN-------GKL---LGDPLDVKMAEAS-TWDLDYDHEAKQHYSKsgtkrfYIIQVFQFH 408
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  564 SVRKSMGTVIPRPNGG-----YRLYTKGASEIIMKKCAfiyghegTLEKFTRDMQERLIREviepmacdGLRTISVAYRD 638
Cdd:cd02082   409 SALQRMSVVAKEVDMItkdfkHYAFIKGAPEKIQSLFS-------HVPSDEKAQLSTLINE--------GYRVLALGYKE 473
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  639 fvpgkaaINEVHIDGEPNWDdEENIMTNLTCLCVVGIEDPVRPEVPDAIRKCQRAGITVRMVTGDNINTARSIASKCGIL 718
Cdd:cd02082   474 -------LPQSEIDAFLDLS-REAQEANVQFLGFIIYKNNLKPDTQAVIKEFKEACYRIVMITGDNPLTALKVAQELEII 545
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  719 RPNDDFLILEGkeFNRRIRDSNgDIQQHLIdkvwPKLRVLARSSPTDKYTLVKgiidsTVSENREVVAVTGDGTNDGPAL 798
Cdd:cd02082   546 NRKNPTIIIHL--LIPEIQKDN-STQWILI----IHTNVFARTAPEQKQTIIR-----LLKESDYIVCMCGDGANDCGAL 613
                         410
                  ....*....|....*..
gi 320541585  799 KKADVGFAMGIAGTDVA 815
Cdd:cd02082   614 KEADVGISLAEADASFA 630
P-type_ATPase_K cd02078
potassium-transporting ATPase ATP-binding subunit, KdpB, a subunit of the prokaryotic ...
672-839 3.46e-18

potassium-transporting ATPase ATP-binding subunit, KdpB, a subunit of the prokaryotic high-affinity potassium uptake system KdpFABC; similar to Escherichia coli KdpB; KdpFABC is a prokaryotic high-affinity potassium uptake system. It is expressed under K(+) limiting conditions when the other potassium transport systems are not able to provide a sufficient flow of K(+) into the bacteria. The KdpB subunit represents the catalytic subunit performing ATP hydrolysis. KdpB is comprised of four domains: the transmembrane domain, the nucleotide-binding domain, the phosphorylation domain, and the actuator domain. The P-type ATPases, are a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319773 [Multi-domain]  Cd Length: 667  Bit Score: 90.01  E-value: 3.46e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  672 VVGIEDPVRPEVPDAIRKCQRAGITVRMVTGDNINTARSIASKCGIlrpnDDFLilegkefnrrirdsngdiqqhlidkv 751
Cdd:cd02078   430 VIYLKDIIKPGIKERFAELRKMGIKTVMITGDNPLTAAAIAAEAGV----DDFL-------------------------- 479
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  752 wpklrvlARSSPTDKYTLVKgiidsTVSENREVVAVTGDGTNDGPALKKADVGFAMGiAGTDVAKEASDIILTDDNFSSI 831
Cdd:cd02078   480 -------AEAKPEDKLELIR-----KEQAKGKLVAMTGDGTNDAPALAQADVGVAMN-SGTQAAKEAGNMVDLDSDPTKL 546

                  ....*...
gi 320541585  832 VKAVMWGR 839
Cdd:cd02078   547 IEVVEIGK 554
P-type_ATPase_cation cd07543
P-type cation-transporting ATPases, similar to human cation-transporting ATPase type 13A1 ...
404-807 1.37e-17

