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Conserved domains on  [gi|1207159541|ref|XP_021324549|]
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calpastatin isoform X19 [Danio rerio]

Protein Classification

calpastatin family protein( domain architecture ID 10286369)

calpastatin family protein specifically inhibits calpain (calcium-dependent cysteine protease)

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Calpain_inhib pfam00748
Calpain inhibitor; This region is found multiple times in calpain inhibitor proteins.
357-502 8.09e-22

Calpain inhibitor; This region is found multiple times in calpain inhibitor proteins.


:

Pssm-ID: 459923 [Multi-domain]  Cd Length: 129  Bit Score: 91.61  E-value: 8.09e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207159541 357 AMDILSGDFTTPASAPVVKAPVPPAQDTKKHAAvpektkdipktkadaLSSDFVAPAHSAPKVSSAAPKTIPPGPPqtPD 436
Cdd:pfam00748   1 LLDALSSDFTSSSAAPKPKKPAPKAEKSSAAAA---------------LAGEVVSAASASSVKSAAPPPEKKRKDE--VM 63
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1207159541 437 EDPFSALGDTLSAPEPpKKQPDLKPKDIVHEKdVTSKKGVRVGERDDTLPPEYR--FKEEDLKKYPPP 502
Cdd:pfam00748  64 DDALDALSDTLGGREP-DPEEDKPPVDKVKEK-AKEEKREKLGERDDTIPPEYRllPAKDKDGKPLLP 129
Calpain_inhib pfam00748
Calpain inhibitor; This region is found multiple times in calpain inhibitor proteins.
513-655 3.66e-13

Calpain inhibitor; This region is found multiple times in calpain inhibitor proteins.


:

Pssm-ID: 459923 [Multi-domain]  Cd Length: 129  Bit Score: 66.95  E-value: 3.66e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207159541 513 ALDILSGDFTTPSAPSAVSPASKSSAKSSDSalDALAGDFVASSSASSVHSAVSGPPRSDRLLsdGTSSALDALSETLGD 592
Cdd:pfam00748   1 LLDALSSDFTSSSAAPKPKKPAPKAEKSSAA--AALAGEVVSAASASSVKSAAPPPEKKRKDE--VMDDALDALSDTLGG 76
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1207159541 593 IKAAPEPaPVLPKTVVKEKtVIEERVSKPGERDDSLPPDQRftaedrkaFEEAKKKDAKPKQP 655
Cdd:pfam00748  77 REPDPEE-DKPPVDKVKEK-AKEEKREKLGERDDTIPPEYR--------LLPAKDKDGKPLLP 129
Calpain_inhib super family cl08287
Calpain inhibitor; This region is found multiple times in calpain inhibitor proteins.
190-346 3.30e-12

Calpain inhibitor; This region is found multiple times in calpain inhibitor proteins.


The actual alignment was detected with superfamily member pfam00748:

Pssm-ID: 459923 [Multi-domain]  Cd Length: 129  Bit Score: 64.26  E-value: 3.30e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207159541 190 ALESLSSTFVSPAQAAPKKTDVKTETigavdvKSAGTTNfappppsQQKQPASSQAAAVTKSPAPPADKKAKMEthaqpa 269
Cdd:pfam00748   1 LLDALSSDFTSSSAAPKPKKPAPKAE------KSSAAAA-------LAGEVVSAASASSVKSAAPPPEKKRKDE------ 61
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1207159541 270 kaktesdssISLDALDALSDTLGASKPPQKlPELKPGQIVDEKkQTSEKGVRVGERDDTLPPQYR--FKEEDLKKYPPP 346
Cdd:pfam00748  62 ---------VMDDALDALSDTLGGREPDPE-EDKPPVDKVKEK-AKEEKREKLGERDDTIPPEYRllPAKDKDGKPLLP 129
Calpain_inhib super family cl08287
Calpain inhibitor; This region is found multiple times in calpain inhibitor proteins.
59-172 2.00e-09

Calpain inhibitor; This region is found multiple times in calpain inhibitor proteins.


