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    cast calpastatin [ Danio rerio (zebrafish) ]

    Gene ID: 563084, updated on 4-Jan-2025

    Summary

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    Official Symbol
    castprovided by ZNC
    Official Full Name
    calpastatinprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-050810-2
    See related
    Ensembl:ENSDARG00000058693 AllianceGenome:ZFIN:ZDB-GENE-050810-2
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    sb:cb966; zgc:194249
    Summary
    Predicted to enable calcium-dependent cysteine-type endopeptidase inhibitor activity. Predicted to act upstream of or within negative regulation of peptidase activity. Is expressed in several structures, including digestive system; embryonic structure; epidermis; pectoral fin; and periderm. Human ortholog(s) of this gene implicated in PLACK syndrome; Parkinson's disease; autoimmune disease (multiple); congenital myasthenic syndrome 1A; and vasculitis. Orthologous to human CAST (calpastatin). [provided by Alliance of Genome Resources, Jan 2025]
    Orthologs
    human mouse all
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    Genomic context

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    See cast in Genome Data Viewer
    Location:
    chromosome: 21
    Exon count:
    35
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 21 NC_007132.7 (11565888..11657036, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 21 NC_007132.6 (11473258..11564424, complement)

    Chromosome 21 - NC_007132.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100537030 Neighboring gene CD8a molecule Neighboring gene uncharacterized LOC137488783 Neighboring gene uncharacterized LOC108180799 Neighboring gene proprotein convertase subtilisin/kexin type 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Characterization and expression of the calpastatin gene in Cyprinus carpio. Chen WX, et al. Genet Mol Res, 2015 Jul 3. PMID 26214419
    2. Characterization of calpastatin gene in fish: its potential role in muscle growth and fillet quality. Salem M, et al. Comp Biochem Physiol B Biochem Mol Biol, 2005 Aug. PMID 15990347
    3. Characterization and comparative expression of zebrafish calpain system genes during early development. Lepage SE, et al. Dev Dyn, 2008 Mar. PMID 18265014
    4. Evidence for Adaptation to the Tibetan Plateau Inferred from Tibetan Loach Transcriptomes. Wang Y, et al. Genome Biol Evol, 2015 Oct 9. PMID 26454018, Free PMC Article
    5. Novel zebrafish caspase-3 substrates. Valencia CA, et al. Biochem Biophys Res Commun, 2007 Sep 21. PMID 17643392

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC194249

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables calcium-dependent cysteine-type endopeptidase inhibitor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables cysteine-type endopeptidase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptidase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within negative regulation of peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    calpastatin

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001130591.2 → NP_001124063.2  calpastatin

      Status: VALIDATED

      Source sequence(s)
      BX005379, BX511081, BX927307
      UniProtKB/TrEMBL
      A0A8M1NI55
      Conserved Domains (1) summary
      pfam00748
      Location:421 → 568
      Calpain_inhib; Calpain inhibitor

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007132.7 Reference GRCz11 Primary Assembly

      Range
      11565888..11657036 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005161041.5 → XP_005161098.1  calpastatin isoform X23

      UniProtKB/TrEMBL
      A0A8M2B7Y6
      Conserved Domains (1) summary
      pfam00748
      Location:326 → 473
      Calpain_inhib; Calpain inhibitor

    2. XM_005161036.5 → XP_005161093.1  calpastatin isoform X16

      UniProtKB/TrEMBL
      A0A8M2B7Y5
      Conserved Domains (1) summary
      pfam00748
      Location:394 → 541
      Calpain_inhib; Calpain inhibitor

    3. XM_005161025.5 → XP_005161082.1  calpastatin isoform X2

      UniProtKB/TrEMBL
      A0A8M2B865
      Conserved Domains (1) summary
      pfam00748
      Location:437 → 584
      Calpain_inhib; Calpain inhibitor

    4. XM_017352808.3 → XP_017208297.1  calpastatin isoform X36

      UniProtKB/TrEMBL
      A0A8M6YWX8
      Conserved Domains (1) summary
      pfam00748
      Location:288 → 435
      Calpain_inhib; Calpain inhibitor