P-type cation-transporting ATPases, similar to human cation-transporting ATPase type 13A1 (ATP13A1) and Saccharomyces manganese-transporting ATPase 1 Spf1p; Saccharomyces Spf1p may mediate manganese transport into the endoplasmic reticulum (ER); one consequence of deletion of SPF1 is severe ER stress. This subfamily also includes Arabidopsis thaliana MIA (Male Gametogenesis Impaired Anthers) protein which is highly abundant in the endoplasmic reticulum and small vesicles of developing pollen grains and tapetum cells. The MIA gene functionally complements a mutant in the SPF1 from Saccharomyces cerevisiae. The expression of ATP13A1 has been followed during mouse development, ATP13A1 transcript expression showed an increase as development progressed, with the highest expression at the peak of neurogenesis. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319843 [Multi-domain]  Cd Length: 804  Bit Score: 88.59  E-value: 1.37e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  404 LIIGVTVLVVAV-PEGLP----LAVTLSLAYSVKKMMKDNNLVR-----HLDACetmgnataiCSDKTGTLTTNRMtVVQ 473
Cdd:cd07543   261 LFLECTLILTSVvPPELPmelsLAVNTSLIALAKLYIFCTEPFRipfagKVDIC---------CFDKTGTLTSDDL-VVE 330
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  474 SYICEKLCK-VLPTLSDIPQHVGNLITmgisvnsayTSNIMAGHNPGDLpiqVGNKTECALLGFVQ---GLGVKYQSIRD 549
Cdd:cd07543   331 GVAGLNDGKeVIPVSSIEPVETILVLA---------SCHSLVKLDDGKL---VGDPLEKATLEAVDwtlTKDEKVFPRSK 398
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  550 EITEDKFTRVYTFNSVRKSMGTV--IPRPNGGYRLY---TKGASEIIMKKCAFIYGH-EGTLEKFTRDmqerlireviep 623
Cdd:cd07543   399 KTKGLKIIQRFHFSSALKRMSVVasYKDPGSTDLKYivaVKGAPETLKSMLSDVPADyDEVYKEYTRQ------------ 466
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  624 macdGLRTISVAYRDFvpgkaainEVHIDGEPNWDDEENIMTNLTCLCVVGIEDPVRPEVPDAIRKCQRAGITVRMVTGD 703
Cdd:cd07543   467 ----GSRVLALGYKEL--------GHLTKQQARDYKREDVESDLTFAGFIVFSCPLKPDSKETIKELNNSSHRVVMITGD 534
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  704 NINTARSIASKCGILRpnDDFLILEGKEfnrrirdsngdiqqhlIDKVW-----PKLRVLARSSPTDKYTLVkgiidSTV 778
Cdd:cd07543   535 NPLTACHVAKELGIVD--KPVLILILSE----------------EGKSNewkliPHVKVFARVAPKQKEFII-----TTL 591
                         410       420
                  ....*....|....*....|....*....
gi 320541585  779 SENREVVAVTGDGTNDGPALKKADVGFAM 807
Cdd:cd07543   592 KELGYVTLMCGDGTNDVGALKHAHVGVAL 620
P-type_ATPase-Cd_Zn_Co_like cd07548
P-type heavy metal-transporting ATPase, similar to Bacillus subtilis CadA which appears to ...
675-839 3.60e-17

P-type heavy metal-transporting ATPase, similar to Bacillus subtilis CadA which appears to transport cadmium, zinc and cobalt but not copper out of the cell; Bacillus subtilis CadA/YvgW appears to transport cadmium, zinc and cobalt but not copper, out of the cell. Functions in metal ion resistance and cellular metal ion homeostasis. CadA/YvgW is also important for sporulation in B. subtilis, the significant specific expression of the cadA/yvgW gene during the late stage of sporulation, is controlled by forespore-specific sigma factor, sigma G, and mother cell-specific sigma factor, sigma E. This subfamily also includes Helicobacter pylori CadA an essential resistance pump with ion specificity towards Cd(2+), Zn(2+) and Co(2+), and Zn-transporting ATPase, ZiaA(N) in Synechocystis PCC 6803. Transcription of ziaA is induced by Zn under the control of the Zn responsive repressor ZiaR. This subclass of P-type ATPase is also referred to as CPx-type ATPases because their amino acid sequences contain a characteristic CPC or CPH motif associated with a stretch of hydrophobic amino acids and N-terminal ion-binding sequences. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319847 [Multi-domain]  Cd Length: 604  Bit Score: 86.52  E-value: 3.60e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  675 IEDPVRPEVPDAIRKCQRAGIT-VRMVTGDNINTARSIASKCGIlrpnddflilegkefnrrirdsngdiqqhliDKVWP 753
Cdd:cd07548   426 ISDEIKEDAKEAIKGLKELGIKnLVMLTGDRKSVAEKVAKKLGI-------------------------------DEVYA 474
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  754 KLrvlarsSPTDKYTLVKGIIDstvsENREVVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFSSIVK 833
Cdd:cd07548   475 EL------LPEDKVEKVEELKA----ESKGKVAFVGDGINDAPVLARADVGIAMGGLGSDAAIEAADVVLMNDEPSKVAE 544