The actual alignment was detected with superfamily member pfam00748:

Pssm-ID: 459923 [Multi-domain]  Cd Length: 129  Bit Score: 56.17  E-value: 2.00e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207159541  59 ATQSSTAAATVKSGAGDPATTQKGSSQVKPQVQVEVGPSAAKV-SADADDPFDALSGTLPSSQPLAPKVHYTGPEIKEpK 137
Cdd:pfam00748  16 PKPKKPAPKAEKSSAAAALAGEVVSAASASSVKSAAPPPEKKRkDEVMDDALDALSDTLGGREPDPEEDKPPVDKVKE-K 94
                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1207159541 138 LKSEKGVLCGERDDTLPPGYRKEDLEKKHGAGVPA 172
Cdd:pfam00748  95 AKEEKREKLGERDDTIPPEYRLLPAKDKDGKPLLP 129
 
Name Accession Description Interval E-value
Calpain_inhib pfam00748
Calpain inhibitor; This region is found multiple times in calpain inhibitor proteins.
357-502 8.09e-22

Calpain inhibitor; This region is found multiple times in calpain inhibitor proteins.


Pssm-ID: 459923 [Multi-domain]  Cd Length: 129  Bit Score: 91.61  E-value: 8.09e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207159541 357 AMDILSGDFTTPASAPVVKAPVPPAQDTKKHAAvpektkdipktkadaLSSDFVAPAHSAPKVSSAAPKTIPPGPPqtPD 436
Cdd:pfam00748   1 LLDALSSDFTSSSAAPKPKKPAPKAEKSSAAAA---------------LAGEVVSAASASSVKSAAPPPEKKRKDE--VM 63
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1207159541 437 EDPFSALGDTLSAPEPpKKQPDLKPKDIVHEKdVTSKKGVRVGERDDTLPPEYR--FKEEDLKKYPPP 502
Cdd:pfam00748  64 DDALDALSDTLGGREP-DPEEDKPPVDKVKEK-AKEEKREKLGERDDTIPPEYRllPAKDKDGKPLLP 129
Calpain_inhib pfam00748
Calpain inhibitor; This region is found multiple times in calpain inhibitor proteins.
513-655 3.66e-13

Calpain inhibitor; This region is found multiple times in calpain inhibitor proteins.


Pssm-ID: 459923 [Multi-domain]  Cd Length: 129  Bit Score: 66.95  E-value: 3.66e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207159541 513 ALDILSGDFTTPSAPSAVSPASKSSAKSSDSalDALAGDFVASSSASSVHSAVSGPPRSDRLLsdGTSSALDALSETLGD 592
Cdd:pfam00748   1 LLDALSSDFTSSSAAPKPKKPAPKAEKSSAA--AALAGEVVSAASASSVKSAAPPPEKKRKDE--VMDDALDALSDTLGG 76
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1207159541 593 IKAAPEPaPVLPKTVVKEKtVIEERVSKPGERDDSLPPDQRftaedrkaFEEAKKKDAKPKQP 655
Cdd:pfam00748  77 REPDPEE-DKPPVDKVKEK-AKEEKREKLGERDDTIPPEYR--------LLPAKDKDGKPLLP 129
Calpain_inhib pfam00748
Calpain inhibitor; This region is found multiple times in calpain inhibitor proteins.
190-346 3.30e-12

Calpain inhibitor; This region is found multiple times in calpain inhibitor proteins.


Pssm-ID: 459923 [Multi-domain]  Cd Length: 129  Bit Score: 64.26  E-value: 3.30e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207159541 190 ALESLSSTFVSPAQAAPKKTDVKTETigavdvKSAGTTNfappppsQQKQPASSQAAAVTKSPAPPADKKAKMEthaqpa 269
Cdd:pfam00748   1 LLDALSSDFTSSSAAPKPKKPAPKAE------KSSAAAA-------LAGEVVSAASASSVKSAAPPPEKKRKDE------ 61
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1207159541 270 kaktesdssISLDALDALSDTLGASKPPQKlPELKPGQIVDEKkQTSEKGVRVGERDDTLPPQYR--FKEEDLKKYPPP 346
Cdd:pfam00748  62 ---------VMDDALDALSDTLGGREPDPE-EDKPPVDKVKEK-AKEEKREKLGERDDTIPPEYRllPAKDKDGKPLLP 129
Calpain_inhib pfam00748
Calpain inhibitor; This region is found multiple times in calpain inhibitor proteins.
59-172 2.00e-09

Calpain inhibitor; This region is found multiple times in calpain inhibitor proteins.