    5. XM_005161049.5 → XP_005161106.1  calpastatin isoform X34

      UniProtKB/TrEMBL
      A0A8M2B7Z6
      Conserved Domains (1) summary
      pfam00748
      Location:292 → 439
      Calpain_inhib; Calpain inhibitor

    6. XM_005161043.5 → XP_005161100.1  calpastatin isoform X25

      UniProtKB/TrEMBL
      A0A8M2B873
      Conserved Domains (1) summary
      pfam00748
      Location:325 → 472
      Calpain_inhib; Calpain inhibitor

    7. XM_068215911.1 → XP_068072012.1  calpastatin isoform X17

      Related
      ENSDARP00000145456.1, ENSDART00000183811.1

    8. XM_005161034.5 → XP_005161091.1  calpastatin isoform X14

      UniProtKB/TrEMBL
      A0A0R4ILE0, A0A8M2B7Y0
      Conserved Domains (1) summary
      pfam00748
      Location:403 → 550
      Calpain_inhib; Calpain inhibitor

    9. XM_021468879.2 → XP_021324554.1  calpastatin isoform X28

      UniProtKB/TrEMBL
      A0A8M9PID2
      Conserved Domains (1) summary
      pfam00748
      Location:320 → 467
      Calpain_inhib; Calpain inhibitor

    10. XM_005161031.5 → XP_005161088.1  calpastatin isoform X10

      UniProtKB/TrEMBL
      A0A8M2B7Y7
      Conserved Domains (1) summary
      pfam00748
      Location:427 → 574
      Calpain_inhib; Calpain inhibitor

    11. XM_017352801.3 → XP_017208290.1  calpastatin isoform X6

      UniProtKB/TrEMBL
      A0A8M6YUH4

    12. XM_068215910.1 → XP_068072011.1  calpastatin isoform X9

      Related
      ENSDARP00000114134.1, ENSDART00000132699.3

    13. XM_005161027.5 → XP_005161084.1  calpastatin isoform X4

      UniProtKB/TrEMBL
      A0A8M2B7Y1, F1QZT8
      Related
      ENSDARP00000076055.4, ENSDART00000081614.4
      Conserved Domains (1) summary
      pfam00748
      Location:431 → 578
      Calpain_inhib; Calpain inhibitor

    14. XM_021468880.2 → XP_021324555.1  calpastatin isoform X30

      UniProtKB/TrEMBL
      A0A8M9PTZ9
      Conserved Domains (1) summary
      pfam00748
      Location:312 → 459
      Calpain_inhib; Calpain inhibitor

    15. XM_021468882.2 → XP_021324557.1  calpastatin isoform X35

      UniProtKB/TrEMBL
      A0A8M9P3E0
      Conserved Domains (1) summary
      pfam00748
      Location:289 → 436
      Calpain_inhib; Calpain inhibitor

    16. XM_005161046.5 → XP_005161103.1  calpastatin isoform X29

      UniProtKB/TrEMBL
      A0A8M2B800
      Conserved Domains (1) summary
      pfam00748
      Location:316 → 463
      Calpain_inhib; Calpain inhibitor

    17. XM_021468877.2 → XP_021324552.1  calpastatin isoform X26

      UniProtKB/TrEMBL
      A0A8M9P3D7
      Conserved Domains (1) summary
      pfam00748
      Location:322 → 469
      Calpain_inhib; Calpain inhibitor

    18. XM_005161040.5 → XP_005161097.1  calpastatin isoform X21

      UniProtKB/TrEMBL
      A0A8M2B7Z1
      Conserved Domains (1) summary
      pfam00748
      Location:349 → 496
      Calpain_inhib; Calpain inhibitor

    19. XM_005161037.5 → XP_005161094.1  calpastatin isoform X18

      UniProtKB/TrEMBL
      A0A8M2B7Z9
      Conserved Domains (1) summary
      pfam00748
      Location:384 → 531
      Calpain_inhib; Calpain inhibitor

    20. XM_017352802.3 → XP_017208291.1  calpastatin isoform X8

      UniProtKB/TrEMBL
      A0A8M6Z304

    21. XM_005161028.5 → XP_005161085.1  calpastatin isoform X5

      UniProtKB/TrEMBL
      A0A0R4IPE6, A0A8M2B7Z3
      Related
      ENSDARP00000136381.2, ENSDART00000162426.2
      Conserved Domains (1) summary
      pfam00748
      Location:427 → 574
      Calpain_inhib; Calpain inhibitor