                  ....*.
gi 320541585  834 AVMWGR 839
Cdd:cd07548   545 AIKIAR 550
Cation_ATPase_N pfam00690
Cation transporter/ATPase, N-terminus; Members of this families are involved in Na+/K+, H+/K+, ...
36-103 8.50e-16

Cation transporter/ATPase, N-terminus; Members of this families are involved in Na+/K+, H+/K+, Ca++ and Mg++ transport.


Pssm-ID: 459907 [Multi-domain]  Cd Length: 68  Bit Score: 72.98  E-value: 8.50e-16
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 320541585    36 NGGIHELCKKLYTSPNEGLSGSKAdeEHRRETFGSNVIPPKPPKTFLTLVWEALQDVTLIILEVAALV 103
Cdd:pfam00690    3 ALSVEEVLKKLGTDLEKGLTEAEA--EKRLKKYGPNELPEKKPKSLWKLFLRQFKDPLIIILLIAAIV 68
kdpB TIGR01497
K+-transporting ATPase, B subunit; This model describes the P-type ATPase subunit of the ...
672-947 3.91e-14

K+-transporting ATPase, B subunit; This model describes the P-type ATPase subunit of the complex responsible for translocating potassium ions across biological membranes in microbes. In E. coli and other species, this complex consists of the proteins KdpA, KdpB, KdpC and KdpF. KdpB is the ATPase subunit, while KdpA is the potassium-ion translocating subunit. The function of KdpC is unclear, although cit has been suggested to couple the ATPase subunit to the ion-translocating subunit, while KdpF serves to stabilize the complex. The potassium P-type ATPases have been characterized as Type IA based on a phylogenetic analysis which places this clade closest to the heavy-metal translocating ATPases (Type IB). Others place this clade closer to the Na+/K+ antiporter type (Type IIC) based on physical characteristics. This model is very clear-cut, with a strong break between trusted hits and noise. All members of the seed alignment, from Clostridium, Anabaena and E. coli are in the characterized table. One sequence above trusted, OMNI|NTL01TA01282, is apparently mis-annotated in the primary literature, but properly annotated by TIGR. [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 130561 [Multi-domain]  Cd Length: 675  Bit Score: 77.23  E-value: 3.91e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585   672 VVGIEDPVRPEVPDAIRKCQRAGITVRMVTGDNINTARSIASKCGIlrpnDDFLilegkefnrrirdsngdiqqhlidkv 751
Cdd:TIGR01497  440 VIYLKDIVKGGIKERFAQLRKMGIKTIMITGDNRLTAAAIAAEAGV----DDFI-------------------------- 489
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585   752 wpklrvlARSSPTDKYTLVKgiidSTVSENReVVAVTGDGTNDGPALKKADVGFAMGiAGTDVAKEASDIILTDDNFSSI 831
Cdd:TIGR01497  490 -------AEATPEDKIALIR----QEQAEGK-LVAMTGDGTNDAPALAQADVGVAMN-SGTQAAKEAANMVDLDSDPTKL 556
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585   832 VKAVMWGRNVYDSIAKFLQFQLTvNVVAVIVAFIGAC-AVQDSPLKAVQMLWV----NLIMDTLASLALATEFPTPDLLL 906
Cdd:TIGR01497  557 IEVVHIGKQLLITRGALTTFSIA-NDVAKYFAIIPAIfAAAYPQLQALNIMCLhspdSAILSALIFNALIIPALIPLALK 635
                          250       260       270       280
                   ....*....|....*....|....*....|....*....|..
gi 320541585   907 RKPYgrtKPLISRTMM-KNILGQALYQLIIIFGLLFVGDVIL 947
Cdd:TIGR01497  636 GVSY---RPLTASALLrRNLWIYGLGGLIVPFIGIKVIDLLI 674
P-type_ATPase_HM cd07553
P-type heavy metal-transporting ATPase; uncharacterized subfamily; Uncharacterized subfamily ...
183-899 8.94e-13