Pssm-ID: 459923 [Multi-domain]  Cd Length: 129  Bit Score: 56.17  E-value: 2.00e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207159541  59 ATQSSTAAATVKSGAGDPATTQKGSSQVKPQVQVEVGPSAAKV-SADADDPFDALSGTLPSSQPLAPKVHYTGPEIKEpK 137
Cdd:pfam00748  16 PKPKKPAPKAEKSSAAAALAGEVVSAASASSVKSAAPPPEKKRkDEVMDDALDALSDTLGGREPDPEEDKPPVDKVKE-K 94
                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1207159541 138 LKSEKGVLCGERDDTLPPGYRKEDLEKKHGAGVPA 172
Cdd:pfam00748  95 AKEEKREKLGERDDTIPPEYRLLPAKDKDGKPLLP 129
PRK10263 PRK10263
DNA translocase FtsK; Provisional
32-218 4.15e-03

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 40.84  E-value: 4.15e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207159541   32 YPIESQQVTPTTTSQVSTVKPAQYEKGATQSSTAAATVKSGAGDPATTQKGSSQVKPQVQvEVGPSAAKVSADADDPFDA 111
Cdd:PRK10263   380 YPQQSQYAQPAVQYNEPLQQPVQPQQPYYAPAAEQPAQQPYYAPAPEQPAQQPYYAPAPE-QPVAGNAWQAEEQQSTFAP 458
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207159541  112 LSGTLPSS---QPLAPKVHYTGPEIKEPKLKSEKGVLCGERDDTLPPGYRKEDLEKKHG------AGVPAGVPEKPKE-V 181
Cdd:PRK10263   459 QSTYQTEQtyqQPAAQEPLYQQPQPVEQQPVVEPEPVVEETKPARPPLYYFEEVEEKRArereqlAAWYQPIPEPVKEpE 538
                          170       180       190
                   ....*....|....*....|....*....|....*..
gi 1207159541  182 PKPISTDDALESLSSTFVSPAQAAPKKTDVKTETIGA 218
Cdd:PRK10263   539 PIKSSLKAPSVAAVPPVEAAAAVSPLASGVKKATLAT 575
 
Name Accession Description Interval E-value
Calpain_inhib pfam00748
Calpain inhibitor; This region is found multiple times in calpain inhibitor proteins.
357-502 8.09e-22

Calpain inhibitor; This region is found multiple times in calpain inhibitor proteins.


Pssm-ID: 459923 [Multi-domain]  Cd Length: 129  Bit Score: 91.61  E-value: 8.09e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207159541 357 AMDILSGDFTTPASAPVVKAPVPPAQDTKKHAAvpektkdipktkadaLSSDFVAPAHSAPKVSSAAPKTIPPGPPqtPD 436
Cdd:pfam00748   1 LLDALSSDFTSSSAAPKPKKPAPKAEKSSAAAA---------------LAGEVVSAASASSVKSAAPPPEKKRKDE--VM 63
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1207159541 437 EDPFSALGDTLSAPEPpKKQPDLKPKDIVHEKdVTSKKGVRVGERDDTLPPEYR--FKEEDLKKYPPP 502
Cdd:pfam00748  64 DDALDALSDTLGGREP-DPEEDKPPVDKVKEK-AKEEKREKLGERDDTIPPEYRllPAKDKDGKPLLP 129
Calpain_inhib pfam00748
Calpain inhibitor; This region is found multiple times in calpain inhibitor proteins.
513-655 3.66e-13

Calpain inhibitor; This region is found multiple times in calpain inhibitor proteins.