    22. XM_068215912.1 → XP_068072013.1  calpastatin isoform X32

    23. XM_021468878.2 → XP_021324553.1  calpastatin isoform X27

      UniProtKB/TrEMBL
      A0A8M9PCR3
      Conserved Domains (1) summary
      pfam00748
      Location:322 → 469
      Calpain_inhib; Calpain inhibitor

    24. XM_021468881.2 → XP_021324556.1  calpastatin isoform X31

      UniProtKB/TrEMBL
      A0A8M9PQJ5
      Conserved Domains (1) summary
      pfam00748
      Location:299 → 446
      Calpain_inhib; Calpain inhibitor

    25. XM_021468876.2 → XP_021324551.1  calpastatin isoform X22

      UniProtKB/TrEMBL
      A0A8M9PQJ2
      Conserved Domains (1) summary
      pfam00748
      Location:326 → 473
      Calpain_inhib; Calpain inhibitor

    26. XM_021468875.2 → XP_021324550.1  calpastatin isoform X20

      UniProtKB/TrEMBL
      A0A8M9PTZ2
      Conserved Domains (1) summary
      pfam00748
      Location:355 → 502
      Calpain_inhib; Calpain inhibitor

    27. XM_021468874.2 → XP_021324549.1  calpastatin isoform X19

      UniProtKB/TrEMBL
      A0A8M9PIC9
      Conserved Domains (1) summary
      pfam00748
      Location:359 → 506
      Calpain_inhib; Calpain inhibitor

    28. XM_021468872.2 → XP_021324547.1  calpastatin isoform X15

      UniProtKB/TrEMBL
      A0A8M9P3D4
      Conserved Domains (1) summary
      pfam00748
      Location:394 → 541
      Calpain_inhib; Calpain inhibitor

    29. XM_021468871.2 → XP_021324546.1  calpastatin isoform X12

      UniProtKB/TrEMBL
      A0A8M9PQI9
      Conserved Domains (1) summary
      pfam00748
      Location:406 → 553
      Calpain_inhib; Calpain inhibitor

    30. XM_021468868.2 → XP_021324543.1  calpastatin isoform X3

      UniProtKB/TrEMBL
      A0A8M9PCQ8
      Conserved Domains (1) summary
      pfam00748
      Location:433 → 580
      Calpain_inhib; Calpain inhibitor

    31. XM_021468870.2 → XP_021324545.1  calpastatin isoform X11

      UniProtKB/TrEMBL
      A0A8M9PTY8
      Conserved Domains (1) summary
      pfam00748
      Location:410 → 557
      Calpain_inhib; Calpain inhibitor

    32. XM_021468869.2 → XP_021324544.1  calpastatin isoform X7

      UniProtKB/TrEMBL
      A0A8M9PIC6
      Conserved Domains (1) summary
      pfam00748
      Location:437 → 584
      Calpain_inhib; Calpain inhibitor

    33. XM_009295209.4 → XP_009293484.1  calpastatin isoform X1

      UniProtKB/TrEMBL
      A0A8M3ALB2
      Conserved Domains (1) summary
      pfam00748
      Location:437 → 584
      Calpain_inhib; Calpain inhibitor

    34. XM_005161048.5 → XP_005161105.1  calpastatin isoform X33

      UniProtKB/TrEMBL
      A0A8M2B7Z6
      Conserved Domains (1) summary
      pfam00748
      Location:292 → 439
      Calpain_inhib; Calpain inhibitor

    35. XM_005161042.5 → XP_005161099.1  calpastatin isoform X24

      UniProtKB/TrEMBL
      A0A8M2B873
      Conserved Domains (1) summary
      pfam00748
      Location:325 → 472
      Calpain_inhib; Calpain inhibitor

    36. XM_005161033.5 → XP_005161090.1  calpastatin isoform X13

      UniProtKB/TrEMBL
      A0A0R4ILE0, A0A8M2B7Y0
      Related
      ENSDARP00000135159.2, ENSDART00000171708.2
      Conserved Domains (1) summary
      pfam00748
      Location:403 → 550
      Calpain_inhib; Calpain inhibitor
    Nucleotide Protein
    Heading Accession and Version

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