P-type heavy metal-transporting ATPase; uncharacterized subfamily; Uncharacterized subfamily of the heavy metal-transporting ATPases (Type IB ATPases) which transport heavy metal ions (Cu(+), Cu(2+), Zn(2+), Cd(2+), Co(2+), etc.) across biological membranes. The characteristic N-terminal heavy metal associated (HMA) domain of this group is essential for the binding of metal ions. This subclass of P-type ATPase is also referred to as CPx-type ATPases because their amino acid sequences contain a characteristic CPC or CPH motif associated with a stretch of hydrophobic amino acids and N-terminal ion-binding sequences. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319851 [Multi-domain]  Cd Length: 610  Bit Score: 72.55  E-value: 8.94e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  183 VGDILVGDIAQVKYGDLLPADGCLIqSNDLKVDESSLTGESDHVKKGPDVDpmVLSGTHVMEGSGKMVVTAVGVNSQAGI 262
Cdd:cd07553   143 ADQIKSGDVYLVASGQRVPVDGKLL-SEQASIDMSWLTGESLPRIVERGDK--VPAGTSLENQAFEIRVEHSLAESWSGS 219
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  263 IFTllgaavdeqeaeikkmKKEAKRANKqknltgendgrsqikgsqapSQRETVTSEItksesegnhlpqssssgaaetg 342
Cdd:cd07553   220 ILQ----------------KVEAQEARK--------------------TPRDLLADKI---------------------- 241
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  343 hkkeksvlqakltklaiqIGYagstiavLTVIILIIQFCIKTFvidekpWKNTYANNLVKHLIigvTVLVVAVPEGLPLA 422
Cdd:cd07553   242 ------------------IHY-------FTVIALLIAVAGFGV------WLAIDLSIALKVFT---SVLIVACPCALALA 287
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  423 VTLSLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTTNRMTVVqsyiceklckvlptlSDIPQHVGNLITMGI 502
Cdd:cd07553   288 TPFTDEIALARLKKKGVLIKNASSLERLSRVRTIVFDKTGTLTRGKSSFV---------------MVNPEGIDRLALRAI 352
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  503 SVNSAYTSNimaghnpgdlPIQvgnktecallgfvqglgvkyQSIRDEITEdkftrvytfnsvrksmgtviprpNGGYRL 582
Cdd:cd07553   353 SAIEAHSRH----------PIS--------------------RAIREHLMA-----------------------KGLIKA 379
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  583 YTKGASEIIMKkcafiyGHEGTLEKFtrdmqerLIREVIEPMACDGLRTISVAYRDfvpgkaainevhidgepnwddeen 662
Cdd:cd07553   380 GASELVEIVGK------GVSGNSSGS-------LWKLGSAPDACGIQESGVVIARD------------------------ 422
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  663 imtnLTCLCVVGIEDPVRPEVPDAIRKCQRAGITVRMVTGDNINTARSIASKCGIlrpnddflilegkefnrrirdsnGD 742
Cdd:cd07553   423 ----GRQLLDLSFNDLLRPDSNREIEELKKGGLSIAILSGDNEEKVRLVGDSLGL-----------------------DP 475
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  743 IQqhlidkvwpklrVLARSSPTDKYTLVKgiidsTVSEnrEVVAVTGDGTNDGPALKKADVGFAMGiAGTDVAKEASDII 822
Cdd:cd07553   476 RQ------------LFGNLSPEEKLAWIE-----SHSP--ENTLMVGDGANDALALASAFVGIAVA-GEVGVSLEAADIY 535
                         650       660       670       680       690       700       710
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 320541585  823 LTDDNFSSIVKAVMWGRNVYDSIAKFLQFQLTVNVVAVIVAFIGACavqdSPLKAVQMLWVNLIMdTLASLALATEF 899
Cdd:cd07553   536 YAGNGIGGIRDLLTLSKQTIKAIKGLFAFSLLYNLVAIGLALSGWI----SPLVAAILMPLSSIT-ILGIVWAALGF 607
zntA PRK11033
zinc/cadmium/mercury/lead-transporting ATPase; Provisional
672-824 2.61e-12