Pssm-ID: 459923 [Multi-domain]  Cd Length: 129  Bit Score: 66.95  E-value: 3.66e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207159541 513 ALDILSGDFTTPSAPSAVSPASKSSAKSSDSalDALAGDFVASSSASSVHSAVSGPPRSDRLLsdGTSSALDALSETLGD 592
Cdd:pfam00748   1 LLDALSSDFTSSSAAPKPKKPAPKAEKSSAA--AALAGEVVSAASASSVKSAAPPPEKKRKDE--VMDDALDALSDTLGG 76
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1207159541 593 IKAAPEPaPVLPKTVVKEKtVIEERVSKPGERDDSLPPDQRftaedrkaFEEAKKKDAKPKQP 655
Cdd:pfam00748  77 REPDPEE-DKPPVDKVKEK-AKEEKREKLGERDDTIPPEYR--------LLPAKDKDGKPLLP 129
Calpain_inhib pfam00748
Calpain inhibitor; This region is found multiple times in calpain inhibitor proteins.
190-346 3.30e-12

Calpain inhibitor; This region is found multiple times in calpain inhibitor proteins.


Pssm-ID: 459923 [Multi-domain]  Cd Length: 129  Bit Score: 64.26  E-value: 3.30e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207159541 190 ALESLSSTFVSPAQAAPKKTDVKTETigavdvKSAGTTNfappppsQQKQPASSQAAAVTKSPAPPADKKAKMEthaqpa 269
Cdd:pfam00748   1 LLDALSSDFTSSSAAPKPKKPAPKAE------KSSAAAA-------LAGEVVSAASASSVKSAAPPPEKKRKDE------ 61
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1207159541 270 kaktesdssISLDALDALSDTLGASKPPQKlPELKPGQIVDEKkQTSEKGVRVGERDDTLPPQYR--FKEEDLKKYPPP 346
Cdd:pfam00748  62 ---------VMDDALDALSDTLGGREPDPE-EDKPPVDKVKEK-AKEEKREKLGERDDTIPPEYRllPAKDKDGKPLLP 129
Calpain_inhib pfam00748
Calpain inhibitor; This region is found multiple times in calpain inhibitor proteins.
59-172 2.00e-09

Calpain inhibitor; This region is found multiple times in calpain inhibitor proteins.


Pssm-ID: 459923 [Multi-domain]  Cd Length: 129  Bit Score: 56.17  E-value: 2.00e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207159541  59 ATQSSTAAATVKSGAGDPATTQKGSSQVKPQVQVEVGPSAAKV-SADADDPFDALSGTLPSSQPLAPKVHYTGPEIKEpK 137
Cdd:pfam00748  16 PKPKKPAPKAEKSSAAAALAGEVVSAASASSVKSAAPPPEKKRkDEVMDDALDALSDTLGGREPDPEEDKPPVDKVKE-K 94
                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1207159541 138 LKSEKGVLCGERDDTLPPGYRKEDLEKKHGAGVPA 172
Cdd:pfam00748  95 AKEEKREKLGERDDTIPPEYRLLPAKDKDGKPLLP 129
PRK10263 PRK10263
DNA translocase FtsK; Provisional
32-218 4.15e-03

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 40.84  E-value: 4.15e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207159541   32 YPIESQQVTPTTTSQVSTVKPAQYEKGATQSSTAAATVKSGAGDPATTQKGSSQVKPQVQvEVGPSAAKVSADADDPFDA 111
Cdd:PRK10263   380 YPQQSQYAQPAVQYNEPLQQPVQPQQPYYAPAAEQPAQQPYYAPAPEQPAQQPYYAPAPE-QPVAGNAWQAEEQQSTFAP 458
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207159541  112 LSGTLPSS---QPLAPKVHYTGPEIKEPKLKSEKGVLCGERDDTLPPGYRKEDLEKKHG------AGVPAGVPEKPKE-V 181
Cdd:PRK10263   459 QSTYQTEQtyqQPAAQEPLYQQPQPVEQQPVVEPEPVVEETKPARPPLYYFEEVEEKRArereqlAAWYQPIPEPVKEpE 538
                          170       180       190
                   ....*....|....*....|....*....|....*..
gi 1207159541  182 PKPISTDDALESLSSTFVSPAQAAPKKTDVKTETIGA 218
Cdd:PRK10263   539 PIKSSLKAPSVAAVPPVEAAAAVSPLASGVKKATLAT 575
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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