zinc/cadmium/mercury/lead-transporting ATPase; Provisional


Pssm-ID: 236827 [Multi-domain]  Cd Length: 741  Bit Score: 71.18  E-value: 2.61e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  672 VVGIEDPVRPEVPDAIRKCQRAGITVRMVTGDNINTARSIASKCGIlrpndDFlilegkefnrrirdsngdiqqhlidkv 751
Cdd:PRK11033  562 LIALQDTLRADARQAISELKALGIKGVMLTGDNPRAAAAIAGELGI-----DF--------------------------- 609
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 320541585  752 wpklrvlaRSS--PTDKYTLVkgiidsTVSENREVVAVTGDGTNDGPALKKADVGFAMGiAGTDVAKEASDIILT 824
Cdd:PRK11033  610 --------RAGllPEDKVKAV------TELNQHAPLAMVGDGINDAPAMKAASIGIAMG-SGTDVALETADAALT 669
copA PRK10671
copper-exporting P-type ATPase CopA;
672-835 2.64e-12

copper-exporting P-type ATPase CopA;


Pssm-ID: 182635 [Multi-domain]  Cd Length: 834  Bit Score: 71.31  E-value: 2.64e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  672 VVGIEDPVRPEVPDAIRKCQRAGITVRMVTGDNINTARSIASKCGILRpnddflilegkefnrrirdsngdiqqhLIDKV 751
Cdd:PRK10671  644 LLAIRDPLRSDSVAALQRLHKAGYRLVMLTGDNPTTANAIAKEAGIDE---------------------------VIAGV 696
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  752 WPKLRVLArssptdkytlvkgiIDSTVSENREVvAVTGDGTNDGPALKKADVGFAMGiAGTDVAKEASDIILTDDNFSSI 831
Cdd:PRK10671  697 LPDGKAEA--------------IKRLQSQGRQV-AMVGDGINDAPALAQADVGIAMG-GGSDVAIETAAITLMRHSLMGV 760

                  ....
gi 320541585  832 VKAV 835
Cdd:PRK10671  761 ADAL 764
Cation_ATPase_N smart00831
Cation transporter/ATPase, N-terminus; This entry represents the conserved N-terminal region ...
39-107 3.24e-12

Cation transporter/ATPase, N-terminus; This entry represents the conserved N-terminal region found in several classes of cation-transporting P-type ATPases, including those that transport H+, Na+, Ca2+, Na+/K+, and H+/K+. In the H+/K+- and Na+/K+-exchange P-ATPases, this domain is found in the catalytic alpha chain. In gastric H+/K+-ATPases, this domain undergoes reversible sequential phosphorylation inducing conformational changes that may be important for regulating the function of these ATPases.


Pssm-ID: 214842 [Multi-domain]  Cd Length: 75  Bit Score: 62.99  E-value: 3.24e-12
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 320541585     39 IHELCKKLYTSPNEGLSGSKADEehRRETFGSNVIPPKPPKTFLTLVWEALQDVTLIILEVAALVSLGL 107
Cdd:smart00831    9 LEEVLERLQTDLEKGLSSEEAAR--RLERYGPNELPPPKKTSPLLRFLRQFHNPLIYILLAAAVLSALL 75
ATP_Ca_trans_C pfam12424
Plasma membrane calcium transporter ATPase C terminal; This domain family is found in ...
1096-1142 2.40e-11

Plasma membrane calcium transporter ATPase C terminal; This domain family is found in eukaryotes, and is approximately 60 amino acids in length. The family is found in association with pfam00689, pfam00122, pfam00702, pfam00690. There is a conserved QTQ sequence motif. This family is the C terminal of a calcium transporting ATPase located in the plasma membrane.


Pssm-ID: 463575  Cd Length: 47  Bit Score: 59.73  E-value: 2.40e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 320541585  1096 GQILWIRGLTRLQTQV-IGGELQERL-IPVpySKSNTDQAIRVVNAFRQ 1142
Cdd:pfam12424    1 GQILWFRGLNRIQTQIrVVKAFQSSLrEGI--QKPYLRNSIHSFMSHPE 47
PRK14010 PRK14010
K(+)-transporting ATPase subunit B;
663-874 1.96e-10

K(+)-transporting ATPase subunit B;


Pssm-ID: 184448 [Multi-domain]  Cd Length: 673  Bit Score: 65.11  E-value: 1.96e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  663 IMTNLTCLCVVGIEDPVRPEVPDAIRKCQRAGITVRMVTGDNINTARSIASKCGILRpnddflilegkefnrrirdsngd 742
Cdd:PRK14010  426 VLEDNEILGVIYLKDVIKDGLVERFRELREMGIETVMCTGDNELTAATIAKEAGVDR----------------------- 482
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  743 iqqhlidkvwpklrVLARSSPTDKYTLVKgiidsTVSENREVVAVTGDGTNDGPALKKADVGFAMGiAGTDVAKEASDII 822
Cdd:PRK14010  483 --------------FVAECKPEDKINVIR-----EEQAKGHIVAMTGDGTNDAPALAEANVGLAMN-SGTMSAKEAANLI 542
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 320541585  823 LTDDNFSSIVKAVMWGRNVYDSIAKFLQFQLTvNVVAVIVAFIGACAVQDSP 874
Cdd:PRK14010  543 DLDSNPTKLMEVVLIGKQLLMTRGSLTTFSIA-NDIAKYFAILPAMFMAAMP 593
P-type_ATPase_FixI-like cd02092
Rhizobium meliloti FixI and related proteins; belongs to P-type heavy metal-transporting ...
674-877 1.48e-09

Rhizobium meliloti FixI and related proteins; belongs to P-type heavy metal-transporting ATPase subfamily; FixI may be a pump of a specific cation involved in symbiotic nitrogen fixation. The Rhizobium fixI gene is part of an operon conserved among rhizobia, fixGHIS. FixG, FixH, FixI, and FixS may participate in a membrane-bound complex coupling the FixI cation pump with a redox process catalyzed by FixG, an iron-sulfur protein. This subclass of P-type ATPase is also referred to as CPx-type ATPases because their amino acid sequences contain a characteristic CPC or CPH motif associated with a stretch of hydrophobic amino acids and N-terminal ion-binding sequences. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319782 [Multi-domain]  Cd Length: 605  Bit Score: 61.99  E-value: 1.48e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  674 GIEDPVRPEVPDAIRKCQRAGITVRMVTGDNINTARSIASKCGILRpnddflilegkefnrrirdsngdiqqhlidkvwp 753
Cdd:cd02092   430 PFEDRPRPDAREAISALRALGLSVEILSGDREPAVRALARALGIED---------------------------------- 475
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  754 klrVLARSSPTDKYTLvkgiIDSTVSENREVVAVtGDGTNDGPALKKADVGFAMGIAgTDVAKEASDIILTDDNFSSIVK 833
Cdd:cd02092   476 ---WRAGLTPAEKVAR----IEELKAQGRRVLMV-GDGLNDAPALAAAHVSMAPASA-VDASRSAADIVFLGDSLAPVPE 546
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 320541585  834 AVMWGRNVYDSIAKFLQFQLTVNVVAVIVAFIGacavQDSPLKA 877
Cdd:cd02092   547 AIEIARRARRLIRQNFALAIGYNVIAVPLAIAG----YVTPLIA 586
Hydrolase pfam00702
haloacid dehalogenase-like hydrolase; This family is structurally different from the alpha ...
643-802 5.44e-07

haloacid dehalogenase-like hydrolase; This family is structurally different from the alpha/beta hydrolase family (pfam00561). This family includes L-2-haloacid dehalogenase, epoxide hydrolases and phosphatases. The structure of the family consists of two domains. One is an inserted four helix bundle, which is the least well conserved region of the alignment, between residues 16 and 96 of Swiss:P24069. The rest of the fold is composed of the core alpha/beta domain. Those members with the characteriztic DxD triad at the N-terminus are probably phosphatidylglycerolphosphate (PGP) phosphatases involved in cardiolipin biosynthesis in the mitochondria.


Pssm-ID: 459910 [Multi-domain]  Cd Length: 191  Bit Score: 51.43  E-value: 5.44e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585   643 KAAINEVHIDGEPNWDDEENIMTNLTCLCVVGIEDPVRPEVPDAIRKCQRAGITVRMVTGDNINTARSIASKCGILRPND 722
Cdd:pfam00702   63 EELDILRGLVETLEAEGLTVVLVELLGVIALADELKLYPGAAEALKALKERGIKVAILTGDNPEAAEALLRLLGLDDYFD 142
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585   723 DFLILEGKEFnrrirdsngdiqqhlidkvwpklrvlARSSPTDKYTLVKgiidsTVSENREVVAVTGDGTNDGPALKKAD 802
Cdd:pfam00702  143 VVISGDDVGV--------------------------GKPKPEIYLAALE-----RLGVKPEEVLMVGDGVNDIPAAKAAG 191
PLN03190 PLN03190
aminophospholipid translocase; Provisional
559-711 2.89e-06

aminophospholipid translocase; Provisional


Pssm-ID: 215623 [Multi-domain]  Cd Length: 1178  Bit Score: 51.82  E-value: 2.89e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  559 VYTFNSVRKSMGTVIPRPNGGYRLYTKGASEiimkkcafiygheGTLEKFTRDMQERLIREV---IEPMACDGLRTISVA 635
Cdd:PLN03190  608 LHEFDSDRKRMSVILGCPDKTVKVFVKGADT-------------SMFSVIDRSLNMNVIRATeahLHTYSSLGLRTLVVG 674
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  636 YRDF------------------VPGKAA-INEVhidgepnwddEENIMTNLTCLCVVGIEDPVRPEVPDAIRKCQRAGIT 696
Cdd:PLN03190  675 MRELndsefeqwhfsfeaastaLIGRAAlLRKV----------ASNVENNLTILGASAIEDKLQQGVPEAIESLRTAGIK 744
                         170
                  ....*....|....*
gi 320541585  697 VRMVTGDNINTARSI 711
Cdd:PLN03190  745 VWVLTGDKQETAISI 759
Cof COG0561
Hydroxymethylpyrimidine pyrophosphatase and other HAD family phosphatases [Coenzyme transport ...
681-827 8.93e-05

Hydroxymethylpyrimidine pyrophosphatase and other HAD family phosphatases [Coenzyme transport and metabolism, General function prediction only];


Pssm-ID: 440327 [Multi-domain]  Cd Length: 192  Bit Score: 44.74  E-value: 8.93e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  681 PEVPDAIRKCQRAGITVRMVTGDNINTARSIASKCGIlrpnDDFLILEG-----KEFNRRIRDSngDIQQHLIDKVWPKL 755
Cdd:COG0561    22 PRTKEALRRLREKGIKVVIATGRPLRSALPLLEELGL----DDPLITSNgaliyDPDGEVLYER--PLDPEDVREILELL 95
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585  756 R-------VLARSSPT---------DKYTLVK------GIidstvsENREVVAVtGDGTNDGPALKKADVGFAMGIAgTD 813
Cdd:COG0561    96 RehglhlqVVVRSGPGfleilpkgvSKGSALKklaerlGI------PPEEVIAF-GDSGNDLEMLEAAGLGVAMGNA-PP 167
                         170
                  ....*....|....
gi 320541585  814 VAKEASDIIlTDDN 827
Cdd:COG0561   168 EVKAAADYV-TGSN 180
Cof-subfamily TIGR00099
Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; This subfamily of ...
785-827 1.75e-03

Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; This subfamily of sequences falls within the Class-IIB subfamily (TIGR01484) of the Haloacid Dehalogenase superfamily of aspartate-nucleophile hydrolases. The use of the name "Cof" as an identifier here is arbitrary and refers to the E. coli Cof protein. This subfamily is notable for the large number of recent paralogs in many species. Listeria, for instance, has 12, Clostridium, Lactococcus and Streptococcus pneumoniae have 8 each, Enterococcus and Salmonella have 7 each, and Bacillus subtilus, Mycoplasma, Staphylococcus and E. coli have 6 each. This high degree of gene duplication is limited to the gamma proteobacteria and low-GC gram positive lineages. The profusion of genes in this subfamily is not coupled with a high degree of divergence, so it is impossible to determine an accurate phylogeny at the equivalog level. Considering the relationship of this subfamily to the other known members of the HAD-IIB subfamily (TIGR01484), sucrose and trehalose phosphatases and phosphomannomutase, it seems a reasonable hypothesis that these enzymes act on phosphorylated sugars. Possibly the diversification of genes in this subfamily represents the diverse sugars and polysaccharides that various bacteria find in their biological niches. The members of this subfamily are restricted almost exclusively to bacteria (one sequences from S. pombe scores above trusted, while another is between trusted and noise). It is notable that no archaea are found in this group, the closest relations to the archaea found here being two Deinococcus sequences. [Unknown function, Enzymes of unknown specificity]


Pssm-ID: 272905 [Multi-domain]  Cd Length: 256  Bit Score: 41.49  E-value: 1.75e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 320541585   785 VAVTGDGTNDGPALKKADVGFAMGIAgTDVAKEASDIIlTDDN 827
Cdd:TIGR00099  207 VIAFGDGMNDIEMLEAAGYGVAMGNA-DEELKALADYV-TDSN 247
Hydrolase_3 pfam08282
haloacid dehalogenase-like hydrolase; This family contains haloacid dehalogenase-like ...
721-834 3.02e-03

haloacid dehalogenase-like hydrolase; This family contains haloacid dehalogenase-like hydrolase enzymes.


Pssm-ID: 429897 [Multi-domain]  Cd Length: 255  Bit Score: 40.68  E-value: 3.02e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320541585   721 NDDFLILEGKEFNR-RIRDSNGDIQQ---HLIDKVWPKLRVlARSSP---------TDKYTLVKGIIdSTVSENREVVAV 787
Cdd:pfam08282  131 IDDFELLEDEDINKiLILLDEEDLDElekELKELFGSLITI-TSSGPgyleimpkgVSKGTALKALA-KHLNISLEEVIA 208
                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*..
gi 320541585   788 TGDGTNDGPALKKADVGFAMGIAgTDVAKEASDIILTDDNFSSIVKA 834
Cdd:pfam08282  209 FGDGENDIEMLEAAGLGVAMGNA-SPEVKAAADYVTDSNNEDGVAKA 254
HAD_Pase cd07516
phosphatase, similar to Escherichia coli Cof and Thermotoga maritima TM0651; belongs to the ...
783-827 9.04e-03

phosphatase, similar to Escherichia coli Cof and Thermotoga maritima TM0651; belongs to the haloacid dehalogenase-like superfamily; Escherichia coli Cof is involved in the hydrolysis of HMP-PP (4-amino-2-methyl-5-hydroxymethylpyrimidine pyrophosphate, an intermediate in thiamin biosynthesis), Cof also has phosphatase activity against the coenzymes pyridoxal phosphate (PLP) and FMN. Thermotoga maritima TM0651 acts as a phosphatase with a phosphorylated carbohydrate molecule as a possible substrate. Escherichia coli YbhA is also a member of this family and catalyzes the dephosphorylation of PLP, YbhA can also hydrolyze erythrose-4-phosphate and fructose-1,6-bis-phosphate. Members of this family belong to the haloacid dehalogenase-like (HAD) hydrolases, a large superfamily of diverse enzymes that catalyze carbon or phosphoryl group transfer reactions on a range of substrates, using an active site aspartate in nucleophilic catalysis. Members of this superfamily include 2-L-haloalkanoic acid dehalogenase, azetidine hydrolase, phosphonoacetaldehyde hydrolase, phosphoserine phosphatase, phosphomannomutase, P-type ATPases and many others. HAD hydrolases are found in all three kingdoms of life, and most genomes are predicted to contain multiple HAD-like proteins. Members possess a highly conserved alpha/beta core domain, and many also possess a small cap domain, the fold and function of which is variable. HAD hydrolases are sometimes referred to as belonging to the DDDD superfamily of phosphohydrolases.


Pssm-ID: 319818 [Multi-domain]  Cd Length: 253  Bit Score: 39.50  E-value: 9.04e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 320541585  783 EVVAVtGDGTNDGPALKKADVGFAMGIAgTDVAKEASDIIlTDDN 827
Cdd:cd07516   201 EVIAF-GDNENDLSMLEYAGLGVAMGNA-IDEVKEAADYV-TLTN 242
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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